clonazepam has been researched along with Restless Legs Syndrome in 46 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Restless Legs Syndrome: A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of clonazepam on the restless legs syndrome was studied in a group of 6 patients." | 9.06 | The treatment of the restless legs syndrome with clonazepam: a prospective controlled study. ( Boghen, D; Elie, R; Godbout, R; Lamothe, L; Montplaisir, J, 1986) |
| "Clonazepam is one of several agents used for the treatment of the restless legs syndrome of ESRD." | 8.79 | Clonazepam: benzodiazepine therapy for the restless legs syndrome. ( Joy, MS, 1997) |
| "Fifteen patients with restless legs syndrome underwent whole-night polysomnographic recordings before and during clonazepam treatment." | 7.68 | Periodic leg movements in sleep with restless legs syndrome: effect of clonazepam treatment. ( Horiguchi, J; Inami, Y; Nishimatsu, O; Sasaki, A; Sukegawa, T, 1992) |
| "Clonazepam is a safe and effective drug for treatment of RLS; however its long-term efficacy needs confirmation." | 6.65 | Clonazepam and vibration in restless legs syndrome. ( Cirignotta, F; Lugaresi, E; Montagna, P; Sassoli de Bianchi, L; Zucconi, M, 1984) |
| " The studies included in the review involved patients with insomnia, REM sleep behavior disorder, sleep bruxism, and restless leg syndrome or PLMS which reported, most often, an increase in total sleep time with clonazepam." | 5.41 | Clonazepam for the management of sleep disorders. ( DelRosso, LM; Ferri, R; Mogavero, MP; Raggi, A, 2023) |
| "The effect of clonazepam on the restless legs syndrome was studied in a group of 6 patients." | 5.06 | The treatment of the restless legs syndrome with clonazepam: a prospective controlled study. ( Boghen, D; Elie, R; Godbout, R; Lamothe, L; Montplaisir, J, 1986) |
| "Clonazepam is one of several agents used for the treatment of the restless legs syndrome of ESRD." | 4.79 | Clonazepam: benzodiazepine therapy for the restless legs syndrome. ( Joy, MS, 1997) |
| "Eighteen patients with restless legs syndrome (RLS) and 4 patients with neuroleptic-induced akathisia (NIA) underwent all-night polysomnographic recordings before and during clonazepam treatment." | 3.69 | A polysomnographic study on periodic limb movements in patients with restless legs syndrome and neuroleptic-induced akathisia. ( Horiguchi, J; Inami, Y; Katagiri, H; Nishimatsu, O; Sasaki, A; Sukegawa, T; Yamawaki, S, 1997) |
| "Fifteen patients with restless legs syndrome underwent whole-night polysomnographic recordings before and during clonazepam treatment." | 3.68 | Periodic leg movements in sleep with restless legs syndrome: effect of clonazepam treatment. ( Horiguchi, J; Inami, Y; Nishimatsu, O; Sasaki, A; Sukegawa, T, 1992) |
| " The present study aimed to compare nCPAP alone (n), nCPAP combined with clonazepam (n+c) and clonazepam alone (c) in patients with mild to moderate SAHS associated with high leg activity." | 2.70 | High leg motor activity in sleep apnea hypopnea patients: efficacy of clonazepam combined with nasal CPAP on polysomnographic variables. ( De Maertelaer, V; Kempenaers, Ch; Kerkhofs, M; Lanquart, JR; Linkowski, R; Noseda, A; Nouvelle, M, 2002) |
| "Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep resulted in sustained efficacy in most cases, with low risk of dosage tolerance, adverse effects, or abuse." | 2.68 | Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults. ( Mahowald, MW; Schenck, CH, 1996) |
