clonidine has been researched along with Acute Brain Injuries in 13 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 8.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| "Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)." | 4.84 | A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008) |
| " The experience with six patients, aged 17-73 years, treated with clonidine for spasticity due to brain injuries of various causes is presented." | 3.69 | Use of clonidine for treatment of spasticity arising from various forms of brain injury: a case series. ( Dall, JT; Harmon, RL; Quinn, CM, 1996) |
| " The average dosage at 4 weeks was 25." | 2.70 | Prospective assessment of tizanidine for spasticity due to acquired brain injury. ( Brunner, RM; Guin-Renfroe, S; Johnson, A; Meythaler, JM, 2001) |
| "Akathisia is also a rare cause of psychomotor agitation in patients with traumatic brain injury (TBI)." | 2.48 | Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature. ( Ribbers, GM; Wielenga-Boiten, JE, 2012) |
| " Planned subgroup analyses include specific alpha-2 agonist agent, study design, clinical diagnosis, dosing regimen, and use of adjunctive agents." | 1.43 | Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol. ( Blinder, H; English, S; Hutton, B; Tran, A, 2016) |
| "To describe the successful treatment of PTSD associated nightmares in two patients with PTSD." | 1.38 | The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury. ( Alao, A; Razi, S; Selvarajah, J, 2012) |
| " Secondary objectives included determining correlations between dosage and age, injury type, location of spasticity, comorbid seizures, or concomitant antispasticity medications." | 1.33 | Oral baclofen and clonidine for treatment of spasticity in children. ( Haase, M; Habersang, R; Lubsch, L; Luedtke, S, 2006) |
| "Treatment with clonidine significantly slowed the rate of recovery (Kruskal-Wallis H = 8." | 1.28 | Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. ( Davis, JN; Goldstein, LB, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, YY | 1 |
| Gao, YX | 1 |
| Gao, W | 1 |
| Xu, Y | 1 |
| Xu, YZ | 1 |
| Wang, YJ | 1 |
| Chang, S | 1 |
| Yu, LG | 1 |
| Zhang, LY | 1 |
| Liao, H | 1 |
| Yang, LF | 1 |
| Pang, T | 1 |
| Qiu, WW | 1 |
| Wielenga-Boiten, JE | 1 |
| Ribbers, GM | 1 |
| Alao, A | 1 |
| Selvarajah, J | 1 |
| Razi, S | 1 |
| Tran, A | 1 |
| Blinder, H | 1 |
| Hutton, B | 1 |
| English, S | 1 |
| Patel, MB | 1 |
| McKenna, JW | 1 |
| Alvarez, JM | 1 |
| Sugiura, A | 1 |
| Jenkins, JM | 1 |
| Guillamondegui, OD | 1 |
| Pandharipande, PP | 1 |
| Lubsch, L | 1 |
| Habersang, R | 1 |
| Haase, M | 1 |
| Luedtke, S | 1 |
| Kamen, L | 1 |
| Henney, HR | 1 |
| Runyan, JD | 1 |
| Dall, JT | 1 |
| Harmon, RL | 1 |
| Quinn, CM | 1 |
| ter Minassian, A | 1 |
| Beydon, L | 1 |
| Decq, P | 1 |
| Bonnet, F | 1 |
| Meythaler, JM | 1 |
| Guin-Renfroe, S | 1 |
| Johnson, A | 1 |
| Brunner, RM | 1 |
| Elovic, E | 1 |
| Payen, D | 1 |
| Quintin, L | 1 |
| Plaisance, P | 1 |
| Chiron, B | 1 |
| Lhoste, F | 1 |
| Goldstein, LB | 1 |
| Davis, JN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Severe Traumatic Brain Injury, A Pilot Randomized Clinical Trial Using Propranolol and Clonidine[NCT01322048] | Phase 2 | 48 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317] | Phase 4 | 184 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01322048)
Timeframe: Post-treatment (t=Day 8)
| Intervention | pg/mL (Median) |
|---|---|
| Adrenergic Blockade | 962 |
| Placebo | 714 |
(NCT01322048)
Timeframe: Baseline to day 28
| Intervention | days (Median) |
|---|---|
| Adrenergic Blockade | 16.2 |
| Placebo | 18.05 |
3 reviews available for clonidine and Acute Brain Injuries
| Article | Year |
|---|---|
Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Brain Injuries; Clonidine; Female; Humans; Psychomotor | 2012 |
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.
Topics: Brain Injuries; Clonidine; Disease Progression; Drug Interactions; Female; Humans; Middle Aged; Mult | 2008 |
Principles of pharmaceutical management of spastic hypertonia.
Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant | 2001 |
2 trials available for clonidine and Acute Brain Injuries
| Article | Year |
|---|---|
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Biomarkers; Br | 2012 |
Prospective assessment of tizanidine for spasticity due to acquired brain injury.
Topics: Administration, Oral; Adult; Aged; Brain Injuries; Clonidine; Cross-Over Studies; Dose-Response Rela | 2001 |
8 other studies available for clonidine and Acute Brain Injuries
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.
Topics: Animals; Brain Injuries; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Design; G | 2015 |
The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury.
Topics: Adult; Brain Injuries; Clonidine; Combat Disorders; Dreams; Humans; Male; Middle Aged; Stress Disord | 2012 |
Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol.
Topics: Adrenergic alpha-2 Receptor Agonists; Brain Injuries; Clonidine; Conscious Sedation; Critical Care; | 2016 |
Oral baclofen and clonidine for treatment of spasticity in children.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Baclofen; Brain Inj | 2006 |
Use of clonidine for treatment of spasticity arising from various forms of brain injury: a case series.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Brain Injuries; Clonidine; Female; Humans; Male; | 1996 |
Changes in cerebral hemodynamics after a single dose of clonidine in severely head-injured patients.
Topics: Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Blood Pressure; Brain Injuries; Carbon Dioxid | 1997 |
Head injury: clonidine decreases plasma catecholamines.
Topics: Acute Disease; Adult; Blood Flow Velocity; Brain Injuries; Carotid Arteries; Cerebrovascular Circula | 1990 |
Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat.
Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebrovascular Disorders; Clonidine; Disease Models, Anim | 1990 |