clonidine has been researched along with ANS (Autonomic Nervous System) Diseases in 41 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the effects of clonidine on blood pressure (BP) and heart rate (HR) in multiple system atrophy (MSA), where the autonomic nervous system lesion site is preganglionic, and in pure autonomic failure (PAF), where it is postganglionic." | 9.12 | Hemodynamic effects of clonidine in two contrasting models of autonomic failure: multiple system atrophy and pure autonomic failure. ( Asahina, M; Mathias, CJ; Watson, L; Young, TM, 2006) |
| "To evaluate the effectiveness of clonidine in the management of unstable blood pressure in severe tetanus." | 9.08 | Management of blood pressure instability in severe tetanus: the use of clonidine. ( Dimopoulos, G; Gregorakos, L; Kerezoudi, E; Thomaides, T, 1997) |
| "In this paper we describe a typical case of tetanus and report our observations with the centrally acting alpha 2-adrenoreceptor agonist clonidine." | 7.69 | Autonomic disturbance in severe tetanus: failure of parenteral clonidine to control blood pressure. ( Brown, JL; Mathias, CJ; Sinding, H, 1994) |
| "Yohimbine (30 mg) produced significant increases in subjective anxiety, autonomic symptoms, blood pressure, and plasma 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) in ten healthy subjects." | 7.66 | Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. ( Charney, DS; Heninger, GR; Redmond, DE, 1983) |
| "Clonidine is felt to be a logical and appropriate drug for the treatment of autonomic dysfunction in severe tetanus." | 6.38 | Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine. ( Nielsen, MS; Sutton, DN; Tremlett, MR; Woodcock, TE, 1990) |
| "The patient was hospitalized for acute disseminated encephalomyelitis in June 2006." | 5.43 | [A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride]. ( Kawamura, N; Kira, J; Murai, H; Shigeto, H; Shimmura, M; Tateishi, T, 2016) |
| "Clonidine is a centrally active alpha 2-adrenoceptor agonist that raises concentrations of GH in serum in healthy people and those with pure autonomic failure (with peripheral lesions), but not in those with MSA (with a central autonomic deficit)." | 5.30 | Distinction of idiopathic Parkinson's disease from multiple-system atrophy by stimulation of growth-hormone release with clonidine. ( Kimber, JR; Mathias, CJ; Watson, L, 1997) |
| "We assessed the effects of clonidine on blood pressure (BP) and heart rate (HR) in multiple system atrophy (MSA), where the autonomic nervous system lesion site is preganglionic, and in pure autonomic failure (PAF), where it is postganglionic." | 5.12 | Hemodynamic effects of clonidine in two contrasting models of autonomic failure: multiple system atrophy and pure autonomic failure. ( Asahina, M; Mathias, CJ; Watson, L; Young, TM, 2006) |
| "To evaluate the effectiveness of clonidine in the management of unstable blood pressure in severe tetanus." | 5.08 | Management of blood pressure instability in severe tetanus: the use of clonidine. ( Dimopoulos, G; Gregorakos, L; Kerezoudi, E; Thomaides, T, 1997) |
| "In this paper we describe a typical case of tetanus and report our observations with the centrally acting alpha 2-adrenoreceptor agonist clonidine." | 3.69 | Autonomic disturbance in severe tetanus: failure of parenteral clonidine to control blood pressure. ( Brown, JL; Mathias, CJ; Sinding, H, 1994) |