| "Treatment with clonazepam was studied in a group of 20 patients suffering from periodic movements in sleep, in a double-blind parallel group design." | 2.66 | Double-blind evaluation of clonazepam on periodic leg movements in sleep. ( Lavie, P; Peled, R, 1987) |
| "Clonazepam is a safe and effective drug for treatment of RLS; however its long-term efficacy needs confirmation." | 2.65 | Clonazepam and vibration in restless legs syndrome. ( Cirignotta, F; Lugaresi, E; Montagna, P; Sassoli de Bianchi, L; Zucconi, M, 1984) |
| "Treatment of restless legs syndrome (RLS) has as its goals alleviation of the primary symptoms of the disorder and establishment of normal sleep." | 2.44 | Restless legs syndrome: nonpharmacologic and pharmacologic treatments. ( Allen, RP; Hening, W; Tenzer, P; Winkelman, JW, 2007) |
| "Ekbom's syndrome, or 'restless legs syndrome' (RLS), not only causes symptoms in the extremities during waking hours, but also sleep disturbance and daytime fatigue." | 2.40 | [Restless legs. A much neglected syndrome]. ( Jönsson, R; Lindberg, E; Mallon, L; Nyström, B; Ulfberg, J, 1999) |
| "Patients with restless legs syndrome often have difficulty describing their symptoms." | 2.37 | Restless legs syndrome. ( Fox, GN, 1986) |
| "PGAD/RGS often coexists with restless legs syndrome (RLS)." | 1.42 | [A case of Parkinson's disease following restless genial sensation]. ( Nishinaka, K; Sawamura, M; Sekiya, T; Toma, K; Udaka, F; Unai, Y, 2015) |
| "To investigate excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD), the reasons for which have not yet been clarified, polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were performed in 46 patients with PD, and, in addition, PSG was performed in 30 healthy controls." | 1.33 | Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study. ( Goldstein, R; Klein, C; Miniovitz, A; Pollak, L; Prokhorov, T; Rabey, JM; Shpirer, I; Theitler, J, 2006) |
| "Sleep-related eating disorders distinct from daytime eating disorders have recently been shown to be associated with sleepwalking (SW), periodic limb movement (PLM) disorder and triazolam abuse in a series of 19 adults." | 1.29 | Additional categories of sleep-related eating disorders and the current status of treatment. ( Hurwitz, TD; Mahowald, MW; O'Connor, KA; Schenck, CH, 1993) |
| "Restless legs syndrome was present in nine members of a family over a span of five generations." | 1.27 | Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study. ( Boghen, D; DeChamplain, J; Godbout, R; Lapierre, G; Montplaisir, J; Young, SN, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (28.26) | 18.7374 |
| 1990's | 14 (30.43) | 18.2507 |
| 2000's | 10 (21.74) | 29.6817 |
| 2010's | 8 (17.39) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Raggi, A | 1 |
| Mogavero, MP | 1 |
| DelRosso, LM | 1 |
| Ferri, R | 2 |
| Hsu, CH | 1 |
| Yu, SM | 1 |
| Lau, SC | 1 |
| Chen, YL | 1 |
| Pei, D | 1 |
| Liu, IC | 1 |
| Sawamura, M | 1 |
| Toma, K | 1 |
| Unai, Y | 1 |
| Sekiya, T | 1 |
| Nishinaka, K | 1 |
| Udaka, F | 1 |
| Yun, CH | 1 |
| Ji, KH | 1 |
| Shinno, H | 2 |
| Yamanaka, M | 1 |
| Ishikawa, I | 1 |
| Danjo, S | 1 |
| Nakamura, Y | 2 |
| Inami, Y | 5 |
| Horiguchi, J | 5 |
| Oka, Y | 1 |
| Otsuki, M | 1 |
