clonazepam has been researched along with Status Epilepticus in 62 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the clinical efficacy of clonazepam in the treatment of status epilepticus." | 9.51 | Clinical efficacy of clonazepam in the treatment of status epilepticus. ( Fang, L; Tong, X; Wu, X; Xu, Y; Zhou, X, 2022) |
| "Clonazepam (CZ) is an anti-epileptic drug used mainly in status epilepticus (SE)." | 7.83 | Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies. ( Abdelmalak, NS; Ibrahim, AB; Naguib, MJ; Nour, SA; Rashed, HM, 2016) |
| "Benzodiazepines (BZD) are recommended as first-line treatment for status epilepticus (SE), with lorazepam (LZP) and midazolam (MDZ) being the most widely used drugs and part of current treatment guidelines." | 7.81 | Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison. ( Alvarez, V; Drislane, FW; Dworetzky, BA; Lee, JW; Novy, J; Rossetti, AO; Westover, MB, 2015) |
| "To study the efficacy of levetiracetam (LEV) combined with short-term clonazepam (CZP) in the treatment of electrical status epilepticus during sleep (ESES) in children with benign childhood epilepsy with centrotemporal spikes (BECCT)." | 7.80 | [Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes]. ( Chen, L; Su, TF; Xu, SQ, 2014) |
| "To report 3 cases with focal lesional epilepsy that had non-convulsive status epilepticus (NCSE) induced by treatment with tiagabine (TGB) and review the previously published cases." | 7.73 | Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy. ( Cowley, M; Kilpatrick, C; Kornberg, AJ; Matkovic, Z; O'Brien, TJ; Vinton, A, 2005) |
| "Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i." | 7.70 | Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures. ( Broźek, G; Hort, J; Komárek, V; Langmeier, M; Mares, P, 1999) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 7.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "We describe two patients in whom clonazepam withdrawal status epilepticus occurred in spite of therapeutic levels of carbamazepine in plasma and cerebrospinal fluid." | 7.67 | Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus. ( Rosati, G; Sechi, GP; Zoroddu, G, 1984) |
| "Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril)." | 7.66 | Intravenous clonazepam in the treatment of status epilepticus in children. ( Congdon, PJ; Forsythe, WI, 1980) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 7.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results." | 7.65 | [Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam]. ( Bücking, PH, 1977) |
| "Clonazepam (CZP) has rarely been included in treatment guidelines for SE; however, this drug has been widely used in the treatment of SE patients and has unique advantages." | 6.52 | Clonazepam in the treatment of status epilepticus. ( Liao, H; Shangguan, Y; Wang, X, 2015) |
| "Benzodiazepines are the first treatment line in status epilepticus (SE)." | 5.91 | Clonazepam Loading Dose in Status Epilepticus: Is More Always Better? ( Beuchat, I; D'Anto, J; Novy, J; Rossetti, AO, 2023) |
| "To explore the clinical efficacy of clonazepam in the treatment of status epilepticus." | 5.51 | Clinical efficacy of clonazepam in the treatment of status epilepticus. ( Fang, L; Tong, X; Wu, X; Xu, Y; Zhou, X, 2022) |
| "Clonazepam (CZP) was administered with PRO, and other antiepileptic drugs (AEDs) concomitant with PRO and THP." | 5.32 | Propofol treatment of refractory status epilepticus: a study of 31 episodes. ( Bogousslavsky, J; Despland, PA; Reichhart, MD; Rossetti, AO; Schaller, MD, 2004) |
