clonidine has been researched along with Acute Kidney Injury in 16 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury." | 9.19 | Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. ( Acedillo, R; Amir, M; Bergese, S; Biccard, B; Bidgoli, SJ; Cata, JP; Cegarra, V; Chan, MT; Chan, V; Clanchet, Mde N; Cuerden, M; Devereaux, PJ; Dresser, G; Fleischmann, E; Font, A; Forget, P; Garg, AX; Gomez, MF; Jones, PM; Kumar, P; Kurz, A; Leslie, K; Malaga, G; Martinsen, K; Mehra, B; Meyhoff, CS; Mizera, R; Mrkobrada, M; Myles, P; Painter, T; Parikh, CR; Parlow, J; Pasin, L; Robinson, A; Roshanov, PS; Sessler, DI; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Walsh, M; Whitlock, R; Wijeysundera, DN; Yusuf, S, 2014) |
| "Clonidine treatment resulted in less outer medullary microvascular damage (demonstrated by colloidal carbon staining), higher outer medullary blood flow 1 to 2 hours after unclamping, fewer casts, and higher creatinine clearance and free water clearance/creatinine clearance 4 to 6 hours after unclamping compared with controls." | 5.26 | Clonidine after renal ischemia to lessen acute renal failure and microvascular damage. ( Hamilton, B; Ideura, T; Saito, H; Silvia, CB; Solez, K, 1980) |
| "To determine whether aspirin compared with placebo, and clonidine compared with placebo, alters the risk of perioperative acute kidney injury." | 5.19 | Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial. ( Acedillo, R; Amir, M; Bergese, S; Biccard, B; Bidgoli, SJ; Cata, JP; Cegarra, V; Chan, MT; Chan, V; Clanchet, Mde N; Cuerden, M; Devereaux, PJ; Dresser, G; Fleischmann, E; Font, A; Forget, P; Garg, AX; Gomez, MF; Jones, PM; Kumar, P; Kurz, A; Leslie, K; Malaga, G; Martinsen, K; Mehra, B; Meyhoff, CS; Mizera, R; Mrkobrada, M; Myles, P; Painter, T; Parikh, CR; Parlow, J; Pasin, L; Robinson, A; Roshanov, PS; Sessler, DI; Srinathan, S; Tiboni, M; Torres, D; VanHelder, T; Villar, JC; Walsh, M; Whitlock, R; Wijeysundera, DN; Yusuf, S, 2014) |
| "Because of acute renal failure resulting from rhabdomyolysis hemodialysis was necessary three times." | 1.35 | ["Liquid ecstasy": gamma-butyrolactone withdrawal delirium with rhabdomyolysis and dialysis dependent renal failure]. ( Busch, HJ; Schwab, T; Supady, A, 2009) |
| "Clonidine treatment resulted in fewer, shorter, and thinner hyaline casts." | 1.26 | The effect of clonidine on tubular obstruction in postischemic acute renal failure in the rabbit demonstrated by microradiography and microdissection. ( Heptinstall, RH; Ideura, T; Solez, K, 1980) |
| "Clonidine treatment resulted in less outer medullary microvascular damage (demonstrated by colloidal carbon staining), higher outer medullary blood flow 1 to 2 hours after unclamping, fewer casts, and higher creatinine clearance and free water clearance/creatinine clearance 4 to 6 hours after unclamping compared with controls." | 1.26 | Clonidine after renal ischemia to lessen acute renal failure and microvascular damage. ( Hamilton, B; Ideura, T; Saito, H; Silvia, CB; Solez, K, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Calzavacca, P | 1 |
| Booth, LC | 1 |
| Lankadeva, YR | 1 |
| Bailey, SR | 1 |
| Burrell, LM | 1 |
| Bailey, M | 1 |
| Bellomo, R | 1 |
| May, CN | 1 |
| Garg, AX | 3 |
| Kurz, A | 2 |
| Sessler, DI | 3 |
| Cuerden, M | 2 |
| Robinson, A | 2 |
| Mrkobrada, M | 2 |
| Parikh, C | 1 |
| Mizera, R | 2 |
| Jones, PM | 2 |
| Tiboni, M | 2 |
| Rodriguez, RG | 1 |
| Popova, E | 1 |
| Rojas Gomez, MF | 1 |
| Meyhoff, CS | 2 |
| Vanhelder, T | 2 |
| Chan, MT | 2 |
| Torres, D | 2 |
| Parlow, J | 2 |
| de Nadal Clanchet, M | 1 |
| Amir, M | 2 |
| Bidgoli, SJ | 2 |
| Pasin, L | 2 |
| Martinsen, K | 2 |
| Malaga, G | 2 |
| Myles, P | 2 |
| Acedillo, R | 2 |
| Roshanov, P | 1 |
| Walsh, M | 2 |
| Dresser, G | 2 |
| Kumar, P | 2 |
| Fleischmann, E | 2 |
| Villar, JC | 2 |
| Painter, T | 2 |
| Biccard, B | 2 |
| Bergese, S | 2 |
| Srinathan, S | 2 |
| Cata, JP | 2 |
| Chan, V | 2 |
| Mehra, B | 2 |
| Leslie, K | 2 |
| Whitlock, R | 2 |
| Devereaux, PJ | 3 |
| Parikh, CR | 1 |
| Font, A | 1 |
| Cegarra, V | 1 |
| Gomez, MF | 1 |
| Clanchet, Mde N | 1 |
| Roshanov, PS | 1 |
| Wijeysundera, DN | 1 |
| Forget, P | 1 |
| Yusuf, S | 1 |
| Winkelmayer, WC | 1 |
| Finkel, KW | 1 |
| Allison, SJ | 1 |
| Sun, J | 1 |
| Liu, H | 1 |
| Supady, A | 1 |
| Schwab, T | 1 |
| Busch, HJ | 1 |
| Yigiter, M | 1 |
| Yildiz, A | 1 |
| Polat, B | 1 |
| Alp, HH | 1 |
| Keles, ON | 1 |
| Salman, AB | 1 |
| Suleyman, H | 1 |
| Arora, P | 1 |
| Kolli, H | 1 |
| Nainani, N | 1 |
| Nader, N | 1 |
| Lohr, J | 1 |
| Eknoyan, G | 2 |