| Tsuchiya, S | 1 |
| Mizuno, S | 1 |
| Kawada, S | 1 |
| Innami, T | 1 |
| Sasaki, A | 4 |
| Hineno, T | 1 |
| Sakamoto, T | 1 |
| Tzonova, D | 1 |
| Larrosa, O | 1 |
| Calvo, E | 1 |
| Granizo, JJ | 1 |
| Williams, AM | 1 |
| de la Llave, Y | 1 |
| García-Borreguero, D | 1 |
| Manconi, M | 1 |
| Zucconi, M | 2 |
| Bassetti, CL | 2 |
| Fulda, S | 1 |
| Aricò, D | 1 |
| Ferini-Strambi, L | 1 |
| Noseda, A | 1 |
| Nouvelle, M | 1 |
| Lanquart, JR | 1 |
| Kempenaers, Ch | 1 |
| De Maertelaer, V | 1 |
| Linkowski, R | 1 |
| Kerkhofs, M | 1 |
| Schenck, CH | 3 |
| Clavadetscher, SC | 1 |
| Gugger, M | 1 |
| Molnar, MZ | 1 |
| Novak, M | 1 |
| Mucsi, I | 1 |
| Shpirer, I | 1 |
| Miniovitz, A | 1 |
| Klein, C | 1 |
| Goldstein, R | 1 |
| Prokhorov, T | 1 |
| Theitler, J | 1 |
| Pollak, L | 1 |
| Rabey, JM | 1 |
| Nomura, T | 1 |
| Inoue, Y | 2 |
| Nakashima, K | 1 |
| Karatas, M | 1 |
| Winkelman, JW | 1 |
| Allen, RP | 1 |
| Tenzer, P | 1 |
| Hening, W | 1 |
| Enomoto, M | 1 |
| Namba, K | 1 |
| Munezawa, T | 1 |
| Matsuura, M | 1 |
| Montagna, P | 1 |
| Sassoli de Bianchi, L | 1 |
| Cirignotta, F | 1 |
| Lugaresi, E | 1 |
| Read, DJ | 1 |
| Feest, TG | 1 |
| Nassim, MA | 1 |
| Braude, W | 1 |
| Barnes, T | 1 |
| Boghen, D | 3 |
| Hurwitz, TD | 1 |
| O'Connor, KA | 1 |
| Mahowald, MW | 2 |
| Nofzinger, EA | 1 |
| Reynolds, CF | 1 |
| Edinger, JD | 1 |
| Fins, AI | 1 |
| Sullivan, RJ | 1 |
| Marsh, GR | 1 |
| Dailey, DS | 1 |
| Young, M | 1 |
| Tan, AK | 1 |
| Tan, CB | 1 |
| Joy, MS | 1 |
| Nozawa, T | 1 |
| Nishimatsu, O | 3 |
| Sukegawa, T | 3 |
| Katagiri, H | 1 |
| Yamawaki, S | 1 |
| Arens, R | 1 |
| Wright, B | 1 |
| Elliott, J | 1 |
| Zhao, H | 1 |
| Wang, PP | 1 |
| Brown, LW | 1 |
| Namey, T | 1 |
| Kaplan, P | 1 |
| Ulfberg, J | 1 |
| Jönsson, R | 1 |
| Lindberg, E | 1 |
| Nyström, B | 1 |
| Mallon, L | 1 |
| Saletu, M | 1 |
| Anderer, P | 1 |
| Saletu-Zyhlarz, G | 1 |
| Prause, W | 1 |
| Semler, B | 1 |
| Zoghlami, A | 1 |
| Gruber, G | 1 |
| Hauer, C | 1 |
| Saletu, B | 1 |
| Matthews, WB | 1 |
| Montplaisir, J | 3 |
| Lapierre, O | 1 |
| Warnes, H | 1 |
| Pelletier, G | 1 |
| Danek, A | 1 |
| Pollmächer, T | 1 |
| Mitler, MM | 1 |
| Browman, CP | 1 |
| Menn, SJ | 1 |
| Gujavarty, K | 1 |
| Timms, RM | 1 |
| Sandyk, R | 1 |
| Bamford, CR | 1 |
| Gillman, MA | 1 |
| Goldsmith, MF | 1 |
| Peled, R | 1 |
| Lavie, P | 1 |
| Lang, AE | 1 |
| Fox, GN | 1 |
| Lamothe, L | 1 |
| Elie, R | 1 |
| Godbout, R | 2 |
| DeChamplain, J | 1 |
| Young, SN | 1 |
| Lapierre, G | 1 |
9 reviews available for clonazepam and Restless Legs Syndrome
| Article | Year |
|---|---|
Clonazepam for the management of sleep disorders.
Topics: Clonazepam; Humans; Leg; Polysomnography; Restless Legs Syndrome; Sleep | 2023 |
Management of restless legs syndrome in patients on dialysis.
Topics: Amines; Anticonvulsants; Benzothiazoles; Clonazepam; Cyclohexanecarboxylic Acids; Dopamine Agents; G | 2006 |
Restless legs syndrome and periodic limb movements during sleep: diagnosis and treatment.
Topics: Analgesics, Opioid; Clonazepam; Diagnosis, Differential; Dopamine; Dopamine Agents; Electric Stimula | 2007 |
Restless legs syndrome: nonpharmacologic and pharmacologic treatments.
Topics: Amines; Anemia, Iron-Deficiency; Anticonvulsants; Benzothiazoles; Clonazepam; Cyclohexanecarboxylic | 2007 |
Clonazepam: benzodiazepine therapy for the restless legs syndrome.