| "Yohimbine (30 mg) produced significant increases in subjective anxiety, autonomic symptoms, blood pressure, and plasma 3-methoxy-4-hydroxy-phenylethyleneglycol (MHPG) in ten healthy subjects." | 3.66 | Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine. ( Charney, DS; Heninger, GR; Redmond, DE, 1983) |
| "The authors believe that diencephalic seizures can present with a spectrum of autonomic features, and treatment should be tailored with the appropriate pharmacologic blockade." | 2.40 | Sympathetic storms in a child with a midbrain glioma: a variant of diencephalic seizures. ( Conway, EJ; DaRosso, RC; Epstein, FJ; Goh, KY; Muszynski, CA, 1999) |
| "Clonidine is felt to be a logical and appropriate drug for the treatment of autonomic dysfunction in severe tetanus." | 2.38 | Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine. ( Nielsen, MS; Sutton, DN; Tremlett, MR; Woodcock, TE, 1990) |
| "The patient was hospitalized for acute disseminated encephalomyelitis in June 2006." | 1.43 | [A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride]. ( Kawamura, N; Kira, J; Murai, H; Shigeto, H; Shimmura, M; Tateishi, T, 2016) |
| "Whether the additional PTSD and functional neurologic deficits were due to a direct effect of the lightning strike on the central nervous system or a secondary response is open to speculation." | 1.39 | Central hyperadrenergic state after lightning strike. ( Ahlskog, JE; Craft, JM; Gelfman, R; Kantor, B; Low, PA; Parsaik, AK; Seime, RJ; Sheldon, SH; Singer, W; Staab, JP, 2013) |
| "Severe tetanus is seen infrequently in the developed world, but often requires intensive care support." | 1.34 | Autonomic dysfunction in tetanus - what lessons can be learnt with specific reference to alpha-2 agonists? ( Boots, R; Deans, R; Freshwater-Turner, D; Hegde, R; Lipman, J; McWhinney, BC; Stuart, J; Udy, A, 2007) |
| "Baroreflex failure after chemodectoma resection We present a case of baroreflex failure secondary to a unilateral injury of the glossopharyngeal nerve." | 1.32 | [Baroreflex failure after chemodectoma resection]. ( Allue, I; Boyero, S; Fernández, C; Gómez Esteban, JC; Lezcano, E; Pérez, T; Sagasta, A; Velasco, F; Zarranz, JJ, 2004) |
| "Clonidine is a centrally active alpha 2-adrenoceptor agonist that raises concentrations of GH in serum in healthy people and those with pure autonomic failure (with peripheral lesions), but not in those with MSA (with a central autonomic deficit)." | 1.30 | Distinction of idiopathic Parkinson's disease from multiple-system atrophy by stimulation of growth-hormone release with clonidine. ( Kimber, JR; Mathias, CJ; Watson, L, 1997) |
| "A clonidine treatment had been stopped 129 h earlier." | 1.27 | [Withdrawal syndrome during epidural administration of morphine after stopping treatment with clonidine]. ( Oksenhendler, G; Petit, J; Ropiquet, S; Winckler, C, 1984) |
| "Diabetic patients with diabetic autonomic neuropathy and orthostatic hypotension had a 30-40% decrease in number of platelet alpha 2-adrenergic receptors, as demonstrated by [3H]clonidine and [3H]yohimbine binding." | 1.27 | Decreased alpha 2-adrenergic receptors on platelet membranes from diabetic patients with autonomic neuropathy and orthostatic hypotension. ( Abrahm, DR; Hollingsworth, PJ; Jim, L; Smith, CB; Sobotka, PA; Vinik, AI; Zucker, LB, 1986) |
| "The paroxysmal hypertension is believed to have resulted from the synergistic effect of the high levels of circulating catecholamines from the tumor and the disruption of autonomic pathways." | 1.27 | Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma. ( Agre, JC; Theologides, A; Wilson, BC; Wright, KC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (26.83) | 18.7374 |
