clonazepam has been researched along with Neuroblastoma in 7 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
Excerpt | Relevance | Reference |
---|---|---|
"We have demonstrated high affinity diazepam binding sites of the Ro5-4864 benzodiazepine receptor subtype on 108CC15 neuroblastoma X glioma hybrid cells." | 3.67 | Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells. ( Snell, CR; Snell, PH, 1984) |
"The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
"We present a child with paraneoplastic opsoclonus myoclonus syndrome who responded well to clonazepam." | 1.36 | Clonazepam responsive opsoclonus myoclonus syndrome: additional evidence in favour of fastigial nucleus disinhibition hypothesis? ( Chandra, S; Kalita, J; Misra, UK; Paliwal, VK; Verma, R, 2010) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (42.86) | 18.7374 |
1990's | 1 (14.29) | 18.2507 |
2000's | 2 (28.57) | 29.6817 |
2010's | 1 (14.29) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Paliwal, VK | 1 |
Chandra, S | 1 |
Verma, R | 1 |
Kalita, J | 1 |
Misra, UK | 1 |
Montoya G, JV | 1 |
Sutachan, JJ | 1 |
Corrales, A | 1 |
Xu, F | 1 |
Blanck, TJ | 1 |
Recio-Pinto, E | 1 |
Snell, CR | 1 |
Snell, PH | 1 |
Diaz, MA | 1 |
Vicent, MG | 1 |
Madero, L | 1 |
Zhu, LP | 1 |
Yu, XD | 1 |
Ling, S | 1 |
Brown, RA | 1 |
Kuo, TH | 1 |
Larcher, JC | 1 |
Vayssiere, JL | 1 |
Le Marquer, FJ | 1 |
Cordeau, LR | 1 |
Keane, PE | 1 |
Bachy, A | 1 |
Gros, F | 1 |
Croizat, BP | 1 |
Gorman, AM | 1 |
O'Beirne, GB | 1 |
Regan, CM | 1 |
Williams, DC | 1 |
1 trial available for clonazepam and Neuroblastoma
Article | Year |
---|---|
High-dose busulfan/melphalan as conditioning for autologous PBPC transplantation in pediatric patients with solid tumors.
Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Agents, Alkylating; Blood Cell Count; Bone Disease | 1999 |
6 other studies available for clonazepam and Neuroblastoma
Article | Year |
---|---|
Clonazepam responsive opsoclonus myoclonus syndrome: additional evidence in favour of fastigial nucleus disinhibition hypothesis?
Topics: Autoantibodies; Cerebellar Cortex; Cerebellar Nuclei; Clonazepam; Efferent Pathways; GABA Modulators | 2010 |
Pulses of extracellular K+ produce two cytosolic Ca2+ transients that display different temperature dependence and carbonyl cyanide m-chlorophenyl sensitivity in SH-SY5Y cells.
Topics: Anticonvulsants; Caffeine; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line, Tumor; Clo | 2008 |
Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Clonazepam; Cy | 1984 |
Mitochondrial Ca(2+)homeostasis in the regulation of apoptotic and necrotic cell deaths.
Topics: Animals; Apoptosis; Calcium; Calcium Signaling; Cell Death; Clonazepam; Cyclosporine; Homeostasis; H | 2000 |
Effects of peripheral benzodiazepines upon the O2 consumption of neuroblastoma cells.
Topics: Animals; Benzodiazepines; Cells, Cultured; Clonazepam; Clone Cells; Diazepam; Flumazenil; Isoquinoli | 1989 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |