clonazepam has been researched along with Sleep Initiation and Maintenance Disorders in 20 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Sleep Initiation and Maintenance Disorders: Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the former, the oral dosage of clonazepam 0." | 7.11 | Comparison of Clonazepam and Tongue Protector in the Treatment of Burning Mouth Syndrome. ( Konopka, T; Zborowski, J, 2022) |
| "We considered akathisia and cancer-related anxiety/agitation as possible causes of restlessness and insomnia, and prescribed clonazepam." | 5.72 | Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report. ( Deguchi, Y; Inoue, K; Itoh, Y; Sakamoto, S; Uchida, S, 2022) |
| " Clonazepam and/or quetiapine were administered for sleep disorders but failed to resolve insomnia and excessive daytime sleepiness (EDS)." | 3.83 | Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia. ( Chen, YL; Hsu, CH; Liu, IC; Pei, D; Yu, SM, 2016) |
| " In the former, the oral dosage of clonazepam 0." | 3.11 | Comparison of Clonazepam and Tongue Protector in the Treatment of Burning Mouth Syndrome. ( Konopka, T; Zborowski, J, 2022) |
| "Cotherapy was effective in reducing insomnia but not anxiety or core symptoms (low mood, suicidality, reduced interest)." | 2.70 | Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression? ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2002) |
| "Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep resulted in sustained efficacy in most cases, with low risk of dosage tolerance, adverse effects, or abuse." | 2.68 | Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults. ( Mahowald, MW; Schenck, CH, 1996) |
| "Clonazepam 0." | 2.67 | Clonazepam: sleep laboratory study of efficacy and withdrawal. ( Baldassano, CF; Kales, A; Kales, JD; Kostakos, K; Manfredi, RL; Vgontzas, AN, 1991) |
| "Treatment with clonazepam was studied in a group of 20 patients suffering from periodic movements in sleep, in a double-blind parallel group design." | 2.66 | Double-blind evaluation of clonazepam on periodic leg movements in sleep. ( Lavie, P; Peled, R, 1987) |
| "We considered akathisia and cancer-related anxiety/agitation as possible causes of restlessness and insomnia, and prescribed clonazepam." | 1.72 | Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report. ( Deguchi, Y; Inoue, K; Itoh, Y; Sakamoto, S; Uchida, S, 2022) |
| "Insomnia is one such condition whose prevalence is rising all over the world." | 1.51 | A case of zolpidem dependence with extremely high daily doses. ( Bajaj, A; Bajaj, V; Kalra, I; Kumar, R; Sharma, D, 2019) |
| "Zolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option in the short-term management of sleep-onset insomnia." | 1.48 | Severe Chronic Abuse of Zolpidem in Refractory Insomnia. ( Bianco, G; Castelnovo, A; Chiaro, G; Maffei, P; Manconi, M, 2018) |
| "In total, 181 chronic insomnia patients were consecutively recruited." | 1.46 | Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. ( Chen, H; He, J; Liu, Y; Luan, X; Qiu, H; Shen, H; Tu, X; Zhao, K; Zhu, Z, 2017) |
| "Clonazepam (CNZ) is a drug used for insomnia treatment." | 1.42 | Executive dysfunction in patients with chronic primary insomnia treated with clonazepam. ( Contreras-González, N; Haro, R; Jiménez-Correa, U; Poblano, A; Téllez-Alanís, B, 2015) |
| "Propriospinal myoclonus arising from a spinal generator may be facilitated by changes in supraspinal control related to vigilance levels." | 1.30 | Propriospinal myoclonus upon relaxation and drowsiness: a cause of severe insomnia. ( Liguori, R; Lugaresi, E; Montagna, P; Plazzi, G; Provini, F, 1997) |
| "Those with insomnia, however, had a shorter intermovement interval than those with hypersomnia, with more leg movements in each activity epoch." | 1.27 | Periodic leg movements in sleep: effect of clonazepam treatment. ( Lavie, P; Ohanna, N; Peled, R; Rubin, AH; Zomer, J, 1985) |
| "Nocturnal myoclonus has been identified as a cause of disturbed sleep and excessive daytime fatigue." | 1.26 | Clonazepam treatment of insomnia due to sleep myoclonus. ( Oshtory, MA; Vijayan, N, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sakamoto, S | 1 |
| Deguchi, Y | 1 |
| Uchida, S | 1 |
| Itoh, Y | 1 |
| Inoue, K | 1 |
| Zborowski, J | 1 |
| Konopka, T | 1 |
| Zhao, K | 1 |
| Luan, X | 1 |
| Liu, Y | 1 |
| Tu, X | 1 |
| Chen, H | 1 |
| Shen, H | 1 |
| Qiu, H | 1 |
| Zhu, Z | 1 |
| He, J | 1 |
| Chiaro, G | 1 |
| Castelnovo, A | 1 |
| Bianco, G | 1 |
| Maffei, P | 1 |
| Manconi, M | 1 |
| Fujishiro, H | 1 |
| Kimura, H | 1 |
| Nakamura, T | 1 |
| Torii, Y | 1 |
| Iritani, S | 1 |
| Ozaki, N | 1 |
| Bajaj, V | 1 |
| Kalra, I | 1 |
| Bajaj, A | 1 |
| Sharma, D | 1 |
| Kumar, R | 1 |
| Contreras-González, N | 1 |
| Téllez-Alanís, B | 1 |
| Haro, R | 1 |
| Jiménez-Correa, U | 1 |
| Poblano, A | 1 |
| Hsu, CH | 1 |
| Chen, YL | 1 |
| Pei, D | 1 |
| Yu, SM | 1 |
| Liu, IC | 1 |
| Smith, WT | 1 |
| Londborg, PD | 1 |
| Glaudin, V | 1 |
| Painter, JR | 1 |
| Oshtory, MA | 1 |
| Vijayan, N | 1 |
| Schenck, CH | 1 |
| Mahowald, MW | 1 |
| Montagna, P | 1 |
| Provini, F | 1 |
| Plazzi, G | 1 |
| Liguori, R | 1 |
| Lugaresi, E | 1 |
| Freeman, S | 1 |
| Szücs, A | 1 |
| Bódizs, R | 1 |
| Barsi, P | 1 |
| Halász, P | 1 |
| Trachman, SB | 1 |
| Kales, A | 1 |
| Manfredi, RL | 1 |
| Vgontzas, AN | 1 |
| Baldassano, CF | 1 |
| Kostakos, K | 1 |
| Kales, JD | 1 |
| Lichtigfeld, FJ | 1 |
| Gillman, MA | 1 |
| Mitler, MM | 1 |
| Browman, CP | 1 |
| Menn, SJ | 1 |
| Gujavarty, K | 1 |
| Timms, RM | 1 |
| Peled, R | 2 |
| Lavie, P | 2 |
| Ohanna, N | 1 |
| Rubin, AH | 1 |
| Zomer, J | 1 |
6 trials available for clonazepam and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Comparison of Clonazepam and Tongue Protector in the Treatment of Burning Mouth Syndrome.
