clonazepam has been researched along with Encephalomyopathies, Mitochondrial in 2 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment of MERRF cells with drugs affecting organellar Ca2+ transport mostly restored both the agonist-dependent mitochondrial Ca2+ uptake and the ensuing stimulation of ATP production." | 1.30 | A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency. ( Brini, M; Davidson, M; King, MP; Pinton, P; Rizzuto, R; Schon, EA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Visch, HJ | 1 |
| Rutter, GA | 1 |
| Koopman, WJ | 1 |
| Koenderink, JB | 1 |
| Verkaart, S | 1 |
| de Groot, T | 1 |
| Varadi, A | 1 |
| Mitchell, KJ | 1 |
| van den Heuvel, LP | 1 |
| Smeitink, JA | 1 |
| Willems, PH | 1 |
| Brini, M | 1 |
| Pinton, P | 1 |
| King, MP | 1 |
| Davidson, M | 1 |
| Schon, EA | 1 |
| Rizzuto, R | 1 |
2 other studies available for clonazepam and Encephalomyopathies, Mitochondrial
| Article | Year |
|---|---|
Inhibition of mitochondrial Na+-Ca2+ exchange restores agonist-induced ATP production and Ca2+ handling in human complex I deficiency.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Cell Nucleus; Clonazepam; Cytosol; Electron Transport C | 2004 |
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Calcium; Calcium Signaling; Cell Line; Clonazepam | 1999 |