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clonazepam and Depressive Disorder, Major

clonazepam has been researched along with Depressive Disorder, Major in 11 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
"Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest."9.09Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2000)
"On the ninth day of ziprasidone administration, galactorrhea appeared."7.73Ziprasidone-induced galactorrhea: a case report. ( Bares, M; Kopecek, M; Mohr, P, 2005)
"Low-dose cotherapy of fluoxetine with clonazepam was safe and accelerated response over 21 days of treatment, decreasing anxiety and sleep disturbance as symptoms and partially suppressed them as SSRI side-effects; it also modestly reduced core symptoms of low mood and loss of interest."5.09Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2000)
"On the ninth day of ziprasidone administration, galactorrhea appeared."3.73Ziprasidone-induced galactorrhea: a case report. ( Bares, M; Kopecek, M; Mohr, P, 2005)
"Anxious depression, defined as major depressive disorder (MDD) accompanied by high levels of anxiety, seems to be both common and difficult to treat, with antidepressant monotherapy often yielding modest results."2.75Fluoxetine-clonazepam cotherapy for anxious depression: an exploratory, post-hoc analysis of a randomized, double blind study. ( Ameral, VE; Baer, L; Brintz, C; Clain, A; Fava, M; Glaudin, V; Londborg, PD; Painter, JR; Papakostas, GI; Smith, WT, 2010)
"Clonazepam has been shown to be an effective supplementary treatment for depression."1.34Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression. ( Arita, S; Morishita, S, 2007)
"Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981."1.30Clonazepam as a therapeutic adjunct to improve the management of psychiatric disorders. ( Aoki, S; Morishita, S; Watanabe, S, 1998)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (27.27)18.2507
2000's5 (45.45)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mowla, A1
Ahmadzadeh, L1
Razeghian Jahromi, L1
Dastgheib, SA1
Papakostas, GI1
Clain, A1
Ameral, VE1
Baer, L1
Brintz, C1
Smith, WT2
Londborg, PD2
Glaudin, V2
Painter, JR2
Fava, M1
Lin, HY1
Lin, CC1
Liu, CC1
Ros, LT1
Kopecek, M1
Bares, M1
Mohr, P1
Sicot, R1
Morishita, S2
Arita, S1
Aoki, S1
Watanabe, S1
Boshes, RA1
Afonso, JA1
Tanev, K1
Schaller, JL1
Behar, D1

Trials

3 trials available for clonazepam and Depressive Disorder, Major

ArticleYear
Comparing Gabapentin with Clonazepam for Residual Sleeping Problems following Antidepressant Therapy in Patients with Major Depressive Disorder: A Randomized Clinical Trial.
    Clinical drug investigation, 2015, Volume: 35, Issue:8

    Topics: Adult; Amines; Antidepressive Agents; Clonazepam; Cyclohexanecarboxylic Acids; Depressive Disorder,

2015
Fluoxetine-clonazepam cotherapy for anxious depression: an exploratory, post-hoc analysis of a randomized, double blind study.
    International clinical psychopharmacology, 2010, Volume: 25, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Clonazepam; Depressive Disorder, Major;

2010
Short-term cotherapy with clonazepam and fluoxetine: anxiety, sleep disturbance and core symptoms of depression.
    Journal of affective disorders, 2000, Volume: 61, Issue:1-2

    Topics: Adult; