Page last updated: 2024-10-25

clonazepam and Syndrome

clonazepam has been researched along with Syndrome in 43 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"To study direction and intensity of autonomic changes in patients with paroxysmal atrial fibrillation (PAF) treated with clonazepam and their dynamics during antiarrhythmic therapy."7.73[Effect of clonazepam and antiarrhythmic drugs on heart rate variability in patients with paroxysmal atrial fibrillation]. ( Khaspekova, NB; Nedostup, AV; San'kova, TA; Solov'ëva, AD, 2005)
" I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride."7.68Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990)
"A study of 21 patients has shown that clonazepam is an effective drug in preventing attacks of pain in trigeminal neuralgia and Sluder's syndrome."7.65Clonazepam in cranial neuralgias. ( Scarlato, G; Smirne, S, 1977)
"The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy."5.07[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994)
"To study direction and intensity of autonomic changes in patients with paroxysmal atrial fibrillation (PAF) treated with clonazepam and their dynamics during antiarrhythmic therapy."3.73[Effect of clonazepam and antiarrhythmic drugs on heart rate variability in patients with paroxysmal atrial fibrillation]. ( Khaspekova, NB; Nedostup, AV; San'kova, TA; Solov'ëva, AD, 2005)
" I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride."3.68Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990)
"The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed."3.65[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977)
"A study of 21 patients has shown that clonazepam is an effective drug in preventing attacks of pain in trigeminal neuralgia and Sluder's syndrome."3.65Clonazepam in cranial neuralgias. ( Scarlato, G; Smirne, S, 1977)
"Post-hypoxic myoclonus (PHM) is a rare neurological complication having two different variants depending on acute or chronic onset after cardiopulmonary resuscitation following cardiac arrest: myoclonic status epilepticus (MSE) and Lance-Adams syndrome (LAS) respectively."3.01Post-hypoxic myoclonus; what we know and gaps in knowledge. ( Ahmed, HS, 2023)
" We investigated the effect of piracetam and clonazepam, an anti-epileptic drug, on high dosage urea-induced myoclonus using an electromyogram in rats."2.41[A pharmacological profile of piracetam (Myocalm), a drug for myoclonus]. ( Nanri, M; Tajima, K, 2000)
"FOXG1 syndrome is a severe encephalopathy that exhibit intellectual disability, emotional disorder, and limited social communication."1.51Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors. ( Chen, D; Chen, H; Li, M; She, X; Wang, C; Yuan, Y; Zhang, W; Zhao, C, 2019)
"Early myoclonus after cardiac arrest (CA) is traditionally viewed as a poor prognostic sign (status myoclonus)."1.46Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort. ( Aicua Rapun, I; Novy, J; Oddo, M; Rossetti, AO; Solari, D, 2017)
"Psychotic features in patients with Parkinson's Disease usually present as visual hallucinations against a background of cognitive deterioration and dopaminomimetic therapy."1.36Isolated delusional syndrome in Parkinson's Disease. ( Bozi, M; Christodoulou, C; Douzenis, A; Gasparinatos, G; Stamboulis, E; Stefanis, C; Stefanis, L; Stefanis, N, 2010)
"Epilepsy was most common among those with maternal deletions and unknown subtypes, with catastrophic epilepsies present in only these two subtypes."1.35Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. ( Braun, EK; Bruno, P; Conant, KD; Nespeca, MP; Said, RR; Thibert, RL; Thiele, EA, 2009)
"Clonazepam was the most effective antiepileptic drug, and it also normalized the EEG when started in childhood or at the onset of puberty."1.30Neurophysiological findings in the northern epilepsy syndrome. ( Hirvasniemi, A; Lang, AH; Siivola, J, 1997)
"Orthostatic tremor is an unusual kind of potentially disabiling tremor appearing immediately when standing."1.30["Primary" orthostatic tremor. 10 clinical electrophysiologic observations]. ( Cassim, F; Destée, A; Guieu, JD; Mastain, B, 1998)
"One also had features of infantile autism."1.29Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994)
"Orthostatic tremor is a disabling condition that responds to benzodiazepine treatment and may be more frequent than previously recognised."1.29Orthostatic tremor (shaky legs syndrome). ( Gates, PC, 1993)
"Posthypoxic myoclonus (Lance-Adams' syndrome) is a rare complication of cardiorespiratory arrest."1.29Posthypoxic myoclonus in intensive care. ( Chamorro, A; del Mar Lluch, M; Millá, J; Miró, O; Nadal, P; Urbano-Márquez, A, 1994)
"Posthypoxic myoclonus is a rare complication of successful cardiopulmonary resusitation."1.28Posthypoxic myoclonus (the Lance-Adams syndrome) in the intensive care unit. ( Harper, SJ; Wilkes, RG, 1991)
"Chronic hypoxemia, hypercarbia, bronchospasm, and inadequate nutrition were present in all."1.28Movement disorder of premature infants with severe bronchopulmonary dysplasia: a new syndrome. ( Perlman, JM; Volpe, JJ, 1989)

