clonazepam has been researched along with Dystonia in 30 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report three cases and a literature review describing a syndrome of intermittent idiopathic focal or segmental dystonic tremor dramatically responsive to clonazepam." | 8.79 | Clonazepam-sensitive intermittent dystonic tremor. ( Burns, RS; Charles, PD; Davis, TL, 1995) |
| "This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia." | 7.69 | Successful treatment of tardive dystonia with clozapine and clonazepam. ( Mckenna, PJ; Mickay, AP; Shapleske, J, 1996) |
| "The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6)." | 7.68 | Effect of intravenous injection of biperiden and clonazepam in dystonia. ( Pakkenberg, H; Povlsen, UJ, 1990) |
| "We report three cases and a literature review describing a syndrome of intermittent idiopathic focal or segmental dystonic tremor dramatically responsive to clonazepam." | 4.79 | Clonazepam-sensitive intermittent dystonic tremor. ( Burns, RS; Charles, PD; Davis, TL, 1995) |
| " Pharmacological treatment with tetrabenazine, clonazepam and trihexiphenydile allowed a very limited improvement of dystonia; the course was complicated by dystonic storms and decompensations resulting from the iatrogenous panhypopituitarism." | 3.74 | [Severe generalized dystonia due to postradiotherapy cerebral calcifications]. ( Anheim, M; Chanson, JB; Fleury, M; Lagha-Boukbiza, O; Sellal, F; Tranchant, C, 2008) |
| "This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia." | 3.69 | Successful treatment of tardive dystonia with clozapine and clonazepam. ( Mckenna, PJ; Mickay, AP; Shapleske, J, 1996) |
| "The acute effect of intravenous injections of biperiden and clonazepam was investigated in 14 patients with various forms of dystonia (segmental dystonia, 2; generalized dystonia, 6; and Meige's syndrome, 6)." | 3.68 | Effect of intravenous injection of biperiden and clonazepam in dystonia. ( Pakkenberg, H; Povlsen, UJ, 1990) |
| " She was given 25 mg of intramuscular diphenhydramine and 1 mg of intramuscular benztropine mesylate, which resulted in little relief; however, 1 mg clonazepam caused both the myoclonic jerks and dystonias to resolve completely." | 3.67 | Acute generalized myoclonus following buspirone administration. ( Bridenbaugh, RH; Jabbari, B; Ritchie, EC, 1988) |
| " Case 1 is a description of the subjective experience of a patient with acute orofacial dystonia from promethazine." | 3.66 | Case vignettes of movement disorders. ( Yung, CY, 1983) |
| " Tolerance developed to the antidyskinetic effect of clonazepam in the five patients whose long-term use of the drug was followed, but a 2-week clonazepam-free period recaptured its antidyskinetic effect." | 2.67 | Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy. ( Jacobson, R; Kaup, BA; Nguyen, JA; Strauss, ME; Tamminga, CA; Thaker, GK, 1990) |
| " Oral administration of high dosage of anticholinergic drugs is firstly recommended for the treatment of dystonia." | 2.41 | [Medical treatment of dystonia]. ( Kachi, T, 2001) |
