clonazepam has been researched along with Substance Withdrawal Syndrome in 67 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "High-potency benzodiazepines, such as clonazepam, are frequently used in the treatment of panic disorder (PD) because of their rapid onset of action and good tolerability." | 9.14 | Tapering clonazepam in patients with panic disorder after at least 3 years of treatment. ( Amrein, R; da Costa, RT; de Carvalho, MR; de Cerqueira, AC; de-Melo-Neto, VL; Freire, RC; Levitan, MN; Lopes, FL; Mezzasalma, MA; Nardi, AE; Nascimento, I; Sardinha, A; Soares-Filho, GL; Valença, AM; Veras, AB; Versiani, M, 2010) |
| "At the therapeutic endpoint, clonazepam (N = 222) proved clinically and statistically superior to placebo (N = 216) in change in the number of panic attacks and in Clinical Global Impressions-Severity of Illness (CGI-S) and CGI-Change scores, Patient's Global Impression of Change scores, amount of fear and avoidance associated with phobic symptoms, and duration of anticipatory anxiety." | 9.09 | Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages. ( Moroz, G; Rosenbaum, JF, 1999) |
| "In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder." | 9.08 | Clonazepam in the treatment of panic disorder with or without agoraphobia: a dose-response study of efficacy, safety, and discontinuance. Clonazepam Panic Disorder Dose-Response Study Group. ( Bowden, CL; Moroz, G; Rosenbaum, JF, 1997) |
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 9.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| " Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety." | 7.96 | Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats. ( Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S, 2020) |
| "We report the effects of withdrawal of clonazepam (CZP) at a rate of 1 mg/week in 23 patients with chronic active epilepsy." | 7.68 | Discontinuation of clonazepam in patients with active epilepsy. ( Chataway, J; Duncan, JS; Fowler, A; Thompson, PJ, 1993) |
| "We describe two patients in whom clonazepam withdrawal status epilepticus occurred in spite of therapeutic levels of carbamazepine in plasma and cerebrospinal fluid." | 7.67 | Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus. ( Rosati, G; Sechi, GP; Zoroddu, G, 1984) |
| ", in proposing a safe CZP withdrawal rate of 0." | 5.29 | Clonazepam withdrawal in 13 patients with active epilepsy and drug side effects. ( Buchanan, N; Sharpe, C, 1994) |
| "High-potency benzodiazepines, such as clonazepam, are frequently used in the treatment of panic disorder (PD) because of their rapid onset of action and good tolerability." | 5.14 | Tapering clonazepam in patients with panic disorder after at least 3 years of treatment. ( Amrein, R; da Costa, RT; de Carvalho, MR; de Cerqueira, AC; de-Melo-Neto, VL; Freire, RC; Levitan, MN; Lopes, FL; Mezzasalma, MA; Nardi, AE; Nascimento, I; Sardinha, A; Soares-Filho, GL; Valença, AM; Veras, AB; Versiani, M, 2010) |
| "At the therapeutic endpoint, clonazepam (N = 222) proved clinically and statistically superior to placebo (N = 216) in change in the number of panic attacks and in Clinical Global Impressions-Severity of Illness (CGI-S) and CGI-Change scores, Patient's Global Impression of Change scores, amount of fear and avoidance associated with phobic symptoms, and duration of anticipatory anxiety." | 5.09 | Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages. ( Moroz, G; Rosenbaum, JF, 1999) |
