clonazepam has been researched along with Seizures in 165 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One study compared clonazepam to carbamazepine as monotherapy for participants with newly diagnosed psychomotor epilepsy (a condition corresponding to what is now termed mesial temporal lobe epilepsy)." | 9.22 | Clonazepam monotherapy for treating people with newly diagnosed epilepsy. ( Bragazzi, NL; Brigo, F; Igwe, SC; Lattanzi, S, 2022) |
| " One study compared clonazepam to carbamazepine as monotherapy for participants with newly diagnosed psychomotor epilepsy (a condition corresponding to what is now termed mesial temporal lobe epilepsy)." | 9.01 | Clonazepam monotherapy for treating people with newly diagnosed epilepsy. ( Bragazzi, NL; Brigo, F; Igwe, SC; Lattanzi, S, 2019) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| " The occurrence of the pentylenetetrazole (PTZ)-induced seizures in mice was significantly prevented by CLZ, even when exposed a lower dose of CLZ-SLN after administration by the oral route." | 7.80 | Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram. ( Allémann, E; Couraud, PO; Delie, F; González-Trujano, ME; Leyva-Gómez, G; López-Ruiz, E; Miller, F; Quintanar-Guerrero, D; Romero, I; Wekslerg, B, 2014) |
| "At our Institute, during the last decade, the incidence of hepatic veno-occlusive disease (HVOD) appears to be on the increase among pediatric patients treated with BU-thiotepa (BU-TTP)-conditioning regimen." | 7.74 | Risk factors for hepatic veno-occlusive disease: a retrospective unicentric study in 116 children autografted after a high-dose BU-thiotepa regimen. ( Amoroso, L; Benhamou, E; Cacchione, A; Couanet, DV; Hartmann, O; LeMaitre, A; Simonnard, N, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 7.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "The neuroactive steroids prevented 6-Hz seizures with rank order of potencies (ED50 values): ganaxolone (6." | 7.72 | Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. ( Kaminski, RM; Livingood, MR; Rogawski, MA, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 7.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "The effects of iloprost, a chemically stable analog of prostacyclin, on motor activity, pentylenetetrazol (PTZ)- and strychnine (ST)-induced seizures were studied in rats." | 7.68 | Effects of intracerebral iloprost injections on motor activity and chemically-induced seizures in rats. ( Akarsu, ES; Ayhan, IH, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " To minimize receptor alterations, several patients with intractable seizures received alternate-day clonazepam therapy, resulting in improved seizure control." | 7.67 | Alternate-day clonazepam treatment of intractable seizures. ( Sher, PK, 1985) |
| "The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures." | 7.66 | Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, L, 1982) |
| "Immediate EEG changes after intravenous administration of clonazepam and a correlation between the EEG changes and the effect of oral administration of the drug were studied in 21 children with minor seizures whose interictal EEG showed a paroxysmal abnormality." | 7.66 | Immediate changes of the electroencephalograms after intravenous injection of clonazepam and their relation to its effect on clinical fits in children with minor seizures. ( Iinuma, K; Onuma, A; Otomo, H; Takamatsu, N; Tamahashi, S, 1978) |
| "Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs." | 5.39 | Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam. ( Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D, 2013) |
| "The ED50 for suppression of behavioral seizures was 6." | 5.36 | Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. ( Reddy, DS; Rogawski, MA, 2010) |
| "Both cortical and hippocampal EEG seizures was extremely poor in this model." | 5.29 | Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. ( Mareś, P; Velísek, L, 1995) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "The time to seizures was increased nearly five times by clonazepam and over three times by very small amounts of propylene glycol." | 5.26 | Protection from oxygen-induced seizures by clonazepam and propylene glycol. ( Beckman, DL; Crittenden, DJ, 1981) |
| "Isoniazid is a useful chemical convulsant in that metabolic events associated with the preseizure state can be easily examined." | 5.26 | Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. ( Abel, MS; McCandless, DW; Schwartzenburg, FC, 1982) |
| "The types of seizures suffered by these patients were atypical petit mal, akinetic, massive infantile spasms, mixed minor motor seizures, myoclonic jerks, psychomotor, classic petit mal and grand mal." | 5.25 | Treatment of minor motor seizures with clonazepam. ( Carson, MJ; Gilden, C, 1975) |
| " One study compared clonazepam to carbamazepine as monotherapy for participants with newly diagnosed psychomotor epilepsy (a condition corresponding to what is now termed mesial temporal lobe epilepsy)." | 5.22 | Clonazepam monotherapy for treating people with newly diagnosed epilepsy. ( Bragazzi, NL; Brigo, F; Igwe, SC; Lattanzi, S, 2022) |
| " The administration of two antiepileptic drugs, Sodium Valproate and Clonazepam, reduces significantly seizures occurrence compared with unmedicated controls." | 5.05 | [DPA and clonazepam activity in febrile convulsions: preliminary results]. ( Florio, C; Sorge, F; Steardo, L; Steardo, R, 1980) |
| " One study compared clonazepam to carbamazepine as monotherapy for participants with newly diagnosed psychomotor epilepsy (a condition corresponding to what is now termed mesial temporal lobe epilepsy)." | 5.01 | Clonazepam monotherapy for treating people with newly diagnosed epilepsy. ( Bragazzi, NL; Brigo, F; Igwe, SC; Lattanzi, S, 2019) |
| " The patient was treated with Carbamazepine and Clonazepam achieving the disappearance of seizures." | 4.12 | Expanding the genetic and clinical characteristics of Protocadherin 19 gene mutations. ( Dell'Isola, GB; Di Cara, G; Fattorusso, A; Imperatore, V; Mencaroni, E; Prontera, P; Striano, P; Tascini, G; Verrotti, A, 2022) |
| " We retrospectively assessed the prophylactic efficacy and safety of levetiracetam and clonazepam against busulfan-induced seizures between 2013 and 2018." | 3.96 | Comparison of clonazepam and levetiracetam in children for prevention of busulfan-induced seizure in hematopoietic stem cell transplantation. ( Deguchi, T; Kato, M; Kiyotani, C; Matsumoto, K; Osumi, T; Shioda, Y; Shirai, R; Terashima, K; Tomizawa, D; Tsujimoto, SI; Uchiyama, T; Utano, T, 2020) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| " Acute seizures were treated with intranasal midazolam." | 3.83 | Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. ( Heimans, JJ; Koekkoek, JA; Postma, TJ; Reijneveld, JC; Taphoorn, MJ, 2016) |
| "Clobazam (CLB), a 1,5-benzodiazepine (BZD), was FDA-approved in October 2011 for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years and older." | 3.80 | Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes. ( Ebert, B; Jensen, HS; Lee, D; Nichol, K, 2014) |
| " The occurrence of the pentylenetetrazole (PTZ)-induced seizures in mice was significantly prevented by CLZ, even when exposed a lower dose of CLZ-SLN after administration by the oral route." | 3.80 | Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram. ( Allémann, E; Couraud, PO; Delie, F; González-Trujano, ME; Leyva-Gómez, G; López-Ruiz, E; Miller, F; Quintanar-Guerrero, D; Romero, I; Wekslerg, B, 2014) |
| "A 54-year-old woman with known epilepsy developed convulsions after using rifampicin and flucloxacillin, despite the use of maintenance treatment in the form of carbamazepine, valproic acid and clonazepam." | 3.80 | [Convulsions due to an interaction between anti-epileptic drugs and rifampicin]. ( Hanrath, MA; Swart, EL, 2014) |
| "Due to their favorable toxicity profile and lack of interactions, benzodiazepines have been proposed as prophylaxis of busulfan induced seizures." | 3.79 | Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan. ( Blanquer, M; Diaz-Carrasco, MS; Moraleda, JM; Olmos, R; Sánchez-Salinas, A; Velasco, J, 2013) |
| " Three tests were used: pentylenetetrazole (PTZ)-induced seizures, isolation-induced ultrasonic vocalizations, and motor performance." | 3.77 | Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats. ( Kubová, H; Mareš, P; Mikulecká, A, 2011) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| "At our Institute, during the last decade, the incidence of hepatic veno-occlusive disease (HVOD) appears to be on the increase among pediatric patients treated with BU-thiotepa (BU-TTP)-conditioning regimen." | 3.74 | Risk factors for hepatic veno-occlusive disease: a retrospective unicentric study in 116 children autografted after a high-dose BU-thiotepa regimen. ( Amoroso, L; Benhamou, E; Cacchione, A; Couanet, DV; Hartmann, O; LeMaitre, A; Simonnard, N, 2008) |
| " The dual and complementary mechanisms of action of etifoxine (directly on the GABA A receptor and indirectly via the neuroactive steroids) may represent a therapeutic benefit in the treatment of various anxiety disorders with abnormal production of neuroactive steroids." | 3.74 | Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes. ( Gillardin, JM; Heulard, I; Verleye, M, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 3.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| "The neuroactive steroids prevented 6-Hz seizures with rank order of potencies (ED50 values): ganaxolone (6." | 3.72 | Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. ( Kaminski, RM; Livingood, MR; Rogawski, MA, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "125 mg/kg) significantly potentiated the protective activity of carbamazepine against maximal electroshock-induced seizures in mice." | 3.71 | 2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice. ( Borowicz, KK; Czuczwar, SJ; Łuszczki, J, 2002) |
| "LY 300164 [7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4, 5H)-2,3-benzodiazepine], an antagonist of AMPA/kainate receptors, at 5 mg/kg exerted a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled seizures in rats." | 3.70 | Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J; Szadkowski, M, 1999) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| " administration, NNC 14-0185 and NNC 14-0189 prevented audiogenic seizures in DBA/2 mice and the clonic convulsions induced in mice by pentylenetetrazole, DMCM (methyl 6, 7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate), 3-mercaptopropionic acid and a low dose of bicuculline." | 3.69 | Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice. ( Hansen, HC; Jackson, HC; Judge, ME; Klitgaard, H; Kristiansen, M; Suzdak, PD; Swedberg, MD, 1996) |
| "Among three calcium channel inhibitors, only nicardipine (10-40 mg/kg) significantly inhibited clonic seizures induced by pentylenetetrazol administered at its CD97 (convulsive dose 97%) of 81 mg/kg, subcutaneously." | 3.69 | Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. ( Brudniak, T; Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z, 1996) |
| " In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole." | 3.69 | Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996) |
| "Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice." | 3.69 | Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice. ( Cohen, AL; Karp, E; Kokate, TG; Rogawski, MA, 1996) |
| "The effects of iloprost, a chemically stable analog of prostacyclin, on motor activity, pentylenetetrazol (PTZ)- and strychnine (ST)-induced seizures were studied in rats." | 3.68 | Effects of intracerebral iloprost injections on motor activity and chemically-induced seizures in rats. ( Akarsu, ES; Ayhan, IH, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " The anticonvulsant activity of tiagabine was evaluated against seizures induced by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), pentylenetetrazol, bicuculline, maximal electrostimulation (MES), or high intensity sound." | 3.68 | Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. ( Andersen, KE; Braestrup, C; Knutsen, LJ; Nielsen, EB; Sonnewald, U; Suzdak, PD, 1991) |
| ") were studied on model motor seizures induced by strychnine, bicuculline, 3-mercaptopropionic acid and metrazol in male laboratory rats (Wistar strain)." | 3.68 | Anticonvulsant effects of clonazepam on chemically induced convulsions. ( Bohuslav, T; Kubová, H; Mares, P, 1990) |
| "Repeated administration of the beta-carboline FG 7142 results in sensitisation to its convulsant effects (chemical kindling); acutely FG 7142 is not convulsant, but following several treatments full seizures develop." | 3.67 | Blockade of FG 7142 kindling by anticonvulsants acting at sites distant from the benzodiazepine receptor. ( Stephens, DN; Weidmann, R, 1989) |
| "We report the cases of 3 patients with medically intractable seizures in whom withdrawal of treatment with a long-acting benzodiazepine (clorazepate dipotassium, 2 patients; clonazepam, 1 patient) was followed by delirium with catatoniclike features." | 3.67 | Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders. ( De Bellis, M; Devinsky, O; Hauser, P; Post, RM; Theodore, WH, 1989) |
| "The rate of development of tolerance to the benzodiazepines clorazepate and clonazepam against pentetrazole-induced seizures in mice was compared." | 3.67 | Tolerance to the anticonvulsant effect of clorazepate and clonazepam in mice. ( Frey, HH; Kurudi, D; Scherkl, R, 1988) |
| "The present study was undertaken to investigate whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin." | 3.67 | Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice. ( Chweh, AY; Swinyard, EA; Wolf, HH, 1985) |
| " Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring." | 3.67 | Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986) |
| "The effects of chronic treatment with clonazepam and sodium valproate were studied on kindled amygdaloid seizures in rats." | 3.67 | The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat. ( Harris, QL; Jarrott, B; Lewis, SJ; Vajda, FJ; Young, NA, 1987) |
| "Eleven children with seizures were treated with clonazepam by rectal route." | 3.67 | [Intrarectal clonazepam in children. Plasma and CSF levels]. ( Bildstein, G; Cano, JP; Chateauneuf, R; Fornaris, M; Netter, JC; Petrus, M, 1988) |
| "Nimodipine, a dihydropyridine that interacts with a Ca++ channel-associated binding site, when delivered (30 to 150 micrograms/kg) intra-arterially (ia) to enflurane-anesthetized cats, produced a dose-dependent suppression of seizures evoked by pentylenetetrazol." | 3.67 | Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats. ( Anderson, RE; Ots, ME; Sundt, TM; Yaksh, TL, 1987) |
| " To minimize receptor alterations, several patients with intractable seizures received alternate-day clonazepam therapy, resulting in improved seizure control." | 3.67 | Alternate-day clonazepam treatment of intractable seizures. ( Sher, PK, 1985) |
| "The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures." | 3.66 | Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, L, 1982) |
