clonazepam has been researched along with Diathesis in 4 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| " Three tests were used: pentylenetetrazole (PTZ)-induced seizures, isolation-induced ultrasonic vocalizations, and motor performance." | 3.77 | Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats. ( Kubová, H; Mareš, P; Mikulecká, A, 2011) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "The control group had more seizure activity (mean = 13." | 1.33 | An evaluation of the use of seizure prone rats when investigating intermediate stage sleep. ( Anch, AM; Duntley, SP; Morrissey, MJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mikulecká, A | 1 |
| Mareš, P | 1 |
| Kubová, H | 1 |
| Morrissey, MJ | 1 |
| Anch, AM | 1 |
| Duntley, SP | 1 |
| Turski, W | 1 |
| Dziki, M | 1 |
| Parada, J | 1 |
| Kleinrok, Z | 1 |
| Cavalheiro, EA | 1 |
| Pollack, MH | 1 |
| Otto, MW | 1 |
| Rosenbaum, JF | 1 |
| Sachs, GS | 1 |
| O'Neil, C | 1 |
| Asher, R | 1 |
| Meltzer-Brody, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Orexin in Human Panic Disorder[NCT02593682] | Phase 4 | 3 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for clonazepam and Diathesis
| Article | Year |
|---|---|
Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats.
Topics: Analysis of Variance; Animals; Animals, Newborn; Clonazepam; Disease Susceptibility; GABA Modulators | 2011 |
An evaluation of the use of seizure prone rats when investigating intermediate stage sleep.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Clonazepam; Diagnosis, Computer-Assisted; Disease Suscept | 2005 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Longitudinal course of panic disorder: findings from the Massachusetts General Hospital Naturalistic Study.
Topics: Alprazolam; Anxiety Disorders; Child, Preschool; Chronic Disease; Clonazepam; Cognitive Behavioral T | 1990 |