Page last updated: 2024-10-25

clonazepam and Pregnancy

clonazepam has been researched along with Pregnancy in 54 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia."8.86Magnesium sulphate versus phenytoin for eclampsia. ( Chou, D; Duley, L; Henderson-Smart, DJ, 2010)
"To study the association between nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatments during pregnancy and prevalence of different congenital abnormalities (CAs)."7.71A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. ( Czeizel, AE; Eros, E; Olsen, J; Rockenbauer, M; Sorensen, HT, 2002)
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy."7.68[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992)
"A case of postpartum eclampsia is reported, controlled by intravenous clonazepam, a benzodiazepine anticonvulsant."7.67Intravenous clonazepam in eclampsia. ( Harding, DL; Leong, CM, 1988)
" The infant developed apnea, cyanosis, and hypotonia within a few hours of birth."7.67Neonatal apnea associated with maternal clonazepam therapy: a case report. ( Coleman, JM; Edgren, BE; Fisher, JB; Mammel, MC, 1985)
" The goal of this study is to evaluate the potential of micelle-like nanoparticles (MNP) for providing safe drug usage in pregnancy and protect both foetus and mother from medication side effects."5.48Investigations on clonazepam-loaded polymeric micelle-like nanoparticles for safe drug administration during pregnancy. ( Elcin, AE; Elcin, YM; Parmaksiz, M; Sezgin-Bayindir, Z; Yuksel, N, 2018)
"Clonazepam (Klonopin) is a benzodiazepine that has been used widely to treat seizures and conditions such as panic attacks and anxiety disorder."5.32Clonazepam use in pregnancy and the risk of malformations. ( Franz, A; Holmes, LB; Houde, K; Lin, AE; Peller, AJ; Westgate, MN, 2004)
"Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment."5.27Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983)
"The objective of this review was to assess the effects of magnesium sulphate compared with phenytoin when used for the care of women with eclampsia."4.86Magnesium sulphate versus phenytoin for eclampsia. ( Chou, D; Duley, L; Henderson-Smart, DJ, 2010)
"1%) received an anti-epileptic medication during pregnancy of which more than half received lamotrigine or levetiracetam."4.12Use of antiepileptic drugs by trimester. ( Benson, RJ; D'Alton, ME; Friedman, AM; Huang, Y; Logue, TC; Pack, AM; Wright, JD, 2022)
"During her first pregnancy, a 37-year-old woman with idiopathic generalised epilepsy that was adequately controlled with lamotrigine experienced a series of epileptic seizures following an elective caesarean section."3.73[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy]. ( Bloem, BR; Renier, WO; Voermans, NC; Zwarts, MJ, 2005)
"We describe cervical dystonia occurring in a 31-year-old, previously well, primigravid, primiparous Chinese woman at 4 weeks' amenorrhea, which was ameliorated with low-dose clonazepam and disappeared completely by the end of the second trimester without recurring despite her being tapered off benzodiazepine therapy."3.73Dystonia gravidarum: a new entity? ( Lim, EC; Ong, BK; Seet, RC; Wilder-Smith, EP, 2006)
"To study the association between nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatments during pregnancy and prevalence of different congenital abnormalities (CAs)."3.71A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy. ( Czeizel, AE; Eros, E; Olsen, J; Rockenbauer, M; Sorensen, HT, 2002)
" The mother had taken clonazepam, a benzodiazepine, and carbamazepine during the entire pregnancy for epilepsy."3.69Paralytic ileus in a fetus-neonate after maternal intake of benzodiazepine. ( Haeusler, MC; Hoellwarth, ME; Holzer, P, 1995)
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy."3.68[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992)
" Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring."3.67Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986)
"A case of postpartum eclampsia is reported, controlled by intravenous clonazepam, a benzodiazepine anticonvulsant."3.67Intravenous clonazepam in eclampsia. ( Harding, DL; Leong, CM, 1988)
" The infant developed apnea, cyanosis, and hypotonia within a few hours of birth."3.67Neonatal apnea associated with maternal clonazepam therapy: a case report. ( Coleman, JM; Edgren, BE; Fisher, JB; Mammel, MC, 1985)
" Case 1 is a description of the subjective experience of a patient with acute orofacial dystonia from promethazine."3.66Case vignettes of movement disorders. ( Yung, CY, 1983)
"Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies."2.35Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976)
"To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy."1.56Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020)
" The goal of this study is to evaluate the potential of micelle-like nanoparticles (MNP) for providing safe drug usage in pregnancy and protect both foetus and mother from medication side effects."1.48Investigations on clonazepam-loaded polymeric micelle-like nanoparticles for safe drug administration during pregnancy. ( Elcin, AE; Elcin, YM; Parmaksiz, M; Sezgin-Bayindir, Z; Yuksel, N, 2018)
"Clonazepam (Klonopin) is a benzodiazepine that has been used widely to treat seizures and conditions such as panic attacks and anxiety disorder."1.32Clonazepam use in pregnancy and the risk of malformations. ( Franz, A; Holmes, LB; Houde, K; Lin, AE; Peller, AJ; Westgate, MN, 2004)
"QUESTIONSeveral of my patients with psychiatric disorders are either planning to conceive or are already pregnant."1.30Counseling psychiatric patients about drug exposures during pregnancy. ( Einarson, A; Koren, G, 1998)
"One also had features of infantile autism."1.29Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994)
"Juvenile myoclonic epilepsy is a relatively common, though under diagnosed, form of epilepsy that commences in adolescence."1.29Juvenile myoclonic epilepsy. ( Buchanan, N, 1995)
"Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment."1.27Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983)
"[3H]muscimol was used for the labeling of GABA receptors and [3H]flunitrazepam for benzodiazepine receptors."1.26Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study. ( Kuhar, MJ; Palacios, JM, 1981)

