clonazepam has been researched along with Disease Models, Animal in 47 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model." | 7.79 | The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "The neuroactive steroids prevented 6-Hz seizures with rank order of potencies (ED50 values): ganaxolone (6." | 7.72 | Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. ( Kaminski, RM; Livingood, MR; Rogawski, MA, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 7.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "Panic attacks are also precipitated by both the infusion of 0." | 5.40 | Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine. ( Müller, CJ; Schenberg, LC; Schimitel, FG; Tufik, S, 2014) |
| "The ED50 for suppression of behavioral seizures was 6." | 5.36 | Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. ( Reddy, DS; Rogawski, MA, 2010) |
| "(-)-Baclofen was the only one of the three compounds tested that reversed in a dose-dependent manner the effects of tone exposure on both the amplitude of the click-evoked potentials recorded from the IC and on measures of the changes in temporal integration based on these potentials." | 5.29 | Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis. ( Møller, AR; Szczepaniak, WS, 1996) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model." | 3.79 | The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| " In this study the anticonvulsant actions of norfluoxetine and fluoxetine were studied and compared to those of phenytoin and clonazepam in pentylenetetrazol-induced mouse epilepsy models." | 3.73 | Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies. ( Harasztosi, C; Kecskeméti, V; Nánási, PP; Pál, B; Riba, P; Rusznák, Z; Szûcs, G; Wagner, R, 2005) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| "The neuroactive steroids prevented 6-Hz seizures with rank order of potencies (ED50 values): ganaxolone (6." | 3.72 | Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice. ( Kaminski, RM; Livingood, MR; Rogawski, MA, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| "We investigated the effects of OT-7100, a novel analgesic compound (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimidi ne), on prostaglandin E2 biosynthesis in vitro, acute hyperalgesia induced by yeast and substance P in rats and hyperalgesia in rats with a chronic constriction injury to the sciatic nerve (Bennett model), which is a model for peripheral neuropathic pain." | 3.70 | The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. ( Iwamoto, T; Kohri, H; Noguchi, K; Ohara, M; Sato, S; Senba, E; Yasuda, T, 1999) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 3.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "Myoclonus is defined as shock-like, brief involuntary abnormal movements in muscle jerking caused by external stimuli; and it arises from progressive myoclonus epilepsy, post-anoxic encephalopathy and Alzheimer's disease, causing disabling symptoms." | 2.41 | [A pharmacological profile of piracetam (Myocalm), a drug for myoclonus]. ( Nanri, M; Tajima, K, 2000) |
| "Panic attacks are also precipitated by both the infusion of 0." | 1.40 | Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine. ( Müller, CJ; Schenberg, LC; Schimitel, FG; Tufik, S, 2014) |
| "Midazolam is a short-acting benzodiazepine that is widely used as an i." | 1.38 | Role of neurosteroids in the anticonvulsant activity of midazolam. ( Dhir, A; Rogawski, MA, 2012) |
| "The ED50 for suppression of behavioral seizures was 6." | 1.36 | Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model. ( Reddy, DS; Rogawski, MA, 2010) |
| " Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel and non-parallel dose-response effects was used to characterize the consequent anticonvulsant interactions between the various drug combinations." | 1.35 | Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. ( Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E, 2009) |
| "Clonazepam was administered 24, 5 and 1 h before test." | 1.34 | Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. ( Barden, AT; Barros, HM; Barschak, AG; da Silva Haeser, A; Deon, M; Gomez, R; Landgraff, S; Schmitt, GO; Sitta, A; Vargas, CR, 2007) |
| "Myoclonus was induced by intraperitoneal injection of 4." | 1.31 | [Effect of piracetam on urea-induced myoclonus in rats]. ( Matsuura, N; Nanri, M; Yamamoto, A, 2000) |
| "Treatment with clonazepam (CZP) (0." | 1.30 | The role of gamma-aminobutyric acid (GABA)-benzodiazepine neurotransmission in an animal model of methamphetamine-induced psychosis. ( Ito, K, 1999) |
| "The auditory-induced myoclonus continues to worsen, reaches a peak about 2 weeks after the arrest, then declines over time to subnormal levels." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "(-)-Baclofen was the only one of the three compounds tested that reversed in a dose-dependent manner the effects of tone exposure on both the amplitude of the click-evoked potentials recorded from the IC and on measures of the changes in temporal integration based on these potentials." | 1.29 | Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis. ( Møller, AR; Szczepaniak, WS, 1996) |
| "p,p'-DDT-induced myoclonus in mice has been proposed as a model of stimulus-sensitive action myoclonus responsive to L-5-HTP and clonazepam treatment." | 1.27 | p,p'-DDT-induced myoclonus in the rat and its application as an animal model of 5-HT-sensitive action myoclonus. ( Jenner, P; Marsden, CD; Pratt, JA; Rothwell, J, 1986) |
| "Uremic myoclonus in humans resembles the reticular reflex form of postanoxic action myoclonus." | 1.27 | Urea-induced stimulus-sensitive myoclonus in the rat. ( Jenner, P; Leigh, N; Marsden, CD; Muscatt, S; Obeso, J; Rothwell, J, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (21.28) | 18.7374 |
| 1990's | 12 (25.53) | 18.2507 |
| 2000's | 12 (25.53) | 29.6817 |
| 2010's | 12 (25.53) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Świąder, MJ | 1 |
| Świąder, K | 1 |
| Zakrocka, I | 1 |
| Krzyżanowski, M | 1 |
| Wróbel, A | 1 |
| Łuszczki, JJ | 1 |
| Czuczwar, SJ | 7 |
| Samarut, É | 1 |
| Swaminathan, A | 1 |
| Riché, R | 1 |
| Liao, M | 1 |
| Hassan-Abdi, R | 1 |
| Renault, S | 1 |
| Allard, M | 1 |
| Dufour, L | 1 |
| Cossette, P | 1 |
| Soussi-Yanicostas, N | 1 |
| Drapeau, P | 1 |
| Mohamed, TM | 1 |
| Ghaffar, HM | 1 |
| El Husseiny, RM | 1 |
| Liu, T | 1 |
| Takimoto, E | 1 |
| Dimaano, VL | 1 |
| DeMazumder, D | 1 |
| Kettlewell, S | 1 |
| Smith, G | 1 |
| Sidor, A | 1 |
| Abraham, TP | 1 |
| O'Rourke, B | 1 |
| Schimitel, FG | 1 |
| Müller, CJ | 1 |
| Tufik, S | 1 |
| Schenberg, LC | 1 |
| Popławska, M | 1 |
| Wróblewska, D | 1 |
| Borowicz, KK | 4 |
| Wojda, E | 1 |
| Wlaz, A | 1 |
| Patsalos, PN | 3 |
| Luszczki, JJ | 5 |
| Dudra-Jastrzebska, M | 1 |
| Andres-Mach, MM | 1 |
| Ratnaraj, N | 2 |
| Reddy, DS | 1 |
| Rogawski, MA | 3 |
| Wayhs, CA | 2 |
| Manfredini, V | 1 |
| Sitta, A | 2 |
| Deon, M | 2 |
| Ribas, G | 1 |
| Vanzin, C | 1 |
| Biancini, G | 1 |
| Ferri, M | 1 |
| Nin, M | 1 |
| Barros, HM | 3 |
| Vargas, CR | 3 |
| Brooks, PL | 1 |
| Peever, JH | 1 |
| Lin, TY | 1 |
| Lu, CW | 1 |
| Huang, SK | 1 |
| Chou, SS | 1 |
| Kuo, YC | 1 |
| Chou, SH | 1 |
| Tzeng, WF | 1 |
| Leu, CY | 1 |
| Huang, RF | 1 |
| Liew, YF | 1 |
| Wang, SJ | 1 |
| Andres-Mach, M | 1 |
| Barcicka-Klosowska, B | 1 |
| Florek-Luszczki, M | 1 |
| Haratym-Maj, A | 1 |
| Dhir, A | 1 |
| Tortato, C | 1 |
| Mescka, CP | 1 |
| Pasquali, MA | 1 |
| Schnorr, CE | 1 |
| Nin, MS | 1 |
| Moreira, JC | 1 |
| Kaminski, RM | 1 |
| Livingood, MR | 1 |
| Badiu, CI | 1 |
| Kecskeméti, V | 1 |
| Rusznák, Z | 1 |
| Riba, P | 1 |
| Pál, B | 1 |
| Wagner, R | 1 |
| Harasztosi, C | 1 |
| Nánási, PP | 1 |
| Szûcs, G | 1 |
| da Silva Haeser, A | 1 |
| Barschak, AG | 1 |
| Barden, AT | 1 |
| Schmitt, GO | 1 |
| Landgraff, S | 1 |
| Gomez, R | 1 |
| Jibiki, I | 1 |
| Lockard, JS | 1 |
| Levy, RH | 1 |
| DuCharme, LL | 1 |
| Congdon, WC | 1 |
| Banfi, S | 1 |
| Fonio, W | 1 |
| Allievi, E | 1 |
| Raimondo, S | 1 |
| Shekhar, A | 1 |
| Truong, DD | 1 |
| Matsumoto, RR | 1 |
| Schwartz, PH | 1 |
| Hussong, MJ | 1 |
| Wasterlain, CG | 1 |
| Suzuki, Y | 1 |
| Edge, J | 1 |
| Mimaki, T | 1 |
| Walson, PD | 1 |
| Szczepaniak, WS | 1 |
| Møller, AR | 1 |
| Gibbs, JW | 1 |
| Sombati, S | 1 |
| DeLorenzo, RJ | 1 |
| Coulter, DA | 1 |
| Suemaru, K | 1 |
| Kawasaki, H | 1 |
| Gomita, Y | 1 |
| Yasuda, T | 1 |
| Iwamoto, T | 1 |
| Ohara, M | 1 |
| Sato, S | 1 |
| Kohri, H | 1 |
| Noguchi, K | 1 |
| Senba, E | 1 |
| Ito, K | 1 |
| Al-Mulla Hummadi, YM | 1 |
| Najim, RA | 1 |
| Farjou, IB | 1 |
| Nanri, M | 2 |
| Yamamoto, A | 1 |
| Matsuura, N | 1 |
| Tajima, K | 1 |
| Luszczki, J | 1 |
| Kleinrok, Z | 1 |
| Meldrum, BS | 1 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Horton, RW | 1 |
| Trimble, M | 1 |
| Stanková, L | 1 |
| Mares, P | 3 |
| Barnhill, JG | 1 |
| Ciraulo, DA | 1 |
| Greenblatt, DJ | 1 |
| Faggart, MA | 1 |
| Harmatz, JS | 1 |
| Makal, V | 1 |
| Kubová, H | 1 |
| Pratt, JA | 1 |
| Rothwell, J | 2 |
| Jenner, P | 2 |
| Marsden, CD | 2 |
| Heidler, I | 2 |
| Mares, J | 2 |
| Trojan, S | 2 |
| Vorlícek, J | 1 |
| Chapman, AG | 1 |
| Carvey, P | 1 |
| Paulseth, JE | 1 |
| Goetz, CG | 1 |
| Klawans, HL | 1 |
| Muscatt, S | 1 |
| Obeso, J | 1 |
| Leigh, N | 1 |
3 reviews available for clonazepam and Disease Models, Animal
| Article | Year |
|---|---|
[Current progress in research and treatment of epilepsy].
Topics: Animals; Brain; Clonazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Kindli | 1984 |
[A pharmacological profile of piracetam (Myocalm), a drug for myoclonus].
Topics: Animals; Anticonvulsants; Clinical Trials, Phase II as Topic; Clonazepam; Disease Models, Animal; Dr | 2000 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; F | 1986 |
44 other studies available for clonazepam and Disease Models, Animal
| Article | Year |
|---|---|
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; | 2018 |
Effects of tramadol, clonazepam, and their combination on brain mitochondrial complexes.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; Electron Tr | 2015 |
Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Cardiomegaly; Clonazepam; Death, Sudden, Cardiac; Disease | 2014 |
Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine.
Topics: Animals; Asphyxia; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Escape Reac | 2014 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Ani | 2015 |
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model.
Topics: Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect.
Topics: Animals; Clonazepam; Depressive Disorder; Diabetes Complications; Disease Models, Animal; GABA Modul | 2010 |
Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice.
Topics: Analysis of Variance; Animals; Brain; Central Nervous System Depressants; Clonazepam; Disease Models | 2011 |
HTDP-2, a new synthetic compound, inhibits glutamate release through reduction of voltage-dependent Ca²⁺ influx in rat cerebral cortex nerve terminals.
Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Calcium; Calcium Channel Blockers; Calci | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
Role of neurosteroids in the anticonvulsant activity of midazolam.
Topics: 5-alpha Reductase Inhibitors; Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Ani | 2012 |
The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression.
Topics: Animals; Catalase; Clonazepam; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2013 |
Allopregnanolone analogs that positively modulate GABA receptors protect against partial seizures induced by 6-Hz electrical stimulation in mice.
Topics: Animals; Anticonvulsants; Clonazepam; Cornea; Disease Models, Animal; Dose-Response Relationship, Dr | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Sensitivity of thalamic GABAergic currents to clonazepam does not differ between control and genetic absence epilepsy rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antic | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.
Topics: Animals; Anticonvulsants; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signa | 2005 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect.
Topics: Analysis of Variance; Animals; Behavior, Animal; Catalase; Clonazepam; Depression; Diabetes Mellitus | 2007 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Topics: Animals; Anticonvulsants; Chlorides; Chronic Disease; Clonazepam; Diazepam; Disease Models, Animal; | 1983 |
Effects of treatment with imipramine and clonazepam on an animal model of panic disorder.
Topics: Analysis of Variance; Animals; Bicuculline; Clonazepam; Disease Models, Animal; Double-Blind Method; | 1994 |
Novel rat cardiac arrest model of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani | 1994 |
Intermittent clonazepam treatment prevents anticonvulsant tolerance in mice.
Topics: Animals; Clonazepam; Disease Models, Animal; Drug Administration Schedule; Drug Tolerance; Epilepsy; | 1993 |
Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis.
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Baclofen; Clonazepam; Diazepam; Disease Models, A | 1996 |
Physiological and pharmacological alterations in postsynaptic GABA(A) receptor function in a hippocampal culture model of chronic spontaneous seizures.
Topics: Animals; Anticonvulsants; Cells, Cultured; Chloride Channels; Clonazepam; Disease Models, Animal; Ep | 1997 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Ani | 1997 |
The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia.
Topics: Amitriptyline; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antide | 1999 |
The role of gamma-aminobutyric acid (GABA)-benzodiazepine neurotransmission in an animal model of methamphetamine-induced psychosis.
Topics: Animals; Behavior, Animal; Central Nervous System Stimulants; Clonazepam; Depression, Chemical; Dise | 1999 |
A new in vitro model for ethanol-induced gastric mucosal damage.
Topics: Animals; Anti-Ulcer Agents; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Et | 1999 |
[Effect of piracetam on urea-induced myoclonus in rats].
Topics: Animals; Clonazepam; Disease Models, Animal; Male; Myoclonus; Neuroprotective Agents; Nootropic Agen | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
Benzodiazepine response and receptor binding after chronic ethanol ingestion in a mouse model.
Topics: Alcoholism; Animals; Behavior, Animal; Benzodiazepines; Body Weight; Cerebral Cortex; Clonazepam; Di | 1991 |
Effect of clonazepam on cortical epileptic afterdischarges in developing rats.
Topics: Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Electric Stimulation; Epilepsies, Myoc | 1991 |
p,p'-DDT-induced myoclonus in the rat and its application as an animal model of 5-HT-sensitive action myoclonus.
Topics: 5-Hydroxytryptophan; Animals; Behavior, Animal; Brain; Clonazepam; DDT; Disease Models, Animal; Elec | 1986 |
Utilization of benzodiazepines for the study of the experimental epileptic seizures.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Clonazepam; Clorazepate Dipotassium; Disease Models | 1985 |
Action of clonazepam and clorazepate on cortical self-sustained after-discharges in the rat.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Clonazepam; Clorazepate Dipotassium; Disease Models, | 1988 |
L-5-HTP-induced myoclonic jumping behavior in guinea pigs: an update.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Bromocriptine; Clonazepam; Disease Models, Animal; Guinea | 1986 |
Urea-induced stimulus-sensitive myoclonus in the rat.
Topics: Animals; Behavior, Animal; Brain Stem; Cats; Clonazepam; Disease Models, Animal; Electroencephalogra | 1986 |