clonazepam has been researched along with Epilepsy, Absence in 42 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Epilepsy, Absence: A seizure disorder usually occurring in childhood characterized by rhythmic electrical brain discharges of generalized onset. Clinical features include a sudden cessation of ongoing activity usually without loss of postural tone. Rhythmic blinking of the eyelids or lip smacking frequently accompanies the SEIZURES. The usual duration is 5-10 seconds, and multiple episodes may occur daily. Juvenile absence epilepsy is characterized by the juvenile onset of absence seizures and an increased incidence of myoclonus and tonic-clonic seizures. (Menkes, Textbook of Child Neurology, 5th ed, p736)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 9.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 7.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 7.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 5.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| " Intravenous clonazepam was investigated in an open trial conducted in 24 patients suffering from status epilepticus." | 3.66 | Treatment of status epilepticus with intravenous clonazepam. ( Le Morvan, P; Singh, AN, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 3.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "Lamotrigine (LTG) is an anti-epileptic drug effective in partial seizures and generalized epilepsy." | 2.69 | Lamotrigine in typical absence epilepsy. ( Buoni, S; Fois, A; Grosso, S, 1999) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| "Carbamazepine (CBZ) was used in seven patients at the onset of AS." | 1.32 | Absence seizures in patients with localization-related epilepsy. ( Hayakawa, F; Nakai, Y; Negoro, T; Okumura, A; Sofue, A; Toyota, N; Watanabe, K, 2003) |
| "The treatment with valproic acid (VPA) and clonazepam (CZP), has been very effective." | 1.30 | [Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients]. ( Bauzano-Poley, E; Delgado-Marqués, MP; Mora-Ramírez, MD; Rodríguez-Barrionuevo, AC; Tosina-García, E, 1998) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epilepsy with age-related onset of symptoms." | 1.29 | Diagnosing juvenile myoclonic epilepsy in an elderly patient. ( Grünewald, RA; Panayiotopoulos, CP, 1994) |
| "Four children with petit mal epilepsy were given clonazepam intravenously during continuous EEG recording." | 1.27 | Kinetics of clonazepam in relation to electroencephalographic and clinical effects. ( Persson, A; Petters, I; Rane, A; Ståhl, Y; Theorell, K; Walson, P, 1983) |
| " They appear to be well absorbed when given by mouth, but their patterns of distribution within the body are different." | 1.26 | Pharmacokinetics of drugs used for petit mal 'absence' epilepsy. ( Eadie, MJ; McKauge, L; Smith, GA; Tyrer, JH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (73.81) | 18.7374 |
| 1990's | 6 (14.29) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 1 (2.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Azad, C | 1 |
| Guglani, V | 1 |
| Wheless, JW | 1 |
| Sofue, A | 1 |
| Okumura, A | 1 |
| Negoro, T | 1 |
| Hayakawa, F | 1 |
| Nakai, Y | 1 |
| Toyota, N | 1 |
| Watanabe, K | 1 |
| Sohal, VS | 1 |
| Huguenard, JR | 1 |
| Badiu, CI | 1 |
| Ståhl, Y | 1 |
| Persson, A | 1 |
| Petters, I | 1 |
| Rane, A | 1 |
| Theorell, K | 1 |
| Walson, P | 1 |
| Reynolds, EH | 1 |
| Shorvon, SD | 1 |
| Bittencourt, PR | 1 |
| Richens, A | 2 |
| Boldyrev, AI | 1 |
| Singh, AN | 1 |
| Le Morvan, P | 1 |
| Primavera, A | 1 |
| Giberti, L | 1 |
| Scotto, P | 1 |
| Cocito, L | 1 |
| Grünewald, RA | 1 |
| Panayiotopoulos, CP | 1 |
| Hosford, DA | 1 |
| Wang, Y | 1 |
| Cao, Z | 1 |
| Rodríguez-Barrionuevo, AC | 1 |
| Bauzano-Poley, E | 1 |
| Delgado-Marqués, MP | 1 |
| Mora-Ramírez, MD | 1 |