| "Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit." | 5.29 | Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994) |
| " Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy." | 4.76 | [Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983) |
| "Clonazepam (CZ) is an anti-epileptic drug used mainly in status epilepticus (SE)." | 3.83 | Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies. ( Abdelmalak, NS; Ibrahim, AB; Naguib, MJ; Nour, SA; Rashed, HM, 2016) |
| "Benzodiazepines (BZD) are recommended as first-line treatment for status epilepticus (SE), with lorazepam (LZP) and midazolam (MDZ) being the most widely used drugs and part of current treatment guidelines." | 3.81 | Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison. ( Alvarez, V; Drislane, FW; Dworetzky, BA; Lee, JW; Novy, J; Rossetti, AO; Westover, MB, 2015) |
| "To study the efficacy of levetiracetam (LEV) combined with short-term clonazepam (CZP) in the treatment of electrical status epilepticus during sleep (ESES) in children with benign childhood epilepsy with centrotemporal spikes (BECCT)." | 3.80 | [Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes]. ( Chen, L; Su, TF; Xu, SQ, 2014) |
| "To report 3 cases with focal lesional epilepsy that had non-convulsive status epilepticus (NCSE) induced by treatment with tiagabine (TGB) and review the previously published cases." | 3.73 | Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy. ( Cowley, M; Kilpatrick, C; Kornberg, AJ; Matkovic, Z; O'Brien, TJ; Vinton, A, 2005) |
| "Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i." | 3.70 | Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures. ( Broźek, G; Hort, J; Komárek, V; Langmeier, M; Mares, P, 1999) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 3.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "We describe two patients in whom clonazepam withdrawal status epilepticus occurred in spite of therapeutic levels of carbamazepine in plasma and cerebrospinal fluid." | 3.67 | Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus. ( Rosati, G; Sechi, GP; Zoroddu, G, 1984) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 3.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril)." | 3.66 | Intravenous clonazepam in the treatment of status epilepticus in children. ( Congdon, PJ; Forsythe, WI, 1980) |
| "Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results." | 3.65 | [Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam]. ( Bücking, PH, 1977) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| "Therapeutic strategies for patients with generalized convulsive status epilepticus (GCSE) need to be improved." | 2.76 | A prehospital randomized trial in convulsive status epilepticus. ( An, K; Baulac, M; Bolgert, F; Carli, P; Dagron, C; Demeret, S; Lamhaut, L; Navarro, V, 2011) |
| "Ongoing convulsive seizures for more than 5 minutes or nonconvulsive seizure activity for more than 10 to 30 minutes is considered early SE." | 2.66 | Drug Trials in Status Epilepticus: Current Evidence and Future Concepts. ( Husain, AM; Mandge, V, 2020) |
| "Clonazepam (CZP) has rarely been included in treatment guidelines for SE; however, this drug has been widely used in the treatment of SE patients and has unique advantages." | 2.52 | Clonazepam in the treatment of status epilepticus. ( Liao, H; Shangguan, Y; Wang, X, 2015) |
