clonazepam has been researched along with Epilepsy, Temporal Lobe in 39 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 9.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 7.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 7.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "The ED50 for suppression of behavioral seizures was 6." | 5.36 | Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. ( Reddy, DS; Rogawski, MA, 2010) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 5.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| " Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy." | 4.76 | [Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983) |
| " Adjunctive treatment with clonazepam resulted in the cessation of the seizures and of persistent, violent hallucinations." | 3.67 | Antiaggressive effect of adjunctive clonazepam in schizophrenia associated with seizure disorder. ( Keats, MM; Mukherjee, S, 1988) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 3.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 3.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Clonazepam, an antiepileptic benzodiazepine derivative was administered into 30 patients mainly with incurable type epilepsy." | 3.65 | [Antiepileptic activity of clonazepam--an antiepileptic benzodiazepine derivative]. ( Iwata, T; Kato, H; Mori, T; Moriuchi, I; Yoshimura, T, 1976) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| "The ED50 for suppression of behavioral seizures was 6." | 1.36 | Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. ( Reddy, DS; Rogawski, MA, 2010) |
| "Carbamazepine was progressively withdrawn and the patient was progressively switched to zonisamide." | 1.35 | Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation. ( Coubes, P; Crespel, A; Gélisse, P; Genton, P; Velizarova, R, 2009) |
| "Treatment with clonazepam in addition to sodium valproate resulted in a remarkable improvement of clinical symptoms (i." | 1.31 | A case of temporal lobe epilepsy with improvement of clinical symptoms and single photon emission computed tomography findings after treatment with clonazepam. ( Ide, M; Mizukami, K; Shiraishi, H; Suzuki, T, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (76.92) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 5 (12.82) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crespel, A | 1 |
| Velizarova, R | 1 |
| Genton, P | 1 |
| Coubes, P | 1 |
| Gélisse, P | 1 |
| Reddy, DS | 1 |
| Rogawski, MA | 1 |
| Klitgaard, H | 1 |
| Matagne, A | 1 |
| Grimee, R | 1 |
| Vanneste-Goemaere, J | 1 |
| Margineanu, DG | 1 |
| Ros, LT | 1 |
| Goforth, HW | 1 |
| Rao, M | 1 |
| Sucholeiki, R | 1 |
| Loiseau, P | 1 |
| Schmidt, D | 1 |
| Murasaki, M | 2 |
| Okamoto, K | 2 |
| Takahashi, A | 2 |
| Nagai, T | 1 |
| Sironi, VA | 2 |
| Miserocchi, G | 1 |
| De Riu, PL | 1 |
| Boldyrev, AI | 1 |
| Singh, AN | 1 |
| Le Morvan, P | 1 |
| Mikkelsen, B | 2 |
| Berggreen, P | 1 |
| Joensen, P | 1 |
| Kristensen, O | 1 |
| Køhler, O | 1 |
| Mikkelsen, BO | 1 |
| Kriel, RL | 1 |
| Cloyd, J | 1 |
| Andersson, B | 1 |
| Kennebäck, G | 1 |
| Persson, A | 1 |
| Valdimarsson, E | 1 |
| Inami, M | 1 |
| Muraoka, H | 1 |
| Sumiyoshi, A | 1 |
| Yamazumi, S | 1 |
| Gibbs, JW | 1 |
| Shumate, MD | 1 |
| Coulter, DA | 1 |
| Ide, M | 1 |
| Mizukami, K | 1 |
| Suzuki, T | 2 |
| Shiraishi, H | 1 |
| Browne, TR | 2 |
| Aucamp, AK | 1 |
| Lance, JW | 1 |
| Anthony, M | 1 |
| Roussounis, SH | 1 |
| de Rudolf, N | 1 |
| Bensch, J | 1 |
| Blennow, G | 1 |
| Ferngren, H | 1 |
| Gamstorp, I | 1 |
| Herrlin, KM | 1 |
| Kubista, J | 1 |
| Arvidsson, A | 1 |
| Dahlström, H | 1 |