| Tosina-García, E | 1 |
| Buoni, S | 1 |
| Grosso, S | 1 |
| Fois, A | 1 |
| Browne, TR | 2 |
| Eadie, MJ | 1 |
| Tyrer, JH | 1 |
| Smith, GA | 1 |
| McKauge, L | 1 |
| Bachman, DS | 1 |
| Watson, B | 1 |
| Aucamp, AK | 1 |
| Speciali, JG | 1 |
| Lison, MP | 1 |
| Lance, JW | 1 |
| Anthony, M | 1 |
| Roussounis, SH | 1 |
| de Rudolf, N | 1 |
| Bensch, J | 1 |
| Blennow, G | 1 |
| Ferngren, H | 1 |
| Gamstorp, I | 1 |
| Herrlin, KM | 1 |
| Kubista, J | 1 |
| Arvidsson, A | 1 |
| Dahlström, H | 1 |
| Nanda, RN | 1 |
| Johnson, RH | 1 |
| Keogh, HJ | 1 |
| Lambie, DG | 1 |
| Melville, ID | 1 |
| Livingston, S | 1 |
| Fazio, C | 1 |
| Manfredi, M | 1 |
| Piccinelli, A | 1 |
| Hussey, HH | 1 |
| Mikkelsen, B | 2 |
| Birket-Smith, E | 2 |
| Bradt, S | 1 |
| Holm, P | 1 |
| Lung, M | 1 |
| Thorn, I | 1 |
| Vestermark, S | 1 |
| Olsen, PZ | 1 |
| Menkes, JH | 1 |
| Bang, F | 1 |
| Sengoku, A | 1 |
| Kawai, I | 1 |
| Hojo, H | 1 |
| Rosenmayr, F | 1 |
| Groh, C | 1 |
| Vondricková, R | 1 |
| Kubová, H | 1 |
| Velísek, L | 1 |
| Mares, P | 1 |
| Rennert, H | 1 |
| Bülau, P | 1 |
| Fröscher, W | 1 |
| Schuchardt, V | 1 |
| Kreiten, K | 1 |
| Amer-Ferrer, G | 1 |
| Alonso-Marné, T | 1 |
| Diez-Tejedor, E | 1 |
| Rodriguez-Albariño, A | 1 |
| Frank, A | 1 |
| Barreiro-Tella, P | 1 |
| Oki, J | 1 |
| Tasaki, T | 1 |
| Kusunoki, Y | 1 |
| Cho, K | 1 |
| Yoshioka, H | 1 |
| Drury, I | 1 |
| Dreifuss, FE | 1 |
3 reviews available for clonazepam and Epilepsy, Absence
| Article | Year |
|---|---|
Acute management of seizures in the syndromes of idiopathic generalized epilepsies.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche | 2003 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
6 trials available for clonazepam and Epilepsy, Absence
| Article | Year |
|---|---|
Lamotrigine in typical absence epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Drug Resistance; Electroencephalog | 1999 |
Clonazepam.
Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies, | 1978 |
A double-blind study of clonazepam in the treatment of therapy-resistant epilepsy in children.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Drug E | 1977 |
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
Topics: Adolescent; Adult; Ambulatory Care; Benzodiazepinones; Brain; Child; Clinical Trials as Topic; Clona | 1977 |
Clonazepam in the treatment of epilepsy. A controlled clinical trial in simple absences, bilateral massive epileptic myoclonus, and atonic seizures.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; | 1976 |
[Prospective randomized study of the effectiveness of clonazepam and diazepam in petit mal status].
Topics: Adolescent; Adult; Aged; Child; Clonazepam; Diazepam; Electroencephalography; Epilepsy, Absence; Evo | 1986 |
33 other studies available for clonazepam and Epilepsy, Absence
| Article | Year |
|---|---|
Eyelid myoclonia with absence seizure precipitated by carbamazepine therapy.
Topics: Carbamazepine; Child; Clonazepam; Epilepsy, Absence; Female; Humans; Myoclonus; Syndrome; Valproic A | 2012 |
Absence seizures in patients with localization-related epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Electroencephalogra | 2003 |
Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus.
Topics: Action Potentials; Animals; Biological Clocks; Clonazepam; Computer Simulation; Electrophysiology; E | 2003 |
Sensitivity of thalamic GABAergic currents to clonazepam does not differ between control and genetic absence epilepsy rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antic | 2004 |
Kinetics of clonazepam in relation to electroencephalographic and clinical effects.
Topics: Adolescent; Benzodiazepinones; Brain; Child; Child, Preschool; Clonazepam; Electroencephalography; E | 1983 |
Monotherapy or polytherapy for epilepsy?