| "A 9-year-old boy with primary myoclonus dystonia with comorbid severe attention deficit hyperactive disorder (ADHD) also had sleep onset and maintenance insomnia." | 1.48 | Sleep-Related Eating Disorder (SRED): Paradoxical Effect of Clonazepam. ( Ghosh, D; Khuhro, AL; Petrecca, AM, 2018) |
| "Secondary paroxysmal dyskinesias (SPDs) are short, episodic, and recurrent movement disorders, classically related to multiple sclerosis (MS)." | 1.46 | Secondary paroxysmal dyskinesia in multiple sclerosis: Clinical-radiological features and treatment. Case report of seven patients. ( Cárcamo-Rodríguez, C; Ciampi, E; Cruz, JP; Godoy-Santín, J; Juri, C; Uribe-San-Martín, R, 2017) |
| "However, dystonia was dramatically improved by a treatment with corticosteroids." | 1.34 | Orofacial dystonia related to Sjogren's syndrome. ( Bonakis, A; Kalfakis, N; Kontaxis, T; Papageorgiou, SG, 2007) |
| "Perioral dystonia and treatment effect were assessed by using subjective global and visual analog scales, examiner-based video movement counts and rating scales, and quantitative EMG." | 1.32 | Treatment of perioral dystonia with botulinum toxin in 4 cases of Meige's syndrome. ( Bakke, M; Dalager, T; Møller, E; Prytz, S; Regeur, L; Werdelin, LM, 2003) |
| " Though both blepharospasm and OMD are thought to represent focal dystonia at different body sites, the extent of improvement achieved with these drugs at the dosage employed differed markedly." | 1.27 | Meige's syndrome: acute and chronic responses to clonazepan and anticholinergics. ( Giménez-Roldán, S; Hípola, D; Mateo, D, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.00) | 18.7374 |
| 1990's | 11 (36.67) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ciampi, E | 1 |
| Uribe-San-Martín, R | 1 |
| Godoy-Santín, J | 1 |
| Cruz, JP | 1 |
| Cárcamo-Rodríguez, C | 1 |
| Juri, C | 1 |
| Ghosh, D | 1 |
| Petrecca, AM | 1 |
| Khuhro, AL | 1 |
| Chanson, JB | 1 |
| Anheim, M | 1 |
| Lagha-Boukbiza, O | 1 |
| Fleury, M | 1 |
| Sellal, F | 1 |
| Tranchant, C | 1 |
| Lin, CC | 1 |
| Lin, PY | 1 |
| Lee, Y | 1 |
| Chang, YY | 1 |
| Chen, CH | 1 |
| Suzuki, K | 1 |
| Takano, M | 1 |
| Hashimoto, K | 1 |
| Numao, A | 1 |
| Nakamura, T | 1 |
| Sakuta, H | 1 |
| Hirata, K | 1 |
| Benbir, G | 1 |
| Senturk, A | 1 |
| Tan, F | 1 |
| Karadeniz, D | 1 |
| Burlina, AP | 1 |
| Edini, C | 1 |
| Burlina, AB | 1 |
| Kachi, T | 1 |
| Møller, E | 1 |
| Werdelin, LM | 1 |
| Bakke, M | 1 |
| Dalager, T | 1 |
| Prytz, S | 1 |
| Regeur, L | 1 |
| Grosse, P | 1 |
| Edwards, M | 1 |
| Tijssen, MAJ | 1 |
| Schrag, A | 1 |
| Lees, AJ | 2 |
| Bhatia, KP | 1 |
| Brown, P | 1 |
| Baek, W | 1 |
| Sheean, G | 1 |
| Papageorgiou, SG | 1 |
| Kontaxis, T | 1 |
| Bonakis, A | 1 |
| Kalfakis, N | 1 |
| Buccoliero, R | 1 |
| Palmeri, S | 1 |
| Malandrini, A | 1 |
| Dotti, MT | 1 |
| Federico, A | 1 |
| Hípola, D | 1 |
| Mateo, D | 1 |
| Giménez-Roldán, S | 1 |
| Sunohara, N | 1 |
| Mukoyama, M | 1 |
| Mano, Y | 1 |
| Satoyoshi, E | 1 |
| Yung, CY | 1 |
| Ortiz, A | 1 |
| Davis, TL | 1 |
| Charles, PD | 1 |
| Burns, RS | 1 |
| Chaudhuri, KR | 1 |
| Leigh, PN | 1 |
| Gibb, WR | 1 |
| Pye, IF | 1 |
| Shapleske, J | 1 |
| Mickay, AP | 1 |
| Mckenna, PJ | 1 |
| Goto, S | 1 |
| Tsuiki, H | 1 |
| Soyama, N | 1 |
