clonazepam has been researched along with Psychomotor Agitation in 26 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Psychomotor Agitation: A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasing the efficacy of an acute 6-week treatment by switching intramuscular haloperidol injection to RIS-OS." | 9.16 | Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia. ( Chen, H; Fang, M; Huang, J; Li, LH; Li, Y; Liu, L; Wang, B; Wang, G; Wu, R; Ye, M; Zhang, L; Zhang, Q; Zhao, JP; Zheng, H; Zhou, J; Zhu, S, 2012) |
| " Lorazepam and clonazepam are of established value in controlling acute psychotic agitation and catatonia." | 6.16 | Emerging uses for high-potency benzodiazepines in psychotic disorders. ( Bodkin, JA, 1990) |
| "We considered akathisia and cancer-related anxiety/agitation as possible causes of restlessness and insomnia, and prescribed clonazepam." | 5.72 | Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report. ( Deguchi, Y; Inoue, K; Itoh, Y; Sakamoto, S; Uchida, S, 2022) |
| "This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasing the efficacy of an acute 6-week treatment by switching intramuscular haloperidol injection to RIS-OS." | 5.16 | Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia. ( Chen, H; Fang, M; Huang, J; Li, LH; Li, Y; Liu, L; Wang, B; Wang, G; Wu, R; Ye, M; Zhang, L; Zhang, Q; Zhao, JP; Zheng, H; Zhou, J; Zhu, S, 2012) |
| "clonazepam is an effective, safe, but slower-acting alternative to I." | 2.67 | A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms. ( Annable, L; Chouinard, G; Holobow, N; Szkrumelak, N; Turnier, L, 1993) |
| "Terminal restlessness is a variant of delirium observed in some patients in their last days of life." | 2.40 | Palliative care: an update on "terminal restlessness". ( Burke, AL, 1997) |
| "We considered akathisia and cancer-related anxiety/agitation as possible causes of restlessness and insomnia, and prescribed clonazepam." | 1.72 | Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report. ( Deguchi, Y; Inoue, K; Itoh, Y; Sakamoto, S; Uchida, S, 2022) |
| "As a result, SSRIinduced akathisia is very frequently under-recognized." | 1.40 | A case of akathisia induced by escitalopram: case report & review of literature. ( Basu, B; De, S; Dutta, N; Gangopadhyay, T; Mandal, B; Mondal, S, 2014) |
| "Vitamin B12 deficiency is a treatable cause of failure to thrive and developmental regression, involuntary movements, and anemia." | 1.39 | Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. ( Belgemen, T; Carman, KB; Yis, U, 2013) |
| "A patient with neuroleptic-induced akathisia was successfully treated with a combination of baclofen (a GABA agonist) and clonazepam (a serotonergic agent)." | 1.27 | Successful treatment of neuroleptic-induced akathisia with baclofen and clonazepam. A case report. ( Sandyk, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (26.92) | 18.7374 |
| 1990's | 10 (38.46) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 6 (23.08) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Sakamoto, S | 1 |
| Deguchi, Y | 1 |
| Uchida, S | 1 |
| Itoh, Y | 1 |
| Inoue, K | 1 |
| Mawhinney, JA | 1 |
| Wilcock, C | 1 |
| Haboubi, H | 1 |
| Roshanzamir, S | 1 |
| Reddy, MSS | 1 |
| Achary, U | 1 |
| Harbishettar, V | 1 |
| Sivakumar, PT | 1 |
| Varghese, M | 1 |
| Carman, KB | 1 |
| Belgemen, T | 1 |
| Yis, U | 1 |
| Basu, B | 1 |
| Gangopadhyay, T | 1 |
| Dutta, N | 1 |
| Mandal, B | 1 |
| De, S | 1 |
| Mondal, S | 1 |
| Eiden, C | 1 |
| Capdevielle, D | 1 |
| Deddouche, C | 1 |
| Boulenger, JP | 1 |
| Blayac, JP | 1 |
| Peyrière, H | 1 |
| Carter, G | 1 |
| Fang, M | 1 |
| Chen, H | 1 |
| Li, LH | 1 |
| Wu, R | 1 |
| Li, Y | 1 |
| Liu, L | 1 |
| Ye, M | 1 |
| Huang, J | 1 |
| Zhu, S | 1 |
| Wang, G | 1 |
| Zhang, Q | 1 |
| Zheng, H | 1 |
| Zhang, L | 1 |
| Wang, B | 1 |
| Zhou, J | 1 |
| Zhao, JP | 1 |
| Kahn, JP | 1 |
| Raheja, RK | 1 |
| Bharwani, I | 1 |
| Penetrante, AE | 1 |
| Benazzi, F | 4 |
| Mazzoli, M | 3 |
| Chouinard, G | 1 |
| Annable, L | 1 |
| Turnier, L | 1 |
| Holobow, N | 1 |
| Szkrumelak, N | 1 |
| Rossi, E | 2 |
| Burke, AL | 1 |
| Barr, M | 1 |
| Bodkin, JA | 1 |
| Ginsburg, ML | 1 |
| Horiguchi, J | 1 |
| Nishimatsu, O | 1 |
| Inami, Y | 1 |
| Kutcher, S | 1 |
| Williamson, P | 1 |
| MacKenzie, S | 2 |
| Marton, P | 1 |
| Ehrlich, M | 1 |
| Kutcher, SP | 1 |
| Galarraga, W | 1 |
| Szalai, J | 1 |
| Smeraski, PJ | 1 |
| Freinhar, JP | 1 |
| Alvarez, WA | 1 |
| Sandyk, R | 1 |
| Fontaine, R | 1 |
2 reviews available for clonazepam and Psychomotor Agitation
| Article | Year |
|---|---|
Palliative care: an update on "terminal restlessness".
