clonazepam has been researched along with REM Sleep Behavior Disorder in 72 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
REM Sleep Behavior Disorder: A disorder characterized by episodes of vigorous and often violent motor activity during REM sleep (SLEEP, REM). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To analyze the differences in sleep structure and nocturnal motor activity between drug-free REM sleep behavior disorder (RBD) patients and those under therapy with clonazepam, and to evaluate the long-term longitudinal changes under continued therapy with clonazepam." | 9.17 | An observational clinical and video-polysomnographic study of the effects of clonazepam in REM sleep behavior disorder. ( Colli, F; Ferini-Strambi, L; Ferri, R; Marelli, S; Oldani, A; Schenck, CH; Zucconi, M, 2013) |
| "We aimed to analyze quantitatively rapid eye movement (REM) sleep electroencephalogram (EEG) in controls, drug-naïve idiopathic REM sleep behavior disorder patients (iRBD), and iRBD patients treated with clonazepam." | 7.85 | REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects. ( Bruni, O; Ferini-Strambi, L; Ferri, R; Manconi, M; Plazzi, G; Rundo, F; Silvani, A; Zucconi, M, 2017) |
| "We used ramelteon to treat two patients with secondary REM sleep behavior disorder (RBD) complications along with neurodegenerative diseases including multiple system atrophy and Parkinson's disease." | 7.79 | Use of ramelteon for the treatment of secondary REM sleep behavior disorder. ( Kawase, S; Nakashima, K; Nomura, T; Watanabe, Y, 2013) |
| "We report the case of an 88-year-old man with Alzheimer's disease (AD) of 8 years duration (emerging shortly after the de novo onset of sleeptalking) who developed REM sleep behavior disorder (RBD) after increasing the nightly dose of rivastigmine, an acetylcholinesterase inhibitor, from 1." | 7.76 | Rivastigmine-induced REM sleep behavior disorder (RBD) in a 88-year-old man with Alzheimer's disease. ( Schenck, CH; Yeh, PY; Yeh, SB, 2010) |
| "Clonazepam is considered to be a first-line treatment for rapid eye movement sleep-related behavior disorder (RBD) in Parkinson's disease (PD)." | 6.90 | Clonazepam for probable REM sleep behavior disorder in Parkinson's disease: A randomized placebo-controlled trial. ( Jeon, B; Kim, HJ; Lee, WW; Park, H; Shin, C, 2019) |
| "Clonazepam has been the first-line therapy for many years, with 2 large case series reporting efficacy with few side effects in the majority of patients." | 5.35 | Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. ( Anderson, KN; Shneerson, JM, 2009) |
| "Clonazepam has been considered the treatment of choice for RBD." | 5.32 | Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. ( Boeve, BF; Ferman, TJ; Silber, MH, 2003) |
| "To analyze the differences in sleep structure and nocturnal motor activity between drug-free REM sleep behavior disorder (RBD) patients and those under therapy with clonazepam, and to evaluate the long-term longitudinal changes under continued therapy with clonazepam." | 5.17 | An observational clinical and video-polysomnographic study of the effects of clonazepam in REM sleep behavior disorder. ( Colli, F; Ferini-Strambi, L; Ferri, R; Marelli, S; Oldani, A; Schenck, CH; Zucconi, M, 2013) |
| "A MEDLINE search (1977-April 2007) using the terms REM sleep behavior disorder, narcolepsy, parkinsonian disorders, levodopa, dopamine agonists, clonazepam, benzodiazepines, and melatonin was used to retrieve relevant articles." | 4.84 | Rapid eye movement sleep behavior disorder. ( Gugger, JJ; Wagner, ML, 2007) |
| "We aimed to analyze quantitatively rapid eye movement (REM) sleep electroencephalogram (EEG) in controls, drug-naïve idiopathic REM sleep behavior disorder patients (iRBD), and iRBD patients treated with clonazepam." | 3.85 | REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects. ( Bruni, O; Ferini-Strambi, L; Ferri, R; Manconi, M; Plazzi, G; Rundo, F; Silvani, A; Zucconi, M, 2017) |