| Nanda, RN | 1 |
| Johnson, RH | 1 |
| Keogh, HJ | 1 |
| Lambie, DG | 1 |
| Melville, ID | 1 |
| Yamauchi, T | 1 |
| Hirabayashi, Y | 1 |
| Kataoka, N | 1 |
| Nishihori, K | 1 |
| Kobayashi, Y | 1 |
| Murata, T | 1 |
| Kobayashi, R | 1 |
| Takahashi, S | 1 |
| Mohri, Y | 1 |
| Franzini, A | 1 |
| Ravagnati, L | 1 |
| Marossero, F | 1 |
| Richens, A | 1 |
| Bang, F | 1 |
| Birket-Smith, E | 1 |
| Kato, H | 1 |
| Mori, T | 1 |
| Moriuchi, I | 1 |
| Yoshimura, T | 1 |
| Iwata, T | 1 |
| Masland, RL | 1 |
| Takahashi, K | 1 |
| Saito, M | 1 |
| Kyo, K | 1 |
| Gomibuchi, K | 1 |
| Niijima, S | 1 |
| Tada, H | 1 |
| Honda, T | 1 |
| Sato, Y | 1 |
| Takahashi, H | 1 |
| Ohtsuka, C | 1 |
| McNamara, ME | 1 |
| Fogel, BS | 1 |
| Tachibana, N | 1 |
| Sugita, Y | 1 |
| Teshima, Y | 1 |
| Hishikawa, Y | 1 |
| Rennert, H | 1 |
| Larrieu, JL | 2 |
| Lagueny, A | 2 |
| Ferrer, X | 1 |
| Julien, J | 2 |
| Garbutt, JC | 1 |
| Gillette, GM | 1 |
| Keats, MM | 1 |
| Mukherjee, S | 1 |
| Frykholm, B | 1 |
3 reviews available for clonazepam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
[Benzodiazepines in the treatment of epilepsy].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam | 1983 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
5 trials available for clonazepam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Carbamazepine; Child; Clinical Trials as Topic; Clonazep | 1981 |
Clonazepam.
Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies, | 1978 |
A double-blind study of clonazepam in the treatment of therapy-resistant epilepsy in children.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Drug E | 1977 |
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
Topics: Adolescent; Adult; Ambulatory Care; Benzodiazepinones; Brain; Child; Clinical Trials as Topic; Clona | 1977 |
A controlled trial of clonazepam in temporal lobe, epilepsy.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clinical Trials as Topic; Clonazepam; Drug Evaluation; | 1975 |
31 other studies available for clonazepam and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Wicket spikes misinterpreted as focal abnormalities in idiopathic generalized epilepsy with prescription of carbamazepine leading to paradoxical aggravation.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Clonazepam; Diagnostic Errors; Drug Thera | 2009 |
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model.
Topics: Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Aspartic Acid; Clonazepam; Electroencephalography; Epilepsy, Temporal Lobe | 2003 |
A case of "double" depression under outpatient treatment conditions.
Topics: Adult; Ambulatory Care; Anticonvulsants; Carbamazepine; Clonazepam; Depressive Disorder, Major; Diag | 2004 |
Chronic interictal psychosis responsive to aripiprazole.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Chronic Disease; Clonazepam; Delusions; | 2004 |
Reduction of two-drug therapy in intractable epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Drug Therapy, Combination; Epilepsy, Temporal Lob | 1983 |
Psychomotor status--a female case in the 34th week of pregnancy.
Topics: Adult; Carbamazepine; Clonazepam; Drugs, Chinese Herbal; Electroencephalography; Epilepsy; Epilepsy, | 1983 |
Clonazepam withdrawal syndrome.
Topics: Adult; Benzodiazepinones; Clonazepam; Drug Administration Schedule; Electroencephalography; Epilepsy | 1984 |
[Clinical evaluation of certain modern antiepileptic preparations].
Topics: Anticonvulsants; Automatism; Carbamazepine; Child; Clonazepam; Diencephalon; Epilepsy; Epilepsy, Abs | 1982 |
Treatment of status epilepticus with intravenous clonazepam.
