clonazepam has been researched along with Neuroleptic Malignant Syndrome in 5 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Haloperidol was stopped and intravenous clonazepam 5mg/kg was begun." | 5.36 | [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. ( Askenazy, F; Benoit, M; Dor, E; Dupuis, G; Myquel, M; Seddiki, Y; Serret, S, 2010) |
| "Serotonin syndrome and neuroleptic malignant syndrome are two drug toxidromes that have often overlapping and confusing clinical pictures." | 2.50 | Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary. ( Ambaliya, A; Dosi, R; Joshi, H; Patell, R, 2014) |
| "Haloperidol was stopped and intravenous clonazepam 5mg/kg was begun." | 1.36 | [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. ( Askenazy, F; Benoit, M; Dor, E; Dupuis, G; Myquel, M; Seddiki, Y; Serret, S, 2010) |
| "The clinical picture was complicated by convulsions, perhaps due to clonazepam withdrawal and possible lithium toxicity." | 1.29 | Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder. ( Cubis, JC; Looi, JC; Saboisky, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dosi, R | 1 |
| Ambaliya, A | 1 |
| Joshi, H | 1 |
| Patell, R | 1 |
| Askenazy, F | 1 |
| Dor, E | 1 |
| Benoit, M | 1 |
| Dupuis, G | 1 |
| Serret, S | 1 |
| Myquel, M | 1 |
| Seddiki, Y | 1 |
| Eiden, C | 1 |
| Capdevielle, D | 1 |
| Deddouche, C | 1 |
| Boulenger, JP | 1 |
| Blayac, JP | 1 |
| Peyrière, H | 1 |
| Solomons, K | 1 |
| Looi, JC | 1 |
| Cubis, JC | 1 |
| Saboisky, J | 1 |
1 review available for clonazepam and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary.
Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Clonazepam; Diagnosis, Differential; GABA M | 2014 |
4 other studies available for clonazepam and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
[Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up].
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Cataplexy; C | 2010 |
Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.
Topics: 4-Butyrolactone; Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Evaluation, | 2011 |
Quetiapine and neuroleptic malignant syndrome.
Topics: Adult; Antipsychotic Agents; Clonazepam; Dibenzothiazepines; Drug Therapy, Combination; Humans; Male | 2002 |
Hyponatremia, convulsions and neuroleptic malignant syndrome in a male with schizoaffective disorder.
Topics: Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Therapy, Combination; GABA Mo | 1995 |