| "In this multicenter, parallel-group, placebo-controlled, fixed-dose study, the efficacy, safety, dosing characteristics, and discontinuation of clonazepam were analyzed in patients with panic disorder." | 5.08 | Clonazepam in the treatment of panic disorder with or without agoraphobia: a dose-response study of efficacy, safety, and discontinuance. Clonazepam Panic Disorder Dose-Response Study Group. ( Bowden, CL; Moroz, G; Rosenbaum, JF, 1997) |
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 5.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "Outpatients treated for panic disorder with alprazolam or clonazepam for a minimum of 6 months and expressing a desire to stop taking the medication (N = 33) were randomly assigned to one of two taper conditions: a slow taper condition alone or a slow taper condition in conjunction with 10 weeks of group cognitive-behavioral therapy." | 5.07 | Discontinuation of benzodiazepine treatment: efficacy of cognitive-behavioral therapy for patients with panic disorder. ( Meltzer-Brody, S; Otto, MW; Pollack, MH; Reiter, SR; Rosenbaum, JF; Sachs, GS, 1993) |
| " Clonazepam, a commonly prescribed benzodiazepine, has been increasingly used as a countermeasure to cocaine side-effects, including sleep reduction and anxiety." | 3.96 | Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats. ( Andersen, ML; Dokkedal-Silva, V; Galduróz, JCF; Tufik, S, 2020) |
| " In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole." | 3.69 | Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996) |
| "We report the effects of withdrawal of clonazepam (CZP) at a rate of 1 mg/week in 23 patients with chronic active epilepsy." | 3.68 | Discontinuation of clonazepam in patients with active epilepsy. ( Chataway, J; Duncan, JS; Fowler, A; Thompson, PJ, 1993) |
| "We describe two patients in whom clonazepam withdrawal status epilepticus occurred in spite of therapeutic levels of carbamazepine in plasma and cerebrospinal fluid." | 3.67 | Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus. ( Rosati, G; Sechi, GP; Zoroddu, G, 1984) |
| "We report the cases of 3 patients with medically intractable seizures in whom withdrawal of treatment with a long-acting benzodiazepine (clorazepate dipotassium, 2 patients; clonazepam, 1 patient) was followed by delirium with catatoniclike features." | 3.67 | Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders. ( De Bellis, M; Devinsky, O; Hauser, P; Post, RM; Theodore, WH, 1989) |
| "Since the clinical data have been equivocal in regard to the effects of clonazepam (CZP) in focal-motor seizures, an alumina gel monkey model was used to evaluate quantitatively its efficacy with respect to this seizure category." | 3.66 | Clonazepam in a focal-motor monkey model: efficacy, tolerance, toxicity, withdrawal, and management. ( Congdon, WC; DuCharme, LL; Levy, RH; Lockard, JS; Salonen, LD, 1979) |
| "Self-reported physical withdrawal symptoms were recorded daily." | 2.77 | High dose benzodiazepine dependence: description of 29 patients treated with flumazenil infusion and stabilised with clonazepam. ( Des Jarlais, DC; Gerra, G; Lugoboni, F; Mathewson, S; Pattaro, C; Quaglio, G; Verbanck, P, 2012) |
| "Despite its acute efficacy for the treatment of panic disorder, benzodiazepines (BZs) are associated with a withdrawal syndrome that closely mimics anxiety sensations, leading to difficulty with treatment discontinuation and often disorder relapse." | 2.75 | Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation. ( Farach, FJ; McHugh, RK; Otto, MW; Pollack, MH; Simon, NM; Worthington, JJ, 2010) |