| 1990's | 14 (34.15) | 18.2507 |
| 2000's | 10 (24.39) | 29.6817 |
| 2010's | 6 (14.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spalink, CL | 1 |
| Barnes, E | 1 |
| Palma, JA | 1 |
| Norcliffe-Kaufmann, L | 1 |
| Kaufmann, H | 1 |
| Parsaik, AK | 1 |
| Ahlskog, JE | 1 |
| Singer, W | 1 |
| Gelfman, R | 1 |
| Sheldon, SH | 1 |
| Seime, RJ | 1 |
| Craft, JM | 1 |
| Staab, JP | 1 |
| Kantor, B | 1 |
| Low, PA | 1 |
| Garcha, AS | 1 |
| Cohen, DL | 1 |
| Duma, SN | 1 |
| Shimmura, M | 1 |
| Kawamura, N | 1 |
| Tateishi, T | 1 |
| Shigeto, H | 1 |
| Murai, H | 1 |
| Kira, J | 1 |
| Tank, J | 1 |
| Heusser, K | 1 |
| Diedrich, A | 2 |
| Luft, FC | 1 |
| Jordan, J | 2 |
| Eikelis, N | 1 |
| Schlaich, M | 1 |
| Aggarwal, A | 1 |
| Kaye, D | 1 |
| Esler, M | 1 |
| Gómez Esteban, JC | 1 |
| Boyero, S | 1 |
| Fernández, C | 1 |
| Sagasta, A | 1 |
| Pérez, T | 1 |
| Velasco, F | 1 |
| Allue, I | 1 |
| Lezcano, E | 1 |
| Zarranz, JJ | 1 |
| Tambasco, N | 1 |
| Corea, F | 1 |
| Bocola, V | 1 |
| Shibao, C | 1 |
| Gamboa, A | 1 |
| Abraham, R | 1 |
| Raj, SR | 1 |
| Black, B | 1 |
| Robertson, D | 5 |
| Biaggioni, I | 2 |
| Young, TM | 1 |
| Asahina, M | 1 |
| Watson, L | 3 |
| Mathias, CJ | 9 |
| Cakmak, HB | 1 |
| Giri, S | 1 |
| Nixdorf, D | 1 |
| Freshwater-Turner, D | 1 |
| Udy, A | 1 |
| Lipman, J | 1 |
| Deans, R | 1 |
| Stuart, J | 1 |
| Boots, R | 1 |
| Hegde, R | 1 |
| McWhinney, BC | 1 |
| Ropiquet, S | 1 |
| Petit, J | 1 |
| Oksenhendler, G | 1 |
| Winckler, C | 1 |
| da Costa, DF | 1 |
| Bannister, R | 1 |
| Landon, J | 1 |
| Charney, DS | 1 |
| Heninger, GR | 1 |
| Redmond, DE | 1 |
| Tollefson, GD | 1 |
| Zoukos, Y | 2 |
| Thomaides, T | 3 |
| Cuzner, ML | 2 |
| Brown, JL | 1 |
| Sinding, H | 1 |
| Pavitt, DV | 1 |
| Kimber, JR | 1 |
| Gregorakos, L | 1 |
| Kerezoudi, E | 1 |
| Dimopoulos, G | 1 |
| Lambert, GW | 1 |
| Kaye, DM | 1 |
| Thompson, JM | 1 |
| Turner, AG | 1 |
| Cox, HS | 1 |
| Vaz, M | 1 |
| Jennings, GL | 1 |
| Wallin, BG | 1 |
| Esler, MD | 1 |
| Clarke, CE | 1 |
| Ray, PS | 1 |
| Speller, JM | 1 |
| Goh, KY | 1 |
| Conway, EJ | 1 |
| DaRosso, RC | 1 |
| Muszynski, CA | 1 |
| Epstein, FJ | 1 |
| Victor, RG | 1 |
| Talman, WT | 1 |
| Cortelli, P | 1 |
| Parchi, P | 1 |
| Contin, M | 1 |
| Sforza, E | 1 |
| Lugaresi, A | 1 |
| Pasquali, R | 1 |
| Lugaresi, E | 1 |
| Thomaides, TN | 2 |
| Chaudhuri, KR | 2 |
| Maule, S | 2 |
| Marsden, CD | 1 |
| Sutton, DN | 1 |
| Tremlett, MR | 1 |
| Woodcock, TE | 1 |
| Nielsen, MS | 1 |
| Staneva-Stoytcheva, D | 1 |
| Raynova, LL | 1 |
| Bogoslovova, T | 1 |
| Ivanov, D | 1 |
| Georgieva, A | 1 |
| Goldberg, MR | 3 |
| Onrot, J | 2 |
| Hollister, AS | 3 |
| Wiley, R | 1 |
| Thompson, JG | 1 |
| Robertson, RM | 2 |
| Abrahm, DR | 1 |
| Hollingsworth, PJ | 1 |
| Smith, CB | 1 |
| Jim, L | 1 |
| Zucker, LB | 1 |
| Sobotka, PA | 1 |
| Vinik, AI | 1 |
| Kincaid, D | 1 |
| Bernard, WD | 1 |
| Lander, RD | 1 |
| Covinsky, JO | 1 |
| Tung, CS | 1 |
| Wright, KC | 1 |
| Agre, JC | 1 |
| Wilson, BC | 1 |
| Theologides, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Pathophysiology and Treatment of Supine Hypertension in Patients With Autonomic Failure[NCT00223717] | Phase 1 | 152 participants (Actual) | Interventional | 2001-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for clonidine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Catecholamine excess: pseudopheochromocytoma and beyond.
