clonazepam has been researched along with Reflex, Abnormal in 9 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Reflex, Abnormal: An abnormal response to a stimulus applied to the sensory components of the nervous system. This may take the form of increased, decreased, or absent reflexes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperekplexia is an exaggerated startle to external stimuli associated with a generalised increase in tone seen in neonates with both sporadic and genetic predisposition." | 1.56 | Abnormal neurodevelopment outcome in case of neonatal hyperekplexia secondary to missense mutation in ( Chopra, S; Choudhury, V; Gupta, NP; Verma, V, 2020) |
| "Later in the clinical course, the myoclonus became stimulus sensitive and was induced by tendon tap given anywhere on the body, with the latency ranging from 50 to 150 ms irrespective of the sites of tapping." | 1.29 | Spinal myoclonus resembling belly dance. ( Araki, K; Kono, I; Nakajima, K; Shibasaki, H; Ueda, Y, 1994) |
| "Treatment with clonazepam was effective in relieving these manifestations in the affected infants and children." | 1.28 | Hyperekplexia: pedigree studies in two families. ( Hayashi, T; Kajii, T; Tachibana, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Gupta, NP | 1 |
| Verma, V | 1 |
| Chopra, S | 1 |
| Choudhury, V | 1 |
| Bakker, MJ | 1 |
| Peeters, EA | 1 |
| Tijssen, MA | 1 |
| Shahar, E | 1 |
| Raviv, R | 1 |
| Schlapbach, LJ | 1 |
| Sozzo, A | 1 |
| Ramelli, G | 1 |
| Bianchetti, MG | 1 |
| Doria Lamba, L | 1 |
| Giribaldi, G | 1 |
| De Negri, E | 1 |
| Follo, R | 1 |
| De Grandis, E | 1 |
| Pintaudi, M | 1 |
| Veneselli, E | 1 |
| Kono, I | 1 |
| Ueda, Y | 1 |
| Araki, K | 1 |
| Nakajima, K | 1 |
| Shibasaki, H | 1 |
| Miller, VS | 1 |
| McMaster, P | 1 |
| Cadzow, S | 1 |
| Vince, J | 1 |
| Appleton, B | 1 |
| Hayashi, T | 1 |
| Tachibana, H | 1 |
| Kajii, T | 1 |
9 other studies available for clonazepam and Reflex, Abnormal
| Article | Year |
|---|---|
Abnormal neurodevelopment outcome in case of neonatal hyperekplexia secondary to missense mutation in
Topics: Anticonvulsants; Child, Preschool; Clonazepam; Diagnosis, Differential; Diagnostic Errors; Humans; H | 2020 |
Clonazepam is an effective treatment for hyperekplexia due to a SLC6A5 (GlyT2) mutation.
Topics: Anticonvulsants; Child; Clonazepam; Electromyography; GABA Plasma Membrane Transport Proteins; Human | 2009 |
Sporadic major hyperekplexia in neonates and infants: clinical manifestations and outcome.
Topics: Anticonvulsants; Benzodiazepines; Clobazam; Clonazepam; Early Diagnosis; Follow-Up Studies; Humans; | 2004 |
Severe normotensive metabolic alkalosis in a 2-month-old boy with hyperekplexia.
Topics: Alkalosis; Bicarbonates; Body Weight; Chlorides; Clonazepam; Family Health; Female; Hernia; Humans; | 2006 |
A case of major form familial hyperekplexia: prenatal diagnosis and effective treatment with clonazepam.
Topics: Anticonvulsants; Child, Preschool; Clonazepam; Family Health; Female; Glutamic Acid; Humans; Lysine; | 2007 |
Spinal myoclonus resembling belly dance.
Topics: Abdominal Muscles; Anterior Horn Cells; Clonazepam; Dancing; Electromyography; Humans; Male; Medulla | 1994 |
Hypertonia, hyperreflexia, and excessive startle response in a neonate.
Topics: Anticonvulsants; Clonazepam; Female; Humans; Infant, Newborn; Muscle Hypertonia; Reflex, Abnormal; R | 1999 |
Hyperekplexia: a rare differential of neonatal fits described in a developing country.
Topics: Anticonvulsants; Clonazepam; Developing Countries; Electrocardiography; Electroencephalography; Huma | 1999 |
Hyperekplexia: pedigree studies in two families.
Topics: Adolescent; Adult; Aged; Asian People; Child; Child, Preschool; Clonazepam; Female; Genes, Dominant; | 1991 |