Page last updated: 2024-10-25

clonidine and Acute Brain Injuries

clonidine has been researched along with Acute Brain Injuries in 13 studies

Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.

Research Excerpts

ExcerptRelevanceReference
"Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)."8.84A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008)
"Tizanidine is an imidazoline central alpha(2)-adrenoceptor agonist widely used to manage spasticity secondary to conditions such as multiple sclerosis (MS), stroke, and spinal cord injury (SCI)."4.84A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. ( Henney, HR; Kamen, L; Runyan, JD, 2008)
" The experience with six patients, aged 17-73 years, treated with clonidine for spasticity due to brain injuries of various causes is presented."3.69Use of clonidine for treatment of spasticity arising from various forms of brain injury: a case series. ( Dall, JT; Harmon, RL; Quinn, CM, 1996)
" The average dosage at 4 weeks was 25."2.70Prospective assessment of tizanidine for spasticity due to acquired brain injury. ( Brunner, RM; Guin-Renfroe, S; Johnson, A; Meythaler, JM, 2001)
"Akathisia is also a rare cause of psychomotor agitation in patients with traumatic brain injury (TBI)."2.48Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature. ( Ribbers, GM; Wielenga-Boiten, JE, 2012)
" Planned subgroup analyses include specific alpha-2 agonist agent, study design, clinical diagnosis, dosing regimen, and use of adjunctive agents."1.43Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol. ( Blinder, H; English, S; Hutton, B; Tran, A, 2016)
"To describe the successful treatment of PTSD associated nightmares in two patients with PTSD."1.38The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury. ( Alao, A; Razi, S; Selvarajah, J, 2012)
" Secondary objectives included determining correlations between dosage and age, injury type, location of spasticity, comorbid seizures, or concomitant antispasticity medications."1.33Oral baclofen and clonidine for treatment of spasticity in children. ( Haase, M; Habersang, R; Lubsch, L; Luedtke, S, 2006)
"Treatment with clonidine significantly slowed the rate of recovery (Kruskal-Wallis H = 8."1.28Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat. ( Davis, JN; Goldstein, LB, 1990)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (30.77)18.2507
2000's4 (30.77)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, YY1
Gao, YX1
Gao, W1
Xu, Y1
Xu, YZ1
Wang, YJ1
Chang, S1
Yu, LG1
Zhang, LY1
Liao, H1
Yang, LF1
Pang, T1
Qiu, WW1
Wielenga-Boiten, JE1
Ribbers, GM1
Alao, A1
Selvarajah, J1
Razi, S1
Tran, A1
Blinder, H1
Hutton, B1
English, S1
Patel, MB1
McKenna, JW1
Alvarez, JM1
Sugiura, A1
Jenkins, JM1
Guillamondegui, OD1
Pandharipande, PP1
Lubsch, L1
Habersang, R1
Haase, M1
Luedtke, S1
Kamen, L1
Henney, HR1
Runyan, JD1
Dall, JT1
Harmon, RL1
Quinn, CM1
ter Minassian, A1
Beydon, L1
Decq, P1
Bonnet, F1
Meythaler, JM1
Guin-Renfroe, S1
Johnson, A1
Brunner, RM1
Elovic, E1
Payen, D1
Quintin, L1
Plaisance, P1
Chiron, B1
Lhoste, F1
Goldstein, LB1
Davis, JN1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
DASH After TBI Study: Decreasing Adrenergic or Sympathetic Hyperactivity After Severe Traumatic Brain Injury, A Pilot Randomized Clinical Trial Using Propranolol and Clonidine[NCT01322048]Phase 248 participants (Actual)Interventional2011-08-31Completed
Study of the Effects on Motor Recovery of Early Post-stroke Spasticity Treatment: Double Blinded Comparison Between Botulinum Toxin and Baclofen.[NCT02462317]Phase 4184 participants (Actual)Interventional2015-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Plasma Norepinephrine Levels

(NCT01322048)
Timeframe: Post-treatment (t=Day 8)

Interventionpg/mL (Median)
Adrenergic Blockade962
Placebo714

Ventilator-free Days

(NCT01322048)
Timeframe: Baseline to day 28

Interventiondays (Median)
Adrenergic Blockade16.2
Placebo18.05

Reviews

3 reviews available for clonidine and Acute Brain Injuries

ArticleYear
Akathisia--rare cause of psychomotor agitation in patients with traumatic brain injury: case report and review of literature.
    Journal of rehabilitation research and development, 2012, Volume: 49, Issue:9

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Brain Injuries; Clonidine; Female; Humans; Psychomotor

2012
A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury.
    Current medical research and opinion, 2008, Volume: 24, Issue:2

    Topics: Brain Injuries; Clonidine; Disease Progression; Drug Interactions; Female; Humans; Middle Aged; Mult

2008
Principles of pharmaceutical management of spastic hypertonia.
    Physical medicine and rehabilitation clinics of North America, 2001, Volume: 12, Issue:4

    Topics: Anti-Dyskinesia Agents; Baclofen; Benzodiazepines; Botulinum Toxins; Brain Injuries; Clonidine; Dant

2001

Trials

2 trials available for clonidine and Acute Brain Injuries

ArticleYear
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial.
    Trials, 2012, Sep-26, Volume: 13

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Adrenergic Fibers; Biomarkers; Br

2012
Prospective assessment of tizanidine for spasticity due to acquired brain injury.
    Archives of physical medicine and rehabilitation, 2001, Volume: 82, Issue:9

    Topics: Administration, Oral; Adult; Aged; Brain Injuries; Clonidine; Cross-Over Studies; Dose-Response Rela

2001

Other Studies

8 other studies available for clonidine and Acute Brain Injuries

ArticleYear
Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Animals; Brain Injuries; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Design; G

2015
The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury.
    International journal of psychiatry in medicine, 2012, Volume: 44, Issue:2

    Topics: Adult; Brain Injuries; Clonidine; Combat Disorders; Dreams; Humans; Male; Middle Aged; Stress Disord

2012
Alpha-2 agonists for sedation in mechanically ventilated neurocritical care patients: a systematic review protocol.
    Systematic reviews, 2016, 09-08, Volume: 5, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Brain Injuries; Clonidine; Conscious Sedation; Critical Care;

2016
Oral baclofen and clonidine for treatment of spasticity in children.
    Journal of child neurology, 2006, Volume: 21, Issue:12

    Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Age Factors; Baclofen; Brain Inj

2006
Use of clonidine for treatment of spasticity arising from various forms of brain injury: a case series.
    Brain injury, 1996, Volume: 10, Issue:6

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Brain Injuries; Clonidine; Female; Humans; Male;

1996
Changes in cerebral hemodynamics after a single dose of clonidine in severely head-injured patients.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:1

    Topics: Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Blood Pressure; Brain Injuries; Carbon Dioxid

1997
Head injury: clonidine decreases plasma catecholamines.
    Critical care medicine, 1990, Volume: 18, Issue:4

    Topics: Acute Disease; Adult; Blood Flow Velocity; Brain Injuries; Carotid Arteries; Cerebrovascular Circula

1990
Clonidine impairs recovery of beam-walking after a sensorimotor cortex lesion in the rat.
    Brain research, 1990, Feb-05, Volume: 508, Issue:2

    Topics: Animals; Brain Injuries; Cerebral Cortex; Cerebrovascular Disorders; Clonidine; Disease Models, Anim

1990