clonazepam has been researched along with Stiff-Person Syndrome in 20 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Stiff-Person Syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral clonazepam is an effective therapy besides behavioral and safety interventions for hereditary cases." | 2.66 | Hyperekplexia and other startle syndromes. ( Pandey, S; Saini, AG, 2020) |
| "Her diagnosis was confirmed as hereditary hyperekplexia with GlRA1 hybrid gene mutations based on the sequencing results." | 1.56 | C.292G>A, a novel glycine receptor alpha 1 subunit gene (GLRA1) mutation found in a Chinese patient with hyperekplexia: A case report. ( Lin, CM; Wu, LL; Zhang, Y; Zheng, XL, 2020) |
| "Treatment with clonazepam markedly reduced the threshold and intensity of the startle response, enabling him to recover independence." | 1.40 | Sporadic hyperekplexia presenting with an ataxic gait. ( Bilbao, I; Losada, J; Maestro, I; Rouco, I; Zarranz, JJ, 2014) |
| "The prognosis is generally good in hereditary hyperekplexia." | 1.33 | Hyperekplexia in two siblings. ( Kannan, B; Kulkarni, ML; Mathadh, P, 2006) |
| " For treatment, the dosage and way of administration of diazepam should be judged according to the severeness of the disease; nitrazepam and clonazepam are effective, too." | 1.28 | [Clinical analysis of 30 cases of stiff-man syndrome]. ( Chen, BJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (25.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| Wu, LL | 1 |
| Zheng, XL | 1 |
| Lin, CM | 1 |
| Saini, AG | 1 |
| Pandey, S | 1 |
| Cai, Q | 1 |
| Wu, C | 1 |
| Xu, W | 1 |
| Liang, Y | 1 |
| Liao, S | 1 |
| Moriyoshi, H | 1 |
| Hata, Y | 1 |
| Inagaki, R | 1 |
| Suzuki, J | 1 |
| Nishida, S | 1 |
| Nishida, N | 1 |
| Ito, Y | 1 |
| Zhang, C | 1 |
| Wang, SG | 1 |
| Wang, Y | 1 |
| Liu, XL | 1 |
| Cao, L | 1 |
| Derksen, A | 1 |
| Stettner, M | 1 |
| Stöcker, W | 2 |
| Seitz, RJ | 1 |
| Rouco, I | 1 |
| Bilbao, I | 1 |
| Losada, J | 1 |
| Maestro, I | 1 |
| Zarranz, JJ | 1 |
| Eisermann, M | 1 |
| Lardeux, C | 1 |
| Nicloux, M | 1 |
| Bahi-Buisson, N | 1 |
| Vanbellinghen, JF | 1 |
| Magny, JF | 1 |
| Kaminska, A | 1 |
| Lapillonne, A | 1 |
| McAbee, GN | 1 |
| Rønne, MS | 1 |
| Nielsen, PB | 1 |
| Mogensen, CB | 1 |
| Saigal, R | 1 |
| Goyal, L | 1 |
| Yadav, R | 1 |
| Agrawal, A | 1 |
| Mital, P | 1 |
| Patel, B | 1 |
| Poon, WT | 1 |
| Au, KM | 1 |
| Chan, YW | 1 |
| Chan, KY | 1 |
| Chow, CB | 1 |
| Tong, SF | 1 |
| Lam, CW | 1 |
| Kulkarni, ML | 1 |
| Kannan, B | 1 |
| Mathadh, P | 1 |
| Garg, R | 1 |
| Ramachandran, R | 1 |
| Sharma, P | 1 |
| Vieregge, P | 1 |
| Branczyk, B | 1 |
| Barnett, W | 1 |
| Soyka, D | 1 |
| Kömpf, D | 1 |
| Prevett, MC | 1 |
| Brown, P | 1 |
| Duncan, JS | 1 |
| Fiol, M | 1 |
| Cammarota, A | 1 |
| Rivero, A | 1 |
| Pardal, A | 1 |
| Nogués, M | 1 |
| Correale, J | 1 |
| Chen, BJ | 1 |
| Ryan, SG | 2 |
| Dixon, MJ | 1 |
| Nigro, MA | 1 |
| Kelts, KA | 1 |
| Markand, ON | 1 |
| Terry, JC | 2 |
| Shiang, R | 1 |
| Wasmuth, JJ | 1 |
| O'Connell, P | 1 |
| Sherman, SL | 1 |
| Sparkes, RS | 1 |
| Torres, MC | 1 |
| Mackey, RW | 1 |
1 review available for clonazepam and Stiff-Person Syndrome
| Article | Year |
|---|---|
Hyperekplexia and other startle syndromes.