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199013 (30.23)18.7374
1990's14 (32.56)18.2507
2000's8 (18.60)29.6817
2010's7 (16.28)24.3611
2020's1 (2.33)2.80

Authors

AuthorsStudies
Ahmed, HS1
Aicua Rapun, I1
Novy, J1
Solari, D1
Oddo, M1
Rossetti, AO1
Chen, D1
Wang, C1
Li, M1
She, X1
Yuan, Y1
Chen, H1
Zhang, W1
Zhao, C1
Lagrand, T1
Winogrodzka, A1
Horváth, K1
Aschermann, Z1
Komoly, S1
Kovács, A1
Kovács, N1
Thibert, RL1
Conant, KD1
Braun, EK1
Bruno, P1
Said, RR1
Nespeca, MP1
Thiele, EA1
Stefanis, N1
Bozi, M1
Christodoulou, C1
Douzenis, A1
Gasparinatos, G1
Stamboulis, E1
Stefanis, C1
Stefanis, L1
Han, S1
Tai, C1
Westenbroek, RE1
Yu, FH1
Cheah, CS1
Potter, GB1
Rubenstein, JL1
Scheuer, T1
de la Iglesia, HO1
Catterall, WA1
Azad, C1
Guglani, V1
Kaga, M1
Horimoto, R1
Hatori, T1
Wheless, JW1
Kreisel, SH1
Binder, J1
Wöhrle, JC1
Krauss, JK1
Hofmann, S1
Bauer, MF1
Hennerici, MG1
Bäzner, H1
Khaspekova, NB1
Solov'ëva, AD1
Nedostup, AV1
San'kova, TA1
Raudino, F1
Bahi-Buisson, N1
Savini, R1
Eisermann, M1
Bulteau, C1
Dulac, O1
Hertz-Pannier, L1
Chiron, C1
Boldyrev, AI1
Tibbles, JA1
Barnes, SE1
Christianson, AL1
Chesler, N1
Kromberg, JG1
Hirvasniemi, A2
Herrala, P1
Leisti, J1
Gates, PC1
Badalian, LO1
Temin, PA1
Medvedev, MI1
Mukhin, KIu1
Iskander, MB1
Kharlamov, DA1
Veselov, NK1
Garg, RK1
Kar, AM1
Dixit, V1
Tan, AK1
Tan, CB1
Lang, AH1
Siivola, J1
Miró, O1
Chamorro, A1
del Mar Lluch, M1
Nadal, P1
Millá, J1
Urbano-Márquez, A1
Rella, JG1
Hoffman, RS1
Nakamura, M1
Yamagata, T1
Momoi, MY1
Yamazaki, T1
Mastain, B1
Cassim, F1
Guieu, JD1
Destée, A1
Tajima, K1
Nanri, M1
Nyland, H1
Mellgren, SI1
Frövig, AG1
Speciali, GG1
Lison, MP1
Westblom, U2
Lance, JW1
Smirne, S1
Scarlato, G1
Berman, W1
Dubowitz, LM1
Bouza, H1
Hird, MF1
Jaeken, J1
Harper, SJ1
Wilkes, RG1
Sandyk, R1
Perlman, JM1
Volpe, JJ1
Koczerginski, D1
Kennedy, SH1
Swinson, RP1
Garcia de Alba, GO1
Malagon Valdez, J1
Franco Delgadillo, J1
Ramos Peek, J1
Guilleminault, C1
Crowe, C1
Quera-Salva, MA1
Miles, L1
Partinen, M1