| Okamura, A | 1 |
| Yamada, K | 1 |
| Yoshikawa, M | 1 |
| Hashimoto, Y | 1 |
| Ushio, Y | 1 |
| Matsuo, H | 1 |
| Okano, M | 1 |
| Kaida, K | 1 |
| Tadano, Y | 1 |
| Kamakura, K | 1 |
| Gerding, LB | 1 |
| Labbate, LA | 1 |
| Lauterbach, EC | 1 |
| Spears, TE | 1 |
| Price, ST | 1 |
| Blake, LM | 1 |
| Marks, RC | 1 |
| Nierman, P | 1 |
| Luchins, DJ | 1 |
| Thaker, GK | 1 |
| Nguyen, JA | 1 |
| Strauss, ME | 1 |
| Jacobson, R | 1 |
| Kaup, BA | 1 |
| Tamminga, CA | 1 |
| Hughes, AJ | 1 |
| Marsden, CD | 1 |
| Povlsen, UJ | 1 |
| Pakkenberg, H | 1 |
| Ritchie, EC | 1 |
| Bridenbaugh, RH | 1 |
| Jabbari, B | 1 |
| Kurlan, R | 1 |
| Behr, J | 1 |
| Medved, L | 1 |
| Shoulson, I | 1 |
3 reviews available for clonazepam and Dystonia
| Article | Year |
|---|---|
[Medical treatment of dystonia].
Topics: Cholinergic Antagonists; Clonazepam; Diazepam; Dopamine Antagonists; Dystonia; Humans; Levodopa; Tor | 2001 |
Clonazepam-sensitive intermittent dystonic tremor.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Clonazepam; Dystonia; Humans; Magnetic Resonance Imaging; | 1995 |
Bipolar disorder in idiopathic dystonia: clinical features and possible neurobiology.
Topics: Antidepressive Agents; Bipolar Disorder; Clonazepam; Cyclothymic Disorder; Drug Therapy, Combination | 1992 |
1 trial available for clonazepam and Dystonia
| Article | Year |
|---|---|
Clonazepam treatment of tardive dyskinesia: a practical GABAmimetic strategy.
Topics: Adult; Antipsychotic Agents; Athetosis; Chorea; Clonazepam; Double-Blind Method; Dyskinesia, Drug-In | 1990 |
26 other studies available for clonazepam and Dystonia
| Article | Year |
|---|---|
Secondary paroxysmal dyskinesia in multiple sclerosis: Clinical-radiological features and treatment. Case report of seven patients.
Topics: Acetazolamide; Adult; Anticonvulsants; Cerebellum; Clonazepam; Dyskinesias; Dystonia; Female; Follow | 2017 |
Sleep-Related Eating Disorder (SRED): Paradoxical Effect of Clonazepam.
Topics: Anticonvulsants; Child; Clonazepam; Dystonia; Feeding and Eating Disorders; Humans; Male; Myoclonus; | 2018 |
[Severe generalized dystonia due to postradiotherapy cerebral calcifications].
Topics: Anti-Dyskinesia Agents; Basal Ganglia; Brain Neoplasms; Calcinosis; Child; Clonazepam; Craniopharyng | 2008 |
Tardive dystonia and tardive sensory syndrome related to trazodone: a case report.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Anxiety Disorders; Clonazepam; Dys | 2008 |
Computer mouse-related dystonia: a novel presentation of task-specific dystonia.
Topics: Aged; Clonazepam; Computers; Cumulative Trauma Disorders; Dystonia; Dystonic Disorders; GABA Antagon | 2012 |
Polysomnographic recording of a child with paroxysmal hypnogenic dyskinesia and NREM parasomnia.
Topics: Anticonvulsants; Cerebral Cortex; Child; Chorea; Clonazepam; Diagnosis, Differential; Dystonia; Huma | 2013 |
Treatment of extrapyramidal symptoms in a patient with homozygous homocystinuria.
Topics: Adult; Anticonvulsants; Clonazepam; Cystathionine beta-Synthase; Dystonia; Female; Homocysteine; Hom | 2002 |
Treatment of perioral dystonia with botulinum toxin in 4 cases of Meige's syndrome.