| "Since the clinical data have been equivocal in regard to the effects of clonazepam (CZP) in focal-motor seizures, an alumina gel monkey model was used to evaluate quantitatively its efficacy with respect to this seizure category." | 3.66 | Clonazepam in a focal-motor monkey model: efficacy, tolerance, toxicity, withdrawal, and management. ( Congdon, WC; DuCharme, LL; Levy, RH; Lockard, JS; Salonen, LD, 1979) |
| "Immediate EEG changes after intravenous administration of clonazepam and a correlation between the EEG changes and the effect of oral administration of the drug were studied in 21 children with minor seizures whose interictal EEG showed a paroxysmal abnormality." | 3.66 | Immediate changes of the electroencephalograms after intravenous injection of clonazepam and their relation to its effect on clinical fits in children with minor seizures. ( Iinuma, K; Onuma, A; Otomo, H; Takamatsu, N; Tamahashi, S, 1978) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "The purpose of this series of experiments was to understand how Clonazepam changes the mechanisms of synchronization in seizures." | 3.65 | [The phenomenon of synchronization in the status epilepticus produced by penicillin and its changes after Clonazepam (author's transl)]. ( Petsche, H; Prohaska, O; Rappelsberger, P; Vollmer, R, 1977) |
| "Therefore, the acute care of prolonged seizures and SE is a constant challenge for healthcare professionals, in both the pre-hospital and the in-hospital settings." | 2.82 | Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability. ( Beuchat, I; Gelhard, S; Kay, L; Kienitz, R; Lucaciu, A; Mann, C; Rosenow, F; Schäfer, JH; Schubert-Bast, S; Siebenbrodt, K; Strzelczyk, A; von Brauchitsch, S; Willems, LM; Zöllner, JP, 2022) |
| " Pharmacokinetic (PK) data were compared with those previously collected in patients (n=127) treated with phenytoin for seizure prophylaxis." | 2.75 | Influence on Busilvex pharmacokinetics of clonazepam compared to previous phenytoin historical data. ( Bacigalupo, A; Buzyn, A; Cahn, JY; Carreras, E; Kröger, N; Puozzo, C; Sanz, G; Vernant, JP, 2010) |
| "Ongoing convulsive seizures for more than 5 minutes or nonconvulsive seizure activity for more than 10 to 30 minutes is considered early SE." | 2.66 | Drug Trials in Status Epilepticus: Current Evidence and Future Concepts. ( Husain, AM; Mandge, V, 2020) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "Evidence for treating seizures in AS mainly derives from low-quality studies." | 1.72 | Pharmacotherapeutic management of seizures in patients with Angleman Syndrome. ( Samanta, D, 2022) |
| "Herein, we present a 13-year-old generalized epilepsy patient with eating-induced generalized seizures since the age of 5." | 1.62 | Eight years follow-up of a generalized epilepsy patient with eating-induced late-onset epileptic spasms and atypical absence with myoclonic jerks. ( Chen, B; Jin, L; Liu, Y; Wang, X; Zhang, W, 2021) |
| "Chronic post-hypoxic myoclonus is a condition in which the predominant clinical picture is myoclonus following hypoxic brain damage, usually due to cardiorespiratory arrest." | 1.62 | [Response to perampanel in a patient with chronic post-hypoxic myoclonus]. ( de Toledo, M; Muro-García, I; Pastor, J; Vega, L; Vieira, A, 2021) |
| "Zolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option in the short-term management of sleep-onset insomnia." | 1.48 | Severe Chronic Abuse of Zolpidem in Refractory Insomnia. ( Bianco, G; Castelnovo, A; Chiaro, G; Maffei, P; Manconi, M, 2018) |
| "Early myoclonus after cardiac arrest (CA) is traditionally viewed as a poor prognostic sign (status myoclonus)." | 1.46 | Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort. ( Aicua Rapun, I; Novy, J; Oddo, M; Rossetti, AO; Solari, D, 2017) |
| "Decrease of both the frequency of seizures and the incidence of ADRs after TDM implementation suggests that TDM may have given clinicians the opportunity to achieve more optimal patient treatment." | 1.46 | Lamotrigine Drug Interactions in Combination Therapy and the Influence of Therapeutic Drug Monitoring on Clinical Outcomes of Adult Patients. ( Brozmanova, H; Grundmann, M; Kacirova, I; Koristkova, B, 2017) |
| "In patients with high-grade glioma seizures occur relatively frequently during the end-of-life phase." | 1.40 | [Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase]. ( Boddaert, MS; Koekkoek, JA; Taphoorn, M, 2014) |
| "An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1." | 1.39 | Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome. ( Catterall, WA; Cheah, CS; Cho, AR; Oakley, JC; Scheuer, T, 2013) |
| "Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs." | 1.39 | Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam. ( Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D, 2013) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| "Benign myoclonic epilepsy in infancy (BMEI) is the youngest form of idiopathic generalized epilepsy, characterized by myoclonic seizures (MS) in the first three years of life in otherwise normal infants, and the lack of other seizure types except for rare simple febrile seizures." | 1.38 | Benign myoclonic epilepsy in infancy with preceding afebrile generalized tonic-clonic seizures in Japan. ( Ito, S; Oguni, H; Osawa, M, 2012) |
| "He experienced convulsions from day 4 and was administered anticonvulsants." | 1.37 | [Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report]. ( Hagioka, S; Maeyama, H; Morimoto, N; Nagae, M; Naito, H; Okada, D; Okahara, S, 2011) |
| "The ED50 for suppression of behavioral seizures was 6." | 1.36 | Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. ( Reddy, DS; Rogawski, MA, 2010) |
| "Clonazepam was stopped." | 1.36 | Late-onset nocturnal intractable seizure during sleep: what is the origin? ( Liesiene, V; Miliauskas, S; Sakalauskas, R; Zemaitis, M, 2010) |
| "The antiseizure activity of benzodiazepines (BDZs) 1-5 in mice and rats as animal models is described." | 1.35 | Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models. ( Cook, JM; Edwankar, CR; Edwankar, RV; Furtmüller, R; Huang, S; Jain, HD; Majumder, S; Murphree, L; Ramerstorfer, J; Rivas, FM; Roth, BL; Sankar, S; Sieghart, W; Stables, JP; Zhou, H, 2009) |
| "The aggravation of habitual seizures and interictal discharges indicate ENM." | 1.35 | A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009) |
| "Clonazepam injection was used to suppress the AS episode and the subintrant myoclonia." | 1.35 | [Idiopathic generalised epilepsies in the elderly: the viewpoint of a geriatrician]. ( Adam, C; Lavallard-Rousseau, MC; Nguyen-Michel, VH; Ourabah, Z; Sebban, C, 2009) |
| "The seizures were noticeable at the first week of life and increased in frequency to last up to 12 hours, namely status gelasticus." | 1.35 | Intractable gelastic seizures during infancy: ictal positron emission tomography (PET) demonstrating epileptiform activity within the hypothalamic hamartoma. ( Genizi, J; Goldsher, D; Keidar, Z; Ravid, S; Shahar, E, 2008) |
| "We are presenting two cases with subacute sclerosing panencephalitis of acute and rapid form, which were initially diagnosed as acute viral encephalitis." | 1.34 | MR imaging, diffusion-weighted imaging and MR spectroscopy findings in acute rapidly progressive subacute sclerosing panencephalitis. ( Anlar, B; Celebi, A; Oguz, KK, 2007) |
| "Reported is the association of REM behavior disorder (RBD) with late-onset, sleep-related, tonic-clonic seizures in two elderly men." | 1.33 | REM behavior disorder associated with epileptic seizures. ( Manni, R; Terzaghi, M, 2005) |
| "The control group had more seizure activity (mean = 13." | 1.33 | An evaluation of the use of seizure prone rats when investigating intermediate stage sleep. ( Anch, AM; Duntley, SP; Morrissey, MJ, 2005) |