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-199028 (51.85)18.7374
1990's9 (16.67)18.2507
2000's11 (20.37)29.6817
2010's2 (3.70)24.3611
2020's4 (7.41)2.80

Authors

AuthorsStudies
Logue, TC1
Huang, Y1
Benson, RJ1
Pack, AM1
Wright, JD1
D'Alton, ME1
Friedman, AM1
Daugaard, CA1
Pedersen, L1
Sun, Y1
Dreier, JW1
Christensen, J1
Koziorowska-Gawron, E1
Koszewicz, M1
Bladowska, J1
Ejma, M1
Budrewicz, S1
Yang, Y1
Wang, B1
Zhong, Z1
Chen, H1
Ding, W1
Hoi, MPM1
Sezgin-Bayindir, Z1
Elcin, AE1
Parmaksiz, M1
Elcin, YM1
Yuksel, N1
Marin, SJ1
Keith, L1
Merrell, M1
McMillin, GA1
Duley, L1
Henderson-Smart, DJ1
Chou, D1
Collins, KO1
Comer, JB1
Oberlander, TF2
Misri, S2
Fitzgerald, CE1
Kostaras, X1
Rurak, D2
Riggs, W1
Lin, AE1
Peller, AJ1
Westgate, MN1
Houde, K1
Franz, A1
Holmes, LB1
Voermans, NC1
Zwarts, MJ1
Renier, WO1
Bloem, BR1
Lim, EC1
Seet, RC1
Wilder-Smith, EP1
Ong, BK1
Buccoliero, R1
Palmeri, S1
Malandrini, A1
Dotti, MT1
Federico, A1
Doria Lamba, L1
Giribaldi, G1
De Negri, E1
Follo, R1
De Grandis, E1
Pintaudi, M1
Veneselli, E1
Saito, H1
Kobayashi, H1
Takeno, S1
Sakai, T1
Pavone, L1
Mollica, F1
Incorpora, G1
Pampiglione, G1
Palacios, JM1
Kuhar, MJ1
Keränen, T1
Sivenius, J1
Peng, DR1
Birgersson, C1
von Bahr, C1
Rane, A1
Murasaki, M1
Okamoto, K1
Takahashi, A1
Nagai, T1
Yung, CY1
Warburton, D1
Boyle, RJ1
Keats, JP1
Vohr, B1
Peuschel, S1
Oh, W1
Morselli, PL1
Franco-Morselli, R1
Aminoff, MJ1
Kriel, RL1
Cloyd, J1
Bossi, L1
Assael, BM1
Avanzini, G1
Battino, D1
Caccamo, ML1
Canger, R1
Como, ML1
Pifarotti, G1
de Giambattista, M1
Franceschetti, S1
Marini, A1
Pardi, G1
Porro, MG1
Rovei, V1
Sanjuan, M1
Soffientini, ME1
Spina, S1
Spreafico, R1
Huang, A1
Barker, JL1
Paul, SM1
Moncada, V1
Skolnick, P1
Christianson, AL1
Chesler, N1
Kromberg, JG1
Buchanan, N1
Leventer, RJ1
Hopkins, IJ1
Shield, LK1
Klein, DF1
Gischler, SJ1
van den Anker, JN1
Haeusler, MC1
Hoellwarth, ME1
Holzer, P1
Einarson, A1
Koren, G1
Wang, GJ1
Thayer, SA1
Eros, E1
Czeizel, AE1
Rockenbauer, M1
Sorensen, HT1
Olsen, J1
Eckstein Grunau, R1
Fitzgerald, C1
Ellwood, AL1
Riggs, KW1
Aucamp, AK1
Reith, H1
Schäfer, H1
Braestrup, C1
Nielsen, M1
Beltrami, M1
Mengaldo, R1
Frassineti, E1
Canevazzi, P1
Mazzei, G1
Hvidberg, EF1
Dam, M1
Sullivan, FM1
McElhatton, PR1
Boringa, JB1
de Jong, GM1
Touw, DJ1
Schlumpf, M2
Parmar, R1
Ramseier, HR1
Lichtensteiger, W2
Ramseier, H1
Miranda, RC1
Wagner, JP1
Kellogg, CK1
Hartikainen-Sorri, AL1
Heikkinen, J1
Nikiforow, R1
Sobrian, SK1
Nandedkar, AK1
Shinnar, S1
Harding, DL1
Leong, CM1
Söderman, P1
Matheson, I1
Calabrese, JR1
Gulledge, AD1
Fisher, JB1
Edgren, BE1
Mammel, MC1
Coleman, JM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127]20 participants (Actual)Interventional2014-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for clonazepam and Pregnancy

