clonazepam has been researched along with Nervous System Diseases in 10 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam has been considered the treatment of choice for RBD." | 5.32 | Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. ( Boeve, BF; Ferman, TJ; Silber, MH, 2003) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 5.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "Ifosfamide is one of the most efficient antimitotic in soft tissue sarcoma." | 5.08 | [High dose ifosfamide at 15 g/m2/cycle: a feasibility study in 10 patients]. ( Baranzelli, MC; Deligny, N; Demaille, MC; Gourmel, B; N'Guyen, M; Pichon, F, 1997) |
| "Clonazepam has been considered the treatment of choice for RBD." | 1.32 | Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. ( Boeve, BF; Ferman, TJ; Silber, MH, 2003) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 1.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sangla, S | 1 |
| Tranchant, C | 1 |
| Boeve, BF | 1 |
| Silber, MH | 1 |
| Ferman, TJ | 1 |
| Keränen, T | 1 |
| Sivenius, J | 1 |
| Erer, B | 1 |
| Polchi, P | 1 |
| Lucarelli, G | 1 |
| Angelucci, E | 1 |
| Baronciani, D | 1 |
| Galimberti, M | 1 |
| Giardini, C | 1 |
| Gaziev, D | 1 |
| Maiello, A | 1 |
| Baranzelli, MC | 1 |
| Pichon, F | 1 |
| Gourmel, B | 1 |
| N'Guyen, M | 1 |
| Deligny, N | 1 |
| Demaille, MC | 1 |
| Rella, JG | 1 |
| Hoffman, RS | 1 |
| Meloni, G | 1 |
| Raucci, U | 1 |
| Pinto, RM | 1 |
| Spalice, A | 1 |
| Vignetti, M | 1 |
| Iannetti, P | 1 |
| Lloyd, GK | 1 |
| Lowenthal, A | 1 |
| Javoy-Agid, F | 1 |
| Constantidinis, J | 1 |
| Greene, P | 1 |
| Shale, H | 1 |
| Fahn, S | 1 |
| Andermann, F | 1 |
| Andermann, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic REM Sleep Behavior Disorder: a Pilot Study[NCT02836743] | Phase 4 | 30 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | ||
| Efficacy and Tolerability of Ramelteon in Patients With REM Behavior Disorder and Parkinsonism: A Placebo Controlled, Double Blind, Randomized, Prospective Pilot Study[NCT00745030] | 3 participants (Actual) | Interventional | 2008-06-30 | Terminated (stopped due to Low subject recruitment and enrollment.) | |||
| A Single Center, Open Label Prospective Observational Pilot Study to Evaluate the Effects of Tasimelteon in Participants With REM Behavior Disorder (RBD)[NCT05922995] | Early Phase 1 | 20 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonazepam and Nervous System Diseases
| Article | Year |
|---|---|
[Writer's cramp].
Topics: Botulinum Toxins, Type A; Clonazepam; Combined Modality Therapy; Cumulative Trauma Disorders; Diagno | 2009 |
Excessive startle syndromes: startle disease, jumping, and startle epilepsy.
Topics: Clonazepam; Diagnosis, Differential; Echolalia; Electroencephalography; Electromyography; Epilepsy; | 1986 |
1 trial available for clonazepam and Nervous System Diseases
| Article | Year |
|---|---|
[High dose ifosfamide at 15 g/m2/cycle: a feasibility study in 10 patients].
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Clonazepam; Dose-Response Relations | 1997 |
7 other studies available for clonazepam and Nervous System Diseases
| Article | Year |
|---|---|
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients.
Topics: Adult; Aged; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resist | 2003 |
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li | 1983 |
CsA-associated neurotoxicity and ineffective prophylaxis with clonazepam in patients transplanted for thalassemia major: analysis of risk factors.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; beta-Thalassemia; Blood | 1996 |
Possible serotonin syndrome from paroxetine and clonazepam.
Topics: Adult; Clonazepam; Contraindications; Drug Interactions; Female; GABA Modulators; Humans; Nervous Sy | 1998 |
Pretransplant conditioning with busulfan and cyclophosphamide in acute leukemia patients: neurological and electroencephalographic prospective study.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Barbiturates; Bone | 1992 |
GABAA receptor complex function in frontal cortex membranes from control and neurological patients.
Topics: Adult; Aged; Alzheimer Disease; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; | 1991 |
Experience with high dosages of anticholinergic and other drugs in the treatment of torsion dystonia.
Topics: Age Factors; Baclofen; Clonazepam; Dystonia Musculorum Deformans; Humans; Nervous System Diseases; P | 1988 |