| " We compare drug-free iRBD patients to both normal controls and drug-free patients with narcolepsy/RBD and evaluate the changes following the long-term use of bedtime clonazepam." | 3.79 | Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder. ( Ferini-Strambi, L; Ferri, R; Marelli, S; Plazzi, G; Schenck, CH; Zucconi, M, 2013) |
| "We used ramelteon to treat two patients with secondary REM sleep behavior disorder (RBD) complications along with neurodegenerative diseases including multiple system atrophy and Parkinson's disease." | 3.79 | Use of ramelteon for the treatment of secondary REM sleep behavior disorder. ( Kawase, S; Nakashima, K; Nomura, T; Watanabe, Y, 2013) |
| "Melatonin and clonazepam were each reported to reduce RBD behaviors and injuries and appeared comparably effective in our naturalistic practice experience." | 3.79 | Treatment outcomes in REM sleep behavior disorder. ( Boeve, BF; Boswell, CL; Dueffert, LG; McCarter, SJ; Olson, EJ; Silber, MH; Slocumb, N; St Louis, EK; Tippmann-Peikert, M, 2013) |
| "We report the case of an 88-year-old man with Alzheimer's disease (AD) of 8 years duration (emerging shortly after the de novo onset of sleeptalking) who developed REM sleep behavior disorder (RBD) after increasing the nightly dose of rivastigmine, an acetylcholinesterase inhibitor, from 1." | 3.76 | Rivastigmine-induced REM sleep behavior disorder (RBD) in a 88-year-old man with Alzheimer's disease. ( Schenck, CH; Yeh, PY; Yeh, SB, 2010) |
| " The efficacy of clonazepam, a standard treatment choice for REM sleep behavior disorders, was investigated in 8 hallucinators." | 3.72 | Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease. ( Inoue, Y; Kawahara, R; Mitani, H; Miyake, M; Nakashima, K; Nomura, T, 2003) |
| "Thirty PD patients with rapid eye movement sleep behavior disorder were randomized to 4 mg of prolonged-release melatonin (Circadin) or matched placebo, ingested orally once-daily before bedtime." | 2.94 | Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial. ( Coeytaux Jackson, A; Fang, BAM; Gilat, M; Grunstein, RR; Hall, JM; Hammond, D; Lewis, SJG; Marshall, NS; Mullins, AE; Wong, KKH; Yee, BJ, 2020) |
| "Clonazepam is considered to be a first-line treatment for rapid eye movement sleep-related behavior disorder (RBD) in Parkinson's disease (PD)." | 2.90 | Clonazepam for probable REM sleep behavior disorder in Parkinson's disease: A randomized placebo-controlled trial. ( Jeon, B; Kim, HJ; Lee, WW; Park, H; Shin, C, 2019) |
| "Patients with rapid eye movement sleep behavior disorder are frequently prone to sleep-related injuries and should be treated to prevent injury with either melatonin 3-12 mg or clonazepam 0." | 2.55 | REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies. ( Boeve, AR; Boeve, BF; St Louis, EK, 2017) |
| "Pramipexole is a possible alternative, but limited literature on its effectiveness exists." | 2.53 | Pramipexole in the treatment of REM sleep behaviour disorder: A critical review. ( Tan, SM; Wan, YM, 2016) |
| "Rapid eye movement sleep behavior disorder is common." | 2.53 | Importance of Rapid Eye Movement Sleep Behavior Disorder to the Primary Care Physician. ( Howell, MJ; McCarter, SJ, 2016) |
| "Patients with Parkinson's disease should be examined by polysomnography as the clinical interview's sensitivity alone can hardly reach 33%." | 2.43 | REM sleep behavior disorder in patients with Parkinson's disease. ( Poryazova, RG; Zachariev, ZI, 2005) |
| "Clonazepam was offered as the first-line treatment (starting dose: 0." | 1.43 | A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder. ( Chan, JW; Ho, CK; Lam, SP; Lam, VK; Li, SX; Liu, Y; Wing, YK; Yu, MW; Zhang, J; Zhou, J, 2016) |