Topics: Adult; Child; Clonazepam; Humans; Hyperekplexia; Infant; Infant, Newborn; Muscle Rigidity; Receptors | 2020 |
19 other studies available for clonazepam and Stiff-Person Syndrome
| Article | Year |
|---|---|
C.292G>A, a novel glycine receptor alpha 1 subunit gene (GLRA1) mutation found in a Chinese patient with hyperekplexia: A case report.
Topics: China; Clonazepam; Female; Humans; Infant; Mutation; Receptors, Glycine; Reflex, Startle; Stiff-Pers | 2020 |
Stiff-person syndrome coexisting with critical illness polyneuropathy: A case report.
Topics: Baclofen; Clonazepam; Diagnosis, Differential; Electromyography; Humans; Immunoglobulins, Intravenou | 2020 |
[A pedigree of hereditary hyperekplexia].
Topics: Accidental Falls; Administration, Oral; Adult; Clonazepam; Female; Humans; Male; Pedigree; Point Mut | 2018 |
Teaching Video NeuroImages: Cautious walking gait in siblings with hereditary hyperekplexia.
Topics: Adult; Clonazepam; Female; GABA Modulators; Gait; Gait Disorders, Neurologic; Humans; Male; Middle A | 2019 |
Antiglycine receptor-related stiff limb syndrome in a patient with chronic lymphocytic leukaemia.
Topics: Aged; Autoantibodies; Baclofen; Clonazepam; Electromyography; GABA Agents; Humans; Leukemia, Lymphoc | 2013 |
Sporadic hyperekplexia presenting with an ataxic gait.
Topics: Clonazepam; Diagnosis, Differential; Electroencephalography; Electromyography; GABA Modulators; Gait | 2014 |
Not all myoclonic jerking and tonic posturing in the neonate is epilepsy.
Topics: Anticonvulsants; Clonazepam; Consanguinity; Diagnosis, Differential; Electroencephalography; Epileps | 2014 |
Clobazam-clonazepam combination effective for stimulus-induced falling in hyperekplexia.
Topics: Accidental Falls; Anticonvulsants; Benzodiazepines; Child; Clobazam; Clonazepam; Drug Therapy, Combi | 2015 |
[Stiff baby syndrome is a rare cause of neonatal hypertonicity].
Topics: Anticonvulsants; Clonazepam; Female; Humans; Infant, Newborn; Rare Diseases; Stiff-Person Syndrome | 2014 |
Stiff Person Syndrome.
Topics: Adult; Antibodies; Anticonvulsants; Autoimmunity; Baclofen; Clonazepam; Electromyography; Glutamate | 2015 |
Novel missense mutation (Y279S) in the GLRA1 gene causing hyperekplexia.
Topics: Anticonvulsants; Base Sequence; Child, Preschool; Clonazepam; DNA Mutational Analysis; Female; Follo | 2006 |
Hyperekplexia in two siblings.
Topics: Anticonvulsants; Child, Preschool; Clonazepam; Female; Humans; Infant, Newborn; Male; Reflex, Startl | 2006 |
Anaesthetic implications of hyperekplexia--'startle disease'.
Topics: Anesthesia; Anesthetics, Inhalation; Anticonvulsants; Child; Clonazepam; Electroencephalography; Hum | 2008 |
[Stiff-man syndrome. Report of 4 cases].
Topics: Adult; Animals; Autoantibodies; Cerebellum; Clonazepam; Dose-Response Relationship, Drug; Drug Admin | 1994 |
Improvement of stiff-man syndrome with vigabatrin.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Drug Therapy, Combination; Female; gamma-Aminobut | 1997 |
Focal stiff-person syndrome.
Topics: Adult; Anticonvulsants; Autoantibodies; Clonazepam; Diagnosis, Differential; Electromyography; Femal | 2001 |
[Clinical analysis of 30 cases of stiff-man syndrome].
Topics: Adolescent; Adult; Clonazepam; Diazepam; Female; Humans; Male; Middle Aged; Nitrazepam; Reference St | 1992 |
Genetic and radiation hybrid mapping of the hyperekplexia region on chromosome 5q.
Topics: Base Sequence; Cell Line, Transformed; Chromosome Mapping; Chromosomes, Human, Pair 5; Clonazepam; D | 1992 |
Startle disease, or hyperekplexia: response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis.
Topics: Adult; Child, Preschool; Chromosomes, Human, Pair 5; Clonazepam; Female; Genes, Dominant; Genetic Ma | 1992 |