Topics: Anti-Anxiety Agents; Clonazepam; GABA Modulators; Humans; Kidney Failure, Chronic; Restless Legs Syn | 1997 |
[Periodic limb movement disorder].
Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Dopamine Agents; Humans; Levodopa; Movement Di | 1998 |
[Restless legs. A much neglected syndrome].
Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Dopamine Agents; Humans; Levodopa; Polysomnography; | 1999 |
The treatment of the restless leg syndrome with or without periodic leg movements in sleep.
Topics: Anti-Anxiety Agents; Clonazepam; Dextropropoxyphene; Dopamine Agents; Humans; Levodopa; Narcotics; P | 1992 |
Restless legs syndrome.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Clonazepam; Cryotherapy; Diagnosis, Differential; Fem | 1986 |
11 trials available for clonazepam and Restless Legs Syndrome
| Article | Year |
|---|---|
Proposed dose equivalence between clonazepam and pramipexole in patients with restless legs syndrome.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Benzothiazoles; Clonazepam; Dose-Response Relationship | 2010 |
Dissociation of periodic leg movements from arousals in restless legs syndrome.
Topics: Anticonvulsants; Antiparkinson Agents; Arousal; Benzothiazoles; Clonazepam; Electroencephalography; | 2012 |
High leg motor activity in sleep apnea hypopnea patients: efficacy of clonazepam combined with nasal CPAP on polysomnographic variables.
Topics: Analysis of Variance; Clonazepam; Combined Modality Therapy; Female; GABA Modulators; Humans; Male; | 2002 |
Clonazepam and vibration in restless legs syndrome.
Topics: Adult; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Drug Evaluation; Female; Humans; Mal | 1984 |
Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Chronic Disease; Clonazepam; Drug Administration Schedule; F | 1996 |
Comparison of cognitive-behavioral therapy and clonazepam for treating periodic limb movement disorder.
Topics: Aged; Anticonvulsants; Clonazepam; Cognitive Behavioral Therapy; Female; Humans; Male; Middle Aged; | 1996 |
Periodic limb movement disorder in neuroleptic-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Clonazepam; Electromyography; | 1997 |
Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam.
Topics: Adult; Aged; Arousal; Clonazepam; Cross-Over Studies; Female; GABA Modulators; Half-Life; Humans; Ma | 2001 |
Nocturnal myoclonus: treatment efficacy of clonazepam and temazepam.
Topics: Adult; Anti-Anxiety Agents; Clinical Trials as Topic; Clonazepam; Female; Humans; Male; Middle Aged; | 1986 |
Double-blind evaluation of clonazepam on periodic leg movements in sleep.
Topics: Clonazepam; Double-Blind Method; Drug Evaluation; Humans; Leg; Movement; Restless Legs Syndrome; Sle | 1987 |
The treatment of the restless legs syndrome with clonazepam: a prospective controlled study.
Topics: Adult; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Female; Humans; Male; Middle Aged; P | 1986 |
26 other studies available for clonazepam and Restless Legs Syndrome
| Article | Year |
|---|---|
Restless legs syndrome/Willis-Ekbom disease in type 2 diabetes as the initial manifestation of Parkinson's disease and major cardiovascular disease.
Topics: Aged; Amines; Analgesics; Anticonvulsants; Antihypertensive Agents; Antiparkinson Agents; Aspirin; B | 2017 |
[A case of Parkinson's disease following restless genial sensation].
Topics: Benzothiazoles; Clonazepam; Drug Therapy, Combination; Female; Humans; Middle Aged; Parkinsonian Dis | 2015 |
Zolpidem-induced sleep-related eating disorder.
Topics: Benzothiazoles; Clonazepam; Dopamine Agonists; Feeding and Eating Disorders; Humans; Hypnotics and S | 2010 |
Successful treatment of restless legs syndrome with the herbal prescription Yokukansan.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antioxidants; Benzothiazoles; Clonazepam; Drugs, Chinese H | 2010 |
[Restless legs syndrome].
Topics: Clonazepam; Disease Progression; Dopamine Agonists; Humans; Hypnotics and Sedatives; Restless Legs S | 2010 |
Breakthrough symptoms during the daytime in patients with restless legs syndrome (Willis-Ekbom disease).
