Page last updated: 2024-10-25

clonazepam and Porphyria

clonazepam has been researched along with Porphyria in 2 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Research Excerpts

ExcerptRelevanceReference
"Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria."5.26Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980)
"Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria."1.26Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19902 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bonkowsky, HL1
Sinclair, PR1
Emery, S1
Sinclair, JF1
Larson, AW1
Wasserstrom, WR1
Felsher, BF1
Chih, JC1

Other Studies

2 other studies available for clonazepam and Porphyria

ArticleYear
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
    Neurology, 1980, Volume: 30, Issue:6

    Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo;

1980
Posttraumatic epilepsy and acute intermittent porphyria: effects of phenytoin, carbamazepine, and clonazepam.
    Neurology, 1978, Volume: 28, Issue:8

    Topics: Acute Disease; Adult; Benzodiazepinones; Carbamazepine; Clonazepam; Epilepsy, Post-Traumatic; Humans

1978