Topics: Burning Mouth Syndrome; Clonazepam; Female; Humans; Quality of Life; Sleep Initiation and Maintenanc | 2022 |
Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression?
Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Anxiety; Clonazepam; Depressi | 2002 |
Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Chronic Disease; Clonazepam; Drug Administration Schedule; F | 1996 |
Clonazepam: sleep laboratory study of efficacy and withdrawal.
Topics: Adult; Clonazepam; Double-Blind Method; Female; Humans; Male; Middle Aged; Sleep; Sleep Initiation a | 1991 |
Nocturnal myoclonus: treatment efficacy of clonazepam and temazepam.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clonazepam; Female; Humans; Male; Middle Aged; | 1986 |
Double-blind evaluation of clonazepam on periodic leg movements in sleep.
Topics: Clonazepam; Double-Blind Method; Drug Evaluation; Humans; Leg; Movement; Restless Legs Syndrome; Sle | 1987 |
14 other studies available for clonazepam and Sleep Initiation and Maintenance Disorders
| Article | Year |
|---|---|
Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report.
Topics: Antiemetics; Antineoplastic Agents; Antipsychotic Agents; Biperiden; Clonazepam; Dopamine; Humans; M | 2022 |
Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months.
Topics: Adult; Antidepressive Agents; Azabicyclo Compounds; Biomarkers; Case-Control Studies; Chronic Diseas | 2017 |
Severe Chronic Abuse of Zolpidem in Refractory Insomnia.
Topics: Aged; Anticonvulsants; Chronic Disease; Clonazepam; Female; Hospitalization; Humans; Levetiracetam; | 2018 |
Hypochondriasis in the elderly and Lewy body disease.
Topics: Aged; Clonazepam; Humans; Hyperacusis; Hypochondriasis; Indenes; Lewy Body Disease; Magnetic Resonan | 2019 |
A case of zolpidem dependence with extremely high daily doses.
Topics: Clonazepam; GABA Modulators; Humans; Hypnotics and Sedatives; Irritable Mood; Male; Middle Aged; Sle | 2019 |
Executive dysfunction in patients with chronic primary insomnia treated with clonazepam.
Topics: Adult; Anticonvulsants; Attention; Chronic Disease; Clonazepam; Cognition Disorders; Executive Funct | 2015 |
Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Clonazepam; Depressive Disorder; Disorders of Ex | 2016 |
Clonazepam treatment of insomnia due to sleep myoclonus.
Topics: Adult; Benzodiazepinones; Clonazepam; Female; Humans; Male; Middle Aged; Myoclonus; Sleep Initiation | 1980 |
Propriospinal myoclonus upon relaxation and drowsiness: a cause of severe insomnia.
Topics: Adult; Aged; Anticonvulsants; Arachnoid Cysts; Arousal; Clonazepam; Humans; Magnetic Resonance Imagi | 1997 |
The realities of clonazepam discontinuation.
Topics: Alprazolam; Anxiety Disorders; Benzodiazepines; Clonazepam; Drug Administration Schedule; GABA Modul | 1997 |
Insomnia and fronto-basal tumor: a case report.
Topics: Brain Neoplasms; Clonazepam; Frontal Lobe; GABA Modulators; Glioma; Humans; Male; Middle Aged; Sleep | 2001 |
Buspirone-induced psychosis in a human immunodeficiency virus-infected man.
Topics: Attitude to Health; Buspirone; Clonazepam; Depressive Disorder; HIV Seropositivity; Humans; Life Cha | 1992 |
Dangerous synergism between sedatives and a hyponatraemic state.
Topics: Clonazepam; Coma; Female; Humans; Hypnotics and Sedatives; Hyponatremia; Middle Aged; Promethazine; | 1990 |
Periodic leg movements in sleep: effect of clonazepam treatment.
Topics: Adult; Aged; Benzodiazepinones; Clonazepam; Disorders of Excessive Somnolence; Electroencephalograph | 1985 |