| " Differences in pharmacokinetic parameters, therefore, will influence the choice of drug." | 2.38 | Pharmacokinetics and clinical use of benzodiazepines in the management of status epilepticus. ( Treiman, DM, 1989) |
| " New antiepileptic drugs have improved medical management, and technical and theoretical advances in pharmacokinetics have permitted physicians to design balanced dosing for individual patients." | 2.36 | Recent developments in the diagnosis and therapy of epilepsy. ( Crandall, PH; Engel, J; Sterman, MB; Troupin, AS; Wasterlain, CG, 1982) |
| "Benzodiazepines are the first treatment line in status epilepticus (SE)." | 1.91 | Clonazepam Loading Dose in Status Epilepticus: Is More Always Better? ( Beuchat, I; D'Anto, J; Novy, J; Rossetti, AO, 2023) |
| " Medication dosing generally followed standard dosing guidelines with very few exceptions." | 1.51 | Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium. ( Payne, E; Wallace, A; Wirrell, E, 2019) |
| "Vitamin B12 deficiency is a treatable cause of failure to thrive and developmental regression, involuntary movements, and anemia." | 1.39 | Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. ( Belgemen, T; Carman, KB; Yis, U, 2013) |
| " Patients' size determined dosing at 0." | 1.36 | Dissolving oral clonazepam wafers in the acute treatment of prolonged seizures. ( Hastriter, EV; Ng, YT; Troester, MM, 2010) |
| "Clonazepam injection was used to suppress the AS episode and the subintrant myoclonia." | 1.35 | [Idiopathic generalised epilepsies in the elderly: the viewpoint of a geriatrician]. ( Adam, C; Lavallard-Rousseau, MC; Nguyen-Michel, VH; Ourabah, Z; Sebban, C, 2009) |
| "Clonazepam (CZP) was administered with PRO, and other antiepileptic drugs (AEDs) concomitant with PRO and THP." | 1.32 | Propofol treatment of refractory status epilepticus: a study of 31 episodes. ( Bogousslavsky, J; Despland, PA; Reichhart, MD; Rossetti, AO; Schaller, MD, 2004) |
| "Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit." | 1.29 | Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994) |
| "Children with seizure disorders frequently are treated with anticonvulsant medications such as clonazepam, valproic acid, carbamazepine, and ethosuximide, which cannot be given parenterally." | 1.27 | Rectal anticonvulsants in pediatric practice. ( Laney, SM; Woody, RC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (43.55) | 18.7374 |
| 1990's | 8 (12.90) | 18.2507 |
| 2000's | 9 (14.52) | 29.6817 |
| 2010's | 13 (20.97) | 24.3611 |
| 2020's | 5 (8.06) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, X | 1 |
| Fang, L | 1 |
| Tong, X | 1 |
| Xu, Y | 1 |
| Wu, X | 1 |
| Kienitz, R | 1 |
| Kay, L | 1 |
| Beuchat, I | 2 |
| Gelhard, S | 1 |
| von Brauchitsch, S | 1 |
| Mann, C | 1 |
| Lucaciu, A | 1 |
| Schäfer, JH | 1 |
| Siebenbrodt, K | 1 |
| Zöllner, JP | 1 |
| Schubert-Bast, S | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Willems, LM | 1 |
| D'Anto, J | 1 |
| Rossetti, AO | 3 |
| Novy, J | 2 |
| Le Coz, J | 1 |
| Chéron, G | 1 |
| Nabbout, R | 1 |
| Patteau, G | 1 |
| Heilbronner, C | 1 |
| Hubert, P | 1 |
| Renolleau, S | 1 |
| Oualha, M | 1 |
| Mandge, V | 1 |
| Husain, AM | 1 |
| Shimogori, K | 1 |
| Doden, T | 1 |
| Oguchi, K | 1 |
| Hashimoto, T | 1 |
| Wallace, A | 1 |
| Wirrell, E | 1 |
| Payne, E | 1 |
| Carman, KB | 1 |
| Belgemen, T | 1 |
| Yis, U | 1 |
| Su, TF | 1 |
| Xu, SQ | 1 |
| Chen, L | 1 |
| Gélisse, P | 1 |
| Crespel, A | 1 |
| Shangguan, Y | 1 |
| Liao, H | 1 |
| Wang, X | 1 |
| Alvarez, V | 1 |
| Lee, JW | 1 |
| Drislane, FW | 1 |