| "Clonazepam (0." | 1.36 | Three patients with cancer who developed rapid-eye-movement sleep behavior disorder. ( Horiguchi, J; Inami, Y; Kamei, M; Maegawa, T; Nakamura, Y; Satake, A; Shinno, H, 2010) |
| "To present a clinical case of idiopathic rapid eye movement sleep behavior disorder (RBD), differential diagnoses, selected treatments, and the pathology involved." | 1.36 | Making the diagnosis: idiopathic rapid eye movement sleep behavior disorder. ( Taub, LF, 2010) |
| "Clonazepam has been the first-line therapy for many years, with 2 large case series reporting efficacy with few side effects in the majority of patients." | 1.35 | Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam. ( Anderson, KN; Shneerson, JM, 2009) |
| "Treatment with clonazepam 0." | 1.35 | REM sleep behavior disorder in a patient with pontine stroke. ( Luning, W; Xi, Z, 2009) |
| "Reported is the association of REM behavior disorder (RBD) with late-onset, sleep-related, tonic-clonic seizures in two elderly men." | 1.33 | REM behavior disorder associated with epileptic seizures. ( Manni, R; Terzaghi, M, 2005) |
| "Based on chart review, patients with Parkinson's disease whose bed partners have reported prominent motor activity while dreaming were identified." | 1.33 | Clinical features of 35 patients with Parkinson's disease displaying REM behavior disorder. ( Apaydin, H; Kiliç, E; Ozekmekçi, S, 2005) |
| "Clonazepam has been considered the treatment of choice for RBD." | 1.32 | Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. ( Boeve, BF; Ferman, TJ; Silber, MH, 2003) |
| "Clonazepam treatment of RBD was completely or partially successful in 87% of the patients who used the drug." | 1.31 | Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. ( Boeve, BF; Olson, EJ; Silber, MH, 2000) |
| "His sleep history disclosed sleepwalking (SW) since 9 years of age." | 1.30 | Sexual behavior in sleep, sleepwalking and possible REM behavior disorder: a case report. ( Aguilar-Roblero, R; Alóe, F; Alves, R; Chagoya De Sanchez, V; Drucker-Colín, R; Fernández-Cancino, F; Rosenthal, L; Tavares, S; Vidrio, S; Villalobos, L; Yáñez, L, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (2.78) | 18.2507 |
| 2000's | 23 (31.94) | 29.6817 |
| 2010's | 33 (45.83) | 24.3611 |
| 2020's | 14 (19.44) | 2.80 |
| Authors | Studies |
|---|---|
| Byun, JI | 2 |
| Shin, YY | 1 |
| Seong, YA | 1 |
| Yoon, SM | 1 |
| Hwang, KJ | 1 |
| Jung, YJ | 1 |
| Cha, KS | 1 |
| Jung, KY | 2 |
| Shin, WC | 1 |
| Ko, YF | 1 |
| Kuo, PH | 1 |
| Wang, CF | 1 |
| Chen, YJ | 1 |
| Chuang, PC | 1 |
| Li, SZ | 1 |
| Chen, BW | 1 |
| Yang, FC | 1 |
| Lo, YC | 1 |
| Yang, Y | 1 |
| Ro, SV | 1 |
| Jaw, FS | 1 |
| Lin, SH | 1 |
| Chen, YY | 1 |
| Cavallotti, S | 1 |
| Stein, HC | 1 |
| Savarese, M | 1 |
| Terzaghi, M | 2 |
| D'Agostino, A | 1 |
| Howell, M | 2 |
| Avidan, AY | 2 |
| Foldvary-Schaefer, N | 2 |
| Malkani, RG | 2 |
| During, EH | 3 |
| Roland, JP | 2 |
| McCarter, SJ | 4 |
| Zak, RS | 3 |
| Carandang, G | 2 |
| Kazmi, U | 2 |
| Ramar, K | 3 |
| Park, K | 1 |
| Shin, YW | 1 |
| Hwang, S | 1 |
| Jeong, E | 1 |
| Kim, TJ | 1 |
| Jun, JS | 1 |
| Shin, JW | 1 |
| Sunwoo, JS | 1 |
| Kim, HJ | 3 |
| Schenck, CH | 9 |
| Dodet, P | 1 |
| Miglis, MG | 1 |
| Gilat, M | 2 |
| Coeytaux Jackson, A | 1 |
| Marshall, NS | 2 |
| Hammond, D | 1 |
| Mullins, AE | 1 |
| Hall, JM | 1 |
| Fang, BAM | 1 |
| Yee, BJ | 1 |
| Wong, KKH | 1 |
| Grunstein, RR | 1 |
| Lewis, SJG | 2 |
| Dokkedal-Silva, V | 1 |
| Kim, LJ | 2 |
| Morelhão, PK | 1 |
| Galduróz, JCF | 1 |
| Tufik, S | 2 |
| Andersen, ML | 1 |
| Lee, HJ | 1 |
| Choi, H | 1 |
| Yoon, IY | 1 |
| Zucconi, M | 5 |
| Ferri, R | 5 |
| Ozone, M | 1 |
| Shimazaki, H | 1 |
| Ichikawa, H | 1 |
| Shigeta, M | 1 |
| Wang, J | 1 |
| Liu, Y | 2 |
| Chau, SWH | 1 |