| "The aims of the present study were (1) to investigate and quantify the pharmacokinetics, including inter-occasion variability and covariate relationships, of busulphan in BMT patients and (2) to develop a user-friendly initial dosing and therapeutic drug monitoring (TDM) strategy for the treatment of those patients with busulphan." | 1.31 | Population pharmacokinetic analysis resulting in a tool for dose individualization of busulphan in bone marrow transplantation recipients. ( Bekassy, A; Hassan, M; Hassan, Z; Jonsson, EN; Karlsson, MO; Ljungman, P; Nilsson, C; Oberg, G; Ringden, O; Sandström, M, 2001) |
| "Eighteen patients with poor risk Ewing's sarcoma (including 11 patients with metastatic disease at presentation) received consolidation therapy of busulphan and melphalan with autologous stem cell rescue." | 1.30 | High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma. ( Ashley, S; Atra, A; Calvagna, V; Pinkerton, CR; Shankar, AG; Shepherd, V; Souhami, RL; Whelan, JS, 1997) |
| "Treatment with diazepam (25 mg/kg; p." | 1.30 | Abecarnil enhances recovery from diazepam tolerance. ( Contarino, A; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A, 1999) |
| "Treatment with clonazepam has abolished the nocturnal behavioural disturbance." | 1.29 | Conversion disorder revisited: severe parasomnia discovered. ( Bokey, K, 1993) |
| "Both cortical and hippocampal EEG seizures was extremely poor in this model." | 1.29 | Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. ( Mareś, P; Velísek, L, 1995) |
| "Measurement of incidence of neonatal seizures and evaluation of the therapeutic strategy used." | 1.29 | [Treatment of convulsions in newborn infants]. ( Baarsma, R; Fischer, K, 1996) |
| "The clinical picture was complicated by convulsions, perhaps due to clonazepam withdrawal and possible lithium toxicity." | 1.29 | Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder. ( Cubis, JC; Looi, JC; Saboisky, J, 1995) |
| "The kindled-convulsion model was used to assess the development of tolerance and cross tolerance to the anticonvulsant effects of antiepileptic drugs." | 1.28 | Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine. ( Hudda, MM; Kim, CK; Pinel, JP; Wong, DJ; Yung, A, 1992) |
| "These seizures were thought to be equivalent to the IMS in Lennox-Gastaut syndrome, which have never been reported before in patients with West syndrome." | 1.28 | Induced microseizures in West syndrome. ( Futagi, Y; Okamoto, N; Otani, K; Tagawa, T; Yabuuchi, H, 1991) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| "Posthypoxic myoclonus is a rare complication of successful cardiopulmonary resusitation." | 1.28 | Posthypoxic myoclonus (the Lance-Adams syndrome) in the intensive care unit. ( Harper, SJ; Wilkes, RG, 1991) |
| "Coma, convulsions, and cardiac conduction defects were observed, similar to those noted with tricyclic and tetracyclic antidepressant poisoning." | 1.28 | Severe self-poisoning with oxetorone: report of one case. ( Deghmani, M; Droy, JM; Galerneau, V; Leroy, A; Leroy, J; Oksenhendler, G; Petit, J; Winckler, C, 1990) |
| "However, ethosuximide must act against generalized absence seizures and against pentylenetetrazol-induced seizures by a third, as yet unknown, mechanism." | 1.27 | Anticonvulsant drug mechanisms of action. ( Macdonald, RL; McLean, MJ; Skerritt, JH, 1985) |
| "When clonazepam was finally withdrawn, a self-limiting abstinence syndrome was observed in all dogs, consisting of behavioral alterations (listlessness, wet dog shakes, dorsal recumbency), tremor, a severe clonic-tonic seizure in 1 case, hyperthermia, and weight loss." | 1.27 | Physical dependence on clonazepam in dogs. ( Frey, HH; Scherkl, R, 1986) |
| "Children with seizure disorders frequently are treated with anticonvulsant medications such as clonazepam, valproic acid, carbamazepine, and ethosuximide, which cannot be given parenterally." | 1.27 | Rectal anticonvulsants in pediatric practice. ( Laney, SM; Woody, RC, 1988) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "The time to seizures was increased nearly five times by clonazepam and over three times by very small amounts of propylene glycol." | 1.26 | Protection from oxygen-induced seizures by clonazepam and propylene glycol. ( Beckman, DL; Crittenden, DJ, 1981) |
| "Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source." | 1.26 | Audiogenic seizure-induced changes in energy metabolites in cerebral cortical and cerebellar layers. ( McCandless, DW; Schwartzenburg, FC, 1982) |
| "Isoniazid is a useful chemical convulsant in that metabolic events associated with the preseizure state can be easily examined." | 1.26 | Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. ( Abel, MS; McCandless, DW; Schwartzenburg, FC, 1982) |
| "Phenobarbital was effective in diminishing the frequency of GHB-induced myoclonic jerks only when given prior to administration of GHB." | 1.26 | Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs. ( Snead, OC, 1978) |
| "In a certain percentage of patients seizures are abolished or diminish in frequency only on attaining such a serum level." | 1.26 | [The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)]. ( Deisenhammer, E; Sommer, R, 1979) |
| "Comparison of the PD50 from clonic seizure at the peak-effect hours revealed that the benzodiazepines were 16 to 96 times more potent than phenobarbitone on a molar basis, while phenobarbitone itself was 12 to 26 times more potent than ethosuximide and trimethadione." | 1.26 | The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats. ( Banerjee, U; Yeoh, PN, 1977) |
| "Different strengths of seizure foci were induced by penicillin G 1000, 3000 and 6000 U injected into the cortex, amygdala and intralaminal thalamus, and the spread of epileptic discharges in the subcortex or surrounding area and to the contralateral area was followed." | 1.26 | [Depressive effects of benzodiazepines on penicillin-induced epileptic discharges]. ( Fukushima, H; Kitagawa, S; Tsuchiya, T, 1976) |
| "The types of seizures suffered by these patients were atypical petit mal, akinetic, massive infantile spasms, mixed minor motor seizures, myoclonic jerks, psychomotor, classic petit mal and grand mal." | 1.25 | Treatment of minor motor seizures with clonazepam. ( Carson, MJ; Gilden, C, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 70 (42.42) | 18.7374 |
| 1990's | 40 (24.24) | 18.2507 |
| 2000's | 19 (11.52) | 29.6817 |
| 2010's | 26 (15.76) | 24.3611 |
| 2020's | 10 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Edafiogho, IO | 1 |
| Hinko, CN | 1 |
| Chang, H | 1 |
| Moore, JA | 1 |
| Mulzac, D | 1 |
| Nicholson, JM | 1 |
| Scott, KR | 1 |
| Da Settimo, A | 1 |
| Primofiore, G | 1 |
| Da Settimo, F | 1 |
| Marini, AM | 1 |
| Novellino, E | 1 |
| Greco, G | 1 |
| Gesi, M | 1 |
| Martini, C | 1 |
| Giannaccini, G | 1 |
| Lucacchini, A | 1 |
| Rivas, FM | 1 |
| Stables, JP | 1 |
| Murphree, L | 1 |
| Edwankar, RV | 1 |
| Edwankar, CR | 1 |
| Huang, S | 1 |
| Jain, HD | 1 |
| Zhou, H | 1 |
| Majumder, S | 1 |
| Sankar, S | 1 |
| Roth, BL | 1 |
| Ramerstorfer, J | 1 |
| Furtmüller, R | 1 |
| Sieghart, W | 1 |
| Cook, JM | 1 |
| Brigo, F | 2 |
| Igwe, SC | 2 |
| Bragazzi, NL | 2 |
| Lattanzi, S | 2 |
| Samanta, D | 1 |
| Kienitz, R | 1 |
| Kay, L | 1 |
| Beuchat, I | 1 |
| Gelhard, S | 1 |
| von Brauchitsch, S | 1 |
| Mann, C | 1 |
| Lucaciu, A | 1 |
| Schäfer, JH | 1 |
| Siebenbrodt, K | 1 |
| Zöllner, JP | 1 |
| Schubert-Bast, S | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Willems, LM | 1 |
