Page last updated: 2024-10-25

clonidine and Acute Pain

clonidine has been researched along with Acute Pain in 8 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.

Research Excerpts

ExcerptRelevanceReference
"Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain."9.30A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019)
"Tizanidine is a centrally acting α2-agonist with muscle relaxant properties."6.82Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016)
"Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain."5.30A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019)
"Tizanidine is a centrally acting α2-agonist with muscle relaxant properties."2.82Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016)
"The frequency of neuropathic pain was assessed using the Douleur Neuropathique 4-question survey (DN4) in the first and second postoperative months."2.78Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain. ( Abdel-Ghaffar, HS; Mohamed, SA, 2013)
"Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic."2.49Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (87.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Ratnasekara, V1
Weinberg, L1
Johnston, SA1
Fletcher, L1
Nugraha, P1
Cox, DRA1
Hu, R1
Meyer, I1
Yoshino, O1
Perini, MV1
Muralidharan, V1
Nikfarjam, M1
Lee, DK1
Dayan, L1
Hochberg, U1
Nahman-Averbuch, H1
Brill, S1
Ablin, JN1
Jacob, G1
Friedman, BW1
Irizarry, E1
Solorzano, C1
Zias, E1
Pearlman, S1
Wollowitz, A1
Jones, MP1
Shah, PD1
Gallagher, EJ1
Landau, R1
Bollag, L1
Ortner, C1
Beltrán-Villalobos, KL1
Ramírez-Marín, PM1
Cruz, CA1
Déciga-Campos, M1
Yazicioğlu, D1
Caparlar, C1
Akkaya, T1
Mercan, U1
Kulaçoğlu, H1
Engelman, E1
Marsala, C1
Mohamed, SA1
Abdel-Ghaffar, HS1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain: A Randomized Trial[NCT03068897]Phase 4320 participants (Actual)Interventional2017-05-03Completed
Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy[NCT02016443]Phase 430 participants (Actual)Interventional2013-11-30Completed
Preemptive Single Dose Tizanidine and Ultrasound Guided Superficial Cervical Block on Pain After Thyroidectomy[NCT02725359]Phase 460 participants (Actual)Interventional2016-04-30Completed
Dexmedetomidine Comme Adjuvant à la rachianesthésie Lors de césariennes électives : Une étude Pilote[NCT05099055]Phase 342 participants (Actual)Interventional2022-03-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Functional Impairment as Measured by the Roland Morris Disability Questionnaire (RMDQ)

"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT03068897)
Timeframe: Baseline and 7 days

Interventionunits on a scale (Mean)
Metaxalone10.1
Tizanidine11.2
Baclofen10.6
Placebo11.1

Levels of Disability

Disability will be assessed with the Roland-Morris Disability Questionnaire (RMDQ) where patients are asked to tick a box if they agree with 24 statements regarding their ability to perform certain activities (dressing, housework, walking). If the don't agree with the statement (able to perform those activities) they need to leave the tick-box blank or unchecked. Every agreement (tick) counts as a point and an absolute value is formed (min: 0, max: 24). The higher the value the higher the disability level. (NCT03068897)
Timeframe: 7 days

Interventionunits on a scale (Median)
Metaxalone5
Tizanidine3
Baclofen6
Placebo3

Number of Participants Who Experience Change in Low Back Pain

Change is assessed by verbal numerical scale of which 0 represents no pain and 10 represents the worst pain imaginable between the baseline ED visit and the one week follow-up (baseline - 1 week ). The baseline questions will refer to the time period immediately prior to ED presentation (Before you came to the ER today, were you able to…..) (NCT03068897)
Timeframe: Baseline and 7 days

InterventionParticipants (Count of Participants)
Metaxalone28
Tizanidine25
Baclofen26
Placebo22

Number of Participants With Need for Medication for Low Back Pain

Patients will be asked what medications they have used for low back pain (NCT03068897)
Timeframe: 7 days

InterventionParticipants (Count of Participants)
Metaxalone49
Tizanidine48
Baclofen49
Placebo46

Reviews

2 reviews available for clonidine and Acute Pain

ArticleYear
Chronic pain after childbirth.
    International journal of obstetric anesthesia, 2013, Volume: 22, Issue:2

    Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea

2013
Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis.
    British journal of anaesthesia, 2013, Volume: 110, Issue:1

    Topics: Acute Pain; Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Endpoint Determination; Fentan

2013

Trials

4 trials available for clonidine and Acute Pain

ArticleYear
Increased Sympathetic Outflow Induces Adaptation to Acute Experimental Pain.
    Pain practice : the official journal of World Institute of Pain, 2018, Volume: 18, Issue:3

    Topics: Acute Pain; Adaptation, Physiological; Adult; Blood Pressure; Clonidine; Female; Heart Rate; Humans;

2018
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
    Annals of emergency medicine, 2019, Volume: 74, Issue:4

    Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Baclofen; Clonidine; Double-Blind Method; Drug Therapy,

2019
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
    European journal of anaesthesiology, 2016, Volume: 33, Issue:3

    Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni

2016
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
    European journal of anaesthesiology, 2016, Volume: 33, Issue:3

    Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni

2016
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
    European journal of anaesthesiology, 2016, Volume: 33, Issue:3

    Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni

2016
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
    European journal of anaesthesiology, 2016, Volume: 33, Issue:3

    Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni

2016
Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:1

    Topics: Acute Pain; Administration, Topical; Adult; Analgesics; Anesthetics, Local; Breast Neoplasms; Bupiva

2013

Other Studies

2 other studies available for clonidine and Acute Pain

ArticleYear
Multimodal intrathecal analgesia (MITA) with morphine for reducing postoperative opioid use and acute pain following hepato-pancreato-biliary surgery: A multicenter retrospective study.
    PloS one, 2023, Volume: 18, Issue:9

    Topics: Acute Pain; Analgesia; Analgesics, Opioid; Bupivacaine; Clonidine; Humans; Morphine; Opioid-Related

2023
Coadministration of tramadol and tizanidine in an experimental acute pain model in rat.
    Drug development research, 2014, Volume: 75, Issue:8

    Topics: Acute Pain; Analgesics; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug

2014