clonazepam has been researched along with Pain in 20 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 9.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome." | 8.85 | Cyclobenzaprine for the treatment of myofascial pain in adults. ( Andriolo, RB; Atallah, AN; da Silva, EM; El Dib, R; Grossmann, E; Januzzi, E; Leite, FM, 2009) |
| "The purpose of this study is to describe the results of clonazepam use in the treatment of phantom limb pain (PLP)." | 8.02 | Clonazepam: An Old "New" Therapy for the Treatment of Phantom Limb Pain-A Brief Report of a Retrospective Study. ( Brunelli, S; Pratesi, L; Traballesi, M, 2021) |
| "To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain." | 7.69 | Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996) |
| " For treating trigeminal neuralgia, carbamazepine had a combined number needed to treat of 2." | 6.17 | Anticonvulsant drugs for management of pain: a systematic review. ( Carroll, D; Jadad, AR; McQuay, H; Moore, A; Wiffen, P, 1995) |
| "Clonazepam has been widely prescribed and is effective, but it is unclear whether clonazepam also affects the symptoms that accompany BMS, or whether such symptoms affect treatment outcomes." | 5.91 | Therapeutic effects of clonazepam in patients with burning mouth syndrome and various symptoms or psychological conditions. ( Bang, JI; Kim, GJ; Kim, MR; Kim, SY; Shin, HI; Sun, DI, 2023) |
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 5.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "All RCTs and quasi-RCTs reporting use of cyclobenzaprine for treating MP with pain assessment as a primary or secondary outcome." | 4.85 | Cyclobenzaprine for the treatment of myofascial pain in adults. ( Andriolo, RB; Atallah, AN; da Silva, EM; El Dib, R; Grossmann, E; Januzzi, E; Leite, FM, 2009) |
| "The purpose of this study is to describe the results of clonazepam use in the treatment of phantom limb pain (PLP)." | 4.02 | Clonazepam: An Old "New" Therapy for the Treatment of Phantom Limb Pain-A Brief Report of a Retrospective Study. ( Brunelli, S; Pratesi, L; Traballesi, M, 2021) |
| " The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2)." | 3.88 | Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( Adamo, D; Aria, M; Fortuna, G; Mignogna, MD; Pecoraro, G, 2018) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "To propose clonazepam for use in the empiric treatment of shooting/shocking phantom limb pain." | 3.69 | Clonazepam for the treatment of lancinating phantom limb pain. ( Bartusch, SL; D'Alessio, JG; Jernigan, JR; Sanders, BJ, 1996) |
| "Burning mouth syndrome is a chronic idiopathic intractable intraoral dysaesthesia that remains a challenge to clinicians due to its poorly understood pathogenesis and inconsistent response to various treatments." | 2.82 | A systematic review of treatment for patients with burning mouth syndrome. ( Hoffmann, J; Renton, T; Smith, JG; Tan, HL, 2022) |
| "The area of static hyperalgesia after intradermal capsaicin injection was the primary endpoint." | 2.78 | Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study. ( Arendt-Nielsen, L; Besson, M; Curatolo, M; Desmeules, J; Vuilleumier, PH, 2013) |
| "Clonazepam has been widely prescribed and is effective, but it is unclear whether clonazepam also affects the symptoms that accompany BMS, or whether such symptoms affect treatment outcomes." | 1.91 | Therapeutic effects of clonazepam in patients with burning mouth syndrome and various symptoms or psychological conditions. ( Bang, JI; Kim, GJ; Kim, MR; Kim, SY; Shin, HI; Sun, DI, 2023) |
