clonazepam has been researched along with Epilepsies, Partial in 34 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Epilepsies, Partial: Conditions characterized by recurrent paroxysmal neuronal discharges which arise from a focal region of the brain. Partial seizures are divided into simple and complex, depending on whether consciousness is unaltered (simple partial seizure) or disturbed (complex partial seizure). Both types may feature a wide variety of motor, sensory, and autonomic symptoms. Partial seizures may be classified by associated clinical features or anatomic location of the seizure focus. A secondary generalized seizure refers to a partial seizure that spreads to involve the brain diffusely. (From Adams et al., Principles of Neurology, 6th ed, pp317)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effect of low-dose clonazepam (CZP) on the amount of epileptiform activity in children with focal and generalized epilepsy." | 9.09 | Reduction of epileptiform activity in response to low-dose clonazepam in children with epilepsy: a randomized double-blind study. ( Amark, P; Dahlin, M; Knutsson, E; Nergårdh, A, 2000) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 9.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| "The neuroactive steroids prevented 6-Hz seizures with rank order of potencies (ED50 values): ganaxolone (6." | 7.72 | Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. ( Kaminski, RM; Livingood, MR; Rogawski, MA, 2004) |
| "Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results." | 7.65 | [Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam]. ( Bücking, PH, 1977) |
| "Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs." | 5.39 | Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam. ( Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D, 2013) |
| "To evaluate the effect of low-dose clonazepam (CZP) on the amount of epileptiform activity in children with focal and generalized epilepsy." | 5.09 | Reduction of epileptiform activity in response to low-dose clonazepam in children with epilepsy: a randomized double-blind study. ( Amark, P; Dahlin, M; Knutsson, E; Nergårdh, A, 2000) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 5.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| "The neuroactive steroids prevented 6-Hz seizures with rank order of potencies (ED50 values): ganaxolone (6." | 3.72 | Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. ( Kaminski, RM; Livingood, MR; Rogawski, MA, 2004) |
| "Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results." | 3.65 | [Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam]. ( Bücking, PH, 1977) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| "Vitamin B12 deficiency is a treatable cause of failure to thrive and developmental regression, involuntary movements, and anemia." | 1.39 | Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. ( Belgemen, T; Carman, KB; Yis, U, 2013) |
| "Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs." | 1.39 | Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam. ( Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D, 2013) |
| "The aggravation of habitual seizures and interictal discharges indicate ENM." | 1.35 | A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009) |
| "The seizures were noticeable at the first week of life and increased in frequency to last up to 12 hours, namely status gelasticus." | 1.35 | Intractable gelastic seizures during infancy: ictal positron emission tomography (PET) demonstrating epileptiform activity within the hypothalamic hamartoma. ( Genizi, J; Goldsher, D; Keidar, Z; Ravid, S; Shahar, E, 2008) |
| "Treatment with clonazepam, frequent hospitalizations (drug-resistancy) and lack of occupational activity were revealed to be additional significant contributing factors." | 1.33 | Risk factors for depression in patients with epilepsy. ( Fiszer, U; Grabowska-Grzyb, A; Jedrzejczak, J; Nagańska, E, 2006) |
| "Carbamazepine (CBZ) was used in seven patients at the onset of AS." | 1.32 | Absence seizures in patients with localization-related epilepsy. ( Hayakawa, F; Nakai, Y; Negoro, T; Okumura, A; Sofue, A; Toyota, N; Watanabe, K, 2003) |