Topics: Adrenal Gland Neoplasms; Adrenergic Agents; Antihypertensive Agents; Autonomic Nervous System Diseas | 2015 |
Pharmacological manipulation of human gastrointestinal blood flow.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Autonomic Nervous System Diseases; Captopril; Cl | 1997 |
Sympathetic storms in a child with a midbrain glioma: a variant of diencephalic seizures.
Topics: Anticonvulsants; Astrocytoma; Autonomic Nervous System Diseases; Brain Neoplasms; Child; Clonidine; | 1999 |
Diagnosis and management of baroreflex failure.
Topics: Antihypertensive Agents; Autonomic Nervous System Diseases; Baroreflex; Bradycardia; Carotid Sinus; | 1995 |
Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine.
Topics: Autonomic Nervous System Diseases; Catecholamines; Clonidine; Humans; Infusions, Intravenous; Magnes | 1990 |
5 trials available for clonidine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
[A role of treatment of autonomic syndrome in patients with tension-type headache].
Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Autonomic Nervous System; Autonomic Nervous S | 2015 |
Interactions between leptin and the human sympathetic nervous system.
Topics: Adult; Aging; Antihypertensive Agents; Autonomic Nervous System Diseases; Clonidine; Epinephrine; Fe | 2003 |
Clonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Autonomic Nervous System; Autonomic Nervous System | 2006 |
Hemodynamic effects of clonidine in two contrasting models of autonomic failure: multiple system atrophy and pure autonomic failure.
Topics: Adrenergic alpha-Agonists; Autonomic Nervous System Diseases; Blood Pressure; Case-Control Studies; | 2006 |
Management of blood pressure instability in severe tetanus: the use of clonidine.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Blood | 1997 |
31 other studies available for clonidine and ANS (Autonomic Nervous System) Diseases
| Article | Year |
|---|---|
Intranasal dexmedetomidine for adrenergic crisis in familial dysautonomia.
Topics: Administration, Intranasal; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; | 2017 |
Central hyperadrenergic state after lightning strike.
Topics: Activities of Daily Living; Adrenergic alpha-Agonists; Anxiety; Arrhythmias, Cardiac; Autonomic Nerv | 2013 |
[A case of paroxysmal sympathetic storm after acute disseminated encephalomyelitis and hypoxic encephalopathy responding to clonidine hydrochloride].
Topics: Adolescent; Autonomic Nervous System Diseases; Biomarkers; Catecholamines; Clonidine; Encephalomyeli | 2016 |
A novel pharmacological approach to determining parasympathetic heart rate reserve in human subjects.
Topics: Adrenergic alpha-Agonists; Adult; Age Factors; Autonomic Nervous System Diseases; Baroreflex; Blood | 2010 |
[Baroreflex failure after chemodectoma resection].
Topics: Aged; Angiography; Antihypertensive Agents; Autonomic Nervous System Diseases; Baroreflex; Blood Pre | 2004 |
Subtotal corpus callosum agenesis with recurrent hyperhidrosis-hypothermia (Shapiro syndrome).
Topics: Abdominal Pain; Adrenergic alpha-Agonists; Adult; Agenesis of Corpus Callosum; Autonomic Nervous Sys | 2005 |
Residual wires and autonomic failure treatment.
Topics: Antihypertensive Agents; Autonomic Nervous System; Autonomic Nervous System Diseases; Cholinesterase | 2006 |
Topical apraclonidine testing of pupillary sympathetic denervation in diabetic patients.
Topics: Adrenergic alpha-Agonists; Artifacts; Autonomic Nervous System Diseases; Clonidine; Diabetic Neuropa | 2006 |
Sympathetically maintained pain presenting first as temporomandibular disorder, then as parotid dysfunction.
Topics: Adrenergic alpha-Agonists; Adult; Anesthetics, Local; Autonomic Nervous System Diseases; Bupivacaine | 2007 |
Autonomic dysfunction in tetanus - what lessons can be learnt with specific reference to alpha-2 agonists?
Topics: Adrenergic alpha-Agonists; Autonomic Nervous System Diseases; Clonidine; Dexmedetomidine; Epinephrin | 2007 |
[Withdrawal syndrome during epidural administration of morphine after stopping treatment with clonidine].