| Westover, MB | 1 |
| Dworetzky, BA | 1 |
| Claassen, J | 1 |
| Navarro, V | 2 |
| Dagron, C | 2 |
| Elie, C | 1 |
| Lamhaut, L | 2 |
| Demeret, S | 2 |
| Urien, S | 1 |
| An, K | 2 |
| Bolgert, F | 2 |
| Tréluyer, JM | 1 |
| Baulac, M | 2 |
| Carli, P | 2 |
| Nour, SA | 1 |
| Abdelmalak, NS | 1 |
| Naguib, MJ | 1 |
| Rashed, HM | 1 |
| Ibrahim, AB | 1 |
| Nguyen-Michel, VH | 1 |
| Ourabah, Z | 1 |
| Sebban, C | 1 |
| Lavallard-Rousseau, MC | 1 |
| Adam, C | 1 |
| Troester, MM | 1 |
| Hastriter, EV | 1 |
| Ng, YT | 1 |
| Linnet, KM | 1 |
| Kragh-Olsen, B | 1 |
| Wheless, JW | 1 |
| Reichhart, MD | 1 |
| Schaller, MD | 1 |
| Despland, PA | 1 |
| Bogousslavsky, J | 1 |
| Vinton, A | 1 |
| Kornberg, AJ | 1 |
| Cowley, M | 1 |
| Matkovic, Z | 1 |
| Kilpatrick, C | 1 |
| O'Brien, TJ | 1 |
| Bahi-Buisson, N | 1 |
| Savini, R | 1 |
| Eisermann, M | 1 |
| Bulteau, C | 1 |
| Dulac, O | 1 |
| Hertz-Pannier, L | 1 |
| Chiron, C | 1 |
| Schorl, M | 1 |
| Fernández-Torre, JL | 1 |
| Leno, C | 1 |
| Sorel, L | 2 |
| Mechler, L | 2 |
| Harmant, J | 2 |
| Loiseau, P | 1 |
| Bleck, TP | 1 |
| Berkovic, SF | 1 |
| Bladin, PF | 1 |
| Sechi, GP | 1 |
| Zoroddu, G | 1 |
| Rosati, G | 1 |
| Fröscher, W | 1 |
| Bittencourt, PR | 1 |
| Richens, A | 1 |
| Johnston, MV | 1 |
| Freeman, JM | 1 |
| Engel, J | 1 |
| Troupin, AS | 1 |
| Crandall, PH | 1 |
| Sterman, MB | 1 |
| Wasterlain, CG | 1 |
| Singh, AN | 1 |
| Le Morvan, P | 1 |
| Tassinari, CA | 1 |
| Daniele, O | 1 |
| Michelucci, R | 1 |
| Bureau, M | 1 |
| Dravet, C | 1 |
| Roger, J | 1 |
| Congdon, PJ | 1 |
| Forsythe, WI | 1 |
| Hilkens, PH | 1 |
| de Weerd, AW | 1 |
| Borgeat, A | 1 |
| Wilder-Smith, OH | 1 |
| Jallon, P | 1 |
| Suter, PM | 1 |
| Primavera, A | 1 |
| Giberti, L | 1 |
| Scotto, P | 1 |
| Cocito, L | 1 |
| Ney, GC | 1 |
| Zimmerman, C | 1 |
| Schaul, N | 1 |
| George, B | 1 |
| Kulkarni, SK | 1 |
| Kokate, TG | 1 |
| Cohen, AL | 1 |
| Karp, E | 1 |
| Rogawski, MA | 1 |
| Hort, J | 1 |
| Broźek, G | 1 |
| Mares, P | 1 |
| Langmeier, M | 1 |
| Komárek, V | 1 |
| Flacke, S | 1 |
| Wüllner, U | 1 |
| Keller, E | 1 |
| Hamzei, F | 1 |
| Urbach, H | 1 |
| Tabarki, B | 1 |
| Yacoub, M | 1 |
| Selmi, H | 1 |
| Oubich, F | 1 |
| Barsaoui, S | 1 |
| Essoussi, AS | 1 |
| Browne, TR | 1 |
| Aucamp, AK | 1 |
| Lagenstein, I | 1 |
| Iffland, E | 1 |
| Bücking, PH | 1 |
| Wauquier, A | 1 |
| Ashton, D | 1 |
| Melis, W | 1 |
| Miyasaka, M | 1 |
| Van Huffelen, AC | 1 |
| Magnus, O | 1 |
| Jolliet, P | 1 |
| Hillion, C | 1 |
| Chevrolet, JC | 1 |
| Treiman, DM | 1 |
| Medici, V | 1 |
| Roth, F | 1 |
| Keller, HP | 1 |
| Garcia de Alba, GO | 1 |
| Malagon Valdez, J | 1 |
| Franco Delgadillo, J | 1 |
| Ramos Peek, J | 1 |
| Woody, RC | 1 |
| Laney, SM | 1 |
| Livingston, JH | 1 |
| Brown, JK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Combined Levetiracetam and Midazolam in Treatment of Generalized Convulsive Status Epilepticus in Children[NCT04926844] | Phase 2 | 144 participants (Actual) | Interventional | 2021-06-20 | Completed | ||
| Efficiency of Levetiracetam Intravenous in Association With Clonazepam Versus Clonazepam Alone in Prehospital Care of Generalised Tonicoclonic Status Epilepticus[NCT01150331] | Phase 3 | 203 participants (Actual) | Interventional | 2009-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for clonazepam and Status Epilepticus
| Article | Year |
|---|---|
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Drug Trials in Status Epilepticus: Current Evidence and Future Concepts.