Topics: Adult; Aged; Benzothiazoles; Circadian Rhythm; Clonazepam; Cross-Sectional Studies; Dopamine Agonist | 2012 |
Restless legs syndrome and periodic limb movements of sleep: global therapeutic considerations.
Topics: Anticonvulsants; Benzodiazepines; Clonazepam; Humans; Nocturnal Myoclonus Syndrome; Olanzapine; Pire | 2002 |
Restless legs syndrome: clinical experience with long-term treatment.
Topics: Adult; Aged; Amines; Clonazepam; Cyclohexanecarboxylic Acids; Dopamine Agonists; Drug Therapy, Combi | 2004 |
Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Benzodiazepines; Clonazepam; Cohort Studies; Comorbid | 2006 |
Clinical characteristics of Restless legs syndrome in patients with Parkinson's disease.
Topics: Age of Onset; Aged; Aging; Anticonvulsants; Clonazepam; Dopamine; Dopamine Agonists; Dose-Response R | 2006 |
Clinical characteristics of restless legs syndrome in end-stage renal failure and idiopathic RLS patients.
Topics: Adult; Age of Onset; Aged; Anticonvulsants; Azepines; Clonazepam; Dopamine Agents; Female; Humans; K | 2008 |
Clonazepam: effective treatment for restless legs syndrome in uraemia.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Clonazepam; Female; Humans; Male; Middle Aged; Restless | 1981 |
Clonazepam: effective treatment for restless legs syndrome in uraemia.
Topics: Clonazepam; Humans; Restless Legs Syndrome; Uremia | 1982 |
Successful treatment of restless legs with clonazepam.
Topics: Benzodiazepinones; Clonazepam; Female; Humans; Male; Middle Aged; Restless Legs Syndrome | 1980 |
Additional categories of sleep-related eating disorders and the current status of treatment.
Topics: Adult; Aged; Child, Preschool; Clinical Protocols; Clonazepam; Combined Modality Therapy; Dopamine A | 1993 |
Sleep impairment and daytime sleepiness in later life.
Topics: Aged; Clonazepam; Diagnosis, Differential; Humans; Male; Polysomnography; Positive-Pressure Respirat | 1996 |
The syndrome of painful legs and moving toes--a case report.
Topics: Baclofen; Clonazepam; Female; GABA Agonists; GABA Modulators; Humans; Middle Aged; Neuromuscular Dis | 1996 |
A polysomnographic study on periodic limb movements in patients with restless legs syndrome and neuroleptic-induced akathisia.
Topics: Aged; Aged, 80 and over; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Case-Contro | 1997 |
Periodic limb movement in sleep in children with Williams syndrome.
Topics: Anticonvulsants; Arousal; Child; Child, Preschool; Clonazepam; Female; Follow-Up Studies; Humans; In | 1998 |
Treatment of the restless legs syndrome with clonazepam.
Topics: Adult; Aged; Benzodiazepinones; Clonazepam; Female; Humans; Male; Restless Legs Syndrome | 1979 |
Periodic leg movements in sleep with restless legs syndrome: effect of clonazepam treatment.
Topics: Aged; Aged, 80 and over; Clonazepam; Female; Humans; Male; Middle Aged; Paresthesia; Polysomnography | 1992 |
[Restless legs syndrome. Clinical aspects, differential diagnosis, therapeutic approaches].
Topics: Adult; Clonazepam; Diagnosis, Differential; Humans; Iron; Male; Middle Aged; Monitoring, Physiologic | 1990 |
Opiates in the restless legs syndrome.
Topics: Acetaminophen; Adult; Aged; Analgesics; Aspirin; Caffeine; Clonazepam; Dextropropoxyphene; Drug Comb | 1987 |
Several research avenues may improve understanding of multiple sclerosis.
Topics: Clonazepam; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Restless Legs Syndrome; Se | 1988 |
Restless legs syndrome and Parkinson's disease: insights into pathophysiology.
Topics: Aged; Clonazepam; Codeine; Dopamine; Humans; Levodopa; Male; Parkinson Disease; Restless Legs Syndro | 1987 |
Familial restless legs with periodic movements in sleep: electrophysiologic, biochemical, and pharmacologic study.
Topics: Adult; Biogenic Amines; Clonazepam; Electrophysiology; Female; Humans; Male; Restless Legs Syndrome; | 1985 |