clonidine has been researched along with A-V Dissociation in 14 studies
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this report, we describe a 15-year-old adolescent girl who experienced continued delirium 5 days after an overdose of quetiapine, trazodone, and clonidine." | 3.76 | Prolonged delirium after quetiapine overdose. ( Pedapati, EV; Rhyee, SH; Thompson, J, 2010) |
| " In toddlers poisoning is seen after ingestion of a single tablet of 150 micrograms clonidine, whilst in adults poisoning may occur already at a dosage just exceeding the therapeutic limit, which is subject to wide individual variation (1 to 3 tablets)." | 1.27 | [Poisoning with clonidin hydrochloride in children and adults]. ( Gössinger, H; Haubenstock, A; Hruby, K; Jung, M; Pfister, R, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (85.71) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rhyee, SH | 1 |
| Pedapati, EV | 1 |
| Thompson, J | 1 |
| Selmi, W | 1 |
| Matricardi, L | 1 |
| Ciaccheri, M | 1 |
| Dolara, A | 1 |
| Manetti, A | 1 |
| Botti, P | 1 |
| Zorn, M | 1 |
| Peruzzi, S | 1 |
| Gössinger, H | 1 |
| Hruby, K | 1 |
| Haubenstock, A | 1 |
| Jung, M | 1 |
| Pfister, R | 1 |
| Rimatori, C | 1 |
| Russo, P | 1 |
| Bender, F | 1 |
| Boucher, M | 3 |
| Dubar, M | 1 |
| Chapuy, E | 2 |
| Chassaing, C | 1 |
| Piancone, RM | 1 |
| Mucedola, LB | 1 |
| Antonucci, G | 1 |
| Lipartiti, P | 1 |
| Marangi, M | 1 |
| Rispoli, M | 1 |
| Kibler, LE | 1 |
| Gazes, PC | 1 |
| Abiuso, P | 1 |
| Abelow, G | 1 |
| Williams, PL | 1 |
| Krafcik, JM | 1 |
| Potter, BB | 1 |
| Hooper, JH | 1 |
| Hearne, MJ | 1 |
| Lefebvre, MA | 1 |
| Mignot, A | 1 |
| Duchêne-Marullaz, P | 2 |
| Marini, M | 1 |
| Cavani, E | 1 |
| Abbatangelo, R | 1 |
| Mascelloni, R | 1 |
| Lavarenne, J | 1 |
| Lapalus, P | 1 |
| Mongheal, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)[NCT01297335] | Phase 2 | 10 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Subjects baseline blood pressure (systolic blood pressure (SBP), and diastolic blood pressure (DBP)), and blood pressures after clonidine injection was compared against baseline to assess efficacy of clonidine in refractory hypertensive subjects. Subject's blood pressure was monitored continuously after intrathecal injection of clonidine until subjects blood pressure nadir and return to pre clonidine injection level. The mean value reported below are the average changes in blood pressure from baseline (pre clonidine injection) in both SBP and DBP during post clonidine injection blood pressure monitoring for 4 hours.~Blood pressure measurements were collected every 10 minutes for first hour after injection, and every 15 minutes after the first hour, up to 4 hours were averaged to report the change from baseline." (NCT01297335)
Timeframe: Baseline, Every 10 Minutes for first hour after clonidine injection, and every 15 minutes after first hour, until 4 hours after clonidine injection
| Intervention | mm Hg (Mean) | |
|---|---|---|
| Change in mean SBP after clonidine injection | Change in DBP after clonidine injection | |
| Intrathecal Clonidine | 79 | 37 |
Subjects were asked to rate severity of two of the most common side effects of clonidine, sedation and sensation of dry mouth, at pre and post (1 hour after) intrathecal administration of clonidine. The mean changes between pre and post injection VAS ratings of sedation and sensation of dry mouth are reported below. The VAS scale ranges from 1 to 10 cm, with higher values indicating higher level of sedation and higher level of dry mouth. (NCT01297335)
Timeframe: Before clonidine injection (Baseline), and at 1 hour after clonidine injection.
| Intervention | cm (Mean) | |
|---|---|---|
| Change in level of sedation | Change in sensation of dry mouth | |
| Intrathecal Clonidine | 3.36 | 3.47 |
Likert scale is 11 point digital pain rating system that asks subjects to rate their pain from 0 to 10. Rating of 0 means no pain at all, and in increasing order, 10 would mean worst pain imaginable/ unbearable pain. (NCT01297335)
Timeframe: Pre-dose and 1 hour post injection.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Pre-injection average Likert score | Post-injection average Likert score | |
| Intrathecal Clonidine | 6.5 | 3.6 |
1 review available for clonidine and A-V Dissociation
| Article | Year |
|---|---|
[Side effects of hypotensive agents].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Bradycardia; Clonidine; Deh | 1982 |
13 other studies available for clonidine and A-V Dissociation
| Article | Year |
|---|---|
Prolonged delirium after quetiapine overdose.
Topics: Adolescent; Antipsychotic Agents; Cholinergic Antagonists; Clonidine; Cytochrome P-450 CYP3A; Deliri | 2010 |
A-V block by an overdose of Clonidine.
Topics: Adult; Clonidine; Female; Heart Block; Humans; Substance-Related Disorders | 1983 |
[Poisoning with clonidin hydrochloride in children and adults].
Topics: Adolescent; Adult; Bradycardia; Bundle-Branch Block; Child; Child, Preschool; Clonidine; Female; Gas | 1983 |
[Luciani-Wenckebach phenomenon during clonidine treatment: a case description].
Topics: Clonidine; Electrocardiography; Heart Block; Heart Conduction System; Humans; Hypertension; Male; Mi | 1980 |
Acute hypertensive crises.
Topics: Acute Disease; Adult; Aged; Clonidine; Diazoxide; Heart Block; Humans; Hypertension; Injections, Int | 1980 |
Interactions of the cardiac chronotropic effects of rilmenidine with the autonomic nervous system in conscious dogs: comparison with clonidine.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Chronic Dis | 1996 |
["Torsades de pointe". Observations on 8 cases].
Topics: Aged; Antihypertensive Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Clonidine; Coronary | 1979 |
Effect of clonidine on atrioventricular conduction.
Topics: Adult; Aged; Atrioventricular Node; Clonidine; Digoxin; Electrocardiography; Female; Heart Block; He | 1977 |
Atrioventricular dissociation in a patient receiving clonidine.
Topics: Adult; Clonidine; Female; Heart Block; Humans; Hypertension | 1978 |
Cardiac toxicity of clonidine.
Topics: Adult; Clonidine; Electrocardiography; Female; Heart Block; Humans | 1977 |
Mechanisms of chronotropic cardiac effects of alinidine and plasma concentration-response relationships in the conscious dog with chronic atrioventricular block.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Clonidine; Dogs; Drug | 1989 |
[Luciani-Wenckeback period and clonidine. Presentation of a case].
Topics: Aged; Clonidine; Electrocardiography; Female; Heart Block; Humans; Hypertension | 1988 |
Effect of clonidine on heart rate in dogs with acute or chronic heart block.
Topics: Anesthesia; Animals; Atropine; Chloralose; Clonidine; Dogs; Dose-Response Relationship, Drug; Female | 1974 |