Topics: Anticonvulsants; Benzodiazepines; Clinical Trials as Topic; Clonazepam; Consensus; Critical Illness; | 2020 |
Clonazepam in the treatment of status epilepticus.
Topics: Animals; Anticonvulsants; Clonazepam; Databases, Factual; Humans; Status Epilepticus | 2015 |
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche | 2003 |
[Benzodiazepines in the treatment of epilepsy].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam | 1983 |
Therapy for status epilepticus.
Topics: Acetazolamide; Anesthesia; Anticonvulsants; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Eth | 1983 |
Recent developments in the diagnosis and therapy of epilepsy.
Topics: Anticonvulsants; Biofeedback, Psychology; Carbamazepine; Clonazepam; Clorazepate Dipotassium; Condit | 1982 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
[Barbiturate coma in the treatment of refractory status epilepticus in adults. Usefulness of continuous electroencephalography in intensive care].
Topics: Adult; Barbiturates; Clonazepam; Critical Care; Drug Therapy, Combination; Electroencephalography; F | 1991 |
Pharmacokinetics and clinical use of benzodiazepines in the management of status epilepticus.
Topics: Benzodiazepines; Chemical Phenomena; Chemistry; Clonazepam; Diazepam; Humans; Lorazepam; Status Epil | 1989 |
7 trials available for clonazepam and Status Epilepticus
| Article | Year |
|---|---|
Clinical efficacy of clonazepam in the treatment of status epilepticus.
Topics: Anticonvulsants; Clonazepam; Diazepam; Humans; Quality of Life; Status Epilepticus; Treatment Outcom | 2022 |
Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial.
Topics: Adult; Aged; Anticonvulsants; Clonazepam; Double-Blind Method; Drug Therapy, Combination; Emergency | 2016 |
A prehospital randomized trial in convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Clonazepam; Double-Blind Method; Drug Therapy, Combination; Emergency Medica | 2011 |
Comparative trial of intravenous lorazepam and clonazepam im status epilepticus.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepinones; Child; Clinical Trials as Topic; Clonazep | 1981 |
Clonazepam.
Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies, | 1978 |
[Treatment of status epilepticus with clonazepam].
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Diazepam; Drug Evaluation; Humans; Phenobar | 1976 |
Non-convulsive status epilepticus resistant to benzodiazepines.
Topics: Adolescent; Benzodiazepines; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Diazepam | 1987 |
45 other studies available for clonazepam and Status Epilepticus
| Article | Year |
|---|---|
Clonazepam Loading Dose in Status Epilepticus: Is More Always Better?
Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Clonazepam; Humans; Retrospective Studies | 2023 |
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit | 2020 |
Thalamic and cerebellar hypermetabolism and cortical hypometabolism during absence status epilepticus.