| Zhang, J | 2 |
| Tsang, J | 1 |
| Yu, MWM | 1 |
| Chan, NY | 1 |
| Chan, JWY | 1 |
| Li, SX | 2 |
| Huang, B | 1 |
| Feng, H | 1 |
| Mok, V | 1 |
| Wing, YK | 3 |
| Testelmans, D | 1 |
| Buyse, B | 1 |
| Iranzo, A | 6 |
| Ramos, LA | 1 |
| Novo, S | 1 |
| Rundo, F | 1 |
| Silvani, A | 1 |
| Bruni, O | 1 |
| Ferini-Strambi, L | 5 |
| Plazzi, G | 4 |
| Manconi, M | 1 |
| St Louis, EK | 2 |
| Boeve, AR | 1 |
| Boeve, BF | 5 |
| Matar, E | 1 |
| Lewis, SJ | 1 |
| Rémi, J | 1 |
| Dauvilliers, Y | 2 |
| Postuma, RB | 2 |
| Luppi, PH | 2 |
| Montplaisir, J | 2 |
| Boeve, B | 1 |
| Fujishiro, H | 1 |
| Kimura, H | 1 |
| Nakamura, T | 1 |
| Torii, Y | 1 |
| Iritani, S | 1 |
| Ozaki, N | 1 |
| Shin, C | 1 |
| Park, H | 1 |
| Lee, WW | 1 |
| Jeon, B | 1 |
| Marelli, S | 2 |
| Montplaisir, JY | 1 |
| Frauscher, B | 1 |
| Hogl, B | 1 |
| Gagnon, JF | 2 |
| Postuma, R | 1 |
| Sonka, K | 1 |
| Jennum, P | 1 |
| Partinen, M | 2 |
| Arnulf, I | 1 |
| Cochen de Cock, V | 1 |
| Heidbreder, A | 1 |
| Mayer, G | 1 |
| Sixel-Döring, F | 1 |
| Trenkwalder, C | 1 |
| Unger, M | 1 |
| Young, P | 1 |
| Inoue, Y | 4 |
| Santamaria, J | 4 |
| Bassetti, C | 1 |
| Möller, JC | 1 |
| Lai, YY | 1 |
| Pavlova, M | 1 |
| Saper, C | 1 |
| Schmidt, P | 1 |
| Siegel, JM | 1 |
| Singer, C | 1 |
| St Louis, E | 1 |
| Videnovic, A | 1 |
| Oertel, W | 1 |
| Nomura, T | 2 |
| Kawase, S | 1 |
| Watanabe, Y | 1 |
| Nakashima, K | 2 |
| Weeks, RG | 1 |
| D'Costa, JA | 1 |
| Aiyappan, V | 1 |
| Chai-Coetzer, CL | 1 |
| Antic, NA | 1 |
| Coelho, FM | 1 |
| Cremaschi, RC | 1 |
| Pereira, DD | 1 |
| Fernández-Arcos, A | 1 |
| Serradell, M | 1 |
| Gaig, C | 1 |
| Canepa, C | 1 |
| Escribá, J | 1 |
| Hoyo, B | 1 |
| Esaki, Y | 1 |
| Kitajima, T | 1 |
| Lam, SP | 1 |
| Yu, MW | 1 |
| Chan, JW | 1 |
| Lam, VK | 1 |
| Ho, CK | 1 |
| Zhou, J | 1 |
| Tan, SM | 1 |
| Wan, YM | 1 |
| Howell, MJ | 2 |
| Shimohata, T | 1 |
| Hirata, K | 1 |
| Abenza Abildúa, MJ | 1 |
| Miralles Martinez, A | 1 |
| Arpa Gutiérrez, FJ | 1 |
| Lores Gutiérrez, V | 1 |
| Algarra Lucas, C | 1 |
| Jimeno Montero, C | 1 |
| Sánchez García, B | 1 |
| Mata Álvarez-Santullano, M | 1 |
| Borrue Fernández, C | 1 |
| Cordero Martín, G | 1 |
| Gutiérrez Cueto, G | 1 |
| Torrecillas Narváez, MD | 1 |
| Thuissard Vasallo, I | 1 |
| Gómez Aceña, A | 1 |
| Tolosa, E | 2 |
| Liebman, RF | 1 |
| Rodriguez, AJ | 1 |
| Zoetmulder, M | 1 |
| Jennum, PJ | 1 |
| Billiard, M | 1 |
| Anderson, KN | 1 |
| Shneerson, JM | 1 |
| Bodkin, CL | 1 |
| Aurora, RN | 1 |
| Maganti, RK | 1 |
| Auerbach, SH | 1 |
| Casey, KR | 1 |
| Chowdhuri, S | 1 |
| Karippot, A | 1 |
| Kristo, DA | 1 |
| Morgenthaler, TI | 1 |
| Yeh, SB | 1 |
| Yeh, PY | 1 |
| Shinno, H | 1 |
| Kamei, M | 1 |
| Maegawa, T | 1 |
| Satake, A | 1 |
| Inami, Y | 1 |
| Horiguchi, J | 1 |
| Nakamura, Y | 1 |
| Taub, LF | 1 |
| Brooks, PL | 1 |
| Peever, JH | 1 |
| Tijero, B | 1 |
| Gómez-Esteban, JC | 1 |
| Berganzo, K | 1 |
| Zarranz, JJ | 1 |
| Arneson, PA | 1 |
| Ylikoski, A | 1 |
| Sasai, T | 1 |
| Matsuura, M | 1 |
| Oldani, A | 1 |
| Colli, F | 1 |
| Boswell, CL | 1 |
| Dueffert, LG | 1 |
| Slocumb, N | 1 |
| Silber, MH | 3 |
| Olson, EJ | 2 |
| Tippmann-Peikert, M | 1 |
| Daly, JJ | 1 |
| Compton, SA | 1 |
| Portet, F | 1 |
| Touchon, J | 1 |
| Syed, BH | 1 |
| Rye, DB | 2 |
| Singh, G | 1 |
| Mitani, H | 1 |
| Kawahara, R | 1 |
| Miyake, M | 1 |
| Ferman, TJ | 1 |
| Massironi, G | 1 |
| Galluzzi, S | 1 |
| Frisoni, GB | 1 |
| Thomas, M | 1 |
| Moore, K | 1 |
| Manni, R | 1 |
| Ozekmekçi, S | 1 |
| Apaydin, H | 1 |
| Kiliç, E | 1 |
| Valldeoriola, F | 1 |
| Martí, MJ | 1 |
| Muñoz, E | 1 |
| Vilaseca, I | 1 |
| Poryazova, RG | 1 |
| Zachariev, ZI | 1 |
| Fantini, ML | 1 |
| Corona, A | 1 |
| Clerici, S | 1 |
| Gugger, JJ | 1 |
| Wagner, ML | 1 |
| Xi, Z | 1 |
| Luning, W | 1 |
| Schuld, A | 1 |