Topics: Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Clonazepam; Delirium; Diazepam; Humans; | 1997 |
Emerging uses for high-potency benzodiazepines in psychotic disorders.
Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum | 1990 |
6 trials available for clonazepam and Psychomotor Agitation
| Article | Year |
|---|---|
Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia.
Topics: Administration, Oral; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; China; Clonazepam; Diagn | 2012 |
Rapid tranquilization with intramuscular clonazepam.
Topics: Adult; Bipolar Disorder; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adm | 1994 |
A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms.
Topics: Adolescent; Adult; Arousal; Bipolar Disorder; Clonazepam; Double-Blind Method; Drug Therapy, Combina | 1993 |
Emerging uses for high-potency benzodiazepines in psychotic disorders.
Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum | 1990 |
Successful clonazepam treatment of neuroleptic-induced akathisia in older adolescents and young adults: a double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Doub | 1989 |
Clonazepam treatment of adolescents with neuroleptic-induced akathisia.
Topics: Administration, Oral; Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clinical Tri | 1987 |
19 other studies available for clonazepam and Psychomotor Agitation
| Article | Year |
|---|---|
Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report.
Topics: Antiemetics; Antineoplastic Agents; Antipsychotic Agents; Biperiden; Clonazepam; Dopamine; Humans; M | 2022 |
Neurotropism of SARS-CoV-2: COVID-19 presenting with an acute manic episode.
Topics: Adult; Affective Symptoms; Betacoronavirus; Cerebrospinal Fluid; Clonazepam; Coronavirus Infections; | 2020 |
Paradoxical reaction to benzodiazepines in elderly - Case series.
Topics: Aged; Aggression; Benzodiazepines; Clonazepam; GABA Modulators; Humans; Lorazepam; Male; Psychomotor | 2018 |
Involuntary movements misdiagnosed as seizure during vitamin B12 treatment.
Topics: Atrophy; Brain; Breast Feeding; Clonazepam; Diagnostic Errors; Dyskinesia, Drug-Induced; Electroence | 2013 |
A case of akathisia induced by escitalopram: case report & review of literature.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Second-Generation; Breast Neoplasms; Citalopram; | 2014 |
Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.
Topics: 4-Butyrolactone; Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Evaluation, | 2011 |
Animal behavior case of the month. Hyperactivity.
Topics: Animals; Anti-Anxiety Agents; Behavior Therapy; Behavior, Animal; Clonazepam; Dogs; Male; Methylphen | 2011 |
Agitated depression, panic anxiety, and clonazepam.
Topics: Clonazepam; Comorbidity; Depressive Disorder; GABA Modulators; Humans; Panic Disorder; Psychomotor A | 2006 |
Efficacy of risperidone for behavioral disorders in the elderly: a clinical observation.
Topics: Aged; Antipsychotic Agents; Clonazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 1995 |
A study of intramuscular clonazepam for psychotic agitation.
Topics: Adult; Aged; Clonazepam; Drug Administration Schedule; Female; Humans; Injections, Intramuscular; Ma | 1993 |
Benzodiazepines and acute psychotic agitation.
Topics: Adult; Aged; Antipsychotic Agents; Clonazepam; Dose-Response Relationship, Drug; Drug Administration | 1992 |
Intramuscular clonazepam for the treatment of psychotic agitation.
Topics: Adult; Aged; Arousal; Clonazepam; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Psyc | 1991 |
Assessment of improvement in treatment trials of acute mania.
Topics: Bipolar Disorder; Clonazepam; Humans; Personality Assessment; Psychomotor Agitation | 1991 |
Clonazepam for agitated patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1991 |
Successful treatment with clonazepam for neuroleptic-induced akathisia.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Clonazepam; Female; Humans; Male; | 1989 |
Clonazepam treatment of multi-infarct dementia.
Topics: Aged; Aggression; Clonazepam; Dementia, Multi-Infarct; Drug Therapy, Combination; Humans; Male; Psyc | 1988 |
Clonazepam treatment of organic brain syndromes in three elderly patients.
Topics: Aged; Clonazepam; Confusion; Humans; Male; Middle Aged; Neurocognitive Disorders; Psychomotor Agitat | 1986 |
Successful treatment of neuroleptic-induced akathisia with baclofen and clonazepam. A case report.
Topics: Akathisia, Drug-Induced; Baclofen; Benzodiazepinones; Clonazepam; Haloperidol; Humans; Male; Middle | 1985 |
Clonazepam for panic disorders and agitation.
Topics: Adult; Agoraphobia; Benzodiazepinones; Clonazepam; Fear; Female; Humans; Male; Panic; Phobic Disorde | 1985 |