clonazepam has been researched along with Epilepsy, Tonic-Clonic in 36 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 7.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 7.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Both cortical and hippocampal EEG seizures was extremely poor in this model." | 5.29 | Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. ( Mareś, P; Velísek, L, 1995) |
| "During her first pregnancy, a 37-year-old woman with idiopathic generalised epilepsy that was adequately controlled with lamotrigine experienced a series of epileptic seizures following an elective caesarean section." | 3.73 | [Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy]. ( Bloem, BR; Renier, WO; Voermans, NC; Zwarts, MJ, 2005) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 3.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 3.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| "An extreme example is Dravet syndrome (DS), an infantile-onset severe epilepsy caused by heterozygous loss of function mutations in SCN1A, the gene encoding the brain type-I voltage-gated sodium channel NaV1." | 1.39 | Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome. ( Catterall, WA; Cheah, CS; Cho, AR; Oakley, JC; Scheuer, T, 2013) |
| "Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide." | 1.35 | Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009) |
| "The treatment with valproic acid (VPA) and clonazepam (CZP), has been very effective." | 1.30 | [Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients]. ( Bauzano-Poley, E; Delgado-Marqués, MP; Mora-Ramírez, MD; Rodríguez-Barrionuevo, AC; Tosina-García, E, 1998) |
| "Juvenile myoclonic epilepsy is a relatively common, though under diagnosed, form of epilepsy that commences in adolescence." | 1.29 | Juvenile myoclonic epilepsy. ( Buchanan, N, 1995) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epilepsy with age-related onset of symptoms." | 1.29 | Diagnosing juvenile myoclonic epilepsy in an elderly patient. ( Grünewald, RA; Panayiotopoulos, CP, 1994) |
| "Both cortical and hippocampal EEG seizures was extremely poor in this model." | 1.29 | Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures. ( Mareś, P; Velísek, L, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (52.78) | 18.7374 |
| 1990's | 10 (27.78) | 18.2507 |
| 2000's | 6 (16.67) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oakley, JC | 1 |
| Cho, AR | 1 |
| Cheah, CS | 1 |
| Scheuer, T | 1 |
| Catterall, WA | 1 |
| Crespel, A | 1 |
| Velizarova, R | 1 |
| Genton, P | 1 |
| Coubes, P | 1 |
| Gélisse, P | 1 |
| Wheless, JW | 1 |
| Voermans, NC | 1 |
| Zwarts, MJ | 1 |
| Renier, WO | 1 |
| Bloem, BR | 1 |
| Bilo, L | 1 |
| Meo, R | 1 |
| Fulvia de Leva, M | 1 |
| Rosoff, DM | 1 |
| Forsythe, WI | 1 |
| Sills, MA | 1 |
| Reynolds, EH | 1 |
| Shorvon, SD | 1 |
| Singh, AN | 1 |
| Le Morvan, P | 1 |
| Buchanan, N | 1 |
| Hirvasniemi, A | 1 |
| Herrala, P | 1 |
| Leisti, J | 1 |
| Duval, X | 1 |
| Chosidow, O | 1 |
| Semah, F | 1 |
| Lipsker, D | 1 |
| Francès, C | 1 |
| Herson, S | 1 |
| Primavera, A | 1 |
| Giberti, L | 1 |
| Scotto, P | 1 |
| Cocito, L | 1 |
| Grünewald, RA | 1 |
| Panayiotopoulos, CP | 1 |
| Velísek, L | 1 |
| Mareś, P | 1 |
| Rodríguez-Barrionuevo, AC | 1 |
| Bauzano-Poley, E | 1 |
| Delgado-Marqués, MP | 1 |
| Mora-Ramírez, MD | 1 |
| Tosina-García, E | 1 |
| Miura, Y | 1 |
| Amano, S | 1 |
| Torii, R | 1 |
| Ihara, N | 1 |
| Browne, TR | 2 |
| Borgheresi, S | 1 |
| Luti, E | 1 |
| Mecherini, L | 1 |
| Buti Cossi, D | 1 |
| Bardini, MR | 1 |
| Lance, JW | 2 |
| Anthony, M | 2 |
| Roussounis, SH | 1 |
| de Rudolf, N | 1 |
| Fazio, C | 1 |
| Manfredi, M | 1 |
| Piccinelli, A | 1 |
| Mikkelsen, B | 3 |
| Birket-Smith, E | 3 |
| Holm, P | 2 |
| Lund, M | 1 |
| Vestermark, S | 2 |
| Olsen, PZ | 2 |
| Richens, A | 1 |
| Bradt, S | 1 |
| Lung, M | 1 |
| Thorn, I | 1 |
| Bang, F | 1 |
| Mazzini, L | 1 |
| Galante, M | 1 |
| Rezzonico, M | 1 |
| Kokodoko, A | 1 |
| Mordel, A | 1 |
| Winkler, E | 1 |
| Almog, S | 1 |
| Tirosh, M | 1 |
| Ezra, D | 1 |
| Liukkonen, J | 1 |
| Koponen, HJ | 1 |
| Nousiainen, U | 1 |
| Wong, T | 1 |
| Tiessen, E | 1 |
| Medici, V | 1 |
| Roth, F | 1 |
| Keller, HP | 1 |
| Fröscher, W | 1 |
| Stoll, KD | 1 |
| Edwards, VE | 1 |
2 reviews available for clonazepam and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche | 2003 |
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
3 trials available for clonazepam and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Clonazepam.
Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies, | 1978 |
A controlled trial on clonazepam INN (Ro 5-4023, Rivotril (R)) in the treatment of focal epilepsy and secondary generalized grand mal epilepsy.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clona | 1975 |
Clonazepam in the treatment of epilepsy. A controlled clinical trial in simple absences, bilateral massive epileptic myoclonus, and atonic seizures.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; | 1976 |
31 other studies available for clonazepam and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
Synergistic GABA-enhancing therapy against seizures in a mouse model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Synergism; Epilepsies, | 2013 |
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera | 2009 |
[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy].
Topics: Adult; Anticonvulsants; Cesarean Section; Clonazepam; Diazepam; Epilepsy; Epilepsy, Generalized; Epi | 2005 |
Levetiracetam in idiopathic generalised epilepsy and porphyria cutanea tarda.
Topics: Administration, Oral; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Epilepsy, Tonic-Clonic | 2006 |
Another case of extended-release bupropion-induced seizure.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Bupropion; Clonazepam; Delayed-Act | 2008 |
One drug for childhood grand mal: medical audit for three-year remissions.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Epilepsy, Tonic-Clo | 1984 |
Monotherapy or polytherapy for epilepsy?
Topics: Adolescent; Adult; Carbamazepine; Clonazepam; Drug Combinations; Drug Interactions; Drug Therapy, Co | 1981 |
Treatment of status epilepticus with intravenous clonazepam.
Topics: Adult; Benzodiazepinones; Clonazepam; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cl | 1982 |
Juvenile myoclonic epilepsy.
Topics: Adolescent; Age of Onset; Animals; Anticonvulsants; Child; Circadian Rhythm; Clonazepam; Cricetinae; | 1995 |
Northern epilepsy syndrome: clinical course and the effect of medication on seizures.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Central Nervous System Diseases; Chil | 1995 |
Lamotrigine versus carbamazepine in epilepsy.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1995 |
Nonconvulsive status epilepticus as a cause of confusion in later life: a report of 5 cases.
Topics: Aged; Cerebral Cortex; Clonazepam; Confusion; Diagnosis, Differential; Epilepsy, Absence; Epilepsy, | 1994 |
Diagnosing juvenile myoclonic epilepsy in an elderly patient.
Topics: Aged; Clonazepam; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; E | 1994 |
Age-dependent anticonvulsant action of clonazepam in the N-methyl-D-aspartate model of seizures.
Topics: Aging; Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Electroencephalography; Epilepsy, Ton | 1995 |
[Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Electroencephalography; Epilepsies, Pa | 1998 |
Clobazam shows a different antiepileptic action profile from clonazepam and zonisamide in Ihara epileptic rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Circadian Rhythm; Clobazam; Clonazep | 2002 |
[Primary generalized epilepsy in childhood. Clinico-statistical study].
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsy, | 1979 |
Sodium valproate and clonazepam in the treatment of intractable epilepsy.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Drug Evaluation; Epilepsy; Epilepsy, Absenc | 1977 |
Clonazepam in the treatment of children with intractable seizures.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Drug Therapy, C | 1977 |
Treatment of epileptic seizures with clonazepam. A reappraisal.
Topics: Administration, Oral; Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Drug Administ | 1975 |
Sensible prescribing. XI.--Juvenile and adult epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile | 1975 |
Sodium valproate in the management of intractable epilepsy: comparison with clonazepam.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Epilepsy, Tonic-Clonic; Female; H | 1975 |
Clonazepam in the treatment of epilepsy. A clinical long-term follow-up study.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Ep | 1976 |
Methylbromide intoxication: a case report.
Topics: Adult; Carbidopa; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclon | 1992 |
Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose.
Topics: Adult; Clonazepam; Diazepam; Drug Overdose; Epilepsy, Tonic-Clonic; Female; Flumazenil; Humans; Imip | 1992 |
Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment.
Topics: Adult; Carbamazepine; Clonazepam; Clozapine; Electroencephalography; Epilepsies, Myoclonic; Epilepsy | 1992 |
Seizure in gradual clonazepam withdrawal.
Topics: Adult; Clonazepam; Epilepsy, Tonic-Clonic; Humans; Male; Substance Withdrawal Syndrome; Tourette Syn | 1989 |
[Grand mal seizures and status epilepticus in general practice-- what's to be done?].
Topics: Adult; Aged; Child, Preschool; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Family Pra | 1986 |
[Clinical treatment of grand mal epileptic status in adults].
Topics: Adult; Barbiturates; Chlormethiazole; Clonazepam; Diazepam; Emergencies; Epilepsy, Tonic-Clonic; Hum | 1986 |
[Antiepileptic monotherapy and combination therapy of simple focal seizures].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Ele | 1985 |
Side effects of clonazepam therapy.
Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E | 1974 |