| "Benzodiazepine withdrawal symptoms were also measured." | 2.69 | Discontinuation of clonazepam in the treatment of social phobia. ( Book, SW; Colket, JT; Connor, KM; Davidson, JR; Ferrell, F; Malik, ML; Miner, CM; Potts, NL; Tupler, LA, 1998) |
| "Clonazepam 0." | 2.67 | Clonazepam: sleep laboratory study of efficacy and withdrawal. ( Baldassano, CF; Kales, A; Kales, JD; Kostakos, K; Manfredi, RL; Vgontzas, AN, 1991) |
| " Eighty-two percent (39) of the patients rated clonazepam as being "better" than alprazolam due to decreased dosing frequency and lack of interdose anxiety." | 2.37 | Rebound anxiety in panic disorder patients treated with shorter-acting benzodiazepines. ( Brotman, AW; Herman, JB; Rosenbaum, JF, 1987) |
| " Here, we report on a case of a 70-year-old Caucasian female with insomnia and difficulty weaning off long-term use of clonazepam suggesting that a slow acetylator phenotype contributing to patient's presentation." | 1.51 | Prolonged clonazepam-induced withdrawal symptoms in an NAT2 ultraslow acetylator. ( Gupta, SV; Ho, TT; Sanchez-Valle, A, 2019) |
| "Insomnia is one such condition whose prevalence is rising all over the world." | 1.51 | A case of zolpidem dependence with extremely high daily doses. ( Bajaj, A; Bajaj, V; Kalra, I; Kumar, R; Sharma, D, 2019) |
| ", in proposing a safe CZP withdrawal rate of 0." | 1.29 | Clonazepam withdrawal in 13 patients with active epilepsy and drug side effects. ( Buchanan, N; Sharpe, C, 1994) |
| "The clinical picture was complicated by convulsions, perhaps due to clonazepam withdrawal and possible lithium toxicity." | 1.29 | Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder. ( Cubis, JC; Looi, JC; Saboisky, J, 1995) |
| "Catatonia has not previously been described." | 1.29 | Catatonia after benzodiazepine withdrawal. ( Mazurek, MF; Rosebush, PI, 1996) |
| "When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss." | 1.27 | Physical dependence on clonazepam in dogs. ( Frey, HH; Scherkl, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (32.84) | 18.7374 |
| 1990's | 23 (34.33) | 18.2507 |
| 2000's | 7 (10.45) | 29.6817 |
| 2010's | 13 (19.40) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Dokkedal-Silva, V | 1 |
| Galduróz, JCF | 1 |
| Tufik, S | 1 |
| Andersen, ML | 1 |
| Lutz, EW | 1 |
| Hines, C | 1 |
| Ho, TT | 1 |
| Gupta, SV | 1 |
| Sanchez-Valle, A | 1 |
| Bajaj, V | 1 |
| Kalra, I | 1 |
| Bajaj, A | 1 |
| Sharma, D | 1 |
| Kumar, R | 2 |
| Demirci, K | 1 |
| Akgönül, M | 1 |
| Demirdaş, A | 1 |
| Akpınar, A | 1 |
| Kacirova, I | 1 |
| Grundmann, M | 1 |
| Silhan, P | 1 |
| Brozmanova, H | 1 |
| Sharma, RC | 1 |
| Sharma, DD | 1 |
| Kanwar, P | 1 |
| Bonnet, U | 1 |
| Specka, M | 1 |
| Hamzavi Abedi, R | 1 |
| Wiltfang, J | 1 |
| Scherbaum, N | 2 |
| Kouzoupis, AV | 1 |
| Konstantakopoulos, G | 1 |
| Oulis, P | 1 |
| Kalfakis, N | 1 |
| Papageorgiou, SG | 1 |
| Nardi, AE | 2 |
| Freire, RC | 1 |
| Valença, AM | 2 |
| Amrein, R | 1 |
| de Cerqueira, AC | 1 |
| Lopes, FL | 1 |
| Nascimento, I | 2 |
| Mezzasalma, MA | 1 |
| Veras, AB | 1 |
| Sardinha, A | 1 |
| de Carvalho, MR | 1 |
| da Costa, RT | 1 |
| Levitan, MN | 1 |
| de-Melo-Neto, VL | 1 |
| Soares-Filho, GL | 1 |
| Versiani, M | 1 |
| Otto, MW | 2 |
| McHugh, RK | 1 |
| Simon, NM | 1 |
| Farach, FJ | 1 |
| Worthington, JJ | 1 |
| Pollack, MH | 2 |
| Kovacs, N | 1 |
| Herold, R | 1 |
| Janszky, J | 1 |
| Komoly, S | 1 |
| Nagy, F | 1 |
| Schifano, F | 1 |