ArticleYear
Magnesium sulphate versus phenytoin for eclampsia.
    The Cochrane database of systematic reviews, 2010, Oct-06, Issue:10

    Topics: Anticonvulsants; Clonazepam; Diazepam; Drug Combinations; Eclampsia; Female; Humans; Magnesium Sulfa

2010
Clinical pharmacokinetics of antiepileptic drugs in adults.
    Pharmacology & therapeutics, 1980, Volume: 10, Issue:1

    Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Disease; Ethosuximide; Female; H

1980
The pharmacological treatment of epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Oct-06, Volume: 56, Issue:15

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies,

1979
[Antiepileptics during pregnancy and lactation. Pharmacokinetic data].
    Deutsche medizinische Wochenschrift (1946), 1979, Jun-01, Volume: 104, Issue:22

    Topics: Anticonvulsants; Bromides; Carbamazepine; Clonazepam; Diazepam; Ethosuximide; Female; Fetus; Humans;

1979
Clinical pharmacokinetics of anticonvulsants.
    Clinical pharmacokinetics, 1976, Volume: 1, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam

1976
Antiepileptic drugs in adolescents.
    Journal of adolescent health care : official publication of the Society for Adolescent Medicine, 1987, Volume: 8, Issue:1

    Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru

1987

Other Studies

48 other studies available for clonazepam and Pregnancy

ArticleYear
Use of antiepileptic drugs by trimester.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25

    Topics: Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Pregnancy; Retros

2022
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
    JAMA network open, 2020, 11-02, Volume: 3, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen

2020
Opsoclonus-myoclonus syndrome with severe clinical course and beneficial outcome: A case report.
    Medicine, 2021, Apr-09, Volume: 100, Issue:14

    Topics: Adult; Anticonvulsants; Clonazepam; Female; Glucocorticoids; Humans; Methylprednisolone; Opsoclonus-

2021
Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission.
    Biochemical pharmacology, 2021, Volume: 192

    Topics: Animals; Clonazepam; Female; GABA Modulators; GABA-A Receptor Agonists; GABAergic Neurons; Male; Men

2021
Investigations on clonazepam-loaded polymeric micelle-like nanoparticles for safe drug administration during pregnancy.
    Journal of microencapsulation, 2018, Volume: 35, Issue:2

    Topics: Acrylic Resins; Cell Line; Clonazepam; Drug Carriers; Drug Liberation; Female; GABA Modulators; Huma

2018
Evaluation of a new ELISA kit for the detection of benzodiazepines in meconium.
    Journal of analytical toxicology, 2009, Volume: 33, Issue:3

    Topics: Benzodiazepines; Calibration; Clonazepam; Enzyme-Linked Immunosorbent Assay; Female; Humans; Hypnoti

2009
Maternal haloperidol therapy associated with dyskinesia in a newborn.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2003, Nov-01, Volume: 60, Issue:21

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Dyskinesia, Drug-Induced; Female; Haloperi

2003
Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:2

    Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Clonazepam; Cohort Studies; Depressive Disorder; Dose

2004
Clonazepam use in pregnancy and the risk of malformations.
    Birth defects research. Part A, Clinical and molecular teratology, 2004, Volume: 70, Issue:8

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Clonazepam; Congenital Abnormalities; Female; Humans;

2004
[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy].
    Nederlands tijdschrift voor geneeskunde, 2005, Jun-18, Volume: 149, Issue:25

