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clonazepam and Spasms, Infantile

clonazepam has been researched along with Spasms, Infantile in 29 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)

Research Excerpts

ExcerptRelevanceReference
"The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy."5.07[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994)
"To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam."3.74Treatment of infantile spasms with sodium valproate followed by benzodiazepines. ( Auvichayapat, N; Auvichayapat, P; Tassniyom, S; Treerotphon, S, 2007)
"The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed."3.65[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977)
"Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures."2.35Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976)
" However, a complete reversal of encephalopathy, on withdrawal of the drug, strongly suggested an adverse drug reaction (ADR) due to valproic acid."1.40Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity. ( Sampath, S; Sivathanu, S; Sunderkumar, S; Veerasamy, M, 2014)
"Beckwith-Wiedemann syndrome (BWS) is etiologically connected with genetic/epigenetic growth dysregulation."1.40[Case of combination of Beckwith-Wiedemann syndrome with West syndrome]. ( Globa, OV; Kremenchugskaya, MR; Kuzenkova, LM; Podkletnova, TV, 2014)
"A 3-year-old boy with West syndrome who was shown to have a cystic lesion on magnetic resonance imagings underwent surgical treatment."1.29West syndrome associated with porencephaly. ( Aihara, N; Ishikawa, T; Kamiya, K; Kanayama, M; Katano, H; Nagai, H; Yamashita, N, 1994)
"These seizures were thought to be equivalent to the IMS in Lennox-Gastaut syndrome, which have never been reported before in patients with West syndrome."1.28Induced microseizures in West syndrome. ( Futagi, Y; Okamoto, N; Otani, K; Tagawa, T; Yabuuchi, H, 1991)
" Dosage of both drugs was within the usual range."1.27Carbamazepine and benzodiazepines in combination--a possibility to improve the efficacy of treatment of patients with 'intractable' infantile spasms? ( Groh, C; Lischka, A; Müller, R; Tatzer, E, 1987)
"Strychnine treatment was initiated because it is a specific antagonist of glycine at postsynaptic membranes."1.26Strychnine therapy in nonketotic hyperglycinemia. ( Arneson, D; Ch'ien, LT; Chance, P; Wilroy, RS, 1979)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199016 (55.17)18.7374
1990's7 (24.14)18.2507
2000's2 (6.90)29.6817
2010's4 (13.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sivathanu, S1
Sampath, S1
Veerasamy, M1
Sunderkumar, S1
Kuzenkova, LM1
Kremenchugskaya, MR1
Globa, OV1
Podkletnova, TV1
Singh, D1
Lau, M1
Ayers, T1
Singh, Y1
Akingbola, O1
Barbiero, L1
Nelson, S1
Jazayeri, MA1
Jensen, JN1
Lew, SM1
Auvichayapat, N1
Tassniyom, S1
Treerotphon, S1
Auvichayapat, P1
Visudhiphan, P1
Kiul'ts, I1
Klaĭf, F1
Pavone, L2
Mollica, F2
Incorpora, G2
Pampiglione, G2
Badalian, LO1
Temin, PA1
Medvedev, MI1
Mukhin, KIu1
Iskander, MB1
Kharlamov, DA1
Veselov, NK1
Katano, H1
Nagai, H1
Aihara, N1
Yamashita, N1
Kamiya, K1
Ishikawa, T1
Kanayama, M1
Kuwahara, M1
Shima, M1
Nakai, H1
Nishino, M1
Fukuzumi, A1
Yoshioka, A1
Suzuki, Y1
Kita, T1
Mano, T1
Arai, H1
Matsuoka, T1
Kodaka, R1
Imai, K1
Nagai, T1
Okada, S1
Browne, TR2
Aucamp, AK1
Speciali, GG1
Lison, MP1
Aicardi, J1
Chevrie, JJ1
Arneson, D1
Ch'ien, LT1
Chance, P1
Wilroy, RS1
Stern, M1
Lagenstein, I1
Menkes, JH1
Meldrum, BS1
Anlezark, G1
Balzamo, E1
Horton, RW1
Trimble, M1
Vestermark, S1
Dubowitz, LM1
Bouza, H1
Hird, MF1
Jaeken, J1
Otani, K1
Tagawa, T1
Futagi, Y1
Okamoto, N1
Yabuuchi, H1
Hakeem, VF1
Wallace, SJ1
Swaiman, KF1
Tatzer, E1
Groh, C1
Müller, R1
Lischka, A1
Oki, J1
Tasaki, T1
Kusunoki, Y1
Cho, K1
Yoshioka, H1

Reviews

3 reviews available for clonazepam and Spasms, Infantile

ArticleYear
The pharmacological treatment of epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Oct-06, Volume: 56, Issue:15

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies,

1979
Clonazepam. A review of a new anticonvulsant drug.
    Archives of neurology, 1976, Volume: 33, Issue:5

    Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To

1976
Myoclonus.
    Neurologic clinics, 1985, Volume: 3, Issue:1

    Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diagnosis, Differential; Electroen

1985

Trials

3 trials available for clonazepam and Spasms, Infantile

ArticleYear
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994, Volume: 94, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E

1994
[Outcome of initial treatment with high-dose vitamin B6, valproate sodium or clonazepam in West syndrome].
    No to hattatsu = Brain and development, 1996, Volume: 28, Issue:5