Topics: Adult; Benzodiazepinones; Clonazepam; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cl | 1982 |
Clonazepam and pregnancy.
Topics: Adult; Benzodiazepinones; Clonazepam; Epilepsy, Temporal Lobe; Female; Humans; Infant, Newborn; Preg | 1982 |
[Psychomotor status epilepticus].
Topics: Clonazepam; Epilepsy, Temporal Lobe; Female; Humans; Middle Aged; Phenytoin | 1981 |
Psychomotor status induced by temporal lobe encephalitis.
Topics: Automatism; Carbamazepine; Clonazepam; Diazepam; Electroencephalography; Encephalitis; Epilepsy, Tem | 1981 |
Differential epilepsy-associated alterations in postsynaptic GABA(A) receptor function in dentate granule and CA1 neurons.
Topics: Animals; Clonazepam; Epilepsy, Temporal Lobe; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampu | 1997 |
A case of temporal lobe epilepsy with improvement of clinical symptoms and single photon emission computed tomography findings after treatment with clonazepam.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Temporal Lobe; Female; Humans; Magnetic Resonance Imag | 2000 |
Sodium valproate and clonazepam in the treatment of intractable epilepsy.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Drug Evaluation; Epilepsy; Epilepsy, Absenc | 1977 |
Clonazepam in the treatment of children with intractable seizures.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Drug Therapy, C | 1977 |
[A clinical study of the clonazepam in the treatment of epilepsy (author's transl)].
Topics: Adolescent; Adult; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Electroencephalography; E | 1978 |
Interictal acute psychoses in temporal lobe epilepsy during withdrawal of anticonvulsant therapy.
Topics: Adult; Carbamazepine; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsy, Tempo | 1979 |
Sensible prescribing. XI.--Juvenile and adult epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile | 1975 |
Clonazepam in the treatment of epilepsy. A clinical long-term follow-up study.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Ep | 1976 |
[Antiepileptic activity of clonazepam--an antiepileptic benzodiazepine derivative].
Topics: Adolescent; Benzodiazepinones; Child; Clonazepam; Electroencephalography; Epilepsy; Epilepsy, Tempor | 1976 |
The effects of clonazepam on rolandic discharge of benign epilepsy of children with centro-temporal EEG foci.
Topics: Adolescent; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epi | 1991 |
Anticonvulsant-responsive panic attacks with temporal lobe EEG abnormalities.
Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Carbamazepine; Clonazepam; Electroencepha | 1990 |
A case of anorexia nervosa associated with epileptic seizures showing favorable responses to sodium valproate and clonazepam.
Topics: Adolescent; Anorexia Nervosa; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epileps | 1989 |
[Some suggestions on epileptic psychoses, their differential diagnosis and therapy].
Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Dementia; Diagnosis, Differential; Diazepam; Drug | 1986 |
[Epilepsy with continuous discharges during slow-wave sleep. Treatment with clobazam].
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clo | 1986 |
Apparent complex partial seizures in a bipolar patient after withdrawal of carbamazepine.
Topics: Bipolar Disorder; Carbamazepine; Clonazepam; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Fem | 1988 |
Antiaggressive effect of adjunctive clonazepam in schizophrenia associated with seizure disorder.
Topics: Adult; Aggression; Clonazepam; Drug Therapy, Combination; Electroconvulsive Therapy; Epilepsy, Tempo | 1988 |
[State of confusion induced by valproic acid and reversed after administration of clonazepam].
Topics: Adult; Benzodiazepinones; Clonazepam; Cognition Disorders; Confusion; Drug Therapy, Combination; Ele | 1985 |
Clonazepam--antipsychotic effect in a case of schizophrenia-like psychosis with epilepsy and in three cases of atypical psychosis.
Topics: Adult; Benzodiazepinones; Clonazepam; Combined Modality Therapy; Electroconvulsive Therapy; Epilepsy | 1985 |