Topics: Aged; Autonomic Nervous System Diseases; Clonidine; Drug Interactions; Epidural Space; Humans; Hyper | 1984 |
Growth hormone response to clonidine is impaired in patients with central sympathetic degeneration.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Growth Hormone; Humans; Hypotension, O | 1984 |
Yohimbine induced anxiety and increased noradrenergic function in humans: effects of diazepam and clonidine.
Topics: Adult; Anxiety; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Diazepam; Drug Interac | 1983 |
Hyperadrenergic hypomania consequent to the abrupt cessation of clonidine.
Topics: Affective Disorders, Psychotic; Aged; Autonomic Nervous System Diseases; Bipolar Disorder; Clonidine | 1981 |
High beta-adrenoceptor density on peripheral blood mononuclear cells in progressive multiple sclerosis: a manifestation of autonomic dysfunction?
Topics: Adult; Aged; Autonomic Nervous System; Autonomic Nervous System Diseases; Clonidine; Epinephrine; Fe | 1994 |
Autonomic disturbance in severe tetanus: failure of parenteral clonidine to control blood pressure.
Topics: Aged; Aged, 80 and over; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Humans; Hyper | 1994 |
Beta-adrenoceptor expression on circulating mononuclear cells of idiopathic Parkinson's disease and autonomic failure patients before and after reduction of central sympathetic outflow by clonidine.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Clonidine; Female; Humans; Leukocytes, Mononuclear; | 1993 |
Distinction of idiopathic Parkinson's disease from multiple-system atrophy by stimulation of growth-hormone release with clonidine.
Topics: Adrenergic alpha-Agonists; Atrophy; Autonomic Nervous System Diseases; Clonidine; Diagnosis, Differe | 1997 |
Internal jugular venous spillover of noradrenaline and metabolites and their association with sympathetic nervous activity.
Topics: Adolescent; Adult; Aged; Autonomic Nervous System Diseases; Brain; Clonidine; Epinephrine; Ganglioni | 1998 |
Failure of the clonidine growth hormone stimulation test to differentiate multiple system atrophy from early or advanced idiopathic Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Aged; Atrophy; Autonomic Nervous System Diseases; Clonidine; Diagnosis, D | 1999 |
Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension.
Topics: Adrenergic alpha-Agonists; Aged; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Dihyd | 2002 |
Isolated failure of noradrenergic transmission in a case with orthostatic hypotension and hyperactivity of gastro-colic reflex.
Topics: Adult; Atropine; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Colon; Defecation; Ed | 1992 |
Differential responses in superior mesenteric artery blood flow may explain the variant pressor responses to clonidine in two groups with sympathetic denervation.
Topics: Aged; Autonomic Nervous System Diseases; Blood Pressure; Cardiac Output; Clonidine; Female; Fingers; | 1992 |
Growth hormone response to clonidine in central and peripheral primary autonomic failure.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Glucose; Catecholamines; Clonidine; Diagnosis, | 1992 |
Changes in the adrenergic reactivity of spontaneously hypertensive rats after abrupt withdrawal of chronic clonidine treatment.
Topics: Animals; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Heart Rate; Male; Rats; Rats, | 1985 |
Isolated failure of autonomic noradrenergic neurotransmission. Evidence for impaired beta-hydroxylation of dopamine.
Topics: Adrenergic Fibers; Adult; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Dopamine; Fe | 1986 |
Decreased alpha 2-adrenergic receptors on platelet membranes from diabetic patients with autonomic neuropathy and orthostatic hypotension.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Platelets; Catecholamines; Clonidine; Diabetic | 1986 |
Postjunctional vascular smooth muscle alpha-2 adrenoreceptors in human autonomic failure.
Topics: Aged; Autonomic Nervous System Diseases; Blood Platelets; Blood Pressure; Clonidine; Dose-Response R | 1987 |
Hypertension caused by clonidine in patients with diabetic autonomic neuropathy.
Topics: Autonomic Nervous System Diseases; Clonidine; Diabetic Neuropathies; Humans; Hypertension | 1987 |
Use of alpha 2 adrenoreceptor agonists and antagonists in the functional assessment of the sympathetic nervous system.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Blood Pressure; Clonidine; Female; Humans; Hypotensi | 1986 |
Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma.
Topics: Adult; Autonomic Nervous System Diseases; Catecholamines; Clonidine; Humans; Hypertension; Male; Neu | 1986 |