clonazepam has been researched along with Spasms, Infantile in 29 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy." | 5.07 | [The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994) |
| "To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam." | 3.74 | Treatment of infantile spasms with sodium valproate followed by benzodiazepines. ( Auvichayapat, N; Auvichayapat, P; Tassniyom, S; Treerotphon, S, 2007) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| " However, a complete reversal of encephalopathy, on withdrawal of the drug, strongly suggested an adverse drug reaction (ADR) due to valproic acid." | 1.40 | Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity. ( Sampath, S; Sivathanu, S; Sunderkumar, S; Veerasamy, M, 2014) |
| "Beckwith-Wiedemann syndrome (BWS) is etiologically connected with genetic/epigenetic growth dysregulation." | 1.40 | [Case of combination of Beckwith-Wiedemann syndrome with West syndrome]. ( Globa, OV; Kremenchugskaya, MR; Kuzenkova, LM; Podkletnova, TV, 2014) |
| "A 3-year-old boy with West syndrome who was shown to have a cystic lesion on magnetic resonance imagings underwent surgical treatment." | 1.29 | West syndrome associated with porencephaly. ( Aihara, N; Ishikawa, T; Kamiya, K; Kanayama, M; Katano, H; Nagai, H; Yamashita, N, 1994) |
| "These seizures were thought to be equivalent to the IMS in Lennox-Gastaut syndrome, which have never been reported before in patients with West syndrome." | 1.28 | Induced microseizures in West syndrome. ( Futagi, Y; Okamoto, N; Otani, K; Tagawa, T; Yabuuchi, H, 1991) |
| " Dosage of both drugs was within the usual range." | 1.27 | Carbamazepine and benzodiazepines in combination--a possibility to improve the efficacy of treatment of patients with 'intractable' infantile spasms? ( Groh, C; Lischka, A; Müller, R; Tatzer, E, 1987) |
| "Strychnine treatment was initiated because it is a specific antagonist of glycine at postsynaptic membranes." | 1.26 | Strychnine therapy in nonketotic hyperglycinemia. ( Arneson, D; Ch'ien, LT; Chance, P; Wilroy, RS, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (55.17) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 2 (6.90) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sivathanu, S | 1 |
| Sampath, S | 1 |
| Veerasamy, M | 1 |
| Sunderkumar, S | 1 |
| Kuzenkova, LM | 1 |
| Kremenchugskaya, MR | 1 |
| Globa, OV | 1 |
| Podkletnova, TV | 1 |
| Singh, D | 1 |
| Lau, M | 1 |
| Ayers, T | 1 |
| Singh, Y | 1 |
| Akingbola, O | 1 |
| Barbiero, L | 1 |
| Nelson, S | 1 |
| Jazayeri, MA | 1 |
| Jensen, JN | 1 |
| Lew, SM | 1 |
| Auvichayapat, N | 1 |
| Tassniyom, S | 1 |
| Treerotphon, S | 1 |
| Auvichayapat, P | 1 |
| Visudhiphan, P | 1 |
| Kiul'ts, I | 1 |
| Klaĭf, F | 1 |
| Pavone, L | 2 |
| Mollica, F | 2 |
| Incorpora, G | 2 |
| Pampiglione, G | 2 |
| Badalian, LO | 1 |
| Temin, PA | 1 |
| Medvedev, MI | 1 |
| Mukhin, KIu | 1 |
| Iskander, MB | 1 |
| Kharlamov, DA | 1 |
| Veselov, NK | 1 |
| Katano, H | 1 |
| Nagai, H | 1 |
| Aihara, N | 1 |
| Yamashita, N | 1 |
| Kamiya, K | 1 |
| Ishikawa, T | 1 |
| Kanayama, M | 1 |
| Kuwahara, M | 1 |
| Shima, M | 1 |
| Nakai, H | 1 |
| Nishino, M | 1 |
| Fukuzumi, A | 1 |
| Yoshioka, A | 1 |
| Suzuki, Y | 1 |
| Kita, T | 1 |
| Mano, T | 1 |
| Arai, H | 1 |
| Matsuoka, T | 1 |
| Kodaka, R | 1 |
| Imai, K | 1 |
| Nagai, T | 1 |
| Okada, S | 1 |
| Browne, TR | 2 |
| Aucamp, AK | 1 |
| Speciali, GG | 1 |
| Lison, MP | 1 |
| Aicardi, J | 1 |
| Chevrie, JJ | 1 |
| Arneson, D | 1 |
| Ch'ien, LT | 1 |
| Chance, P | 1 |
| Wilroy, RS | 1 |
| Stern, M | 1 |
| Lagenstein, I | 1 |
| Menkes, JH | 1 |
| Meldrum, BS | 1 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Horton, RW | 1 |
| Trimble, M | 1 |
| Vestermark, S | 1 |
| Dubowitz, LM | 1 |
| Bouza, H | 1 |
| Hird, MF | 1 |
| Jaeken, J | 1 |
| Otani, K | 1 |
| Tagawa, T | 1 |
| Futagi, Y | 1 |
| Okamoto, N | 1 |
| Yabuuchi, H | 1 |
| Hakeem, VF | 1 |
| Wallace, SJ | 1 |
| Swaiman, KF | 1 |
| Tatzer, E | 1 |
| Groh, C | 1 |
| Müller, R | 1 |
| Lischka, A | 1 |
| Oki, J | 1 |
| Tasaki, T | 1 |
| Kusunoki, Y | 1 |
| Cho, K | 1 |
| Yoshioka, H | 1 |
3 reviews available for clonazepam and Spasms, Infantile
| Article | Year |
|---|---|
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
Myoclonus.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diagnosis, Differential; Electroen | 1985 |
3 trials available for clonazepam and Spasms, Infantile
| Article | Year |
|---|---|
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E | 1994 |
[Outcome of initial treatment with high-dose vitamin B6, valproate sodium or clonazepam in West syndrome].