| "Clonazepam is an antimuscarinic, muscle relaxing oral drug." | 1.40 | [Catheter-related bladder discomfort after urological surgery: importance of the type of surgery and efficiency of treatment by clonazepam]. ( Baron, T; Bourez, S; de la Taille, A; Maro, S; Salomon, L; Zarattin, D, 2014) |
| "Clonazepam (0." | 1.36 | Three patients with cancer who developed rapid-eye-movement sleep behavior disorder. ( Horiguchi, J; Inami, Y; Kamei, M; Maegawa, T; Nakamura, Y; Satake, A; Shinno, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 5 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brunelli, S | 1 |
| Pratesi, L | 1 |
| Traballesi, M | 1 |
| Sangalli, L | 1 |
| Miller, CS | 1 |
| Alvarenga-Brant, R | 1 |
| Costa, FO | 1 |
| Mattos-Pereira, G | 1 |
| Esteves-Lima, RP | 1 |
| Belém, FV | 1 |
| Lai, H | 1 |
| Ge, L | 1 |
| Gomez, RS | 1 |
| Martins, CC | 1 |
| Shin, HI | 1 |
| Bang, JI | 1 |
| Kim, GJ | 1 |
| Kim, MR | 1 |
| Sun, DI | 1 |
| Kim, SY | 1 |
| Tan, HL | 1 |
| Smith, JG | 1 |
| Hoffmann, J | 1 |
| Renton, T | 1 |
| Adamo, D | 1 |
| Mignogna, MD | 1 |
| Pecoraro, G | 1 |
| Aria, M | 1 |
| Fortuna, G | 1 |
| Okamoto, M | 1 |
| Takahagi, S | 1 |
| Kamegashira, A | 1 |
| Yanase, Y | 1 |
| Hide, M | 1 |
| Vuilleumier, PH | 1 |
| Besson, M | 1 |
| Desmeules, J | 1 |
| Arendt-Nielsen, L | 1 |
| Curatolo, M | 1 |
| Maro, S | 1 |
| Zarattin, D | 1 |
| Baron, T | 1 |
| Bourez, S | 1 |
| de la Taille, A | 1 |
| Salomon, L | 1 |
| Leite, FM | 1 |
| Atallah, AN | 1 |
| El Dib, R | 1 |
| Grossmann, E | 1 |
| Januzzi, E | 1 |
| Andriolo, RB | 1 |
| da Silva, EM | 1 |
| Shinno, H | 1 |
| Kamei, M | 1 |
| Maegawa, T | 1 |
| Satake, A | 1 |
| Inami, Y | 1 |
| Horiguchi, J | 1 |
| Nakamura, Y | 1 |
| Lucas, KH | 1 |
| Terpening, CM | 1 |
| Elliott, DP | 1 |
| Bartoshuk, LM | 1 |
| Snyder, DJ | 1 |
| Grushka, M | 1 |
| Berger, AM | 1 |
| Duffy, VB | 1 |
| Kveton, JF | 1 |
| Kryshanovskiĭ, GN | 1 |
| Grafova, VN | 1 |
| Danilova, EI | 1 |
| Swerdlow, M | 1 |
| Cundill, JG | 1 |
| McQuay, H | 1 |
| Carroll, D | 1 |
| Jadad, AR | 1 |
| Wiffen, P | 1 |
| Moore, A | 1 |
| Sullivan, M | 1 |
| Toshima, M | 1 |
| Lynn, P | 1 |
| Roy-Byrne, P | 1 |
| Bartusch, SL | 1 |
| Sanders, BJ | 1 |
| D'Alessio, JG | 1 |
| Jernigan, JR | 1 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Oberlander, TF | 1 |
| Eckstein Grunau, R | 1 |
| Fitzgerald, C | 1 |
| Ellwood, AL | 1 |
| Misri, S | 1 |
| Rurak, D | 1 |
| Riggs, KW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Gaba-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers[NCT01011036] | Phase 3 | 17 participants (Actual) | Interventional | 2009-12-31 | Completed | ||
| Burning Mouth Disorder (BMD) - a Neuropathic Pain Disorder? An Investigation Using Qualitative and Quantitative Sensory Testing (QST)[NCT00504387] | 12 participants (Anticipated) | Observational | 2007-04-30 | Recruiting | |||
| Erenumab as a Therapeutic Approach for the Management of Trigeminal Neuropathic Pain (TNP)[NCT05142228] | Phase 2 | 5 participants (Actual) | Interventional | 2022-04-01 | Terminated (stopped due to Low enrollment rate) | ||
| Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127] | 20 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for clonazepam and Pain
| Article | Year |
|---|---|
Treatments for Burning Mouth Syndrome: A Network Meta-analysis.
