Page last updated: 2024-10-25
clonidine and ACL Injuries
clonidine has been researched along with ACL Injuries in 1 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
Research Excerpts
Excerpt | Relevance | Reference |
"Clonidine has been shown to prolong sensory analgesia when given as an adjunct to peripheral nerve blocks but has not been evaluated when given in conjunction with a femoral-sciatic nerve block." | 2.71 | The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction. ( Couture, DJ; Cuniff, HM; Maye, JP; Pellegrini, J, 2004) |
Research
Studies (1)
Timeframe | Studies, this research(%) | All Research% |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
Couture, DJ | 1 |
Cuniff, HM | 1 |
Maye, JP | 1 |
Pellegrini, J | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status |
A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140] | Phase 4 | 160 participants (Actual) | Interventional | 2013-12-31 | Completed |
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Block Set up Time
Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one
Intervention | minutes (Median) |
---|
Plain Ropivacaine | 6 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 6 |
Ropivacaine + Dexamethasone | 4.5 |
Duration of Analgesia
Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative
Intervention | minutes (Median) |
---|
Plain Ropivacaine | 911 |
Ropivacaine + Buprenorphine | 1026.5 |
Ropivacaine + Clonidine | 1181 |
Ropivacaine + Dexamethasone | 982 |
Motor Duration of Block
Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
Intervention | minutes (Median) |
---|
Plain Ropivacaine | 1120 |
Ropivacaine + Buprenorphine | 1198 |
Ropivacaine + Clonidine | 1090 |
Ropivacaine + Dexamethasone | 1143.5 |
Number of Patient With Blood Pressure Changes in the Second Stage Recovery Area
Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 5 |
Ropivacaine + Buprenorphine | 1 |
Ropivacaine + Clonidine | 5 |
Ropivacaine + Dexamethasone | 0 |
Number of Patients Reporting Itching at Home
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 1 |
Ropivacaine + Buprenorphine | 2 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 0 |
Number of Patients Reporting Itching in the PACU
Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 5 |
Ropivacaine + Buprenorphine | 2 |
Ropivacaine + Clonidine | 6 |
Ropivacaine + Dexamethasone | 3 |
Number of Patients Reporting Nausea at Home
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 4 |
Ropivacaine + Buprenorphine | 9 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 3 |
Number of Patients Reporting Nausea in the PACU
PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 4 |
Ropivacaine + Buprenorphine | 9 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 9 |
Number of Patients Vomiting in the PACU (Post-Anesthesia Care Unit)
Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 0 |
Ropivacaine + Buprenorphine | 1 |
Ropivacaine + Clonidine | 0 |
Ropivacaine + Dexamethasone | 0 |
Number of Patients With Blood Pressure (BP) Changes in the PACU
Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 8 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 7 |
Ropivacaine + Dexamethasone | 2 |
Pain Score Reported by Patients at First Phone Call
Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3
Intervention | units on a scale (Median) |
---|
Plain Ropivacaine | 4 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 4 |
Ropivacaine + Dexamethasone | 3 |
Patient Reporting Vomiting at Home
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
Intervention | Participants (Count of Participants) |
---|
Plain Ropivacaine | 0 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 1 |
Sensory Duration of Block
Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
Intervention | minutes (Median) |
---|
Plain Ropivacaine | 923.5 |
Ropivacaine + Buprenorphine | 982 |
Ropivacaine + Clonidine | 940.5 |
Ropivacaine + Dexamethasone | 1066 |
Surgical Length
Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)
Intervention | minutes (Median) |
---|
Plain Ropivacaine | 68.5 |
Ropivacaine + Buprenorphine | 65 |
Ropivacaine + Clonidine | 73.5 |
Ropivacaine + Dexamethasone | 71 |
Surgical Position
Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
Intervention | Participants (Count of Participants) |
---|
| Beach Chair | Lateral | Supine |
---|
Plain Ropivacaine | 38 | 2 | 0 |
,Ropivacaine + Buprenorphine | 31 | 6 | 3 |
,Ropivacaine + Clonidine | 31 | 7 | 2 |
,Ropivacaine + Dexamethasone | 32 | 6 | 2 |
Trials
1 trial available for clonidine and ACL Injuries