| Dell'Isola, GB | 1 |
| Mencaroni, E | 1 |
| Fattorusso, A | 1 |
| Tascini, G | 1 |
| Prontera, P | 1 |
| Imperatore, V | 1 |
| Di Cara, G | 1 |
| Striano, P | 1 |
| Verrotti, A | 1 |
| Tsujimoto, SI | 1 |
| Shirai, R | 1 |
| Utano, T | 1 |
| Osumi, T | 1 |
| Matsumoto, K | 2 |
| Shioda, Y | 1 |
| Kiyotani, C | 1 |
| Uchiyama, T | 1 |
| Deguchi, T | 1 |
| Terashima, K | 1 |
| Tomizawa, D | 1 |
| Kato, M | 1 |
| Le Coz, J | 1 |
| Chéron, G | 1 |
| Nabbout, R | 1 |
| Patteau, G | 1 |
| Heilbronner, C | 1 |
| Hubert, P | 1 |
| Renolleau, S | 1 |
| Oualha, M | 1 |
| Świąder, MJ | 1 |
| Świąder, K | 1 |
| Zakrocka, I | 1 |
| Krzyżanowski, M | 1 |
| Wróbel, A | 1 |
| Łuszczki, JJ | 1 |
| Czuczwar, SJ | 14 |
| Wang, X | 1 |
| Chen, B | 1 |
| Jin, L | 1 |
| Zhang, W | 1 |
| Liu, Y | 1 |
| Mandge, V | 1 |
| Husain, AM | 1 |
| Muro-García, I | 1 |
| Vieira, A | 1 |
| Vega, L | 1 |
| Pastor, J | 1 |
| de Toledo, M | 1 |
| Aicua Rapun, I | 1 |
| Novy, J | 1 |
| Solari, D | 1 |
| Oddo, M | 1 |
| Rossetti, AO | 1 |
| Grundmann, M | 1 |
| Koristkova, B | 1 |
| Brozmanova, H | 1 |
| Kacirova, I | 1 |
| Abbas, H | 1 |
| Refai, H | 1 |
| El Sayed, N | 1 |
| Chiaro, G | 1 |
| Castelnovo, A | 1 |
| Bianco, G | 1 |
| Maffei, P | 1 |
| Manconi, M | 1 |
| Oakley, JC | 1 |
| Cho, AR | 1 |
| Cheah, CS | 1 |
| Scheuer, T | 1 |
| Catterall, WA | 1 |
| Diaz-Carrasco, MS | 1 |
| Olmos, R | 1 |
| Blanquer, M | 1 |
| Velasco, J | 1 |
| Sánchez-Salinas, A | 1 |
| Moraleda, JM | 1 |
| Pocsay, G | 1 |
| Gazdag, A | 1 |
| Engelhardt, J | 1 |
| Szaniszló, I | 1 |
| Szolnoki, Z | 1 |
| Forczek, G | 1 |
| Mikló, L | 1 |
| Koekkoek, JA | 2 |
| Boddaert, MS | 1 |
| Taphoorn, M | 1 |
| Jensen, HS | 1 |
| Nichol, K | 1 |
| Lee, D | 1 |
| Ebert, B | 1 |
| Leyva-Gómez, G | 1 |
| González-Trujano, ME | 1 |
| López-Ruiz, E | 1 |
| Couraud, PO | 1 |
| Wekslerg, B | 1 |
| Romero, I | 1 |
| Miller, F | 1 |
| Delie, F | 1 |
| Allémann, E | 1 |
| Quintanar-Guerrero, D | 1 |
| Gowdar, G | 1 |
| Nyamagoudar, A | 1 |
| Chezhian I, P | 1 |
| Hanrath, MA | 1 |
| Swart, EL | 1 |
| Postma, TJ | 1 |
| Heimans, JJ | 1 |
| Reijneveld, JC | 1 |
| Taphoorn, MJ | 1 |
| Nakamura, T | 1 |
| Arima-Yoshida, F | 1 |
| Sakaue, F | 1 |
| Nasu-Nishimura, Y | 1 |
| Takeda, Y | 1 |
| Matsuura, K | 1 |
| Akshoomoff, N | 1 |
| Mattson, SN | 1 |
| Grossfeld, PD | 1 |
| Manabe, T | 1 |
| Akiyama, T | 1 |
| Yang, Z | 1 |
| Liu, X | 1 |
| Qin, J | 1 |
| Zhang, Y | 1 |
| Bao, X | 1 |
| Chang, X | 1 |
| Wang, S | 1 |
| Wu, Y | 1 |
| Xiong, H | 1 |
| Cacchione, A | 1 |
| LeMaitre, A | 1 |
| Couanet, DV | 1 |
| Benhamou, E | 1 |
| Amoroso, L | 1 |
| Simonnard, N | 1 |
| Hartmann, O | 1 |
| Nguyen-Michel, VH | 1 |
| Ourabah, Z | 1 |
| Sebban, C | 1 |
| Lavallard-Rousseau, MC | 1 |
| Adam, C | 1 |
| Dudra-Jastrzebska, M | 1 |
| Andres-Mach, MM | 1 |
| Ratnaraj, N | 3 |
| Patsalos, PN | 3 |
| Luszczki, JJ | 5 |
| Reddy, DS | 1 |
| Rogawski, MA | 4 |
| Miliauskas, S | 1 |
| Liesiene, V | 1 |
| Zemaitis, M | 1 |
| Sakalauskas, R | 1 |
| Carreras, E | 1 |
| Cahn, JY | 1 |
| Puozzo, C | 1 |
| Kröger, N | 1 |
| Sanz, G | 1 |
| Buzyn, A | 1 |
| Bacigalupo, A | 1 |
| Vernant, JP | 1 |
| Mikulecká, A | 1 |
| Mareš, P | 11 |
| Kubová, H | 6 |
| Naito, H | 1 |
| Nagae, M | 1 |
| Okahara, S | 1 |
| Maeyama, H | 1 |
| Okada, D | 1 |
| Hagioka, S | 1 |
| Morimoto, N | 1 |
| Andres-Mach, M | 1 |
| Barcicka-Klosowska, B | 1 |
| Florek-Luszczki, M | 1 |
| Haratym-Maj, A | 1 |
| Patejdl, R | 1 |
| Borchert, K | 1 |
| Pagumbke, H | 1 |
| Benecke, R | 1 |
| Grossmann, A | 1 |
| Prall, F | 1 |
| Kahl, C | 1 |
| Freund, M | 1 |
| Schmitt, M | 1 |
| Walter, U | 1 |
| Dhir, A | 1 |
| Ito, S | 1 |
| Oguni, H | 1 |
| Osawa, M | 1 |
| Merdariu, D | 1 |
| Delanoë, C | 1 |
| Mahfoufi, N | 1 |
| Bellavoine, V | 1 |
| Auvin, S | 1 |
| England, R | 1 |
| Dholakia, N | 1 |
| Tukmachi, E | 1 |
| Murphy De Souza, T | 1 |
| Moss, B | 1 |
| Ovaisi, S | 1 |
| Kaminski, RM | 1 |
| Livingood, MR | 1 |
| Borowicz, KK | 5 |
| Manni, R | 1 |
| Terzaghi, M | 1 |
| Morrissey, MJ | 1 |
| Anch, AM | 1 |
| Duntley, SP | 1 |
| Oguz, KK | 1 |
| Celebi, A | 1 |
| Anlar, B | 1 |
| Shahar, E | 1 |
| Goldsher, D | 1 |
| Genizi, J | 1 |
| Ravid, S | 1 |
| Keidar, Z | 1 |
| Verleye, M | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| Turski, L | 1 |
| Kleinrok, Z | 7 |
| Woody, RC | 2 |
| Steardo, L | 1 |
| Florio, C | 1 |
| Sorge, F | 1 |
| Steardo, R | 1 |
| Lundy, PM | 1 |
| Shaw, RK | 1 |
| Maresová, D | 1 |
| Schickerová, R | 1 |
| Bonkowsky, HL | 1 |
| Sinclair, PR | 1 |
| Emery, S | 1 |
| Sinclair, JF | 1 |
| Johnston, MV | 1 |
| Freeman, JM | 1 |
| Aminoff, MJ | 1 |
| Pockberger, H | 1 |
| Petsche, H | 3 |
| Rappelsberger, P | 2 |
| Beckman, DL | 1 |
| Crittenden, DJ | 1 |
| McCandless, DW | 2 |
| Schwartzenburg, FC | 2 |
| Abel, MS | 1 |
| Lockard, JS | 2 |
| Levy, RH | 2 |
| DuCharme, LL | 2 |
| Congdon, WC | 2 |
| Albright, PS | 1 |
| Chmielewska, B | 1 |
| Kozicka, M | 2 |
| Banfi, S | 1 |
| Fonio, W | 1 |
| Allievi, E | 1 |
| Raimondo, S | 1 |
| Zouhar, A | 1 |
| Dhar, AK | 1 |
| Kutt, H | 1 |
| Bolden, RO | 1 |
| Felsenthal, G | 1 |
| Cohen, BS | 1 |
| Vorlícek, J | 1 |
| Pohl, M | 1 |
| Zelízko, M | 1 |
| Auta, J | 1 |
| Romeo, E | 1 |
| Kozikowski, A | 1 |
| Ma, D | 1 |
| Costa, E | 1 |
| Guidotti, A | 1 |
| Bokey, K | 1 |
| Weilburg, JB | 1 |
| Schachter, S | 1 |
| Sachs, GS | 1 |
| Worth, J | 1 |
| Pollack, MH | 1 |
| Ives, JR | 1 |
| Schomer, DL | 1 |
| Velísek, L | 3 |
| Fischer, K | 1 |
| Baarsma, R | 1 |
| Looi, JC | 1 |
| Cubis, JC | 1 |
| Saboisky, J | 1 |
| Erer, B | 1 |
| Polchi, P | 1 |
| Lucarelli, G | 1 |
| Angelucci, E | 1 |
| Baronciani, D | 1 |
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5 reviews available for clonazepam and Seizures
| Article | Year |
|---|---|
Clonazepam monotherapy for treating people with newly diagnosed epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Humans; Seizures | 2022 |
Benzodiazepines in the Management of Seizures and Status Epilepticus: A Review of Routes of Delivery, Pharmacokinetics, Efficacy, and Tolerability.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Diazepam; gamma-Aminobutyric Acid; Humans; Lorazepam; | 2022 |
Clonazepam monotherapy for treating people with newly diagnosed epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Humans; Quality of Life; Randomi | 2019 |
Drug Trials in Status Epilepticus: Current Evidence and Future Concepts.
Topics: Anticonvulsants; Benzodiazepines; Clinical Trials as Topic; Clonazepam; Consensus; Critical Illness; | 2020 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
2 trials available for clonazepam and Seizures
| Article | Year |
|---|---|
Influence on Busilvex pharmacokinetics of clonazepam compared to previous phenytoin historical data.
Topics: Adolescent; Adult; Alkylating Agents; Anticonvulsants; Busulfan; Clonazepam; Cyclophosphamide; Drug | 2010 |
[DPA and clonazepam activity in febrile convulsions: preliminary results].
Topics: Benzodiazepinones; Child, Preschool; Clinical Trials as Topic; Clonazepam; Humans; Infant; Receptors | 1980 |
158 other studies available for clonazepam and Seizures
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of enaminones.
Topics: Amines; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electric Stimulation; Kindling, Neur | 1992 |
N'-Phenylindol-3-ylglyoxylohydrazide derivatives: synthesis, structure-activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors.
Topics: Animals; Anticonvulsants; Binding, Competitive; Brain; Cattle; Cerebral Cortex; Convulsants; Diazepa | 1998 |
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.