Topics: Adolescent; Anticonvulsants; Cerebral Cortex; Clonazepam; Delta Rhythm; Electroencephalography; Fema | 2017 |
Seizure Rescue Medication Use among US Pediatric Epilepsy Providers: A Survey of the Pediatric Epilepsy Research Consortium.
Topics: Administration, Intranasal; Administration, Oral; Administration, Rectal; Adolescent; Age Factors; A | 2019 |
Involuntary movements misdiagnosed as seizure during vitamin B12 treatment.
Topics: Atrophy; Brain; Breast Feeding; Clonazepam; Diagnostic Errors; Dyskinesia, Drug-Induced; Electroence | 2013 |
[Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes].
Topics: Anticonvulsants; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Electroencephalogra | 2014 |
Mixed myoclonic-absence status epilepticus in juvenile myoclonic epilepsy.
Topics: Anticonvulsants; Bipolar Disorder; Catatonia; Clonazepam; Electroencephalography; Epilepsies, Myoclo | 2015 |
Practice variability and efficacy of clonazepam, lorazepam, and midazolam in status epilepticus: A multicenter comparison.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Clonazepam; Cohort Studies; Female | 2015 |
Dr No: double drug fails to eliminate status epilepticus.
Topics: Clonazepam; Emergency Medical Services; Female; Humans; Male; Piracetam; Status Epilepticus | 2016 |
Intranasal brain-targeted clonazepam polymeric micelles for immediate control of status epilepticus: in vitro optimization, ex vivo determination of cytotoxicity, in vivo biodistribution and pharmacodynamics studies.
Topics: Administration, Intranasal; Animals; Brain; Chemistry, Pharmaceutical; Clonazepam; Drug Carriers; Dr | 2016 |
[Idiopathic generalised epilepsies in the elderly: the viewpoint of a geriatrician].
Topics: Aged; Aged, 80 and over; Anticonvulsants; Clonazepam; Electroencephalography; Epilepsy, Generalized; | 2009 |
Dissolving oral clonazepam wafers in the acute treatment of prolonged seizures.
Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, | 2010 |
[Non-convulsive status epilepticus in 12-year-old].
Topics: Anticonvulsants; Child; Clonazepam; Diagnosis, Differential; Electroencephalography; Female; Humans; | 2010 |
Propofol treatment of refractory status epilepticus: a study of 31 episodes.
Topics: Adult; Anesthetics, Intravenous; Anticonvulsants; Clonazepam; Coma; Dose-Response Relationship, Drug | 2004 |
Tiagabine-induced generalised non convulsive status epilepticus in patients with lesional focal epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Electroencephalography; Epilepsy; Female; Humans; Ma | 2005 |
Misleading effects of clonazepam in symptomatic electrical status epilepticus during sleep syndrome.
Topics: Anticonvulsants; Child; Clonazepam; Cognition Disorders; Electroencephalography; Humans; Male; Motor | 2006 |
Giant somatosensory evoked potentials as indicator of nonconvulsive status epilepticus.
Topics: Aged; Anticonvulsants; Clonazepam; Coma; Electroencephalography; Evoked Potentials, Somatosensory; F | 2008 |
Teaching NeuroImage: Simple partial frontal status epilepticus with recurrent asymmetric tonic seizures.
Topics: Adult; Anticonvulsants; Atrophy; Clinical Protocols; Clonazepam; Drug Combinations; Electroencephalo | 2008 |
[Comparative study of the intravenous injection of lorazepam and clonazepam in status epilepticus].
Topics: Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Electrocardiography; Female; Humans; Injections, | 1980 |
Absence status in adults.
Topics: Adult; Clonazepam; Electroencephalography; Female; Humans; Male; Middle Aged; Status Epilepticus; Va | 1983 |
Failure of carbamazepine to prevent clonazepam withdrawal status epilepticus.
Topics: Adult; Benzodiazepinones; Carbamazepine; Clonazepam; Humans; Male; Status Epilepticus; Substance Wit | 1984 |
[Termination of status epilepticus with sodium valproate].