Topics: Adolescent; Adult; Carbamazepine; Clonazepam; Drug Combinations; Drug Interactions; Drug Therapy, Co | 1981 |
Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Chlormethiazole; Clona | 1981 |
[Clinical evaluation of certain modern antiepileptic preparations].
Topics: Anticonvulsants; Automatism; Carbamazepine; Child; Clonazepam; Diencephalon; Epilepsy; Epilepsy, Abs | 1982 |
Treatment of status epilepticus with intravenous clonazepam.
Topics: Adult; Benzodiazepinones; Clonazepam; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Cl | 1982 |
Nonconvulsive status epilepticus as a cause of confusion in later life: a report of 5 cases.
Topics: Aged; Cerebral Cortex; Clonazepam; Confusion; Diagnosis, Differential; Epilepsy, Absence; Epilepsy, | 1994 |
Diagnosing juvenile myoclonic epilepsy in an elderly patient.
Topics: Aged; Clonazepam; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; E | 1994 |
Differential effects mediated by GABAA receptors in thalamic nuclei in lh/lh model of absence seizures.
Topics: Animals; Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Fe | 1997 |
[Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Electroencephalography; Epilepsies, Pa | 1998 |
Pharmacokinetics of drugs used for petit mal 'absence' epilepsy.
Topics: Administration, Oral; Benzodiazepinones; Biotransformation; Clonazepam; Drug Interactions; Epilepsy, | 1977 |
Clonazepam in treatment of absence seizures with automatisms.
Topics: Adolescent; Automatism; Benzodiazepinones; Child; Clonazepam; Epilepsy, Absence; Female; Humans; Mal | 1978 |
Absence status and the concurrent administration of clonazepam and valproate sodium.
Topics: Benzodiazepinones; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy, Absence; Huma | 1979 |
[Value of electroencephalographic findings in the prognosis of Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsy, | 1978 |
Sodium valproate and clonazepam in the treatment of intractable epilepsy.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Drug Evaluation; Epilepsy; Epilepsy, Absenc | 1977 |
Clonazepam in the treatment of children with intractable seizures.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Drug Therapy, C | 1977 |
Medical treatment of epilepsy: part I.
Topics: Anticonvulsants; Bromides; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combina | 1978 |
Treatment of epileptic seizures with clonazepam. A reappraisal.
Topics: Administration, Oral; Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Drug Administ | 1975 |
Sensible prescribing. XI.--Juvenile and adult epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile | 1975 |
Editorial: Clonazepam: a new anticonvulsant.
Topics: Anticonvulsants; Benzodiazepinones; Clonazepam; Epilepsy, Absence; Humans; Legislation, Drug; Spasm; | 1976 |
Clonazepam: a new anticonvulsant.
Topics: Benzodiazepinones; Clonazepam; Epilepsy, Absence; Humans; Seizures | 1976 |
Diagnosis and treatment of minor motor seizures.
Topics: Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; In | 1976 |
Clonazepam in the treatment of epilepsy. A clinical long-term follow-up study.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Ep | 1976 |
[Lennox syndrome with the late onset in puberty].
Topics: Adult; Age Factors; Arsenic Poisoning; Clonazepam; Electroencephalography; Epilepsy, Absence; Female | 1976 |
Petit mal status initiated by photic stimulation.
Topics: Child; Clonazepam; Electroencephalography; Epilepsy, Absence; Humans; Infusions, Parenteral; Male; P | 1976 |
Clonazepam effect on rhythmic EEG activity elicited by metrazol.
Topics: Animals; Clonazepam; Electroencephalography; Epilepsy, Absence; Male; Pentylenetetrazole; Periodicit | 1991 |
[Some suggestions on epileptic psychoses, their differential diagnosis and therapy].
Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Dementia; Diagnosis, Differential; Diazepam; Drug | 1986 |
Absence status following metrizamide myelography: management of nonresponders.
Topics: Clonazepam; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; Humans; Mal | 1988 |
[Combination of sodium valproate and clonazepam in the treatment of symptomatic West syndrome and Lennox syndrome].
Topics: Administration, Oral; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Therapy, Combinat | 1985 |
Pyknoleptic petit mal.
Topics: Adolescent; Age Factors; Animals; Bibliographies as Topic; Child; Child, Preschool; Clonazepam; Diag | 1985 |