| "Clonazepam has recently been found by us to selectively diminish RD in BCECT." | 1.30 | Rhythmic slow activity in benign childhood epilepsy with centrotemporal spikes. ( Mitsudome, A; Ogawa, A; Ohu, M; Yasumoto, S, 1997) |
| "Acute intermittent porphyria is an autosomal dominant inborn error of heme biosynthesis." | 1.30 | [Acute intermittent porphyria associated with epilepsy in a child: diagnostic and therapeutic difficulties]. ( Carrière, JP; Chaix, Y; Gencourt, C; Grouteau, E, 1997) |
| "The treatment with valproic acid (VPA) and clonazepam (CZP), has been very effective." | 1.30 | [Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients]. ( Bauzano-Poley, E; Delgado-Marqués, MP; Mora-Ramírez, MD; Rodríguez-Barrionuevo, AC; Tosina-García, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (50.00) | 18.7374 |
| 1990's | 7 (20.59) | 18.2507 |
| 2000's | 8 (23.53) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carman, KB | 1 |
| Belgemen, T | 1 |
| Yis, U | 1 |
| Yang, Z | 1 |
| Liu, X | 1 |
| Qin, J | 1 |
| Zhang, Y | 1 |
| Bao, X | 1 |
| Chang, X | 1 |
| Wang, S | 1 |
| Wu, Y | 1 |
| Xiong, H | 1 |
| Merdariu, D | 1 |
| Delanoë, C | 1 |
| Mahfoufi, N | 1 |
| Bellavoine, V | 1 |
| Auvin, S | 1 |
| Dahlin, MG | 1 |
| Amark, PE | 1 |
| Nergårdh, AR | 1 |
| Sofue, A | 1 |
| Okumura, A | 1 |
| Negoro, T | 1 |
| Hayakawa, F | 1 |
| Nakai, Y | 1 |
| Toyota, N | 1 |
| Watanabe, K | 1 |
| Kaminski, RM | 1 |
| Livingood, MR | 1 |
| Rogawski, MA | 1 |
| Grabowska-Grzyb, A | 1 |
| Jedrzejczak, J | 1 |
| Nagańska, E | 1 |
| Fiszer, U | 1 |
| Shahar, E | 1 |
| Goldsher, D | 1 |
| Genizi, J | 1 |
| Ravid, S | 1 |
| Keidar, Z | 1 |
| Hinge, HH | 1 |
| Hall, JH | 1 |
| Marshall, PC | 1 |
| Hacke, W | 1 |
| Hilkens, PH | 1 |
| de Weerd, AW | 1 |
| Mitsudome, A | 1 |
| Ohu, M | 1 |
| Yasumoto, S | 1 |
| Ogawa, A | 1 |
| Chaix, Y | 1 |
| Gencourt, C | 1 |
| Grouteau, E | 1 |
| Carrière, JP | 1 |
| Rodríguez-Barrionuevo, AC | 1 |
| Bauzano-Poley, E | 1 |
| Delgado-Marqués, MP | 1 |
| Mora-Ramírez, MD | 1 |
| Tosina-García, E | 1 |
| Gibbs, JW | 1 |
| Morton, LD | 1 |
| Amaker, B | 1 |
| Ward, JD | 1 |
| Holloway, KL | 1 |
| Coulter, DA | 1 |
| Dahlin, M | 1 |
| Knutsson, E | 1 |
| Amark, P | 1 |
| Nergårdh, A | 1 |
| Kmieć, T | 1 |
| Jóźwiak, S | 1 |
| Kuczyński, D | 1 |
| Karkowska, B | 1 |
| Bachański, M | 1 |
| Browne, TR | 2 |
| Fiedlerová, D | 1 |
| Grosmanová, A | 1 |
| Striano, S | 1 |
| Fels, A | 1 |
| Vacca, G | 1 |
| Roussounis, SH | 1 |
| de Rudolf, N | 1 |
| Nanda, RN | 1 |
| Johnson, RH | 1 |
| Keogh, HJ | 1 |
| Lambie, DG | 1 |
| Melville, ID | 1 |
| Bücking, PH | 1 |
| Yamauchi, T | 1 |
| Hirabayashi, Y | 1 |
| Kataoka, N | 1 |
| Nishihori, K | 1 |
| Kobayashi, Y | 1 |
| Murata, T | 1 |
| Kobayashi, R | 1 |
| Suzuki, T | 1 |
| Takahashi, S | 1 |
| Mohri, Y | 1 |
| Mikkelsen, B | 1 |
| Birket-Smith, E | 1 |
| Holm, P | 1 |
| Lund, M | 1 |
| Vestermark, S | 1 |
| Olsen, PZ | 1 |
| Hosoda, N | 1 |
| Miura, H | 1 |
| Takanashi, S | 1 |
| Shirai, H | 1 |
| Sunaoshi, W | 1 |
| Commander, M | 1 |
| Green, SH | 1 |
| Prendergast, M | 1 |
| Mares, P | 1 |
| Schickerová, R | 1 |
| Cellerová, M | 1 |
| Hrubý, M | 1 |
| Tobĕrný, M | 1 |
| Aasly, J | 1 |
| Albretsen, C | 1 |
| Minabe, Y | 1 |
| Fujii, T | 1 |
| Kurachi, M | 1 |
| Beran, RG | 1 |
| Lewis, J | 1 |
| Nolte, J | 1 |
| Yip, E | 1 |
| Fröscher, W | 1 |
| Stoll, KD | 1 |
1 review available for clonazepam and Epilepsies, Partial
| Article | Year |
|---|---|
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
6 trials available for clonazepam and Epilepsies, Partial
| Article | Year |
|---|---|
Reduction of seizures with low-dose clonazepam in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Epilepsies, Partial; Epilepsy, Gen | 2003 |
Reduction of epileptiform activity in response to low-dose clonazepam in children with epilepsy: a randomized double-blind study.
Topics: Anticonvulsants; Child; Child, Preschool; Clonazepam; Cross-Over Studies; Double-Blind Method; Drug | 2000 |
[Gabitril as an additive drug in therapy of intractable epileptic seizures in children].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi | 2000 |
Clonazepam.
