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clonazepam and Psychotic Disorders

clonazepam has been researched along with Psychotic Disorders in 30 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)

Research Excerpts

ExcerptRelevanceReference
" Lorazepam and clonazepam are of established value in controlling acute psychotic agitation and catatonia."6.16Emerging uses for high-potency benzodiazepines in psychotic disorders. ( Bodkin, JA, 1990)
"Haloperidol was stopped and intravenous clonazepam 5mg/kg was begun."5.36[Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. ( Askenazy, F; Benoit, M; Dor, E; Dupuis, G; Myquel, M; Seddiki, Y; Serret, S, 2010)
"clonazepam is an effective, safe, but slower-acting alternative to I."2.67A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms. ( Annable, L; Chouinard, G; Holobow, N; Szkrumelak, N; Turnier, L, 1993)
"Clonazepam is a high-potency benzodiazepine labeled for use as an anticonvulsant."2.37Clonazepam: new uses and potential problems. ( Cohen, LS; Rosenbaum, JF, 1987)
"Haloperidol was stopped and intravenous clonazepam 5mg/kg was begun."1.36[Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. ( Askenazy, F; Benoit, M; Dor, E; Dupuis, G; Myquel, M; Seddiki, Y; Serret, S, 2010)
"Clonazepam was either given as monotherapy, or as in the case of lithium non-responders, as adjunctive therapy."1.32Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. ( Barnas, C; Kasper, S; Konstantinidis, A; Pjrek, E; Schindler, S; Stamenkovic, M; Tauscher, J; Willeit, M; Winkler, D; Wolf, R, 2003)
"The clinical picture was complicated by convulsions, perhaps due to clonazepam withdrawal and possible lithium toxicity."1.29Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder. ( Cubis, JC; Looi, JC; Saboisky, J, 1995)
"Clonazepam treatment led to a decrease in agitation and logorrhea, without the side effects associated with neuroleptics."1.27Use of clonazepam in mania and schizoaffective disorders. ( Bell, IR; Binder, RL; Link, NA; Victor, BS, 1984)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19908 (26.67)18.7374
1990's10 (33.33)18.2507
2000's5 (16.67)29.6817
2010's6 (20.00)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Mawhinney, JA1
Wilcock, C1
Haboubi, H1
Roshanzamir, S1
Nelson, MA1
Lochhead, JD1
Maguire, GA1
Kar, SK1
Shahi, MK1
Roy, P1
Bhojani, S1
Aldana-Bernier, L1
Sikder, M1
Pawelzik, T1
Murphy, RA1
Hallahan, B1
Askenazy, F1
Dor, E1
Benoit, M1
Dupuis, G1
Serret, S1
Myquel, M1
Seddiki, Y1
Kimiagar, I1
Dobronevsky, E1
Prokhorov, T1
Miniovitz, A1
Rabey, JM1
Winkler, D1
Willeit, M1
Wolf, R1
Stamenkovic, M1
Tauscher, J1
Pjrek, E1
Konstantinidis, A1
Schindler, S1
Barnas, C1
Kasper, S1
Collins, KO1
Comer, JB1
Sicot, R1
Duggal, HS1
Mendhekar, DN1
Wolf, J1
Salo, R1
Victor, BS1
Link, NA1
Binder, RL1
Bell, IR1
Benazzi, F4
Mazzoli, M3
Chouinard, G1
Annable, L1
Turnier, L1
Holobow, N1
Szkrumelak, N1
Rossi, E2
Looi, JC1
Cubis, JC1
Saboisky, J1
Pujalte, D1
Bottaï, T1
Huë, B1
Alric, R1
Pouget, R1
Blayac, JP1
Petit, P1
Gladwell, SR1
Kaufman, KR1
Driver, MV1
O'Connor, M1
Rooney, MD1
Nienaber, CP1
Sachs, GS1
Bodkin, JA1
Kutcher, S1
Williamson, P1
MacKenzie, S2
Marton, P1
Ehrlich, M1
Kutcher, SP1
Galarraga, W1
Szalai, J1
Cohen, LS1
Rosenbaum, JF1
Honer, WG1
Rosenberg, RG1
Turey, M1
Fisher, WA1
Greenspan, D1
Levin, D1
Frykholm, B1

Reviews

2 reviews available for clonazepam and Psychotic Disorders

ArticleYear
Emerging uses for high-potency benzodiazepines in psychotic disorders.
    The Journal of clinical psychiatry, 1990, Volume: 51 Suppl

    Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum

1990
Clonazepam: new uses and potential problems.
    The Journal of clinical psychiatry, 1987, Volume: 48 Suppl

    Topics: Adult; Antipsychotic Agents; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Female; Hum

1987

Trials

6 trials available for clonazepam and Psychotic Disorders

ArticleYear
Rapid tranquilization with intramuscular clonazepam.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1994, Volume: 39, Issue:7

    Topics: Adult; Bipolar Disorder; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adm

1994
A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38 Suppl 4

    Topics: Adolescent; Adult; Arousal; Bipolar Disorder; Clonazepam; Double-Blind Method; Drug Therapy, Combina

1993
A double-blind comparison of clonazepam and placebo in the treatment of neuroleptic-induced akathisia.
    Clinical neuropharmacology, 1994, Volume: 17, Issue:3

    Topics: Adult; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Clonazepam; Dose-Response Rel

1994
Emerging uses for high-potency benzodiazepines in psychotic disorders.
    The Journal of clinical psychiatry, 1990, Volume: 51 Suppl

    Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum

1990
Successful clonazepam treatment of neuroleptic-induced akathisia in older adolescents and young adults: a double-blind, placebo-controlled study.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Doub

1989
Clonazepam treatment of adolescents with neuroleptic-induced akathisia.
    The American journal of psychiatry, 1987, Volume: 144, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clinical Tri

1987

Other Studies

23 other studies available for clonazepam and Psychotic Disorders

ArticleYear
Neurotropism of SARS-CoV-2: COVID-19 presenting with an acute manic episode.
    BMJ case reports, 2020, Jun-14, Volume: 13, Issue:6

    Topics: Adult; Affective Symptoms; Betacoronavirus; Cerebrospinal Fluid; Clonazepam; Coronavirus Infections;

2020
Anti-NMDA receptor encephalitis presenting as a primary psychotic disorder.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2017, Volume: 29, Issue:3

    Topics: Adolescent; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antipsychotic Agents; Autoantibodies; C

2017
Understanding the anxiety phenomenology in psychotic prodrome: A case report.
    Asian journal of psychiatry, 2017, Volume: 28

    Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Biguanides; Clonazepam; Drug Therapy, Combinatio

2017
Psychotic disorder after contact with a potentially rabid animal and post-exposure prophylactic anti-rabies treatment.
    Clinical schizophrenia & related psychoses, 2014, Volume: 8, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clonazepam; Diag

2014
Psychosis improved dysphonia.
    BMJ case reports, 2013, Dec-09, Volume: 2013

    Topics: Acute Disease; Adult; Anti-Anxiety Agents; Antipsychotic Agents; Clonazepam; Diagnosis, Differential

2013
[Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up].
    L'Encephale, 2010, Volume: 36, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Cataplexy; C

2010
Rapid improvement of tardive dyskinesia with tetrabenazine, clonazepam and clozapine combined: a naturalistic long-term follow-up study.
    Journal of neurology, 2012, Volume: 259, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Adult; Antipsychotic Agents; Clonazepam; Clozapine; Drug Therapy, Comb

2012
Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:2

    Topics: Adult; Aged; Bipolar Disorder; Clonazepam; Depressive Disorder; Female; Humans; Male; Middle Aged; P

2003
Maternal haloperidol therapy associated with dyskinesia in a newborn.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2003, Nov-01, Volume: 60, Issue:21

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Dyskinesia, Drug-Induced; Female; Haloperi

2003
[Love, humor and psychosis in an atypical depression].
    L'Encephale, 2005, Volume: 31 Pt 2

    Topics: Antidepressive Agents; Antipsychotic Agents; Azabicyclo Compounds; Benzodiazepines; Clonazepam; Cycl

2005
Clozapine-induced tardive dystonia (blepharospasm).
    The Journal of neuropsychiatry and clinical neurosciences, 2007,Winter, Volume: 19, Issue:1

    Topics: Anticonvulsants; Antipsychotic Agents; Blepharospasm; Blinking; Clonazepam; Clozapine; Dyskinesia, D

2007
Water, water, everywhere, nor any drop to drink: climate change delusion.
    The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:4

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Climate

2008
Use of clonazepam in mania and schizoaffective disorders.
    The American journal of psychiatry, 1984, Volume: 141, Issue:9

    Topics: Acute Disease; Adult; Benzodiazepinones; Bipolar Disorder; Clonazepam; Drug Administration Schedule;

1984
A study of intramuscular clonazepam for psychotic agitation.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1993, Volume: 38, Issue:1

    Topics: Adult; Aged; Clonazepam; Drug Administration Schedule; Female; Humans; Injections, Intramuscular; Ma

1993
Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder.
    The Australian and New Zealand journal of psychiatry, 1995, Volume: 29, Issue:4

    Topics: Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Therapy, Combination; GABA Mo

1995
Psychosis or epilepsy? Differentiation in a complex case.
    Developmental medicine and child neurology, 1979, Volume: 21, Issue:1

    Topics: Adolescent; Brain; Child Behavior; Clonazepam; Diagnosis, Differential; Electroencephalography; Epil

1979
Benzodiazepines and acute psychotic agitation.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1992, Volume: 37, Issue:10

    Topics: Adult; Aged; Antipsychotic Agents; Clonazepam; Dose-Response Relationship, Drug; Drug Administration

1992
Neuroleptic-induced dislocation of the jaw.
    The British journal of psychiatry : the journal of mental science, 1992, Volume: 161

    Topics: Adult; Clonazepam; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Haloperidol; Humans; Joint D

1992
Intramuscular clonazepam for the treatment of psychotic agitation.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:9

    Topics: Adult; Aged; Arousal; Clonazepam; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Psyc

1991
Use of clonazepam for bipolar affective disorder.
    The Journal of clinical psychiatry, 1990, Volume: 51 Suppl

    Topics: Acute Disease; Adult; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Therapy, Combination;

1990
Respiratory failure after clonazepam and amobarbital.
    The American journal of psychiatry, 1986, Volume: 143, Issue:11

    Topics: Amobarbital; Clonazepam; Coma; Drug Therapy, Combination; Humans; Male; Middle Aged; Psychotic Disor

1986
Use of clonazepam in a patient with schizoaffective disorder.
    The American journal of psychiatry, 1985, Volume: 142, Issue:6

    Topics: Adult; Benzodiazepinones; Clonazepam; Hallucinations; Humans; Lithium; Loxapine; Male; Psychotic Dis

1985
Clonazepam--antipsychotic effect in a case of schizophrenia-like psychosis with epilepsy and in three cases of atypical psychosis.
    Acta psychiatrica Scandinavica, 1985, Volume: 71, Issue:5

    Topics: Adult; Benzodiazepinones; Clonazepam; Combined Modality Therapy; Electroconvulsive Therapy; Epilepsy

1985