| D'Offizi, S | 1 |
| Piccione, M | 1 |
| Corazza, O | 1 |
| Deluca, P | 1 |
| Davey, Z | 1 |
| Di Melchiorre, G | 1 |
| Di Furia, L | 1 |
| Farré, M | 1 |
| Flesland, L | 1 |
| Mannonen, M | 1 |
| Majava, A | 1 |
| Pagani, S | 1 |
| Peltoniemi, T | 1 |
| Siemann, H | 1 |
| Skutle, A | 1 |
| Torrens, M | 1 |
| Pezzolesi, C | 1 |
| van der Kreeft, P | 1 |
| Eiden, C | 1 |
| Capdevielle, D | 1 |
| Deddouche, C | 1 |
| Boulenger, JP | 1 |
| Blayac, JP | 1 |
| Peyrière, H | 1 |
| Aggarwal, A | 1 |
| Choudhary, S | 1 |
| Jiloha, RC | 1 |
| Quaglio, G | 1 |
| Pattaro, C | 1 |
| Gerra, G | 1 |
| Mathewson, S | 1 |
| Verbanck, P | 1 |
| Des Jarlais, DC | 1 |
| Lugoboni, F | 1 |
| Rosenberg, MH | 1 |
| Deerfield, LJ | 1 |
| Baruch, EM | 1 |
| Nieves, JE | 1 |
| Stack, KM | 1 |
| Harrison, ME | 1 |
| Gorman, JM | 1 |
| Mowla, A | 1 |
| Firoozabadi, A | 1 |
| Borhani Haghighi, A | 1 |
| Sahraian, A | 1 |
| Chouinard, G | 2 |
| Labonte, A | 1 |
| Fontaine, R | 1 |
| Annable, L | 1 |
| Scharf, MB | 1 |
| Feil, P | 1 |
| Sechi, GP | 1 |
| Zoroddu, G | 1 |
| Rosati, G | 1 |
| Sironi, VA | 2 |
| Miserocchi, G | 1 |
| De Riu, PL | 1 |
| Aminoff, MJ | 1 |
| Zimbroff, DL | 1 |
| Berigan, TR | 1 |
| Harazin, J | 1 |
| Williams, HL | 1 |
| Buchanan, N | 2 |
| Sharpe, C | 1 |
| Chataway, J | 1 |
| Fowler, A | 1 |
| Thompson, PJ | 1 |
| Duncan, JS | 1 |
| Sullivan, M | 1 |
| Toshima, M | 1 |
| Lynn, P | 1 |
| Roy-Byrne, P | 1 |
| Sachs, GS | 1 |
| Reiter, SR | 1 |
| Meltzer-Brody, S | 1 |
| Rosenbaum, JF | 5 |
| Looi, JC | 1 |
| Cubis, JC | 1 |
| Saboisky, J | 1 |
| Rosebush, PI | 1 |
| Mazurek, MF | 1 |
| Löscher, W | 1 |
| Rundfeldt, C | 1 |
| Hönack, D | 1 |
| Ebert, U | 1 |
| Benazzi, F | 1 |
| Freeman, S | 1 |
| Moroz, G | 2 |
| Bowden, CL | 1 |
| Connor, KM | 1 |
| Davidson, JR | 1 |
| Potts, NL | 1 |
| Tupler, LA | 1 |
| Miner, CM | 1 |
| Malik, ML | 1 |
| Book, SW | 1 |
| Colket, JT | 1 |
| Ferrell, F | 1 |
| Gupta, N | 1 |
| Bhargava, VK | 1 |
| Pandhi, P | 1 |
| Lerner, AG | 1 |
| Skladman, I | 1 |
| Kodesh, A | 1 |
| Sigal, M | 1 |
| Shufman, E | 1 |
| Covington, EC | 1 |
| Lockard, JS | 1 |
| Levy, RH | 1 |
| Congdon, WC | 1 |
| DuCharme, LL | 1 |
| Salonen, LD | 1 |
| Franzini, A | 1 |
| Ravagnati, L | 1 |
| Marossero, F | 1 |
| Horiguchi, J | 1 |
| Nishimatsu, O | 1 |
| Galpern, WR | 1 |
| Lumpkin, M | 1 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Miller, LG | 2 |
| McElroy, SL | 1 |
| Keck, PE | 1 |
| Lawrence, JM | 1 |
| Kales, A | 1 |
| Manfredi, RL | 1 |
| Vgontzas, AN | 1 |
| Baldassano, CF | 1 |
| Kostakos, K | 1 |
| Kales, JD | 1 |
| Alvarez, WA | 1 |
| Zona, MA | 1 |
| Patterson, JF | 2 |
| Wong, T | 2 |
| Tiessen, E | 1 |
| Hauser, P | 1 |
| Devinsky, O | 1 |
| De Bellis, M | 1 |
| Theodore, WH | 1 |
| Post, RM | 1 |
| Ghadirian, AM | 1 |
| Gauthier, S | 1 |
| Herman, JB | 1 |
| Brotman, AW | 1 |
| Albeck, JH | 1 |
| Eppel, AB | 1 |
| Scherkl, R | 1 |
| Frey, HH | 1 |
| Toreva, D | 1 |
| Kostadinova, I | 1 |
| Garbutt, JC | 1 |
| Gillette, GM | 1 |
| Davies, MF | 1 |
| Sasaki, SE | 1 |
| Carlen, PL | 1 |
| Jaffe, R | 1 |
| Gibson, E | 1 |
| O'Flaherty, S | 1 |
| Evans, M | 1 |
| Epps, A | 1 |
| Edwards, VE | 1 |
4 reviews available for clonazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Anticonvulsants for neuropathic pain and detoxification.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Clonazepam; Cyclohexanecarboxylic Acids; Gabapenti | 1998 |
Chronic benzodiazepine administration: from the patient to the gene.
