clonazepam has been researched along with Glioma in 11 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Acute seizures were treated with intranasal midazolam." | 3.83 | Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study. ( Heimans, JJ; Koekkoek, JA; Postma, TJ; Reijneveld, JC; Taphoorn, MJ, 2016) |
| " To elucidate the biological role of the PBD receptor on mitochondria, we examined the effect of PBDs on mitochondrial morphology in C6 and T98G glioma cells using rhodamine 123 and quantitative electron microscopy." | 3.68 | Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells. ( Becker, DP; Black, KL; Ikezaki, K; Shiraishi, T, 1991) |
| "We have demonstrated high affinity diazepam binding sites of the Ro5-4864 benzodiazepine receptor subtype on 108CC15 neuroblastoma X glioma hybrid cells." | 3.67 | Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells. ( Snell, CR; Snell, PH, 1984) |
| "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
| "The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay." | 3.67 | Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988) |
| "In patients with high-grade glioma seizures occur relatively frequently during the end-of-life phase." | 1.40 | [Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase]. ( Boddaert, MS; Koekkoek, JA; Taphoorn, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koekkoek, JA | 2 |
| Boddaert, MS | 1 |
| Taphoorn, M | 1 |
| Postma, TJ | 1 |
| Heimans, JJ | 1 |
| Reijneveld, JC | 1 |
| Taphoorn, MJ | 1 |
| Snell, CR | 1 |
| Snell, PH | 1 |
| Zlobina, GP | 1 |
| Kondakova, LI | 1 |
| Khalansky, AS | 1 |
| Ikezaki, K | 3 |
| Nomura, T | 1 |
| Takahashi, M | 1 |
| Fritz-Zieroth, B | 1 |
| Inamura, T | 1 |
| Fukui, M | 1 |
| Szücs, A | 1 |
| Bódizs, R | 1 |
| Barsi, P | 1 |
| Halász, P | 1 |
| Selleri, S | 1 |
| Bruni, F | 1 |
| Costagli, C | 1 |
| Costanzo, A | 1 |
| Guerrini, G | 1 |
| Ciciani, G | 1 |
| Costa, B | 1 |
| Martini, C | 1 |
| Shiraishi, T | 1 |
| Black, KL | 2 |
| Becker, DP | 1 |
| Toga, AW | 1 |
| Gorman, AM | 1 |
| O'Beirne, GB | 1 |
| Regan, CM | 1 |
| Williams, DC | 1 |
| Pawlikowski, M | 1 |
| Kunert-Radek, J | 1 |
| Radek, A | 1 |
| Stepien, H | 1 |
11 other studies available for clonazepam and Glioma
| Article | Year |
|---|---|
[Gliomas: fighting until the end against epilepsy; administration of antiepileptic drugs in the end-of-life phase].
Topics: Anticonvulsants; Clonazepam; Epilepsy; Glioma; Humans; Midazolam; Seizures; Terminal Care | 2014 |
Antiepileptic drug treatment in the end-of-life phase of glioma patients: a feasibility study.
Topics: Administration, Buccal; Administration, Intranasal; Aged; Brain Neoplasms; Clonazepam; Feasibility S | 2016 |
Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Clonazepam; Cy | 1984 |
Specific binding of [3H]diazepam in mouse glioblastoma: the influence of clonazepam and Ro 5-4864 on [3H]diazepam binding.
Topics: Animals; Benzodiazepinones; Binding Sites; Cell Line; Clonazepam; Diazepam; Glioma; Mice; Neuroglia | 1984 |
Selective and prolonged MRI enhancement by Mn-TPPS in an experimental rat brain tumour with peripheral benzodiazepine receptors.
Topics: Animals; Brain Neoplasms; Clonazepam; Contrast Media; Glioma; Isoquinolines; Kidney; Magnetic Resona | 1994 |
Insomnia and fronto-basal tumor: a case report.
Topics: Brain Neoplasms; Clonazepam; Frontal Lobe; GABA Modulators; Glioma; Humans; Male; Middle Aged; Sleep | 2001 |
2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands.
Topics: Acetamides; Animals; Benzodiazepinones; Binding Sites; Cerebral Cortex; Clonazepam; Flumazenil; Glio | 2001 |
Peripheral benzodiazepine induces morphological changes and proliferation of mitochondria in glioma cells.
Topics: Animals; Benzodiazepinones; Cell Line; Clonazepam; Culture Media, Serum-Free; Fluorescent Dyes; Glio | 1991 |
Imaging of brain tumors using peripheral benzodiazepine receptor ligands.
Topics: Animals; Autoradiography; Brain Neoplasms; Clonazepam; Female; Flunitrazepam; Glioma; Image Processi | 1989 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz | 1988 |