clonazepam has been researched along with Machado-Joseph Disease in 2 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Machado-Joseph Disease: A dominantly-inherited ATAXIA first described in people of Azorean and Portuguese descent, and subsequently identified in Brazil, Japan, China, and Australia. This disorder is classified as one of the SPINOCEREBELLAR ATAXIAS (Type 3) and has been associated with a mutation of the MJD1 gene on chromosome 14. Clinical features include progressive ataxia, DYSARTHRIA, postural instability, nystagmus, eyelid retraction, and facial FASCICULATIONS. DYSTONIA is prominent in younger patients (referred to as Type I Machado-Joseph Disease). Type II features ataxia and ocular signs; Type III features MUSCULAR ATROPHY and a sensorimotor neuropathy; and Type IV features extrapyramidal signs combined with a sensorimotor neuropathy. (From Clin Neurosci 1995;3(1):17-22; Ann Neurol 1998 Mar;43(3):288-96)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We diagnosed him with Machado-Joseph disease according to the genetic test." | 1.48 | Tremor during orthostatism as the initial symptom of Machado-Joseph disease. ( Kano, T; Matsushima, M; Naganuma, R; Sasaki, H; Sato, C; Shirai, S; Takahashi, I; Yabe, I, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shirai, S | 1 |
| Yabe, I | 1 |
| Naganuma, R | 1 |
| Sato, C | 1 |
| Takahashi, I | 1 |
| Matsushima, M | 1 |
| Kano, T | 1 |
| Sasaki, H | 1 |
| Syed, BH | 1 |
| Rye, DB | 1 |
| Singh, G | 1 |
2 other studies available for clonazepam and Machado-Joseph Disease
| Article | Year |
|---|---|
Tremor during orthostatism as the initial symptom of Machado-Joseph disease.
Topics: Clonazepam; Electromyography; Humans; Machado-Joseph Disease; Male; Middle Aged; Pedigree; Treatment | 2018 |
REM sleep behavior disorder and SCA-3 (Machado-Joseph disease).
Topics: Clonazepam; Electromyography; GABA Modulators; Humans; Machado-Joseph Disease; Male; Middle Aged; Mo | 2003 |