Topics: Anticonvulsants; Child; Child, Preschool; Clonazepam; Female; Humans; Infant; Male; Pyridoxine; Spas | 1996 |
Clonazepam.
Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies, | 1978 |
23 other studies available for clonazepam and Spasms, Infantile
| Article | Year |
|---|---|
Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity.
Topics: Adrenocorticotropic Hormone; Ammonia; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Female | 2014 |
[Case of combination of Beckwith-Wiedemann syndrome with West syndrome].
Topics: Anticonvulsants; Beckwith-Wiedemann Syndrome; Child; Clonazepam; Electroencephalography; Epilepsy, G | 2014 |
De Novo Heterogeneous Mutations in SCN2A and GRIN2A Genes and Seizures With Ictal Vocalizations.
Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Electroencephalography; Female; Fructose; Huma | 2016 |
Craniosynostosis following hemispherectomy in a 2.5-month-old boy with intractable epilepsy.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Clonazepam; Craniosynostoses; Craniotomy; Electroencep | 2011 |
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination | 2007 |
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination | 2007 |
[Treatment of rapid nodding "salaam" spasms in childhood].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Clonazepam; Electroencephalography; Female; Humans; I | 1980 |
Infantile spasms syndrome in monozygotic twins.
Topics: Adrenocorticotropic Hormone; Clonazepam; Diseases in Twins; Electroencephalography; Female; Follow-U | 1980 |
West syndrome associated with porencephaly.
Topics: Adrenocorticotropic Hormone; Brain Diseases; Child, Preschool; Clonazepam; Comorbidity; Cysts; Elect | 1994 |
A case of West syndrome with atypical massive gray matter heterotopia that is well controlled by ACTH therapy.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Brain Diseases; Choristoma; Clonazepam; Drug Th | 1996 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
[Infantile spasms].
Topics: Adrenocorticotropic Hormone; Child; Clonazepam; Glucocorticoids; Humans; Nitrazepam; Prognosis; Spas | 1978 |
Strychnine therapy in nonketotic hyperglycinemia.
Topics: Benzoates; Clonazepam; Drug Therapy, Combination; Electroencephalography; Enzymes; Female; Glycine; | 1979 |
[Hypsarrhythmia as a cause of recurrent infantile apnoea (author's transl)].
Topics: Apnea; Bronchitis; Clonazepam; Electroencephalography; Female; Humans; Infant; Recurrence; Spasms, I | 1979 |
Diagnosis and treatment of minor motor seizures.
Topics: Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; In | 1976 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
[Clonazepam for long-term therapy of epilepsy in childhood].
Topics: Benzodiazepinones; Child; Child, Preschool; Clonazepam; Epilepsy; Female; Humans; Infant; Infant, Ne | 1975 |
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob | 1992 |
Induced microseizures in West syndrome.
Topics: Adrenocorticotropic Hormone; Clonazepam; Electroencephalography; Female; Humans; Infant; Seizures; S | 1991 |
EEG monitoring of therapy for neonatal seizures.
Topics: Anticonvulsants; Chloral Hydrate; Clonazepam; Diazepam; Drug Therapy, Combination; Electroencephalog | 1990 |
Infantile spasms syndrome in monozygotic twins. A 7-year follow-up.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diseases in Twins; Drug Therapy, C | 1985 |
Carbamazepine and benzodiazepines in combination--a possibility to improve the efficacy of treatment of patients with 'intractable' infantile spasms?
Topics: Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combination; Female; Follow-Up Stu | 1987 |
[Combination of sodium valproate and clonazepam in the treatment of symptomatic West syndrome and Lennox syndrome].
Topics: Administration, Oral; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Therapy, Combinat | 1985 |