Topics: Alprazolam; Animals; Benzodiazepines; Clonazepam; Down-Regulation; Drug Tolerance; Flumazenil; Human | 1991 |
Rebound anxiety in panic disorder patients treated with shorter-acting benzodiazepines.
Topics: Acute Disease; Adult; Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Clonazepam; Fear; Female; | 1987 |
Withdrawal and detoxification from benzodiazepine dependence: a potential role for clonazepam.
Topics: Adolescent; Adult; Aged; Alprazolam; Anti-Anxiety Agents; Clonazepam; Diazepam; Drug Tolerance; Huma | 1987 |
11 trials available for clonazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Tapering clonazepam in patients with panic disorder after at least 3 years of treatment.
Topics: Adolescent; Adult; Aged; Clonazepam; Female; Follow-Up Studies; Humans; Male; Middle Aged; Panic Dis | 2010 |
Efficacy of CBT for benzodiazepine discontinuation in patients with panic disorder: Further evaluation.
Topics: Adult; Alprazolam; Benzodiazepines; Clonazepam; Cognitive Behavioral Therapy; Dose-Response Relation | 2010 |
High dose benzodiazepine dependence: description of 29 patients treated with flumazenil infusion and stabilised with clonazepam.
Topics: Adult; Antidepressive Agents; Benzodiazepines; Clonazepam; Drug Therapy, Combination; Female; Flumaz | 2012 |
New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines.
Topics: Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Bipolar Disorder; Bromazepam; C | 1983 |
Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study.
Topics: Adult; Anxiety Disorders; Chronic Disease; Clonazepam; Double-Blind Method; Female; Hospitalization; | 1993 |
Discontinuation of benzodiazepine treatment: efficacy of cognitive-behavioral therapy for patients with panic disorder.
Topics: Adult; Alprazolam; Ambulatory Care; Benzodiazepines; Clonazepam; Cognitive Behavioral Therapy; Combi | 1993 |
Clonazepam in the treatment of panic disorder with or without agoraphobia: a dose-response study of efficacy, safety, and discontinuance. Clonazepam Panic Disorder Dose-Response Study Group.
Topics: Adolescent; Adult; Aged; Agoraphobia; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Met | 1997 |
Discontinuation of clonazepam in the treatment of social phobia.
Topics: Adult; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Admi | 1998 |
Efficacy, safety, and gradual discontinuation of clonazepam in panic disorder: a placebo-controlled, multicenter study using optimized dosages.
Topics: Adolescent; Adult; Aged; Agoraphobia; Ambulatory Care; Clonazepam; Comorbidity; Double-Blind Method; | 1999 |
Usefulness of antiparkinsonian drugs during neuroleptic treatment and the effect of clonazepam on akathisia and parkinsonism occurred after antiparkinsonian drug withdrawal: a double-blind study.
Topics: Akathisia, Drug-Induced; Antiparkinson Agents; Antipsychotic Agents; Chronic Disease; Clonazepam; Do | 1992 |
Clonazepam: sleep laboratory study of efficacy and withdrawal.
Topics: Adult; Clonazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Sleep; Sleep Initiation a | 1991 |
52 other studies available for clonazepam and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Combined cocaine and clonazepam administration induces REM sleep loss and anxiety-like withdrawal behaviors in rats.
Topics: Animals; Anxiety; Behavior, Animal; Clonazepam; Cocaine; Corticosterone; Exploratory Behavior; Male; | 2020 |
Recurrent clonazepam withdrawal delirium in a postoperative neurosurgical patient: a case report.
Topics: Benzodiazepines; Clonazepam; Delirium; Humans; Male; Middle Aged; Postoperative Period; Substance Wi | 2021 |
Prolonged clonazepam-induced withdrawal symptoms in an NAT2 ultraslow acetylator.
Topics: Acetylation; Aged; Arylamine N-Acetyltransferase; Clonazepam; Cytochrome P-450 CYP3A; Drug-Related S | 2019 |
A case of zolpidem dependence with extremely high daily doses.
Topics: Clonazepam; GABA Modulators; Humans; Hypnotics and Sedatives; Irritable Mood; Male; Middle Aged; Sle | 2019 |
Does melissa officinalis cause withdrawal or dependence?
