clonazepam has been researched along with Porphyria in 2 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bonkowsky, HL | 1 |
| Sinclair, PR | 1 |
| Emery, S | 1 |
| Sinclair, JF | 1 |
| Larson, AW | 1 |
| Wasserstrom, WR | 1 |
| Felsher, BF | 1 |
| Chih, JC | 1 |
2 other studies available for clonazepam and Porphyria
| Article | Year |
|---|---|
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
Posttraumatic epilepsy and acute intermittent porphyria: effects of phenytoin, carbamazepine, and clonazepam.
Topics: Acute Disease; Adult; Benzodiazepinones; Carbamazepine; Clonazepam; Epilepsy, Post-Traumatic; Humans | 1978 |