Topics: Clonazepam; Diazepam; Humans; Infant; Phenytoin; Status Epilepticus; Valproic Acid | 1980 |
Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Chlormethiazole; Clona | 1981 |
Pharmacologic advances in seizure control.
Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Humans; Kinetics; Phenytoin; Seizures; Status Epi | 1981 |
Treatment of status epilepticus with intravenous clonazepam.
Topics: Adult; Benzodiazepinones; Clonazepam; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cl | 1982 |
Benzodiazepines: efficacy in status epilepticus.
Topics: Adult; Aged; Benzodiazepines; Child; Clonazepam; Diazepam; Electroencephalography; Humans; Status Ep | 1983 |
Intravenous clonazepam in the treatment of status epilepticus in children.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Diazepam; Electroencephalography | 1980 |
Non-convulsive status epilepticus as cause for focal neurological deficit.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Damage, Chronic; Clonazepam; Diagnosis, Diffe | 1995 |
Propofol in the management of refractory status epilepticus: a case report.
Topics: Clonazepam; Coma; Drug Therapy, Combination; Electroencephalography; Glasgow Coma Scale; Humans; Inf | 1994 |
Nonconvulsive status epilepticus as a cause of confusion in later life: a report of 5 cases.
Topics: Aged; Cerebral Cortex; Clonazepam; Confusion; Diagnosis, Differential; Epilepsy, Absence; Epilepsy, | 1994 |
Psychogenic status epilepticus induced by a provocative technique.
Topics: Adult; Anti-Dyskinesia Agents; Anticonvulsants; Clonazepam; Electroencephalography; Emergencies; Fem | 1996 |
Protective effects of GABAergic drugs and other anticonvulsants in lithium-pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Baclofen; Clonazepam; Diazepam; Dizocilpine Maleate; Ethanol; GABA Agents; | 1996 |
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Desoxycorticosterone; Dose-Response Relationship, Drug; Excita | 1996 |
Cognitive functions after pilocarpine-induced status epilepticus: changes during silent period precede appearance of spontaneous recurrent seizures.
Topics: Animals; Cell Count; Clonazepam; Cognition; Hippocampus; Ketamine; Male; Maze Learning; Memory; Pilo | 1999 |
Reversible changes in echo planar perfusion- and diffusion-weighted MRI in status epilepticus.
Topics: Aged; Anticonvulsants; Blood Volume; Brain; Cerebrovascular Circulation; Clonazepam; Delta Rhythm; D | 2000 |
Infantile status epilepticus in Tunisia. Clinical, etiological and prognostic aspects.
Topics: Anticonvulsants; Central Nervous System Infections; Chi-Square Distribution; Child, Preschool; Clona | 2001 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
[Intraveneous therapy of petit mal status with diazepame and clonazepame (author's transl)].
Topics: Anticonvulsants; Benzodiazepinones; Child; Clonazepam; Diazepam; Electroencephalography; Female; Hum | 1977 |
[Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam].
Topics: Adolescent; Adult; Benzodiazepinones; Brain; Chronic Disease; Clonazepam; Electroencephalography; Ep | 1977 |
Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Clonazepam; Diazepam; Dogs; Electric St | 1979 |
Status epilepticus: discussion from experience in adult cases.
Topics: Adolescent; Adult; Clonazepam; Diazepam; Female; Humans; Phenytoin; Status Epilepticus | 1979 |
[Grand mal seizures and status epilepticus in general practice-- what's to be done?].
Topics: Adult; Aged; Child, Preschool; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Family Pra | 1986 |
[Clinical treatment of grand mal epileptic status in adults].
Topics: Adult; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Hum | 1986 |
Status epilepticus within the Lennox-Gastaut syndrome: clinical characteristics and management.
Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Status Epilepticus; Syndrome; Val | 1987 |
Rectal anticonvulsants in pediatric practice.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child, Preschoo | 1988 |