Topics: Adult; Clonazepam; Humans; Male; Melissa; Plants, Medicinal; Substance Withdrawal Syndrome; Substanc | 2015 |
A Case Report of Clonazepam Dependence: Utilization of Therapeutic Drug Monitoring During Withdrawal Period.
Topics: Adult; Clonazepam; Drug Monitoring; GABA Modulators; Humans; Male; Substance Withdrawal Syndrome | 2016 |
Opium Withdrawal Delirium: Two Case Reports.
Topics: Adult; Analgesics, Opioid; Anticonvulsants; Clonazepam; Delirium; Humans; Male; Middle Aged; Opioid- | 2017 |
Severe protracted alcohol withdrawal syndrome: prevalence and pharmacological treatment at an inpatient detoxification unit--a naturalistic study.
Topics: Adult; Aged; Alcoholism; Amines; Anticonvulsants; Chlormethiazole; Clonazepam; Cyclohexanecarboxylic | 2009 |
A case of severe toluene withdrawal syndrome treated with clonazepam.
Topics: Administration, Inhalation; Anticonvulsants; Clonazepam; Humans; Male; Severity of Illness Index; Su | 2010 |
Tics status: a movement disorder emergency: observations.
Topics: Adolescent; Antipsychotic Agents; Clonazepam; Creatine Kinase; Diagnostic and Statistical Manual of | 2011 |
Is there a recreational misuse potential for pregabalin? Analysis of anecdotal online reports in comparison with related gabapentin and clonazepam data.
Topics: Amines; Anticonvulsants; Clonazepam; Cross-Sectional Studies; Cyclohexanecarboxylic Acids; Dose-Resp | 2011 |
Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.
Topics: 4-Butyrolactone; Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Evaluation, | 2011 |
Opioid withdrawal delirium.
Topics: Clonazepam; Delirium; GABA Modulators; Heroin Dependence; Humans; Male; Narcotics; Substance Withdra | 2011 |
Two cases of severe gamma-hydroxybutyrate withdrawal delirium on a psychiatric unit: recommendations for management.
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Clonazepam; Clonidine; Delirium; Hospitalization; H | 2003 |
Dysphagia: a rare form of dyskinesia?
Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Deglutition Disorders; Dyskinesia, Drug-Induced; | 2007 |
Megadose clonazepam dependence: a case report.
Topics: Adult; Anticonvulsants; Borderline Personality Disorder; Carbamazepine; Clonazepam; Dose-Response Re | 2007 |
Acute effects of drug administration and withdrawal on the benzodiazepine receptor.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Clonazepam; Diazepam; Flurazepam; Humans; Lorazepam; Male | 1983 |
Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus.
Topics: Adult; Benzodiazepinones; Carbamazepine; Clonazepam; Humans; Male; Status Epilepticus; Substance Wit | 1984 |
Clonazepam withdrawal syndrome.
Topics: Adult; Benzodiazepinones; Clonazepam; Drug Administration Schedule; Electroencephalography; Epilepsy | 1984 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Switching patients from clozapine to risperidone therapy.
Topics: Antipsychotic Agents; Clonazepam; Clozapine; Drug Administration Schedule; Drug Therapy, Combination | 1995 |
Use of flumazenil in conjunction with electroconvulsive therapy.
Topics: Adult; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Female; Flumazenil; Humans; Subst | 1995 |
Clonazepam withdrawal in 13 patients with active epilepsy and drug side effects.
Topics: Adolescent; Adult; Child; Child, Preschool; Clonazepam; Epilepsy; Female; Humans; Male; Middle Aged; | 1994 |
Discontinuation of clonazepam in patients with active epilepsy.
Topics: Adolescent; Adult; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Elect | 1993 |
Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder.
Topics: Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Therapy, Combination; GABA Mo | 1995 |
Catatonia after benzodiazepine withdrawal.
Topics: Aged; Aged, 80 and over; Alprazolam; Anti-Anxiety Agents; Catatonia; Clonazepam; Diazepam; Female; H | 1996 |
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba | 1996 |
Dangerous interaction with nefazodone added to fluoxetine, desipramine, venlafaxine, valproate and clonazepam combination therapy.
Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Desipramine; Drug Ther | 1997 |
The realities of clonazepam discontinuation.
Topics: Alprazolam; Anxiety Disorders; Benzodiazepines; Clonazepam; Drug Administration Schedule; GABA Modul | 1997 |
Tolerance and withdrawal to anticonvulsant action of clonazepam: role of nitric oxide.