Topics: Animals; Anticonvulsants; Benzodiazepines; Convulsants; Hippocampus; Kindling, Neurologic; Ligands; | 2009 |
Pharmacotherapeutic management of seizures in patients with Angleman Syndrome.
Topics: Anticonvulsants; Cannabidiol; Child; Clobazam; Clonazepam; Ethosuximide; Humans; Lamotrigine; Leveti | 2022 |
Expanding the genetic and clinical characteristics of Protocadherin 19 gene mutations.
Topics: Cadherins; Carbamazepine; Child, Preschool; Clonazepam; Epilepsy; Female; Humans; Infant; Mutation; | 2022 |
Comparison of clonazepam and levetiracetam in children for prevention of busulfan-induced seizure in hematopoietic stem cell transplantation.
Topics: Adolescent; Busulfan; Child; Child, Preschool; Clonazepam; Female; Hematopoietic Stem Cell Transplan | 2020 |
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
Eight years follow-up of a generalized epilepsy patient with eating-induced late-onset epileptic spasms and atypical absence with myoclonic jerks.
Topics: Adolescent; China; Clonazepam; Eating; Epilepsy, Generalized; Follow-Up Studies; Humans; Male; Myocl | 2021 |
[Response to perampanel in a patient with chronic post-hypoxic myoclonus].
Topics: Anticonvulsants; Carcinoma, Papillary; Clonazepam; Drug Therapy, Combination; Electroencephalography | 2021 |
Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort.
Topics: Adult; Aged, 80 and over; Anticonvulsants; Cardiopulmonary Resuscitation; Clonazepam; Drug Combinati | 2017 |
Lamotrigine Drug Interactions in Combination Therapy and the Influence of Therapeutic Drug Monitoring on Clinical Outcomes of Adult Patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Drug Monitoring; Drug Therapy, | 2017 |
Superparamagnetic Iron Oxide-Loaded Lipid Nanocarriers Incorporated in Thermosensitive In Situ Gel for Magnetic Brain Targeting of Clonazepam.
Topics: Animals; Anticonvulsants; Brain; Clonazepam; Delayed-Action Preparations; Drug Delivery Systems; Dru | 2018 |
Severe Chronic Abuse of Zolpidem in Refractory Insomnia.
Topics: Aged; Anticonvulsants; Chronic Disease; Clonazepam; Female; Hospitalization; Humans; Levetiracetam; | 2018 |
Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Synergism; Epilepsies, | 2013 |
Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Anticonvulsants; Busulfan; Clonazepam; Dose-Re | 2013 |
[Hashimoto encephalopathy].
Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Antipsychotic Agents; Autoantibodies; Brain Disease | 2013 |
[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase].
Topics: Anticonvulsants; Clonazepam; Epilepsy; Glioma; Humans; Midazolam; Seizures; Terminal Care | 2014 |
Clobazam and its active metabolite N-desmethylclobazam display significantly greater affinities for α₂- versus α₁-GABA(A)-receptor complexes.
Topics: Allosteric Site; Animals; Anticonvulsants; Benzodiazepines; Binding Sites; Brain; Clobazam; Clonazep | 2014 |
Nanoparticle formulation improves the anticonvulsant effect of clonazepam on the pentylenetetrazole-induced seizures: behavior and electroencephalogram.
Topics: Animals; Anticonvulsants; Cell Line; Clonazepam; Drug Carriers; Electroencephalography; Humans; Lipi | 2014 |
Schimmelpenning feuerstein-mims syndrome with isolated enlargement of left temporal lobe.
Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Electroencephalography; Hearing Loss, Sensorin | 2015 |
[Convulsions due to an interaction between anti-epileptic drugs and rifampicin].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cytochrome P-450 Enzyme System; Drug Interactions; Epile | 2014 |
Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study.
Topics: Administration, Buccal; Administration, Intranasal; Aged; Brain Neoplasms; Clonazepam; Feasibility S | 2016 |
PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Clonazepam; Excitatory Amino Acid Agonists; GAB | 2016 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; | 2009 |
Risk factors for hepatic veno-occlusive disease: a retrospective unicentric study in 116 children autografted after a high-dose BU-thiotepa regimen.
Topics: Adolescent; Antineoplastic Agents; Brain Neoplasms; Busulfan; Carboplatin; Child; Child, Preschool; | 2008 |
[Idiopathic generalised epilepsies in the elderly: the viewpoint of a geriatrician].
Topics: Aged; Aged, 80 and over; Anticonvulsants; Clonazepam; Electroencephalography; Epilepsy, Generalized; | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model.
Topics: Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Topics: Anticonvulsants; Clonazepam; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography | 2010 |
Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Clonazepam; Disease Susceptibility; GABA Modulators | 2011 |
[Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report].
Topics: Acetamides; Anticonvulsants; Clonazepam; Gastric Lavage; Herbicides; Humans; Male; Middle Aged; Mult | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
Posterior reversible encephalopathy syndrome (PRES): an unusual primary manifestation of a diffuse large B-cell lymphoma.
Topics: Agraphia; Anticonvulsants; Antineoplastic Agents; Brain; Brain Neoplasms; Clonazepam; Handwriting; H | 2011 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
Benign myoclonic epilepsy in infancy with preceding afebrile generalized tonic-clonic seizures in Japan.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Clonazepam; Electroenceph | 2012 |
Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam.
Topics: Anticonvulsants; Clonazepam; Dioxolanes; Electroencephalography; Epilepsies, Partial; Female; Head M | 2013 |
Replace clonazepam with an alternative antiepileptic drug to reduce drug misuse.
Topics: Anticonvulsants; Clonazepam; Humans; Prescription Drug Misuse; Prisons; Seizures | 2012 |
Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Cornea; Disease Models, Animal; Dose-Response Relationship, Dr | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
REM behavior disorder associated with epileptic seizures.
Topics: Aged; Anticonvulsants; Brain; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Middle Age | 2005 |
An evaluation of the use of seizure prone rats when investigating intermediate stage sleep.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Clonazepam; Diagnosis, Computer-Assisted; Disease Suscept | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Ther | 2005 |
MR imaging, diffusion-weighted imaging and MR spectroscopy findings in acute rapidly progressive subacute sclerosing panencephalitis.
Topics: Anticonvulsants; Brain; Child; Clonazepam; Diffusion Magnetic Resonance Imaging; Electroencephalogra | 2007 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
Intractable gelastic seizures during infancy: ictal positron emission tomography (PET) demonstrating epileptiform activity within the hypothalamic hamartoma.
Topics: Anticonvulsants; Clonazepam; Electroencephalography; Epilepsies, Partial; Female; Hamartoma; Humans; | 2008 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convul | 2008 |
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Chlordiazepoxide; Clonazepam; Dose-Response Relationship, | 1982 |
Recent advances in anticonvulsant management of childhood seizure disorders.
Topics: Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Clonazepam; Human | 1984 |
Modification of cholinergically induced convulsive activity and cyclic GMP levels in the CNS.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Central Nervous System; Cerebellum; Cholinesterase I | 1983 |
Effect of antiepileptic drugs on metrazol convulsions during ontogenesis in the rat.
Topics: Age Factors; Animals; Anticonvulsants; Clonazepam; Ethosuximide; Male; Pentylenetetrazole; Rats; Sei | 1981 |
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
Pharmacologic advances in seizure control.
Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Humans; Kinetics; Phenytoin; Seizures; Status Epi | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
[Influence of clonazepam on interictal penicillin-spikes (author's transl)].
Topics: Animals; Benzodiazepinones; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Drug; Electroen | 1981 |
Protection from oxygen-induced seizures by clonazepam and propylene glycol.
Topics: Animals; Benzodiazepinones; Carbamazepine; Cats; Clonazepam; Hyperbaric Oxygenation; Polyethylene Gl | 1981 |
Audiogenic seizure-induced changes in energy metabolites in cerebral cortical and cerebellar layers.
Topics: Acoustic Stimulation; Adenosine Triphosphate; Animals; Cerebellum; Cerebral Cortex; Clonazepam; Ener | 1982 |
Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism.
Topics: Adenosine Triphosphate; Animals; Cerebellar Cortex; Cerebral Cortex; Clonazepam; Energy Metabolism; | 1982 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
Effects of carbamazepine, clonazepam, and phenytoin on seizure threshold in amygdala and cortex.