| Kraus, T | 1 |
| Haack, M | 1 |
| Hinze-Selch, D | 1 |
| Pollmächer, T | 1 |
| Alves, R | 1 |
| Alóe, F | 1 |
| Tavares, S | 1 |
| Vidrio, S | 1 |
| Yáñez, L | 1 |
| Aguilar-Roblero, R | 1 |
| Rosenthal, L | 1 |
| Villalobos, L | 1 |
| Fernández-Cancino, F | 1 |
| Drucker-Colín, R | 1 |
| Chagoya De Sanchez, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety of Melatonin and Rivotril Treatment for Idiopathic Rapid Eye Movement Sleep Disorder: Prospective Randomized Study.[NCT03255642] | 34 participants (Actual) | Interventional | 2017-11-09 | Completed | |||
| A Randomized Double-Blind, Double-Dummy, Crossover Study to Evaluate the Efficacy and Safety of Prolonged-Release Melatonin and Clonazepam in Patients With Rapid Eye Movement (REM) Sleep Behavior Disorder in Parkinson Disease[NCT02789592] | Phase 2 | 30 participants (Anticipated) | Interventional | 2016-07-31 | Not yet recruiting | ||
| DREAMER - IsolateD REM Sleep Without Atonia as a Risk Factor for REM Sleep Behavior disordER: Constitution of a Cohort for a Long-term Prospective Follow-up Study[NCT06140511] | 600 participants (Anticipated) | Observational | 2023-11-20 | Not yet recruiting | |||
| A Single Center, Open Label Prospective Observational Pilot Study to Evaluate the Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)[NCT05922995] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism: a Prospective, Randomized, Double-blind and Placebo-controlled Trial[NCT02312908] | Phase 2 | 40 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic REM Sleep Behavior Disorder: a Pilot Study[NCT02836743] | Phase 4 | 30 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Efficacy and Tolerability of Ramelteon in Patients With REM Behavior Disorder and Parkinsonism: A Placebo Controlled, Double Blind, Randomized, Prospective Pilot Study[NCT00745030] | 3 participants (Actual) | Interventional | 2008-06-30 | Terminated (stopped due to Low subject recruitment and enrollment.) | |||
| Redictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study [FAttori di Rischio PREdittivi di Conversione Nell'RBD Idiopatico. STudio ItalianO[NCT05262543] | 300 participants (Anticipated) | Observational | 2020-05-25 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
19 reviews available for clonazepam and REM Sleep Behavior Disorder
| Article | Year |
|---|---|
Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline.
Topics: Adult; Clonazepam; Humans; Melatonin; REM Sleep Behavior Disorder; Rivastigmine; Sleep; United State | 2023 |
Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline.
Topics: Adult; Clonazepam; Humans; Melatonin; REM Sleep Behavior Disorder; Rivastigmine; Sleep; United State | 2023 |
Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline.
Topics: Adult; Clonazepam; Humans; Melatonin; REM Sleep Behavior Disorder; Rivastigmine; Sleep; United State | 2023 |
Management of REM sleep behavior disorder: an American Academy of Sleep Medicine clinical practice guideline.
Topics: Adult; Clonazepam; Humans; Melatonin; REM Sleep Behavior Disorder; Rivastigmine; Sleep; United State | 2023 |
REM behavior disorder: When Parkinson's disease meets Morpheus.
Topics: Aged; Clonazepam; Humans; Melatonin; Parkinson Disease; REM Sleep Behavior Disorder; Synucleinopathi | 2023 |
A critical review of the pharmacological treatment of REM sleep behavior disorder in adults: time for more and larger randomized placebo-controlled trials.
Topics: Aged; Clonazepam; Double-Blind Method; Humans; Melatonin; Randomized Controlled Trials as Topic; REM | 2022 |
The Isolated Form of Rapid Eye Movement Sleep Behavior Disorder: The Upcoming Challenges.
Topics: Clonazepam; Dementia; Diagnostic Tests, Routine; Humans; Melatonin; Parkinson Disease; REM Sleep Beh | 2021 |
REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies.
