clonazepam has been researched along with Emesis in 6 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In prospective alternative crossover test, we confirmed significant superiority of a three-drug combination of clonazepam (C) lorazepam (L) and dexamethasone (D) to (L) and (D) to control vomiting induced by 50 mg/m CDDP containing chemotherapy for gynecological malignancies (p less than 0." | 7.68 | [Evaluation of antiemetic effect of clonazepam, metoclopramide, dexamethasone and diphenhydramine for prevention of cisplatin-induced vomiting]. ( Asano, H; Hatae, M; Hokanishi, H; Mitsuo, M; Nakamura, Y; Onishi, Y; Sakurai, K, 1990) |
| "We considered akathisia and cancer-related anxiety/agitation as possible causes of restlessness and insomnia, and prescribed clonazepam." | 5.72 | Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report. ( Deguchi, Y; Inoue, K; Itoh, Y; Sakamoto, S; Uchida, S, 2022) |
| "Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs." | 5.39 | Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam. ( Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D, 2013) |
| "In prospective alternative crossover test, we confirmed significant superiority of a three-drug combination of clonazepam (C) lorazepam (L) and dexamethasone (D) to (L) and (D) to control vomiting induced by 50 mg/m CDDP containing chemotherapy for gynecological malignancies (p less than 0." | 3.68 | [Evaluation of antiemetic effect of clonazepam, metoclopramide, dexamethasone and diphenhydramine for prevention of cisplatin-induced vomiting]. ( Asano, H; Hatae, M; Hokanishi, H; Mitsuo, M; Nakamura, Y; Onishi, Y; Sakurai, K, 1990) |
| "We considered akathisia and cancer-related anxiety/agitation as possible causes of restlessness and insomnia, and prescribed clonazepam." | 1.72 | Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report. ( Deguchi, Y; Inoue, K; Itoh, Y; Sakamoto, S; Uchida, S, 2022) |
| "Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs." | 1.39 | Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam. ( Auvin, S; Bellavoine, V; Delanoë, C; Mahfoufi, N; Merdariu, D, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sakamoto, S | 1 |
| Deguchi, Y | 1 |
| Uchida, S | 1 |
| Itoh, Y | 1 |
| Inoue, K | 1 |
| Hayashi, M | 1 |
| Takao, Y | 1 |
| Hata, C | 1 |
| Teramachi, H | 1 |
| Tsuchiya, T | 1 |
| Merdariu, D | 1 |
| Delanoë, C | 1 |
| Mahfoufi, N | 1 |
| Bellavoine, V | 1 |
| Auvin, S | 1 |
| Ruaño, G | 1 |
| Blair, CL | 1 |
| Bower, B | 1 |
| Windemuth, A | 1 |
| Kocherla, M | 1 |
| Aleman, Y | 1 |
| Pearlson, G | 1 |
| Goethe, JW | 1 |
| Schwartz, HI | 1 |
| Eguchi, F | 1 |
| Shindo, M | 1 |
| Emoto, M | 1 |
| Mohtai, H | 1 |
| Hachisuga, T | 1 |
| Kawarabayashi, T | 1 |
| Shirakawa, K | 1 |
| Hatae, M | 1 |
| Nakamura, Y | 1 |
| Mitsuo, M | 1 |
| Sakurai, K | 1 |
| Asano, H | 1 |
| Onishi, Y | 1 |
| Hokanishi, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| DNA Diagnostics for Minimizing Metabolic Side-Effects of Antipsychotics[NCT00752960] | 1,000 participants (Anticipated) | Observational | 2007-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for clonazepam and Emesis
| Article | Year |
|---|---|
Clonazepam use for prevention of acute and delayed vomiting induced by Cisplatin-based chemotherapy for lung cancer.
Topics: Adult; Aged; Antiemetics; Cisplatin; Clonazepam; Dose-Response Relationship, Drug; Female; Humans; L | 2010 |
[The prevention of cancer chemotherapy-induced emesis with granisetron and clonazepam].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clonazepam; Drug Ad | 1995 |
4 other studies available for clonazepam and Emesis
| Article | Year |
|---|---|
Prolonged extrapyramidal symptoms induced by long-term, intermittent administration of low-dose olanzapine along with metoclopramide for emesis: A case report.
Topics: Antiemetics; Antineoplastic Agents; Antipsychotic Agents; Biperiden; Clonazepam; Dopamine; Humans; M | 2022 |
Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam.
Topics: Anticonvulsants; Clonazepam; Dioxolanes; Electroencephalography; Epilepsies, Partial; Female; Head M | 2013 |
Somatic complications of psychotropic medications in a patient with multiple CYP2 drug metabolism deficiencies.
Topics: Clonazepam; Cytochrome P-450 Enzyme System; Female; GABA Modulators; Headache; Humans; Middle Aged; | 2007 |
[Evaluation of antiemetic effect of clonazepam, metoclopramide, dexamethasone and diphenhydramine for prevention of cisplatin-induced vomiting].
Topics: Adult; Antiemetics; Cisplatin; Clonazepam; Dexamethasone; Diphenhydramine; Female; Humans; Metoclopr | 1990 |