Reviews

5 reviews available for clonazepam and Syndrome

ArticleYear
Post-hypoxic myoclonus; what we know and gaps in knowledge.
    Tropical doctor, 2023, Volume: 53, Issue:4

    Topics: Cardiopulmonary Resuscitation; Clonazepam; Humans; Hypoxia; Myoclonus; Syndrome; Valproic Acid

2023
[Treatment of tardive syndromes].
    Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata, 2014, Volume: 29, Issue:2

    Topics: Amantadine; Antipsychotic Agents; Botulinum Toxins; Central Nervous System Agents; Cholinergic Antag

2014
[Progressive epilepsy with mental retardation(PEMR)].
    Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6

    Topics: Animals; Child; Child, Preschool; Chromosomes, Human, Pair 8; Clonazepam; Diagnosis, Differential; D

2002
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
    Epilepsia, 2003, Volume: 44 Suppl 2

    Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche

2003
[A pharmacological profile of piracetam (Myocalm), a drug for myoclonus].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2000, Volume: 116, Issue:4

    Topics: Animals; Anticonvulsants; Clinical Trials, Phase II as Topic; Clonazepam; Disease Models, Animal; Dr

2000

Trials

1 trial available for clonazepam and Syndrome

ArticleYear
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994, Volume: 94, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E

1994

Other Studies

37 other studies available for clonazepam and Syndrome

ArticleYear
Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort.
    Resuscitation, 2017, Volume: 115

    Topics: Adult; Aged, 80 and over; Anticonvulsants; Cardiopulmonary Resuscitation; Clonazepam; Drug Combinati

2017
Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors.
    Cerebral cortex (New York, N.Y. : 1991), 2019, 07-22, Volume: 29, Issue:8

    Topics: Animals; Behavior, Animal; Brain Diseases; Cerebral Cortex; Clonazepam; Cognition; Depression; Emoti

2019
Late relapse myoclonus in a case of Lance-Adams syndrome.
    BMJ case reports, 2013, Nov-29, Volume: 2013

    Topics: Aged; Clonazepam; Humans; Hypoxia, Brain; Male; Myoclonus; Recurrence; Syndrome

2013
Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options.
    Epilepsia, 2009, Volume: 50, Issue:11

    Topics: Adolescent; Adult; Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbid

2009
Isolated delusional syndrome in Parkinson's Disease.
    Parkinsonism & related disorders, 2010, Volume: 16, Issue:8

    Topics: Aged; Amantadine; Antiparkinson Agents; Benserazide; Benzothiazoles; Catechols; Clonazepam; Female;

2010
Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission.
    Nature, 2012, Sep-20, Volume: 489, Issue:7416

    Topics: Animals; Anxiety; Autistic Disorder; Clonazepam; Epilepsies, Myoclonic; GABA Modulators; GABAergic N

2012
Eyelid myoclonia with absence seizure precipitated by carbamazepine therapy.
    Indian pediatrics, 2012, Volume: 49, Issue:10

    Topics: Carbamazepine; Child; Clonazepam; Epilepsy, Absence; Female; Humans; Myoclonus; Syndrome; Valproic A