    Topics: Anticonvulsants; Child; Child, Preschool; Clonazepam; Female; Humans; Infant; Male; Pyridoxine; Spas

1996
Clonazepam.
    The New England journal of medicine, 1978, Oct-12, Volume: 299, Issue:15

    Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies,

1978

Other Studies

23 other studies available for clonazepam and Spasms, Infantile

ArticleYear
Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity.
    BMJ case reports, 2014, Apr-15, Volume: 2014

    Topics: Adrenocorticotropic Hormone; Ammonia; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Female

2014
[Case of combination of Beckwith-Wiedemann syndrome with West syndrome].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 2014, Issue:9-10

    Topics: Anticonvulsants; Beckwith-Wiedemann Syndrome; Child; Clonazepam; Electroencephalography; Epilepsy, G

2014
De Novo Heterogeneous Mutations in SCN2A and GRIN2A Genes and Seizures With Ictal Vocalizations.
    Clinical pediatrics, 2016, Volume: 55, Issue:9

    Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Electroencephalography; Female; Fructose; Huma

2016
Craniosynostosis following hemispherectomy in a 2.5-month-old boy with intractable epilepsy.
    Journal of neurosurgery. Pediatrics, 2011, Volume: 8, Issue:5

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Clonazepam; Craniosynostoses; Craniotomy; Electroencep

2011
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:9

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination

2007
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2007, Volume: 90, Issue:10

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination

2007
[Treatment of rapid nodding "salaam" spasms in childhood].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1980, Volume: 80, Issue:10

    Topics: Adrenocorticotropic Hormone; Child, Preschool; Clonazepam; Electroencephalography; Female; Humans; I

1980
Infantile spasms syndrome in monozygotic twins.
    Archives of disease in childhood, 1980, Volume: 55, Issue:11

    Topics: Adrenocorticotropic Hormone; Clonazepam; Diseases in Twins; Electroencephalography; Female; Follow-U

1980
West syndrome associated with porencephaly.
    Pediatric neurosurgery, 1994, Volume: 21, Issue:3

    Topics: Adrenocorticotropic Hormone; Brain Diseases; Child, Preschool; Clonazepam; Comorbidity; Cysts; Elect

1994
A case of West syndrome with atypical massive gray matter heterotopia that is well controlled by ACTH therapy.
    Acta paediatrica Japonica : Overseas edition, 1996, Volume: 38, Issue:3

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Brain Diseases; Choristoma; Clonazepam; Drug Th

1996
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
    Arquivos de neuro-psiquiatria, 1977, Volume: 35, Issue:3

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia

1977
[Infantile spasms].
    Archives francaises de pediatrie, 1978, Volume: 35, Issue:9

    Topics: Adrenocorticotropic Hormone; Child; Clonazepam; Glucocorticoids; Humans; Nitrazepam; Prognosis; Spas

1978
Strychnine therapy in nonketotic hyperglycinemia.
    Pediatrics, 1979, Volume: 63, Issue:3

    Topics: Benzoates; Clonazepam; Drug Therapy, Combination; Electroencephalography; Enzymes; Female; Glycine;

1979
[Hypsarrhythmia as a cause of recurrent infantile apnoea (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1979, Volume: 127, Issue:2

    Topics: Apnea; Bronchitis; Clonazepam; Electroencephalography; Female; Humans; Infant; Recurrence; Spasms, I

1979
Diagnosis and treatment of minor motor seizures.
    Pediatric clinics of North America, 1976, Volume: 23, Issue:3

    Topics: Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; In

1976
Photically induced epilepsy in Papio papio as a model for drug studies.
    Advances in neurology, 1975, Volume: 10

    Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose-

1975
[Clonazepam for long-term therapy of epilepsy in childhood].
    Ugeskrift for laeger, 1975, Oct-06, Volume: 137, Issue:41

    Topics: Benzodiazepinones; Child; Child, Preschool; Clonazepam; Epilepsy; Female; Humans; Infant; Infant, Ne

1975
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
    Lancet (London, England), 1992, Jul-11, Volume: 340, Issue:8811

    Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob

1992
Induced microseizures in West syndrome.
    Brain & development, 1991, Volume: 13, Issue:3

    Topics: Adrenocorticotropic Hormone; Clonazepam; Electroencephalography; Female; Humans; Infant; Seizures; S

1991
EEG monitoring of therapy for neonatal seizures.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:10

    Topics: Anticonvulsants; Chloral Hydrate; Clonazepam; Diazepam; Drug Therapy, Combination; Electroencephalog

1990
Infantile spasms syndrome in monozygotic twins. A 7-year follow-up.
    Italian journal of neurological sciences, 1985, Volume: 6, Issue:4

    Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diseases in Twins; Drug Therapy, C

1985
Carbamazepine and benzodiazepines in combination--a possibility to improve the efficacy of treatment of patients with 'intractable' infantile spasms?
    Brain & development, 1987, Volume: 9, Issue:4

    Topics: Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Female; Follow-Up Stu

1987
[Combination of sodium valproate and clonazepam in the treatment of symptomatic West syndrome and Lennox syndrome].
    No to hattatsu = Brain and development, 1985, Volume: 17, Issue:1

    Topics: Administration, Oral; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Therapy, Combinat

1985