Topics: Central Nervous System Depressants; Clonazepam; GABA Modulators; Humans; Lewy Body Disease; Melatoni | 2017 |
REM sleep behaviour disorder: not just a bad dream.
Topics: Clonazepam; Humans; Hypnotics and Sedatives; Melatonin; Polysomnography; REM Sleep Behavior Disorder | 2017 |
[Wild dreams and injured bed partners - The REM-sleep-behavior disorder as a precursor of neurodegenerative disorders].
Topics: Aged; Clonazepam; Diagnosis, Differential; Dreams; Electroencephalography; Humans; Male; Neurodegene | 2017 |
REM sleep behaviour disorder.
Topics: alpha-Synuclein; Antidepressive Agents; Central Nervous System Depressants; Clonazepam; Diagnosis, D | 2018 |
Pramipexole in the treatment of REM sleep behaviour disorder: A critical review.
Topics: Benzothiazoles; Clonazepam; Dopamine Agonists; Humans; Observational Studies as Topic; Polysomnograp | 2016 |
Importance of Rapid Eye Movement Sleep Behavior Disorder to the Primary Care Physician.
Topics: Central Nervous System Depressants; Clonazepam; Diagnosis, Differential; GABA Modulators; Humans; Me | 2016 |
Diagnosis, disease notification, and management of rapid eye movement (REM) sleep behavior disorder.
Topics: alpha-Synuclein; Clonazepam; Diagnosis, Differential; Humans; Neurodegenerative Diseases; REM Sleep | 2017 |
The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases.
Topics: Anticonvulsants; Brain; Clonazepam; Dreams; Humans; Neurodegenerative Diseases; Neurotransmitter Age | 2009 |
A patient with epilepsy and new onset of nocturnal symptoms.
Topics: Aged; Anticonvulsants; Clonazepam; Electroencephalography; Epilepsy; Humans; Nocturnal Paroxysmal Dy | 2009 |
[Rapid eye movement sleep behaviour disorder--diagnosis, causes and treatment].
Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Humans; Polysomnography; REM Sleep Behavior Di | 2009 |
REM sleep behavior disorder and narcolepsy.
Topics: Antidepressive Agents; Cataplexy; Clonazepam; Humans; Melatonin; Narcolepsy; Polysomnography; Preval | 2009 |
Rapid eye movement sleep behavior disorder in women: relevance to general and specialty medical practice.
Topics: Clonazepam; Diagnosis, Differential; Disease Progression; Early Diagnosis; Female; GABA Modulators; | 2009 |
[REM sleep behavior disorder (RBD)].
Topics: Clonazepam; Diagnosis, Differential; GABA Modulators; Humans; Melatonin; Parkinson Disease; Polysomn | 2012 |
REM sleep behavior disorder in patients with Parkinson's disease.
Topics: Anticonvulsants; Antiparkinson Agents; Clonazepam; Humans; Levodopa; Parkinson Disease; Polysomnogra | 2005 |
Rapid eye movement sleep behavior disorder.
Topics: Anticonvulsants; Antiparkinson Agents; Benzothiazoles; Clonazepam; Comorbidity; Dopamine Agonists; G | 2007 |
6 trials available for clonazepam and REM Sleep Behavior Disorder
| Article | Year |
|---|---|
Comparative efficacy of prolonged-release melatonin versus clonazepam for isolated rapid eye movement sleep behavior disorder.
Topics: Clonazepam; Humans; Melatonin; Polysomnography; Prospective Studies; REM Sleep Behavior Disorder | 2023 |
Quantification Analysis of Sleep Based on Smartwatch Sensors for Parkinson's Disease.
Topics: Algorithms; Clonazepam; Humans; Parkinson Disease; REM Sleep Behavior Disorder; Sleep | 2022 |
Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial.
Topics: Aged; Clonazepam; Double-Blind Method; Eye Movements; Fatigue; Female; Humans; Male; Melatonin; Midd | 2020 |
Clonazepam for probable REM sleep behavior disorder in Parkinson's disease: A randomized placebo-controlled trial.
Topics: Aged; Anticonvulsants; Clonazepam; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Mid | 2019 |
Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder.
Topics: Aged; Antiparkinson Agents; Benzothiazoles; Clonazepam; Female; Humans; Male; Middle Aged; Pramipexo | 2013 |
An observational clinical and video-polysomnographic study of the effects of clonazepam in REM sleep behavior disorder.
Topics: Aged; Clonazepam; Electromyography; Female; GABA Modulators; Humans; Longitudinal Studies; Male; Pol | 2013 |
47 other studies available for clonazepam and REM Sleep Behavior Disorder
| Article | Year |
|---|---|
Aggressiveness in the dreams of drug-naïve and clonazepam-treated patients with isolated REM sleep behavior disorder.
Topics: Aged; Clonazepam; Dreams; Female; Humans; Male; Middle Aged; Polysomnography; REM Sleep Behavior Dis | 2022 |
Quantitative measurement of motor activity during sleep in isolated REM sleep behavior disorder patients using actigraphy before and after treatment with clonazepam.