Topics: Amygdala; Animals; Benzodiazepinones; Carbamazepine; Cerebral Cortex; Clonazepam; Differential Thres | 1983 |
Effect of combined treatment of diphenylhydantoin with clonazepam and chlordiazepoxide on the threshold for maximal electroconvulsions in mice.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Chlordiazepoxide; Clonazepam; Drug Interactions; Electr | 1983 |
Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Topics: Animals; Anticonvulsants; Chlorides; Chronic Disease; Clonazepam; Diazepam; Disease Models, Animal; | 1983 |
Influence of clonazepam and ethosuximide on ECoG pattern induced by metrazol during ontogenesis in rats.
Topics: Age Factors; Animals; Benzodiazepinones; Cerebral Cortex; Clonazepam; Dose-Response Relationship, Dr | 1982 |
Improved gas chromatographic procedure for the determination of clonazepam levels in plasma using a nitrogen-sensitive detector.
Topics: Anticonvulsants; Benzodiazepinones; Chromatography, Gas; Clonazepam; Humans; Reference Values; Seizu | 1981 |
Tonic seizures in a patient with multiple sclerosis.
Topics: Carbamazepine; Clonazepam; Female; Humans; Middle Aged; Multiple Sclerosis; Phenytoin; Seizures | 1980 |
Stable anticonvulsant action of benzodiazepines during development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Clonazepam; Electric Stimulation; Electroencephal | 1993 |
Is the site of action of ethosuximide in the hindbrain?
Topics: Animals; Anticonvulsants; Brain Stem; Clonazepam; Decerebrate State; Electrocardiography; Electroenc | 1994 |
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
Topics: Aggression; Allosteric Regulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; | 1993 |
Conversion disorder revisited: severe parasomnia discovered.
Topics: Arousal; Cerebral Cortex; Clonazepam; Combat Disorders; Conversion Disorder; Dreams; Evoked Potentia | 1993 |
Focal paroxysmal EEG changes during atypical panic attacks.
Topics: Adult; Brain; Brain Diseases; Carbamazepine; Clonazepam; Electroencephalography; Female; Humans; Mag | 1993 |
Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Electroencephalography; Epilepsy, Ton | 1995 |
[Treatment of convulsions in newborn infants].
Topics: Anticonvulsants; Clonazepam; Drug Administration Schedule; Drug Therapy, Combination; Humans; Infant | 1996 |
Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder.
Topics: Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Therapy, Combination; GABA Mo | 1995 |
CsA-associated neurotoxicity and ineffective prophylaxis with clonazepam in patients transplanted for thalassemia major: analysis of risk factors.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; beta-Thalassemia; Blood | 1996 |
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
Topics: Acoustic Stimulation; Amygdala; Animals; Anticonvulsants; Bicuculline; Carbolines; Clonazepam; Diaze | 1996 |
Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Clonazepam; Drug Interactions; Ethosuximide; Flu | 1996 |
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba | 1996 |
Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Desoxycorticosterone; Dose-Response Relationship, Drug; Excita | 1996 |
The realities of clonazepam discontinuation.
Topics: Alprazolam; Anxiety Disorders; Benzodiazepines; Clonazepam; Drug Administration Schedule; GABA Modul | 1997 |
High-dose busulphan/melphalan with autologous stem cell rescue in Ewing's sarcoma.
Topics: Adolescent; Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; | 1997 |
Anticonvulsant effects of nimodipine and two novel dihydropyridines (PCA 50922 and PCA 50941) against seizures elicited by pentylenetetrazole and electroconvulsive shock in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Clonazepam; Dihydropyr | 1998 |
A potential anti-asthmatic drug, CR 2039, enhances the anticonvulsive activity of some antiepileptic drugs against pentetrazol in mice.
Topics: Animals; Anticonvulsants; Benzamides; Bronchodilator Agents; Clonazepam; Convulsants; Dose-Response | 1998 |
Paroxysmal kinesigenic dyskinesia in infancy.
Topics: Age of Onset; Anticonvulsants; Clonazepam; Female; Humans; Infant; Movement Disorders; Seizures | 1999 |
Abecarnil enhances recovery from diazepam tolerance.
Topics: Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Carbolines; Cell Membrane; Cerebral Cortex; | 1999 |
Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Benzodiazepines; Clonazepam; Drug Sy | 1999 |
Hyperekplexia: a rare differential of neonatal fits described in a developing country.
Topics: Anticonvulsants; Clonazepam; Developing Countries; Electrocardiography; Electroencephalography; Huma | 1999 |
Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Clonazepam; Evoked Po | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
Population pharmacokinetic analysis resulting in a tool for dose individualization of busulphan in bone marrow transplantation recipients.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Area Un | 2001 |
2-Chloroadenosine, a preferential agonist of adenosine A1 receptors, enhances the anticonvulsant activity of carbamazepine and clonazepam in mice.
Topics: 2-Chloroadenosine; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy | 2002 |
[Inhibitory processes in the cerebral cortex and the anticonvulsive action of benzodiazepine derivatives].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain; Cats; Cerebral Cortex; Clonazepam; Diazepam; E | 1977 |
Gamma hydroxybutyrate in the monkey. III. Effect of intravenous anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Diazepam; Electroencephalography; Ethosuximi | 1978 |
Absence status and the concurrent administration of clonazepam and valproate sodium.
Topics: Benzodiazepinones; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy, Absence; Huma | 1979 |
Clonazepam in a focal-motor monkey model: efficacy, tolerance, toxicity, withdrawal, and management.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Benzodiazepinones; Clonazepam; Drug Tolerance; Electr | 1979 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Anticonvulsant drug actions on in vitro and in vivo levels of cyclic AMP in the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Brain; Carbamazepine; Cerebellum; Cerebral Cortex; Clonazepam; | 1979 |
A comparative study of the efficacy of newer antiepiletpic drugs on experimentally-induced febrile convulsions.
Topics: Animals; Anticonvulsants; Body Temperature; Carbamazepine; Clonazepam; Male; Mice; Phenobarbital; Se | 1977 |
Combination of clonazepam and sodium valproate in the treatment of refractory epileptic seizures in 12 children.
Topics: Benzodiazepinones; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Valproi | 1979 |
[The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)].
Topics: Antacids; Anticonvulsants; Biological Availability; Carbamazepine; Chromatography, Gas; Clonazepam; | 1979 |
[The phenomenon of synchronization in the status epilepticus produced by penicillin and its changes after Clonazepam (author's transl)].
Topics: Animals; Benzodiazepinones; Brain; Clonazepam; Penicillin G; Rabbits; Seizures | 1977 |
Clonazepam in the treatment of children with intractable seizures.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Drug Therapy, C | 1977 |
Psychosis or epilepsy? Differentiation in a complex case.
Topics: Adolescent; Brain; Child Behavior; Clonazepam; Diagnosis, Differential; Electroencephalography; Epil | 1979 |
Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Brain; Clonazepam; Diazepam; Dogs; Electric St | 1979 |
[Further statistical study of simple febrile convulsions in childhood].
Topics: Age Factors; Child; Child, Preschool; Clonazepam; Humans; Infant; Italy; Seizures; Seizures, Febrile | 1979 |
The temporal dimensions of anticonvulsant action of some newer benzodiazepines against metrazol induced seizures in mice and rats.
Topics: Animals; Benzodiazepines; Clonazepam; Diazepam; Drug Evaluation, Preclinical; Ethosuximide; Female; | 1977 |
[Clonazepam in the treatment of eclamptic convulsive crises].
Topics: Adult; Benzodiazepinones; Clonazepam; Drug Evaluation; Eclampsia; Female; Humans; Pregnancy; Seizure | 1978 |
Immediate changes of the electroencephalograms after intravenous injection of clonazepam and their relation to its effect on clinical fits in children with minor seizures.
Topics: Administration, Oral; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Electroencephalography | 1978 |
Drug contamination of mortars and pestles.
Topics: Animals; Clonazepam; Decontamination; Drug Compounding; Drug Contamination; Male; Mice; Pentylenetet | 1978 |
Clonazepam: a new anticonvulsant.
Topics: Benzodiazepinones; Clonazepam; Epilepsy, Absence; Humans; Seizures | 1976 |
Topography of the EEG: survey and prospects.