Topics: Adult; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clonazepam; Epilepsies, | 1978 |
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
Topics: Adolescent; Adult; Ambulatory Care; Benzodiazepinones; Brain; Child; Clinical Trials as Topic; Clona | 1977 |
A controlled trial on clonazepam INN (Ro 5-4023, Rivotril (R)) in the treatment of focal epilepsy and secondary generalized grand mal epilepsy.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Child; Child, Preschool; Clinical Trials as Topic; Clona | 1975 |
27 other studies available for clonazepam and Epilepsies, Partial
| Article | Year |
|---|---|
Involuntary movements misdiagnosed as seizure during vitamin B12 treatment.
Topics: Atrophy; Brain; Breast Feeding; Clonazepam; Diagnostic Errors; Dyskinesia, Drug-Induced; Electroence | 2013 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; | 2009 |
Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam.
Topics: Anticonvulsants; Clonazepam; Dioxolanes; Electroencephalography; Epilepsies, Partial; Female; Head M | 2013 |
Absence seizures in patients with localization-related epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Electroencephalogra | 2003 |
Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Cornea; Disease Models, Animal; Dose-Response Relationship, Dr | 2004 |
Risk factors for depression in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Depression; Epilepsies, Partial; Epilepsy, Complex P | 2006 |
Intractable gelastic seizures during infancy: ictal positron emission tomography (PET) demonstrating epileptiform activity within the hypothalamic hamartoma.
Topics: Anticonvulsants; Clonazepam; Electroencephalography; Epilepsies, Partial; Female; Hamartoma; Humans; | 2008 |
[Status epilepticus following lumbar myelography with metrizamide (Amipaque)].
Topics: Clonazepam; Epilepsies, Partial; Female; Humans; Metrizamide; Middle Aged; Myelography; Phenytoin | 1983 |
Clonazepam therapy in reading epilepsy.
Topics: Adult; Benzodiazepinones; Clonazepam; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Par | 1980 |
[Status of simple partial seizures with alexia (author's transl)].
Topics: Aphasia; Clonazepam; Dyslexia, Acquired; Electroencephalography; Epilepsies, Partial; Evoked Potenti | 1981 |
Non-convulsive status epilepticus as cause for focal neurological deficit.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Damage, Chronic; Clonazepam; Diagnosis, Diffe | 1995 |
Rhythmic slow activity in benign childhood epilepsy with centrotemporal spikes.
Topics: Child; Child, Preschool; Clonazepam; Electroencephalography; Epilepsies, Partial; Epilepsy; Female; | 1997 |
[Acute intermittent porphyria associated with epilepsy in a child: diagnostic and therapeutic difficulties].
Topics: Anticonvulsants; Child; Clonazepam; Drug Therapy, Combination; Epilepsies, Partial; Humans; Male; Po | 1997 |
[Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Electroencephalography; Epilepsies, Pa | 1998 |
Physiological analysis of Rasmussen's encephalitis: patch clamp recordings of altered inhibitory neurotransmitter function in resected frontal cortical tissue.
Topics: Cell Size; Cells, Cultured; Cerebral Cortex; Child; Chronic Disease; Clonazepam; Dose-Response Relat | 1998 |
[Therapy of resistant forms of epilepsy using rivotril].
Topics: Adult; Age Factors; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Resistance; Epileps | 1978 |
Effects of intravenously administered clonazepam on the interictal paroxysmal activity in various electroclinical forms of epilepsy.
Topics: Adolescent; Adult; Aged; Benzodiazepinones; Cerebral Cortex; Child; Child, Preschool; Clonazepam; Di | 1978 |
Clonazepam in the treatment of children with intractable seizures.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Evaluation; Drug Therapy, C | 1977 |
[Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam].
Topics: Adolescent; Adult; Benzodiazepinones; Brain; Chronic Disease; Clonazepam; Electroencephalography; Ep | 1977 |
[A clinical study of the clonazepam in the treatment of epilepsy (author's transl)].
Topics: Adolescent; Adult; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Electroencephalography; E | 1978 |
The long-term effectiveness of clonazepam therapy in the control of partial seizures in children difficult to control with carbamazepine monotherapy.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Clonazepam; Dose-Response Relationship, Drug; Dr | 1991 |
Behavioural disturbances in children treated with clonazepam.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Child, Preschool; Cl | 1991 |
Influence of clonazepam on cortical epileptogenic foci in the rat.
Topics: Animals; Cerebral Cortex; Clonazepam; Electrocardiography; Epilepsies, Partial; Male; Penicillins; R | 1987 |
[Reading epilepsy].
Topics: Adult; Clonazepam; Epilepsies, Myoclonic; Epilepsies, Partial; Humans; Male; Reading | 1988 |
[A case of visual seizure suspected of mirror-focus generation].
Topics: Adult; Brain; Clonazepam; Electroencephalography; Epilepsies, Partial; Humans; Male; Photic Stimulat | 1988 |
Clinical relevance of therapeutic drug level estimation with respect to clonazepam and carbamazepine: preliminary report.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Dru | 1987 |
[Antiepileptic monotherapy and combination therapy of simple focal seizures].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Ele | 1985 |