clonidine has been researched along with Acute Pain in 8 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain." | 9.30 | A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019) |
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 6.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "Adding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain." | 5.30 | A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain. ( Friedman, BW; Gallagher, EJ; Irizarry, E; Jones, MP; Pearlman, S; Shah, PD; Solorzano, C; Wollowitz, A; Zias, E, 2019) |
| "Tizanidine is a centrally acting α2-agonist with muscle relaxant properties." | 2.82 | Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial. ( Akkaya, T; Caparlar, C; Kulaçoğlu, H; Mercan, U; Yazicioğlu, D, 2016) |
| "The frequency of neuropathic pain was assessed using the Douleur Neuropathique 4-question survey (DN4) in the first and second postoperative months." | 2.78 | Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain. ( Abdel-Ghaffar, HS; Mohamed, SA, 2013) |
| "Recent awareness that chronic pain may occur after childbirth has prompted clinicians and researchers to investigate this topic." | 2.49 | Chronic pain after childbirth. ( Bollag, L; Landau, R; Ortner, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Ratnasekara, V | 1 |
| Weinberg, L | 1 |
| Johnston, SA | 1 |
| Fletcher, L | 1 |
| Nugraha, P | 1 |
| Cox, DRA | 1 |
| Hu, R | 1 |
| Meyer, I | 1 |
| Yoshino, O | 1 |
| Perini, MV | 1 |
| Muralidharan, V | 1 |
| Nikfarjam, M | 1 |
| Lee, DK | 1 |
| Dayan, L | 1 |
| Hochberg, U | 1 |
| Nahman-Averbuch, H | 1 |
| Brill, S | 1 |
| Ablin, JN | 1 |
| Jacob, G | 1 |
| Friedman, BW | 1 |
| Irizarry, E | 1 |
| Solorzano, C | 1 |
| Zias, E | 1 |
| Pearlman, S | 1 |
| Wollowitz, A | 1 |
| Jones, MP | 1 |
| Shah, PD | 1 |
| Gallagher, EJ | 1 |
| Landau, R | 1 |
| Bollag, L | 1 |
| Ortner, C | 1 |
| Beltrán-Villalobos, KL | 1 |
| Ramírez-Marín, PM | 1 |
| Cruz, CA | 1 |
| Déciga-Campos, M | 1 |
| Yazicioğlu, D | 1 |
| Caparlar, C | 1 |
| Akkaya, T | 1 |
| Mercan, U | 1 |
| Kulaçoğlu, H | 1 |
| Engelman, E | 1 |
| Marsala, C | 1 |
| Mohamed, SA | 1 |
| Abdel-Ghaffar, HS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain: A Randomized Trial[NCT03068897] | Phase 4 | 320 participants (Actual) | Interventional | 2017-05-03 | Completed | ||
| Investigation of the Effectiveness of Tizanidine on Pain After Herniorrhaphy[NCT02016443] | Phase 4 | 30 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Preemptive Single Dose Tizanidine and Ultrasound Guided Superficial Cervical Block on Pain After Thyroidectomy[NCT02725359] | Phase 4 | 60 participants (Actual) | Interventional | 2016-04-30 | Completed | ||
| Dexmedetomidine Comme Adjuvant à la rachianesthésie Lors de césariennes électives : Une étude Pilote[NCT05099055] | Phase 3 | 42 participants (Actual) | Interventional | 2022-03-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The Roland Morris Disability Questionnaire (RMDQ) is a 24 item instrument that evaluates the impact of low back pain on one's daily life. It is most sensitive for patients with mild to moderate disability due to acute, sub-acute or chronic low back pain. Each question can be answered as either a yes or no. The score ranges from 0 to 24 where a higher score reflects greater impairment and, therefore, worsening in the quality of life. The change in RMDQ is obtained by subtracting the RMDQ score at one week after discharge from the baseline score." (NCT03068897)
Timeframe: Baseline and 7 days
| Intervention | units on a scale (Mean) |
|---|---|
| Metaxalone | 10.1 |
| Tizanidine | 11.2 |
| Baclofen | 10.6 |
| Placebo | 11.1 |
Disability will be assessed with the Roland-Morris Disability Questionnaire (RMDQ) where patients are asked to tick a box if they agree with 24 statements regarding their ability to perform certain activities (dressing, housework, walking). If the don't agree with the statement (able to perform those activities) they need to leave the tick-box blank or unchecked. Every agreement (tick) counts as a point and an absolute value is formed (min: 0, max: 24). The higher the value the higher the disability level. (NCT03068897)
Timeframe: 7 days
| Intervention | units on a scale (Median) |
|---|---|
| Metaxalone | 5 |
| Tizanidine | 3 |
| Baclofen | 6 |
| Placebo | 3 |
Change is assessed by verbal numerical scale of which 0 represents no pain and 10 represents the worst pain imaginable between the baseline ED visit and the one week follow-up (baseline - 1 week ). The baseline questions will refer to the time period immediately prior to ED presentation (Before you came to the ER today, were you able to…..) (NCT03068897)
Timeframe: Baseline and 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metaxalone | 28 |
| Tizanidine | 25 |
| Baclofen | 26 |
| Placebo | 22 |
Patients will be asked what medications they have used for low back pain (NCT03068897)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Metaxalone | 49 |
| Tizanidine | 48 |
| Baclofen | 49 |
| Placebo | 46 |
2 reviews available for clonidine and Acute Pain
| Article | Year |
|---|---|
Chronic pain after childbirth.
Topics: Acute Pain; Adrenergic alpha-Agonists; Adult; Amines; Analgesics; Anesthetics, Dissociative; Cesarea | 2013 |
Efficacy of adding clonidine to intrathecal morphine in acute postoperative pain: meta-analysis.
Topics: Acute Pain; Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Endpoint Determination; Fentan | 2013 |
4 trials available for clonidine and Acute Pain
| Article | Year |
|---|---|
Increased Sympathetic Outflow Induces Adaptation to Acute Experimental Pain.
Topics: Acute Pain; Adaptation, Physiological; Adult; Blood Pressure; Clonidine; Female; Heart Rate; Humans; | 2018 |
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain.
Topics: Acute Pain; Adult; Analgesics, Non-Narcotic; Baclofen; Clonidine; Double-Blind Method; Drug Therapy, | 2019 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial.
Topics: Acute Pain; Adult; Aged; Analgesics; Clonidine; Double-Blind Method; Female; Hernia, Inguinal; Herni | 2016 |
Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain.
Topics: Acute Pain; Administration, Topical; Adult; Analgesics; Anesthetics, Local; Breast Neoplasms; Bupiva | 2013 |
2 other studies available for clonidine and Acute Pain
| Article | Year |
|---|---|
Multimodal intrathecal analgesia (MITA) with morphine for reducing postoperative opioid use and acute pain following hepato-pancreato-biliary surgery: A multicenter retrospective study.
Topics: Acute Pain; Analgesia; Analgesics, Opioid; Bupivacaine; Clonidine; Humans; Morphine; Opioid-Related | 2023 |
Coadministration of tramadol and tizanidine in an experimental acute pain model in rat.
Topics: Acute Pain; Analgesics; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |