clonazepam has been researched along with Hypermyotonia in 12 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with clonazepam was effective in relieving these manifestations in the affected infants and children." | 1.28 | Hyperekplexia: pedigree studies in two families. ( Hayashi, T; Kajii, T; Tachibana, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bakker, MJ | 1 |
| Peeters, EA | 1 |
| Tijssen, MA | 1 |
| Zhou, L | 1 |
| Chillag, KL | 1 |
| Nigro, MA | 1 |
| Gaitatzis, A | 1 |
| Kartsounis, LD | 1 |
| Gacinovic, S | 1 |
| Costa, DC | 1 |
| Harvey, K | 1 |
| Harvey, RJ | 1 |
| de Silva, RN | 1 |
| Shahar, E | 1 |
| Raviv, R | 1 |
| Rivera, S | 1 |
| Villega, F | 1 |
| de Saint-Martin, A | 1 |
| Matis, J | 1 |
| Escande, B | 1 |
| Chaigne, D | 1 |
| Astruc, D | 1 |
| Schlapbach, LJ | 1 |
| Sozzo, A | 1 |
| Ramelli, G | 1 |
| Bianchetti, MG | 1 |
| Doria Lamba, L | 1 |
| Giribaldi, G | 1 |
| De Negri, E | 1 |
| Follo, R | 1 |
| De Grandis, E | 1 |
| Pintaudi, M | 1 |
| Veneselli, E | 1 |
| Leventer, RJ | 1 |
| Hopkins, IJ | 1 |
| Shield, LK | 1 |
| Lobera, E | 1 |
| Campistol, J | 1 |
| García-García, JJ | 1 |
| Colomer, J | 1 |
| Riverola, A | 1 |
| Miller, VS | 1 |
| Ryan, SG | 1 |
| Sherman, SL | 1 |
| Terry, JC | 1 |
| Sparkes, RS | 1 |
| Torres, MC | 1 |
| Mackey, RW | 1 |
| Hayashi, T | 1 |
| Tachibana, H | 1 |
| Kajii, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Mutations of the Glycine Gene Associated With Hyperekplexia on Central Pain Processing[NCT01476514] | 9 participants (Actual) | Interventional | 2011-10-31 | Terminated (stopped due to Recruitment problems) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonazepam and Hypermyotonia
| Article | Year |
|---|---|
Hyperekplexia: a treatable neurogenetic disease.
Topics: Animals; Clonazepam; GABA Modulators; Humans; Models, Animal; Muscle Hypertonia; Mutation; Receptors | 2002 |
Frontal lobe dysfunction in sporadic hyperekplexia--case study and literature review.
Topics: Adult; Anticonvulsants; Brain Diseases; Clonazepam; DNA Mutational Analysis; Electroencephalography; | 2004 |
10 other studies available for clonazepam and Hypermyotonia
| Article | Year |
|---|---|
Clonazepam is an effective treatment for hyperekplexia due to a SLC6A5 (GlyT2) mutation.
Topics: Anticonvulsants; Child; Clonazepam; Electromyography; GABA Plasma Membrane Transport Proteins; Human | 2009 |
Sporadic major hyperekplexia in neonates and infants: clinical manifestations and outcome.
Topics: Anticonvulsants; Benzodiazepines; Clobazam; Clonazepam; Early Diagnosis; Follow-Up Studies; Humans; | 2004 |
Congenital hyperekplexia: five sporadic cases.
Topics: Anticonvulsants; Baths; Clonazepam; Female; Humans; Infant, Newborn; Male; Muscle Hypertonia; Noise; | 2006 |
Severe normotensive metabolic alkalosis in a 2-month-old boy with hyperekplexia.
Topics: Alkalosis; Bicarbonates; Body Weight; Chlorides; Clonazepam; Family Health; Female; Hernia; Humans; | 2006 |
A case of major form familial hyperekplexia: prenatal diagnosis and effective treatment with clonazepam.
Topics: Anticonvulsants; Child, Preschool; Clonazepam; Family Health; Female; Glutamic Acid; Humans; Lysine; | 2007 |
Hyperekplexia as cause of abnormal intrauterine movements.
Topics: Adult; Apnea; Clonazepam; Female; Fetal Diseases; Humans; Infant, Newborn; Muscle Hypertonia; Pregna | 1995 |
[Congenital hyperekplexia as a cause of neonatal hypertonia].
Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Humans; Infant; Male; Muscle Hypertonia; Refle | 1997 |
Hypertonia, hyperreflexia, and excessive startle response in a neonate.
Topics: Anticonvulsants; Clonazepam; Female; Humans; Infant, Newborn; Muscle Hypertonia; Reflex, Abnormal; R | 1999 |
Startle disease, or hyperekplexia: response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis.
Topics: Adult; Child, Preschool; Chromosomes, Human, Pair 5; Clonazepam; Female; Genes, Dominant; Genetic Ma | 1992 |
Hyperekplexia: pedigree studies in two families.
Topics: Adolescent; Adult; Aged; Asian People; Child; Child, Preschool; Clonazepam; Female; Genes, Dominant; | 1991 |