clonazepam has been researched along with Narcolepsy in 4 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Narcolepsy: A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compare drug-free iRBD patients to both normal controls and drug-free patients with narcolepsy/RBD and evaluate the changes following the long-term use of bedtime clonazepam." | 3.79 | Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder. ( Ferini-Strambi, L; Ferri, R; Marelli, S; Plazzi, G; Schenck, CH; Zucconi, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferri, R | 1 |
| Zucconi, M | 1 |
| Marelli, S | 1 |
| Plazzi, G | 1 |
| Schenck, CH | 2 |
| Ferini-Strambi, L | 1 |
| Billiard, M | 1 |
| Schuld, A | 1 |
| Kraus, T | 1 |
| Haack, M | 1 |
| Hinze-Selch, D | 1 |
| Pollmächer, T | 1 |
| Mahowald, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Redictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study [FAttori di Rischio PREdittivi di Conversione Nell'RBD Idiopatico. STudio ItalianO[NCT05262543] | 300 participants (Anticipated) | Observational | 2020-05-25 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonazepam and Narcolepsy
| Article | Year |
|---|---|
REM sleep behavior disorder and narcolepsy.
Topics: Antidepressive Agents; Cataplexy; Clonazepam; Humans; Melatonin; Narcolepsy; Polysomnography; Preval | 2009 |
REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Chronic Disease; Clonazepam; Diagnosis, Differential; Elec | 2002 |
2 other studies available for clonazepam and Narcolepsy
| Article | Year |
|---|---|
Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder.
Topics: Aged; Chin; Clonazepam; Facial Muscles; Female; GABA Modulators; Humans; Male; Middle Aged; Narcolep | 2013 |
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder.
Topics: Anticonvulsants; Clonazepam; Humans; Male; Middle Aged; Narcolepsy; Polysomnography; REM Sleep Behav | 1999 |