Topics: Botulinum Toxins, Type A; Cholinergic Antagonists; Clonazepam; Dystonia; Electromyography; Facial Mu | 2003 |
Patterns of EMG-EMG coherence in limb dystonia.
Topics: Adult; Anterior Compartment Syndrome; Anti-Dyskinesia Agents; Anticonvulsants; Antiparkinson Agents; | 2004 |
Occupational dystonia affecting truncal muscles in a bricklayer.
Topics: Anticonvulsants; Clonazepam; Dystonia; Electromyography; Humans; Male; Middle Aged; Muscle, Skeletal | 2007 |
Orofacial dystonia related to Sjogren's syndrome.
Topics: Adrenal Cortex Hormones; Brain; Clonazepam; Dystonia; Dystonic Disorders; Face; Female; Humans; Leve | 2007 |
A case of dystonia with onset during pregnancy.
Topics: Adult; Anticonvulsants; Central Nervous System; Clonazepam; Dystonia; Female; Foot; Humans; Hypothyr | 2007 |
Meige's syndrome: acute and chronic responses to clonazepan and anticholinergics.
Topics: Aged; Basal Ganglia Diseases; Benzodiazepinones; Clonazepam; Dystonia; Female; Follow-Up Studies; Hu | 1984 |
Action-induced rhythmic dystonia: an autopsy case.
Topics: 5-Hydroxytryptophan; Cerebral Infarction; Clonazepam; Dystonia; Electroencephalography; Electromyogr | 1984 |
Case vignettes of movement disorders.
Topics: Adult; Amantadine; Brain Injuries; Clonazepam; Diagnosis, Differential; Dystonia; Female; Haloperido | 1983 |
Neuropharmacological profile of Meige's disease: overview and a case report.
Topics: Aged; Baclofen; Benztropine; Clonazepam; Doxepin; Drug Therapy, Combination; Dystonia; Facial Muscle | 1983 |
The moving ear syndrome: a focal dyskinesia.
Topics: Adult; Anti-Dyskinesia Agents; Anticonvulsants; Botulinum Toxins; Clonazepam; Dystonia; Ear, Externa | 1996 |
Successful treatment of tardive dystonia with clozapine and clonazepam.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Clozapine; Drug Therapy, Combination; Dyst | 1996 |
Stereotactic selective Vo-complex thalamotomy in a patient with dystonic writer's cramp.
Topics: Adolescent; Clonazepam; Dose-Response Relationship, Drug; Dystonia; Electromyography; Female; Handwr | 1997 |
[A Japanese family with paroxysmal dystonic choreoathetosis].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Athetosis; Caffeine; Child; Chorea; Chromoso | 1997 |
Use of clonazepam in an elderly bipolar patient with tardive dyskinesia: a case report.
Topics: Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Dyskinesia | 1999 |
Clozapine and clonazepam in tardive dystonia.
Topics: Adult; Antipsychotic Agents; Clonazepam; Clozapine; Dystonia; Female; Humans; Schizophrenia | 1991 |
Paroxysmal dystonic head tremor.
Topics: Adult; Clonazepam; Dystonia; Humans; Male; Muscle Contraction; Neck Muscles; Torticollis; Tremor | 1991 |
Effect of intravenous injection of biperiden and clonazepam in dystonia.
Topics: Adult; Biperiden; Clonazepam; Dystonia; Female; Humans; Injections, Intravenous; Male; Middle Aged; | 1990 |
Acute generalized myoclonus following buspirone administration.
Topics: Acute Disease; Akathisia, Drug-Induced; Anxiety Disorders; Buspirone; Clonazepam; Depressive Disorde | 1988 |
Myoclonus and dystonia: a family study.
Topics: Clonazepam; Dystonia; Ethanol; Female; Genes, Dominant; Humans; Male; Myoclonus; Pedigree | 1988 |