Topics: Actigraphy; Clonazepam; Humans; Motor Activity; Prospective Studies; REM Sleep Behavior Disorder; Sl | 2023 |
Clinical trials in REM sleep behavior disorder: an urgent need for better evidence.
Topics: Aged; Anticonvulsants; Central Nervous System Depressants; Clinical Trials as Topic; Clonazepam; Fem | 2019 |
Use of clonazepam in REM sleep behavior disorder: association with fall-related injuries and alternative treatments.
Topics: Accidental Falls; Clonazepam; Humans; Polysomnography; REM Sleep Behavior Disorder | 2020 |
Age of Diagnosis and Comorbid PLMD Predict Poor Response of REM Behavior Disorder to Clonazepam.
Topics: Clonazepam; GABA Modulators; Humans; Polysomnography; REM Sleep Behavior Disorder; Retrospective Stu | 2021 |
Use of clonazepam in REM sleep behavior disorder is not associated with fall-related injuries.
Topics: Accidental Falls; Clonazepam; Humans; Polysomnography; REM Sleep Behavior Disorder | 2020 |
Efficacy of yokukansan compared with clonazepam for rapid eye movement sleep behaviour disorder: a preliminary retrospective study.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Clonazepam; Drugs, Chinese Herbal; Female; GABA Modulators | 2020 |
Residual Injurious Symptoms and Its Association With Neurodegenerative Outcomes in Idiopathic Rapid Eye Movement Sleep Behavior Disorder: A Retrospective, Longitudinal Follow-up Study.
Topics: Clonazepam; Female; Follow-Up Studies; Humans; Male; Polysomnography; REM Sleep Behavior Disorder; R | 2020 |
REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects.
Topics: Aged; Clonazepam; Electroencephalography; Female; Humans; Male; Polysomnography; REM Sleep Behavior | 2017 |
Hypochondriasis in the elderly and Lewy body disease.
Topics: Aged; Clonazepam; Humans; Hyperacusis; Hypochondriasis; Indenes; Lewy Body Disease; Magnetic Resonan | 2019 |
Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder.
Topics: Aged; Chin; Clonazepam; Facial Muscles; Female; GABA Modulators; Humans; Male; Middle Aged; Narcolep | 2013 |
Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.
Topics: Clinical Trials as Topic; Clonazepam; Consensus; GABA Modulators; Humans; Melatonin; Neuroprotective | 2013 |
Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.
Topics: Clinical Trials as Topic; Clonazepam; Consensus; GABA Modulators; Humans; Melatonin; Neuroprotective | 2013 |
Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.
Topics: Clinical Trials as Topic; Clonazepam; Consensus; GABA Modulators; Humans; Melatonin; Neuroprotective | 2013 |
Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.
Topics: Clinical Trials as Topic; Clonazepam; Consensus; GABA Modulators; Humans; Melatonin; Neuroprotective | 2013 |
Use of ramelteon for the treatment of secondary REM sleep behavior disorder.
Topics: Aged; Clonazepam; Female; Humans; Indenes; Male; Middle Aged; Multiple System Atrophy; Parkinson Dis | 2013 |
Rapid eye movement behaviour disorder.
Topics: Aged; Anticonvulsants; Clonazepam; Humans; Male; Polysomnography; REM Sleep Behavior Disorder; Sleep | 2014 |
Continuous positive airway pressure treatment associated with face injury during rapid eye movement behavior disorder.
Topics: Aged, 80 and over; Clonazepam; Continuous Positive Airway Pressure; Facial Injuries; Female; Humans; | 2015 |
The Clinical Phenotype of Idiopathic Rapid Eye Movement Sleep Behavior Disorder at Presentation: A Study in 203 Consecutive Patients.
Topics: Aged; Aged, 80 and over; Clonazepam; Continuous Positive Airway Pressure; Dementia; Electromyography | 2016 |
Park sleep: a non-motor dominant Parkinson's disease phenotype.
Topics: Aged; Clonazepam; Humans; Levodopa; Male; Parkinson Disease; REM Sleep Behavior Disorder | 2016 |
Alternatives to Clonazepam in REM Behavior Disorder Treatment.
Topics: Clonazepam; Humans; Melatonin; Polysomnography; REM Sleep Behavior Disorder | 2016 |
Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder.
Topics: Clonazepam; Humans; Polysomnography; REM Sleep Behavior Disorder; Sleep, REM | 2016 |
A prospective, naturalistic follow-up study of treatment outcomes with clonazepam in rapid eye movement sleep behavior disorder.
Topics: Aged; Aggression; Clonazepam; Dreams; Female; Follow-Up Studies; GABA Modulators; Humans; Male; Poly | 2016 |
Conditions associated with REM sleep behaviour disorder: Description of a hospital series.