    Topics: Adult; Anticonvulsants; Cesarean Section; Clonazepam; Diazepam; Epilepsy; Epilepsy, Generalized; Epi

2005
Dystonia gravidarum: a new entity?
    Movement disorders : official journal of the Movement Disorder Society, 2006, Volume: 21, Issue:1

    Topics: Adult; Clonazepam; Dose-Response Relationship, Drug; Estrogens; Female; Humans; Infant, Newborn; Pre

2006
A case of dystonia with onset during pregnancy.
    Journal of the neurological sciences, 2007, Sep-15, Volume: 260, Issue:1-2

    Topics: Adult; Anticonvulsants; Central Nervous System; Clonazepam; Dystonia; Female; Foot; Humans; Hypothyr

2007
A case of major form familial hyperekplexia: prenatal diagnosis and effective treatment with clonazepam.
    Journal of child neurology, 2007, Volume: 22, Issue:6

    Topics: Anticonvulsants; Child, Preschool; Clonazepam; Family Health; Female; Glutamic Acid; Humans; Lysine;

2007
Fetal toxicity of benzodiazepines in rats.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 46, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Clonazepam; Diazepam; F

1984
Infantile spasms syndrome in monozygotic twins.
    Archives of disease in childhood, 1980, Volume: 55, Issue:11

    Topics: Adrenocorticotropic Hormone; Clonazepam; Diseases in Twins; Electroencephalography; Female; Follow-U

1980
Ontogeny of high-affinity GABA and benzodiazepine receptors in the rat cerebellum: an autoradiographic study.
    Brain research, 1981, Volume: 254, Issue:4

    Topics: Aging; Animals; Autoradiography; Cerebellum; Clonazepam; Female; Flunitrazepam; gamma-Aminobutyric A

1981
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li

1983
Polymorphic acetylation of 7-amino-clonazepam in human liver cytosol.
    Pediatric pharmacology (New York, N.Y.), 1984, Volume: 4, Issue:3

    Topics: Acetylation; Benzodiazepinones; Clonazepam; Cytosol; Female; Gestational Age; Humans; In Vitro Techn

1984
Psychomotor status--a female case in the 34th week of pregnancy.
    Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:4

    Topics: Adult; Carbamazepine; Clonazepam; Drugs, Chinese Herbal; Electroencephalography; Epilepsy; Epilepsy,

1983
Case vignettes of movement disorders.
    Brain research bulletin, 1983, Volume: 11, Issue:2

    Topics: Adult; Amantadine; Brain Injuries; Clonazepam; Diagnosis, Differential; Dystonia; Female; Haloperido

1983
Nonketotic hyperglycinemia. Effects of therapy with strychnine.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:3

    Topics: Amino Acid Metabolism, Inborn Errors; Clonazepam; Diseases in Twins; Epilepsies, Myoclonic; Female;

1980
Drug treatment of epilepsy.
    Comprehensive therapy, 1981, Volume: 7, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female;

1981
Clonazepam and pregnancy.
    Annals of neurology, 1982, Volume: 11, Issue:5

    Topics: Adult; Benzodiazepinones; Clonazepam; Epilepsy, Temporal Lobe; Female; Humans; Infant, Newborn; Preg

1982
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
    Obstetrical & gynecological survey, 1980, Volume: 35, Issue:9

    Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt

1980
Characterization of benzodiazepine receptors in primary cultures of fetal mouse brain and spinal cord neurons.
    Brain research, 1980, May-26, Volume: 190, Issue:2

    Topics: Animals; Binding, Competitive; Brain; Clonazepam; Culture Techniques; Diazepam; Female; gamma-Aminob

1980
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
    Developmental medicine and child neurology, 1994, Volume: 36, Issue:4

    Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family

1994
Juvenile myoclonic epilepsy.
    Journal of paediatrics and child health, 1995, Volume: 31, Issue:4

    Topics: Adolescent; Age of Onset; Animals; Anticonvulsants; Child; Circadian Rhythm; Clonazepam; Cricetinae;

1995
Hyperekplexia as cause of abnormal intrauterine movements.
    Lancet (London, England), 1995, Feb-18, Volume: 345, Issue:8947

    Topics: Adult; Apnea; Clonazepam; Female; Fetal Diseases; Humans; Infant, Newborn; Muscle Hypertonia; Pregna

1995
Pregnancy and panic disorder.
    The Journal of clinical psychiatry, 1994, Volume: 55, Issue:7

    Topics: Anti-Anxiety Agents; Clonazepam; Female; Humans; Panic Disorder; Pregnancy; Pregnancy Complications;

