clonidine has been researched along with Abnormal Deep Tendon Reflex in 13 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "15 mg clonidine (Catapresan) in 11 patients (averaged age 60 years) with symptomatic bradycardia (dizzy spells, syncope, palpitations)." | 3.66 | [Clinidine-induced bradycardia: studies of the effect on the human sinus node (author's transl)]. ( Horn, H; Neuss, H; Schlepper, M; Thormann, J, 1981) |
| " The average dosage at 4 weeks was 25." | 2.70 | Prospective assessment of tizanidine for spasticity due to acquired brain injury. ( Brunner, RM; Guin-Renfroe, S; Johnson, A; Meythaler, JM, 2001) |
| " However, the dose-response curve for clonidine-induced inhibition of the JOR was clearly shifted to the right in rats exposed to repeated tail pinch (ED50 was increased by 152%, P < 0." | 1.30 | Repeated tail pinch leads to desensitization of postsynaptic alpha2-adrenoceptors which modulate the jaw-opening reflex in the rat. ( Areso, P; García-Vallejo, P; Gómez, FM; Infante, C; Magdaleno, F, 1998) |
| " However, chronic variable stress led to an enhancement of the inhibitory effect of clonidine on the amplitude of JOR, resulting in a shift to the left of the dose-response curve in comparison with that of the control group (ED50 was reduced by 37%, P = 0." | 1.30 | Chronic variable stress induces supersensitivity of central alpha2-adrenoceptors which modulate the jaw-opening reflex in the rat. ( García-Vallejo, P; Ginestal, E; Giralt, MT; Gómez, FM; Infante, C, 1998) |
| "Autonomic hyperreflexia occurs in spinal cord injured patients." | 1.27 | Autonomic hyperreflexia in spinal cord injured patients: trigger mechanism--dressing changes of pressure sores. ( Hall, PA; Young, JV, 1983) |
| "The paroxysmal hypertension is believed to have resulted from the synergistic effect of the high levels of circulating catecholamines from the tumor and the disruption of autonomic pathways." | 1.27 | Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma. ( Agre, JC; Theologides, A; Wilson, BC; Wright, KC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sullivan, RW | 1 |
| Ryzewski, M | 1 |
| Holland, MG | 1 |
| Marraffa, JM | 1 |
| Hall, PA | 1 |
| Young, JV | 1 |
| Meinck, HM | 2 |
| Ricker, K | 1 |
| Conrad, B | 2 |
| Thormann, J | 1 |
| Neuss, H | 1 |
| Horn, H | 1 |
| Schlepper, M | 1 |
| Gómez, FM | 2 |
| García-Vallejo, P | 2 |
| Infante, C | 2 |
| Magdaleno, F | 1 |
| Areso, P | 1 |
| Ginestal, E | 1 |
| Giralt, MT | 1 |
| Denys, P | 2 |
| Chartier-Kastler, E | 2 |
| Azouvi, P | 2 |
| Remy-Neris, O | 1 |
| Bussel, B | 2 |
| Yakovleff, A | 1 |
| Richard, F | 1 |
| Meythaler, JM | 1 |
| Guin-Renfroe, S | 1 |
| Johnson, A | 1 |
| Brunner, RM | 1 |
| Fung, J | 1 |
| Stewart, JE | 1 |
| Barbeau, H | 1 |
| Dietz, V | 1 |
| Wright, KC | 1 |
| Agre, JC | 1 |
| Wilson, BC | 1 |
| Theologides, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
1 review available for clonidine and Abnormal Deep Tendon Reflex
| Article | Year |
|---|---|
[Spasticity: therapy of increased reflexes or movement disorder?].
Topics: Baclofen; Clonidine; Combined Modality Therapy; Dantrolene; Diazepam; Glycine; Humans; Locomotion; M | 1990 |
4 trials available for clonidine and Abnormal Deep Tendon Reflex
| Article | Year |
|---|---|
Intrathecal clonidine for refractory detrusor hyperreflexia in spinal cord injured patients: a preliminary report.
Topics: Adrenergic alpha-Agonists; Clonidine; Dose-Response Relationship, Drug; Female; Humans; Injections, | 1998 |
Intrathecal catheter with subcutaneous port for clonidine test bolus injection. A new route and type of treatment for detrusor hyperreflexia in spinal cord-injured patients.
Topics: Adult; Catheters, Indwelling; Clonidine; Feasibility Studies; Female; Humans; Male; Middle Aged; Mus | 2000 |
Prospective assessment of tizanidine for spasticity due to acquired brain injury.
Topics: Administration, Oral; Adult; Aged; Brain Injuries; Clonidine; Cross-Over Studies; Dose-Response Rela | 2001 |
The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects.
Topics: Adult; Biomechanical Phenomena; Clonidine; Combined Modality Therapy; Cyproheptadine; Double-Blind M | 1990 |
8 other studies available for clonidine and Abnormal Deep Tendon Reflex
| Article | Year |
|---|---|
Compounded ointment results in severe toxicity in a pediatric patient.
Topics: Administration, Cutaneous; Amines; Analgesics; Body Surface Area; Bradycardia; Clonidine; Combined M | 2013 |
Autonomic hyperreflexia in spinal cord injured patients: trigger mechanism--dressing changes of pressure sores.
Topics: Adult; Autonomic Nervous System; Bandages; Clonidine; Humans; Male; Pressure Ulcer; Reflex, Abnormal | 1983 |
The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine.
Topics: Adult; Brain Stem; Clomipramine; Clonidine; Diazepam; Electromyography; Female; Humans; Muscle Rigid | 1984 |
[Clinidine-induced bradycardia: studies of the effect on the human sinus node (author's transl)].
Topics: Aged; Arrhythmias, Cardiac; Bradycardia; Carotid Sinus; Clonidine; Female; Heart Rate; Humans; Male; | 1981 |
Repeated tail pinch leads to desensitization of postsynaptic alpha2-adrenoceptors which modulate the jaw-opening reflex in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Jaw; Male; Rats; Ra | 1998 |
Chronic variable stress induces supersensitivity of central alpha2-adrenoceptors which modulate the jaw-opening reflex in the rat.
Topics: Adrenal Glands; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1998 |
Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma.
Topics: Adult; Autonomic Nervous System Diseases; Catecholamines; Clonidine; Humans; Hypertension; Male; Neu | 1986 |
Neuropharmacological investigations in the stiff-man syndrome.
Topics: Adrenergic Fibers; Central Nervous System Diseases; Clonidine; Diazepam; Female; Humans; Methampheta | 1986 |