Topics: Animals; Anticonvulsants; Clonazepam; Drug Tolerance; Female; Male; Nitric Oxide; Nitroarginine; Pen | 2000 |
Smoking and panic disorder.
Topics: Adult; Anticonvulsants; Clonazepam; Female; Humans; Nicotine; Panic Disorder; Psychiatric Status Rat | 2001 |
LSD-induced Hallucinogen Persisting Perception Disorder treated with clonazepam: two case reports.
Topics: Adult; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies | 2001 |
Clonazepam in a focal-motor monkey model: efficacy, tolerance, toxicity, withdrawal, and management.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Benzodiazepinones; Clonazepam; Drug Tolerance; Electr | 1979 |
Interictal acute psychoses in temporal lobe epilepsy during withdrawal of anticonvulsant therapy.
Topics: Adult; Carbamazepine; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tempo | 1979 |
Chronic benzodiazepine administration. VII. Behavioral tolerance and withdrawal and receptor alterations associated with clonazepam administration.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cereb | 1991 |
Treatment of panic disorder and benzodiazepine withdrawal with valproate.
Topics: Adult; Agoraphobia; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Humans; Male; Panic Diso | 1991 |
Switching patients from alprazolam to clonazepam.
Topics: Agoraphobia; Alprazolam; Anxiety Disorders; Clonazepam; Dose-Response Relationship, Drug; Drug Admin | 1990 |
Seizure in gradual clonazepam withdrawal, Vol. 14, No. 3, September, 1989, p. 484.
Topics: Clonazepam; Dose-Response Relationship, Drug; Humans; Seizures; Substance Withdrawal Syndrome | 1990 |
Withdrawal from alprazolam dependency using clonazepam: clinical observations.
Topics: Alprazolam; Ambulatory Care; Clonazepam; Hospitalization; Humans; Male; Middle Aged; Stress Disorder | 1990 |
Seizure in gradual clonazepam withdrawal.
Topics: Adult; Clonazepam; Epilepsy, Tonic-Clonic; Humans; Male; Substance Withdrawal Syndrome; Tourette Syn | 1989 |
Clonazepam in treatment of bipolar psychotic patients after discontinuation of neuroleptics.
Topics: Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Administration Schedule; Humans; Research D | 1989 |
Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders.
Topics: Adult; Benzodiazepines; Catatonia; Clonazepam; Clorazepate Dipotassium; Delirium; Encephalitis; Fema | 1989 |
Convulsions in patients abruptly withdrawn from clonazepam while receiving neuroleptic medication.
Topics: Adult; Antipsychotic Agents; Clonazepam; Drug Therapy, Combination; Female; Humans; Male; Mental Dis | 1987 |
Imipramine and clonazepam for panic disorder.
Topics: Anxiety Disorders; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Fear; Humans; Imipram | 1989 |
Physical dependence on clonazepam in dogs.
Topics: Animals; Benzodiazepinones; Body Temperature; Body Weight; Clonazepam; Dogs; Female; Flumazenil; Mal | 1986 |
Experimental characterisation of the withdrawal syndrome after 14 days treatment with clonazepam.
Topics: Animals; Clonazepam; Drug Administration Schedule; Female; Male; Motor Activity; Rats; Rats, Inbred | 1987 |
Apparent complex partial seizures in a bipolar patient after withdrawal of carbamazepine.
Topics: Bipolar Disorder; Carbamazepine; Clonazepam; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Fem | 1988 |
Alprazolam dependency: use of clonazepam for withdrawal.
Topics: Adult; Alprazolam; Anxiety Disorders; Clonazepam; Humans; Hydrocortisone; Male; Substance Withdrawal | 1988 |
Benzodiazepine-induced epileptiform activity in vitro.
Topics: Animals; Clonazepam; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Neurons; R | 1987 |
Clonazepam withdrawal psychosis.
Topics: Adult; Benzodiazepinones; Clonazepam; Female; Humans; Paranoid Disorders; Substance Withdrawal Syndr | 1986 |
Choreoathetosis and clonazepam.
Topics: Adolescent; Athetosis; Benzodiazepinones; Chorea; Clonazepam; Epilepsy; Humans; Male; Substance With | 1985 |
Side effects of clonazepam therapy.
Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E | 1974 |