2012
Dystonia in the Mohr-Tranebjaerg syndrome responds to GABAergic substances.
    Movement disorders : official journal of the Movement Disorder Society, 2004, Volume: 19, Issue:10

    Topics: Adult; Clonazepam; Cognition Disorders; Dystonic Disorders; GABA Modulators; Genetic Diseases, X-Lin

2004
[Effect of clonazepam and antiarrhythmic drugs on heart rate variability in patients with paroxysmal atrial fibrillation].
    Kardiologiia, 2005, Volume: 45, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Anticonvulsants; Atrial Fibrillation; Autonomic Nervous System;

2005
SUNCT: a new case with some unusual features.
    The journal of headache and pain, 2005, Volume: 6, Issue:6

    Topics: Adult; Clonazepam; Conjunctival Diseases; GABA Modulators; Headache; Humans; Magnetic Resonance Imag

2005
Misleading effects of clonazepam in symptomatic electrical status epilepticus during sleep syndrome.
    Pediatric neurology, 2006, Volume: 34, Issue:2

    Topics: Anticonvulsants; Child; Clonazepam; Cognition Disorders; Electroencephalography; Humans; Male; Motor

2006
[Clinical evaluation of certain modern antiepileptic preparations].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1982, Volume: 82, Issue:6

    Topics: Anticonvulsants; Automatism; Carbamazepine; Child; Clonazepam; Diencephalon; Epilepsy; Epilepsy, Abs

1982
Paroxysmal dystonic choreoathetosis of Mount and Reback.
    Pediatrics, 1980, Volume: 65, Issue:1

    Topics: Adult; Aged; Athetosis; Child, Preschool; Chorea; Clonazepam; Female; Genes, Dominant; Humans; Male;

1980
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
    Developmental medicine and child neurology, 1994, Volume: 36, Issue:4

    Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family

1994
Northern epilepsy syndrome: clinical course and the effect of medication on seizures.
    Epilepsia, 1995, Volume: 36, Issue:8

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Central Nervous System Diseases; Chil

1995
Orthostatic tremor (shaky legs syndrome).
    Clinical and experimental neurology, 1993, Volume: 30

    Topics: Aged; Aged, 80 and over; Arm; Chlordiazepoxide; Clonazepam; Female; Humans; Leg; Male; Middle Aged;

1993
Opsoclonus--myoclonus syndrome in an adult: a case report and response to clonazepam.
    Indian journal of ophthalmology, 1996, Volume: 44, Issue:2

    Topics: Adult; Anticonvulsants; Clonazepam; Follow-Up Studies; Humans; Male; Myoclonus; Ocular Motility Diso

1996
The syndrome of painful legs and moving toes--a case report.
    Singapore medical journal, 1996, Volume: 37, Issue:4

    Topics: Baclofen; Clonazepam; Female; GABA Agonists; GABA Modulators; Humans; Middle Aged; Neuromuscular Dis

1996
Neurophysiological findings in the northern epilepsy syndrome.
    Acta neurologica Scandinavica, 1997, Volume: 95, Issue:1

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Brain; Child; Child, Preschool; Clona

1997
Posthypoxic myoclonus in intensive care.
    European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 1994, Volume: 1, Issue:3

    Topics: Aged; Anticonvulsants; Cardiopulmonary Resuscitation; Clonazepam; Critical Care; Female; Follow-Up S

1994
Possible serotonin syndrome from paroxetine and clonazepam.
    Journal of toxicology. Clinical toxicology, 1998, Volume: 36, Issue:3

    Topics: Adult; Clonazepam; Contraindications; Drug Interactions; Female; GABA Modulators; Humans; Nervous Sy

1998
Drop episodes in Coffin-Lowry syndrome: exaggerated startle responses treated with clonazepam.
    Pediatric neurology, 1998, Volume: 19, Issue:2

    Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Clonazepam; Electroencephalography; Electromyograph

