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clonazepam and Neuroblastoma

clonazepam has been researched along with Neuroblastoma in 7 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"We have demonstrated high affinity diazepam binding sites of the Ro5-4864 benzodiazepine receptor subtype on 108CC15 neuroblastoma X glioma hybrid cells."3.67Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells. ( Snell, CR; Snell, PH, 1984)
"The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture."3.67Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989)
"We present a child with paraneoplastic opsoclonus myoclonus syndrome who responded well to clonazepam."1.36Clonazepam responsive opsoclonus myoclonus syndrome: additional evidence in favour of fastigial nucleus disinhibition hypothesis? ( Chandra, S; Kalita, J; Misra, UK; Paliwal, VK; Verma, R, 2010)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19903 (42.86)18.7374
1990's1 (14.29)18.2507
2000's2 (28.57)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paliwal, VK1
Chandra, S1
Verma, R1
Kalita, J1
Misra, UK1
Montoya G, JV1
Sutachan, JJ1
Corrales, A1
Xu, F1
Blanck, TJ1
Recio-Pinto, E1
Snell, CR1
Snell, PH1
Diaz, MA1
Vicent, MG1
Madero, L1
Zhu, LP1
Yu, XD1
Ling, S1
Brown, RA1
Kuo, TH1
Larcher, JC1
Vayssiere, JL1
Le Marquer, FJ1
Cordeau, LR1
Keane, PE1
Bachy, A1
Gros, F1
Croizat, BP1
Gorman, AM1
O'Beirne, GB1
Regan, CM1
Williams, DC1

Trials

1 trial available for clonazepam and Neuroblastoma

ArticleYear
High-dose busulfan/melphalan as conditioning for autologous PBPC transplantation in pediatric patients with solid tumors.
    Bone marrow transplantation, 1999, Volume: 24, Issue:11

    Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Agents, Alkylating; Blood Cell Count; Bone Disease

1999

Other Studies

6 other studies available for clonazepam and Neuroblastoma

ArticleYear
Clonazepam responsive opsoclonus myoclonus syndrome: additional evidence in favour of fastigial nucleus disinhibition hypothesis?
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:5

    Topics: Autoantibodies; Cerebellar Cortex; Cerebellar Nuclei; Clonazepam; Efferent Pathways; GABA Modulators

2010
Pulses of extracellular K+ produce two cytosolic Ca2+ transients that display different temperature dependence and carbonyl cyanide m-chlorophenyl sensitivity in SH-SY5Y cells.
    Brain research, 2008, Jun-05, Volume: 1213

    Topics: Anticonvulsants; Caffeine; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; Clo

2008
Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells.
    British journal of pharmacology, 1984, Volume: 83, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Clonazepam; Cy

1984
Mitochondrial Ca(2+)homeostasis in the regulation of apoptotic and necrotic cell deaths.
    Cell calcium, 2000, Volume: 28, Issue:2

    Topics: Animals; Apoptosis; Calcium; Calcium Signaling; Cell Death; Clonazepam; Cyclosporine; Homeostasis; H

2000
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
    European journal of pharmacology, 1989, Feb-28, Volume: 161, Issue:2-3

    Topics: Animals; Benzodiazepines; Cells, Cultured; Clonazepam; Clone Cells; Diazepam; Flumazenil; Isoquinoli

1989
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
    Journal of neurochemistry, 1989, Volume: 53, Issue:3

    Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma

1989