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clonazepam and Stevens-Johnson Syndrome

clonazepam has been researched along with Stevens-Johnson Syndrome in 3 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
"Epilepsy is very difficult to treat and often involves the combination of two or more AEDs."1.56Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Noguchi, Y1
Takaoka, M1
Hayashi, T1
Tachi, T1
Teramachi, H1
Fukasawa, T1
Takahashi, H1
Takahashi, K1
Tanemura, N1
Amagai, M1
Urushihara, H1
Duval, X1
Chosidow, O1
Semah, F1
Lipsker, D1
Francès, C1
Herson, S1

Other Studies

3 other studies available for clonazepam and Stevens-Johnson Syndrome

ArticleYear
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination;

2020
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with anticonvulsants in a Japanese population: Matched case-control and cohort studies.
    Allergology international : official journal of the Japanese Society of Allergology, 2021, Volume: 70, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Clonazepam; Cohort Studies; Diazepam; F

2021
Lamotrigine versus carbamazepine in epilepsy.
    Lancet (London, England), 1995, May-20, Volume: 345, Issue:8960

    Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi

1995