1998
["Primary" orthostatic tremor. 10 clinical electrophysiologic observations].
    Revue neurologique, 1998, Volume: 154, Issue:4

    Topics: Adult; Aged; Anti-Anxiety Agents; Arm; Clonazepam; Diazepam; Electromyography; Female; Humans; Leg;

1998
Stiff-man syndrome with central and peripheral nervous manifestations.
    Journal of neurology, 1978, Dec-07, Volume: 219, Issue:3

    Topics: Clonazepam; Diazepam; Electromyography; Humans; Male; Middle Aged; Muscle Rigidity; Muscles; NADH, N

1978
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
    Arquivos de neuro-psiquiatria, 1977, Volume: 35, Issue:3

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia

1977
Stiff-man syndrome and clonazepam.
    JAMA, 1977, May-02, Volume: 237, Issue:18

    Topics: Benzodiazepinones; Clonazepam; Diazepam; Female; Humans; Middle Aged; Muscle Rigidity; Spasm; Syndro

1977
Familial paroxysmal dystonic choreoathetosis of Mount and Reback and its differentiation from related syndromes.
    Transactions of the American Neurological Association, 1977, Volume: 102

    Topics: Adolescent; Adult; Athetosis; Barbiturates; Child; Child, Preschool; Chorea; Clonazepam; Female; Hum

1977
[Stiff--man syndrome].
    Lakartidningen, 1978, Mar-22, Volume: 75, Issue:12

    Topics: Clonazepam; Diagnosis, Differential; Diazepam; Female; Humans; Middle Aged; Muscle Rigidity; Syndrom

1978
Clonazepam in cranial neuralgias.
    The Medical journal of Australia, 1977, Jan-22, Volume: 1, Issue:4

    Topics: Adult; Aged; Benzodiazepinones; Clonazepam; Cranial Nerves; Facial Neuralgia; Female; Humans; Male;

1977
Letter: The ketogenic diet, West and Lennox syndromes.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:2

    Topics: Child; Child, Preschool; Clonazepam; Diazepam; Humans; Infant; Intellectual Disability; Myoclonus; N

1975
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
    Lancet (London, England), 1992, Jul-11, Volume: 340, Issue:8811

    Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob

1992
Posthypoxic myoclonus (the Lance-Adams syndrome) in the intensive care unit.
    Anaesthesia, 1991, Volume: 46, Issue:3

    Topics: Clonazepam; Critical Care; Diagnosis, Differential; Humans; Hypoxia; Male; Middle Aged; Myoclonus; R

1991
Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen.
    Italian journal of neurological sciences, 1990, Volume: 11, Issue:6

    Topics: Baclofen; Causalgia; Clonazepam; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans;

1990
Movement disorder of premature infants with severe bronchopulmonary dysplasia: a new syndrome.
    Pediatrics, 1989, Volume: 84, Issue:2

    Topics: Bronchopulmonary Dysplasia; Clonazepam; Follow-Up Studies; Humans; Hypoxia; Infant, Newborn; Movemen

1989
Clonazepam and lithium--a toxic combination in the treatment of mania?
    International clinical psychopharmacology, 1989, Volume: 4, Issue:3

    Topics: Adult; Bipolar Disorder; Clonazepam; Female; Humans; Lithium; Male; Middle Aged; Nervous System; Syn

1989
Status epilepticus within the Lennox-Gastaut syndrome: clinical characteristics and management.
    Clinical EEG (electroencephalography), 1987, Volume: 18, Issue:2

    Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Status Epilepticus; Syndrome; Val

1987
Periodic leg movement, sleep fragmentation and central sleep apnoea in two cases: reduction with Clonazepam.
    The European respiratory journal, 1988, Volume: 1, Issue:8

    Topics: Adult; Clonazepam; Female; Humans; Leg; Male; Middle Aged; Myoclonus; Sleep Apnea Syndromes; Sleep W

1988