| Bulger, RE | 2 |
| Dobyan, DC | 2 |
| Senekjian, HO | 1 |
| Antoszewski, Z | 1 |
| Bross, W | 1 |
| Wlodarski, JM | 1 |
| Ideura, T | 2 |
| Solez, K | 2 |
| Heptinstall, RH | 1 |
| Leroux-Robert, C | 1 |
| Charmes, JP | 1 |
| Benevent, D | 1 |
| Rince, M | 1 |
| Silvia, CB | 1 |
| Hamilton, B | 1 |
| Saito, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Large, International, Placebo-controlled, Factorial Trial to Assess the Impact of Clonidine and Acetyl-salicylic Acid (ASA) in Patients Undergoing Noncardiac Surgery Who Are at Risk of a Perioperative Cardiovascular Event[NCT01082874] | Phase 3 | 10,010 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01082874)
Timeframe: 30 days
| Intervention | participants (Number) |
|---|---|
| Active Clonidine and Active ASA | 173 |
| Active Clonidine and Placebo ASA | 194 |
| Placebo Clonidine and Active ASA | 178 |
| Placebo Clonidine and Placebo ASA | 161 |
1 review available for clonidine and Acute Kidney Injury
| Article | Year |
|---|---|
Preventable risk factors for acute kidney injury in patients undergoing cardiac surgery.
Topics: Acute Kidney Injury; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Asp | 2012 |
2 trials available for clonidine and Acute Kidney Injury
| Article | Year |
|---|---|
Aspirin and clonidine in non-cardiac surgery: acute kidney injury substudy protocol of the Perioperative Ischaemic Evaluation (POISE) 2 randomised controlled trial.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Anti-Inflammatory Agents, Non-Steroidal; | 2014 |
Perioperative aspirin and clonidine and risk of acute kidney injury: a randomized clinical trial.
Topics: Acute Kidney Injury; Administration, Cutaneous; Administration, Oral; Adrenergic alpha-2 Receptor Ag | 2014 |
13 other studies available for clonidine and Acute Kidney Injury
| Article | Year |
|---|---|
Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia.
Topics: Acute Kidney Injury; Animals; Arginine Vasopressin; Bacteremia; Cardiac Output; Clonidine; Disease M | 2019 |
Prevention of acute kidney injury using vasoactive or antiplatelet treatment: three strikes and out?
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aspirin; Cardiac Surgical Procedures; Clo | 2014 |
Acute kidney injury: Effect of perioperative aspirin and clonidine on AKI.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Male; | 2015 |
Perioperative treatment with aspirin or clonidine and risk of acute kidney injury.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Male; | 2015 |
Perioperative treatment with aspirin or clonidine and risk of acute kidney injury--reply.
Topics: Acute Kidney Injury; Adrenergic alpha-2 Receptor Agonists; Aspirin; Clonidine; Female; Humans; Male; | 2015 |
["Liquid ecstasy": gamma-butyrolactone withdrawal delirium with rhabdomyolysis and dialysis dependent renal failure].
Topics: 4-Butyrolactone; Acute Kidney Injury; Adrenergic alpha-Agonists; Benzodiazepines; Clonidine; GABA Mo | 2009 |
The protective effects of metyrosine, lacidipine, clonidine, and moxonidine on kidney damage induced by unilateral ureteral obstruction in rats.
Topics: Acute Kidney Injury; alpha-Methyltyrosine; Animals; Biopsy, Needle; Clonidine; Dihydropyridines; Dis | 2012 |
Mercuric chloride-induced acute renal failure in the rat. I. Correlation of functional and morphologic changes and their modification by clonidine.
Topics: Acute Kidney Injury; Animals; Clonidine; Glomerular Filtration Rate; Kidney; Kidney Tubules, Proxima | 1982 |
Protective effect of oral clonidine in the prophylaxis and therapy of mercuric chloride--induced acute renal failure in the rat.
Topics: Acute Kidney Injury; Animals; Clonidine; Creatinine; Kidney Concentrating Ability; Kidney Tubules; M | 1983 |
[Preparation of patients with arterial hypertension for surgical interventions].
Topics: Acute Kidney Injury; Adolescent; Adult; Clonidine; Female; Hip; Humans; Hypertension; Male; Middle A | 1981 |
The effect of clonidine on tubular obstruction in postischemic acute renal failure in the rabbit demonstrated by microradiography and microdissection.
Topics: Acute Kidney Injury; Animals; Clonidine; Creatinine; Female; Ischemia; Kidney; Kidney Tubules; Micro | 1980 |
[Treatment of malignant arterial hypertension].
Topics: Acute Kidney Injury; Clonidine; Diazoxide; Dihydralazine; Diuretics; Humans; Hypertension, Malignant | 1980 |
Clonidine after renal ischemia to lessen acute renal failure and microvascular damage.
Topics: Acute Kidney Injury; Animals; Clonidine; Creatinine; Disease Models, Animal; Diuresis; Female; Ische | 1980 |