Page last updated: 2024-10-25

clonazepam and Multiple Sclerosis

clonazepam has been researched along with Multiple Sclerosis in 9 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)

Research Excerpts

ExcerptRelevanceReference
"25 patients with multiple sclerosis (MS) and other spastic disorders, 33 MS patients and 10 control patients with MS were given clonazepam, baclofen or placebo over a period of 5 days to 20 weeks."5.04Clonazepam, baclofen and placebo in the treatment of spasticity. ( Cendrowski, W; Sobczyk, W, 1977)
"Secondary paroxysmal dyskinesias (SPDs) are short, episodic, and recurrent movement disorders, classically related to multiple sclerosis (MS)."1.46Secondary paroxysmal dyskinesia in multiple sclerosis: Clinical-radiological features and treatment. Case report of seven patients. ( Cárcamo-Rodríguez, C; Ciampi, E; Cruz, JP; Godoy-Santín, J; Juri, C; Uribe-San-Martín, R, 2017)
"The head tremor was the so-called "yes-yes" type which shakes back and forth."1.37[Case of multiple sclerosis with "yes-yes" type head tremor]. ( Itoyama, Y; Izumi, R; Nagata, M; Nakashima, I; Nishiyama, S; Omata, K; Suzuki, N, 2011)
"A patient representing with palatal myoclonus was diagnosed as suffering from possible multiple sclerosis."1.26[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam]. ( Baxter, DW; Gauthier, S; Young, SN, 1981)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19904 (44.44)18.7374
1990's1 (11.11)18.2507
2000's2 (22.22)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ciampi, E1
Uribe-San-Martín, R1
Godoy-Santín, J1
Cruz, JP1
Cárcamo-Rodríguez, C1
Juri, C1
Omata, K1
Suzuki, N1
Izumi, R1
Nagata, M1
Nishiyama, S1
Nakashima, I1
Itoyama, Y1
Sarrigiannis, P1
Tsakanicas, C1
Anagnostouli, M1
Karandreas, N1
Gauthier, S1
Young, SN1
Baxter, DW1
Bolden, RO1
Felsenthal, G1
Cohen, BS1
Inobe, J1
Arakawa, T1
Mori, T1
Kumamoto, T1
Tsuda, T1
Cendrowski, W1
Sobczyk, W1
Smith, CR1
Scheinberg, L1
Goldsmith, MF1

Trials

1 trial available for clonazepam and Multiple Sclerosis

ArticleYear
Clonazepam, baclofen and placebo in the treatment of spasticity.
    European neurology, 1977, Volume: 16, Issue:1-6

    Topics: Adolescent; Adult; Aged; Aminobutyrates; Baclofen; Benzodiazepinones; Clinical Trials as Topic; Clon

1977

Other Studies

8 other studies available for clonazepam and Multiple Sclerosis

ArticleYear
Secondary paroxysmal dyskinesia in multiple sclerosis: Clinical-radiological features and treatment. Case report of seven patients.
    Multiple sclerosis (Houndmills, Basingstoke, England), 2017, Volume: 23, Issue:13

    Topics: Acetazolamide; Adult; Anticonvulsants; Cerebellum; Clonazepam; Dyskinesias; Dystonia; Female; Follow

2017
[Case of multiple sclerosis with "yes-yes" type head tremor].
    Rinsho shinkeigaku = Clinical neurology, 2011, Volume: 51, Issue:4

    Topics: Adult; Anticonvulsants; Cervical Vertebrae; Clonazepam; Female; Head; Humans; Magnetic Resonance Ima

2011
Spastic paretic hemifacial contracture (SPHC) in a patient with multiple sclerosis. A clinical, EMG and neuroimaging study.
    Neurophysiologie clinique = Clinical neurophysiology, 2004, Volume: 34, Issue:3-4

    Topics: Adult; Amines; Baclofen; Blinking; Brain; Clonazepam; Cyclohexanecarboxylic Acids; Electromyography;

2004
[Palatal myoclonus associated with a decrease in 5-hydroxy-indole acetic acid in cerebrospinal fluid and responding to clonazepam].
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1981, Volume: 8, Issue:1

    Topics: Benzodiazepinones; Clonazepam; Female; Humans; Hydroxyindoleacetic Acid; Middle Aged; Multiple Scler

1981
Tonic seizures in a patient with multiple sclerosis.
    Maryland state medical journal, 1980, Volume: 29, Issue:1

    Topics: Carbamazepine; Clonazepam; Female; Humans; Middle Aged; Multiple Sclerosis; Phenytoin; Seizures

1980
[Acquired pendular nystagmus associated with the lesion of tegmentum mesencephali in a patient with probable multiple sclerosis].
    Rinsho shinkeigaku = Clinical neurology, 2000, Volume: 40, Issue:10

    Topics: Adult; Brain Diseases; Clonazepam; Diazepam; Female; gamma-Aminobutyric Acid; Humans; Multiple Scler

2000
Coincidence of myoclonus and multiple sclerosis: dramatic response to clonazepam.
    Neurology, 1990, Volume: 40, Issue:10

    Topics: Clonazepam; Female; Humans; Middle Aged; Multiple Sclerosis; Myoclonus

1990
Several research avenues may improve understanding of multiple sclerosis.
    JAMA, 1988, Jul-08, Volume: 260, Issue:2

    Topics: Clonazepam; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Restless Legs Syndrome; Se

1988