Topics: Anticonvulsants; Clonazepam; Female; Humans; Male; Middle Aged; Neurodegenerative Diseases; Polysomn | 2019 |
Drug treatment of REM sleep behavior disorder: the use of drug therapies other than clonazepam.
Topics: Adjuvants, Anesthesia; Aged; Azabicyclo Compounds; Central Nervous System Depressants; Clonazepam; C | 2009 |
Best practice guide for the treatment of REM sleep behavior disorder (RBD).
Topics: Benzothiazoles; Central Nervous System Depressants; Clonazepam; Dopamine Agonists; GABA Modulators; | 2010 |
Rivastigmine-induced REM sleep behavior disorder (RBD) in a 88-year-old man with Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cholinesterase Inhibitors; Clonazepam; Dose-R | 2010 |
Three patients with cancer who developed rapid-eye-movement sleep behavior disorder.
Topics: Aged; Antipsychotic Agents; Clonazepam; Delirium; Diagnosis, Differential; Female; GABA Modulators; | 2010 |
Making the diagnosis: idiopathic rapid eye movement sleep behavior disorder.
Topics: Aged; Anticonvulsants; Biomarkers; Central Nervous System Depressants; Clonazepam; Diagnosis, Differ | 2010 |
Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice.
Topics: Analysis of Variance; Animals; Brain; Central Nervous System Depressants; Clonazepam; Disease Models | 2011 |
[REM sleep behaviour disorder and "pure" autonomic failure. Presentation of two cases].
Topics: Aged; Clonazepam; Female; GABA Modulators; Heart; Heart Rate; Humans; Magnetic Resonance Imaging; Ma | 2012 |
A novel therapy for REM sleep behavior disorder (RBD).
Topics: Aged; Aged, 80 and over; Behavior Therapy; Clinical Alarms; Clonazepam; Drug Resistance; Female; Fol | 2011 |
Treatment outcomes in REM sleep behavior disorder.
Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Depressants; Clonazepam; Drug Therapy, Combin | 2013 |
Rapid eye movement (REM) sleep behaviour disorder; an easily missed diagnosis, a readily treatable condition.
Topics: Aged; Aged, 80 and over; Clonazepam; GABA Modulators; Humans; Male; Polysomnography; REM Sleep Behav | 2002 |
[REM Sleep behavioral disorder].
Topics: Anticonvulsants; Choline; Clonazepam; Dopamine; Female; Humans; Male; Middle Aged; Polysomnography; | 2002 |
REM sleep behavior disorder and SCA-3 (Machado-Joseph disease).
Topics: Clonazepam; Electromyography; GABA Modulators; Humans; Machado-Joseph Disease; Male; Middle Aged; Mo | 2003 |
Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease.
Topics: Aged; Anticonvulsants; Antiparkinson Agents; Cerebral Cortex; Circadian Rhythm; Clinical Trials as T | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Drug treatment of REM sleep behavior disorders in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Benzodiazepines; Cholinesterase Inhibitors; Clonazepam; Do | 2003 |
Falling asleep.
Topics: Accidental Falls; Aged; Clonazepam; Female; GABA Modulators; Humans; Polysomnography; REM Sleep Beha | 2004 |
REM behavior disorder associated with epileptic seizures.
Topics: Aged; Anticonvulsants; Brain; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Middle Age | 2005 |
Clinical features of 35 patients with Parkinson's disease displaying REM behavior disorder.
Topics: Age Factors; Aged; Antiparkinson Agents; Case-Control Studies; Clonazepam; Dyskinesias; Female; GABA | 2005 |
Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD.
Topics: Age of Onset; Aged; Anticonvulsants; Brain; Clonazepam; Female; Humans; Logistic Models; Male; Middl | 2005 |
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder.
Topics: Aged; Aggression; Brain Stem; Circadian Rhythm; Clonazepam; Dreams; Female; GABA Modulators; Humans; | 2005 |
Making the diagnosis.
Topics: Clonazepam; Diagnosis, Differential; Humans; Hypnotics and Sedatives; Polysomnography; REM Sleep Beh | 2005 |
Update on the pharmacology of REM sleep behavior disorder.
Topics: Anticonvulsants; Clonazepam; Humans; Monoamine Oxidase Inhibitors; REM Sleep Behavior Disorder | 2006 |
REM sleep behavior disorder in a patient with pontine stroke.
Topics: Aged; Brain Stem Infarctions; Clonazepam; GABA Modulators; Humans; Magnetic Resonance Imaging; Male; | 2009 |
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder.
Topics: Anticonvulsants; Clonazepam; Humans; Male; Middle Aged; Narcolepsy; Polysomnography; REM Sleep Behav | 1999 |
Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Aging; Anticonvulsants; Atrophy; Brain; Clonazepam; De | 2000 |
Sexual behavior in sleep, sleepwalking and possible REM behavior disorder: a case report.
Topics: Adult; Anticonvulsants; Clonazepam; Electroencephalography; Electromyography; Humans; Male; REM Slee | 1999 |