Topics: Burning Mouth Syndrome; Clonazepam; Humans; Network Meta-Analysis; Pain; Quality of Life | 2023 |
A systematic review of treatment for patients with burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Clonazepam; Humans; Pain; Thioctic Acid | 2022 |
Cyclobenzaprine for the treatment of myofascial pain in adults.
Topics: Adult; Amitriptyline; Anesthetics, Local; Clonazepam; Fascia; Humans; Lidocaine; Muscle Relaxants, C | 2009 |
Anticonvulsant drugs for management of pain: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diabetic Neuropathies; Humans; Pain; Phenytoin; Treatmen | 1995 |
3 trials available for clonazepam and Pain
| Article | Year |
|---|---|
Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled study.
Topics: Adolescent; Adult; Analgesics; Benzodiazepines; Clobazam; Clonazepam; Cross-Sectional Studies; Doubl | 2013 |
Anticonvulsant drugs for management of pain: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diabetic Neuropathies; Humans; Pain; Phenytoin; Treatmen | 1995 |
Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study.
Topics: Adult; Anxiety Disorders; Chronic Disease; Clonazepam; Double-Blind Method; Female; Hospitalization; | 1993 |
14 other studies available for clonazepam and Pain
| Article | Year |
|---|---|
Clonazepam: An Old "New" Therapy for the Treatment of Phantom Limb Pain-A Brief Report of a Retrospective Study.
Topics: Clonazepam; Female; Humans; Male; Middle Aged; Pain; Phantom Limb; Retrospective Studies | 2021 |
Low-dose naltrexone for treatment of burning mouth syndrome.
Topics: Burning Mouth Syndrome; Clonazepam; Female; Fibromyalgia; Headache; Humans; Middle Aged; Naltrexone; | 2023 |
Therapeutic effects of clonazepam in patients with burning mouth syndrome and various symptoms or psychological conditions.
Topics: Burning Mouth Syndrome; Clonazepam; Dysgeusia; Humans; Pain; Retrospective Studies; Xerostomia | 2023 |
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Benzodiazepines; Burning Mouth Syndrome; Cl | 2018 |
Successful treatment of refractory dermal pain with etizolam and clonazepam in a patient with acquired idiopathic generalized anhidrosis.
Topics: Adult; Biopsy; Clonazepam; Diazepam; Drug Resistance; Drug Therapy, Combination; Gabapentin; Glucoco | 2019 |
[Catheter-related bladder discomfort after urological surgery: importance of the type of surgery and efficiency of treatment by clonazepam].
Topics: Adult; Aged; Aged, 80 and over; Clonazepam; Female; Humans; Male; Middle Aged; Pain; Prospective Stu | 2014 |
Three patients with cancer who developed rapid-eye-movement sleep behavior disorder.
Topics: Aged; Antipsychotic Agents; Clonazepam; Delirium; Diagnosis, Differential; Female; GABA Modulators; | 2010 |
Regarding the management of persistent pain in older persons.
Topics: Aged; Analgesics; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Geriatrics; Humans; Pain; | 2003 |
Taste damage: previously unsuspected consequences.
Topics: Burning Mouth Syndrome; Clonazepam; Female; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Mo | 2005 |
[Effect of benzodiazepines on neuropathologic syndromes of spinal origin].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clonazepam; Diazepam; Myoclonus; P | 1984 |
Anticonvulsant drugs used in the treatment of lancinating pain. A comparison.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Female; Humans | 1981 |
Clonazepam for the treatment of lancinating phantom limb pain.
Topics: Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Clonazepam; Disarticulation; Drug Therapy, Co | 1996 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
Prolonged prenatal psychotropic medication exposure alters neonatal acute pain response.
Topics: Animals; Clonazepam; Facial Expression; Female; GABA Modulators; Heart Rate; Humans; Infant, Newborn | 2002 |