1994
[Neurological symptoms in newborn infants as a result of the use of psychopharmaceuticals during pregnancy].
    Nederlands tijdschrift voor geneeskunde, 1993, Nov-06, Volume: 137, Issue:45

    Topics: Clonazepam; Female; Humans; Infant, Newborn; Infant, Premature; Male; Muscle Hypotonia; Pregnancy; P

1993
Paralytic ileus in a fetus-neonate after maternal intake of benzodiazepine.
    Prenatal diagnosis, 1995, Volume: 15, Issue:12

    Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Female; Fetal Diseases; Humans; Infant,

1995
Counseling psychiatric patients about drug exposures during pregnancy.
    Canadian family physician Medecin de famille canadien, 1998, Volume: 44

    Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Clonazepam; Embryonic and Fetal Developmen

1998
NMDA-induced calcium loads recycle across the mitochondrial inner membrane of hippocampal neurons in culture.
    Journal of neurophysiology, 2002, Volume: 87, Issue:2

    Topics: Animals; Calcium; Calcium Channels; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultu

2002
A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolum and clonazepam treatment during pregnancy.
    European journal of obstetrics, gynecology, and reproductive biology, 2002, Mar-10, Volume: 101, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Alprazolam; Anti-Anxiety Agents; Antico

2002
Prolonged prenatal psychotropic medication exposure alters neonatal acute pain response.
    Pediatric research, 2002, Volume: 51, Issue:4

    Topics: Animals; Clonazepam; Facial Expression; Female; GABA Modulators; Heart Rate; Humans; Infant, Newborn

2002
Ontogenetic development of benzodiazepine receptors in the rat brain.
    Brain research, 1978, May-19, Volume: 147, Issue:1

    Topics: Animals; Animals, Newborn; Binding, Competitive; Brain; Clonazepam; Diazepam; Female; Gestational Ag

1978
[Clonazepam in the treatment of eclamptic convulsive crises].
    Minerva anestesiologica, 1978, Volume: 44, Issue:4

    Topics: Adult; Benzodiazepinones; Clonazepam; Drug Evaluation; Eclampsia; Female; Humans; Pregnancy; Seizure

1978
A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
    Toxicology and applied pharmacology, 1977, Volume: 40, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Fema

1977
[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy].
    Nederlands tijdschrift voor geneeskunde, 1992, Jul-25, Volume: 136, Issue:30

    Topics: Adult; Clomipramine; Clonazepam; Depressive Disorder; Female; Humans; Infant, Newborn; Male; Neonata

1992
Prenatal benzodiazepine immunosuppression: possible involvement of peripheral benzodiazepine site.
    Developmental pharmacology and therapeutics, 1990, Volume: 15, Issue:3-4

    Topics: Animals; Autoradiography; Benzodiazepinones; Binding Sites; Cell Division; Clonazepam; Convulsants;

1990
Prenatal diazepam induced persisting depression of cellular immune responses.
    Life sciences, 1989, Volume: 44, Issue:7

    Topics: Animals; Clonazepam; Corticosterone; Diazepam; Female; Fetus; Immunity, Cellular; Lymphocyte Activat

1989
Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats.
    Neurochemical research, 1989, Volume: 14, Issue:11

    Topics: Animals; Benzodiazepines; Brain; Clonazepam; Diazepam; Female; Flumazenil; Gestational Age; Pregnanc

1989
[Progressive myoclonus epilepsy and pregnancy].
    Duodecim; laaketieteellinen aikakauskirja, 1986, Volume: 102, Issue:2

    Topics: Adult; Benzodiazepinones; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies,

1986
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5

    Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital;

1986
Intravenous clonazepam in eclampsia.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1988, Volume: 28, Issue:1

    Topics: Adult; Blood Pressure; Clonazepam; Drug Administration Schedule; Drug Therapy, Combination; Eclampsi

1988
Clonazepam in breast milk.
    European journal of pediatrics, 1988, Volume: 147, Issue:2

    Topics: Clonazepam; Female; Humans; Infant, Newborn; Milk, Human; Phenytoin; Pregnancy

1988
Carbamazepine, clonazepam use during pregnancy.
    Psychosomatics, 1986, Volume: 27, Issue:6

    Topics: Abnormalities, Drug-Induced; Benzodiazepinones; Carbamazepine; Clonazepam; Epilepsy; Female; Humans;

1986
Neonatal apnea associated with maternal clonazepam therapy: a case report.
    Obstetrics and gynecology, 1985, Volume: 66, Issue:3 Suppl

    Topics: Adult; Apnea; Benzodiazepinones; Clonazepam; Female; Humans; Infant, Newborn; Infant, Premature, Dis

1985