Topics: Alpha Rhythm; Animals; Cerebral Cortex; Clonazepam; Data Display; Electroencephalography; Haplorhini | 1976 |
[Depressive effects of benzodiazepines on penicillin-induced epileptic discharges].
Topics: Animals; Benzodiazepines; Cats; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Electroencep | 1976 |
Letter: The ketogenic diet, West and Lennox syndromes.
Topics: Child; Child, Preschool; Clonazepam; Diazepam; Humans; Infant; Intellectual Disability; Myoclonus; N | 1975 |
Treatment of minor motor seizures with clonazepam.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Female; Humans; Infant; Male; Se | 1975 |
Effects of intracerebral iloprost injections on motor activity and chemically-induced seizures in rats.
Topics: Animals; Clonazepam; Iloprost; Injections, Intraventricular; Male; Motor Activity; Rats; Seizures | 1992 |
Effects of clonazepam on picrotoxin-induced convulsions.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Epilepsy; Injections, Intrap | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Tolerance to the anticonvulsant effects of phenobarbital, trimethadione, and clonazepam in kindled rats: cross tolerance to carbamazepine.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Drug Tolerance; Electrodes, Im | 1992 |
Reduction of seizure frequency by clonazepam during cobalt experimental epilepsy.
Topics: Animals; Clonazepam; Cobalt; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Fem | 1992 |
Interactions between angiotensin II, diazepam, clonazepam and di-n-propylacetate in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Clonazepam; Diazepam; Drug Interactions; Electric Stimulation; Ionophores; | 1991 |
Induced microseizures in West syndrome.
Topics: Adrenocorticotropic Hormone; Clonazepam; Electroencephalography; Female; Humans; Infant; Seizures; S | 1991 |
Genetic difference in sensitivity to beta-carboline: evidence for the involvement of brain benzodiazepine receptors.
Topics: Animals; Brain; Carbolines; Clonazepam; Convulsants; Flunitrazepam; Kinetics; Mice; Mice, Inbred BAL | 1991 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Convulsants; Diazepam; Female; GABA Antagonists; g | 1991 |
Posthypoxic myoclonus (the Lance-Adams syndrome) in the intensive care unit.
Topics: Clonazepam; Critical Care; Diagnosis, Differential; Humans; Hypoxia; Male; Middle Aged; Myoclonus; R | 1991 |
Clonazepam in neonatal seizures: dose regimens and therapeutic efficacy.
Topics: Asphyxia Neonatorum; Cerebral Hemorrhage; Clonazepam; Female; Humans; Infant, Newborn; Infant, Prema | 1991 |
Anticonvulsant effects of clonazepam on chemically induced convulsions.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Clonazepam; Dose-Response Relations | 1990 |
Profound stress-induced alterations in flurazepam's antiseizure efficacy can be attenuated.
Topics: Animals; Carbolines; Clonazepam; Cold Temperature; Diazepam; Dose-Response Relationship, Drug; Elect | 1990 |
Seizure in gradual clonazepam withdrawal, Vol. 14, No. 3, September, 1989, p. 484.
Topics: Clonazepam; Dose-Response Relationship, Drug; Humans; Seizures; Substance Withdrawal Syndrome | 1990 |
Severe self-poisoning with oxetorone: report of one case.
Topics: Adult; Benzoxepins; Chromatography, High Pressure Liquid; Clonazepam; Coma; Electrocardiography; Eme | 1990 |
Anticonvulsant drug mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clonazepa | 1985 |
Influence of clonazepam and valproate on kainate-induced model of psychomotor seizures.
Topics: Animals; Anticonvulsants; Clonazepam; Kainic Acid; Rats; Seizures; Valproic Acid | 1989 |
Repeated swim stress alters brain benzodiazepine receptors measured in vivo.
Topics: Animals; Brain; Cerebrovascular Circulation; Clonazepam; Flumazenil; Male; Mice; Pentylenetetrazole; | 1989 |
Blockade of FG 7142 kindling by anticonvulsants acting at sites distant from the benzodiazepine receptor.
Topics: Animals; Anticonvulsants; Carbolines; Clonazepam; Dibenzocycloheptenes; Dizocilpine Maleate; Female; | 1989 |
Potentiation of the anticonvulsant action of clonazepam by phenytoin could be demonstrated in adult as well as young rats.
Topics: Aging; Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Ph | 1989 |
Benzodiazepine withdrawal delirium with catatonic features. Occurrence in patients with partial seizure disorders.
Topics: Adult; Benzodiazepines; Catatonia; Clonazepam; Clorazepate Dipotassium; Delirium; Encephalitis; Fema | 1989 |
Synergistic anticonvulsant action of diazepam & clonazepam with amino-oxyacetic acid against isoniazid-induced convulsions in rats.
Topics: Acetates; Aminooxyacetic Acid; Animals; Clonazepam; Diazepam; Drug Therapy, Combination; Isoniazid; | 1989 |
[Effects of anticonvulsants on the cyclic nucleotide content of the plasma and cerebellum of convulsive rats].
Topics: Animals; Anticonvulsants; Cerebellum; Clonazepam; Cyclic AMP; Cyclic GMP; Diazepam; Male; Organophos | 1987 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relation | 1986 |
Convulsions in patients abruptly withdrawn from clonazepam while receiving neuroleptic medication.
Topics: Adult; Antipsychotic Agents; Clonazepam; Drug Therapy, Combination; Female; Humans; Male; Mental Dis | 1987 |
Tolerance to the anticonvulsant effect of clorazepate and clonazepam in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Clonazepam; Clorazepate Dipotassium; Drug Tolerance; | 1988 |
Benzodiazepine receptors are not involved in the neurotoxicity and anti-electroshock activity of phenytoin in mice.
Topics: Animals; Benzodiazepinones; Clonazepam; Drug Interactions; Electroshock; Flumazenil; Male; Mice; Phe | 1985 |
Convulsant effect of Ro 5-4864, a peripheral type benzodiazepine, on the baboon (Papio papio).
Topics: Animals; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Dose-Response Relationship, Drug; | 1986 |
Physical dependence on clonazepam in dogs.
Topics: Animals; Benzodiazepinones; Body Temperature; Body Weight; Clonazepam; Dogs; Female; Flumazenil; Mal | 1986 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; | 1986 |
The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat.
Topics: Amygdala; Animals; Anticonvulsants; Clonazepam; Drug Tolerance; Kindling, Neurologic; Male; Rats; Ra | 1987 |
Rectal anticonvulsants in pediatric practice.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child, Preschoo | 1988 |
Experimental characterisation of the withdrawal syndrome after 14 days treatment with clonazepam.
Topics: Animals; Clonazepam; Drug Administration Schedule; Female; Male; Motor Activity; Rats; Rats, Inbred | 1987 |
[Intrarectal clonazepam in children. Plasma and CSF levels].
Topics: Administration, Rectal; Child; Child, Preschool; Clonazepam; Female; Humans; Infant; Male; Seizures | 1988 |
Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold.
Topics: Animals; Brain; Clonazepam; Kindling, Neurologic; Male; Microinjections; Rats; Rats, Inbred Strains; | 1987 |
Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats.
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Clonaz | 1987 |
Influence of clonazepam on electrocorticographic changes induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Clonazepam; Electrodes, Implanted; Electroencephalography; Male; Pentylenetetrazole; | 1987 |
Cholinergic induction of seizures in the rat prefrontal cortex.
Topics: Animals; Carbachol; Cerebral Cortex; Clonazepam; Diazepam; Electroencephalography; Male; Microinject | 1986 |
[Clonazepam-induced tonic seizure].
Topics: Adolescent; Catecholamines; Clonazepam; Electroencephalography; Female; Humans; Seizures; Sleep Stag | 1986 |
Clonazepam pharmacokinetics and therapeutic efficacy in neonatal seizures.
Topics: Adult; Clonazepam; Female; Half-Life; Humans; Infant, Newborn; Infusions, Intravenous; Kinetics; Mal | 1986 |
Alternate-day clonazepam treatment of intractable seizures.
Topics: Adult; Benzodiazepinones; Child, Preschool; Clonazepam; Female; Humans; Infant; Seizures | 1985 |
[Convulsive crises in childhood].
Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi | 1985 |
Anticonvulsant effect of clonazepam in the dog: development of tolerance and physical dependence.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Clonazepam; Dogs; Drug Tolerance; Electroencephalograph | 1985 |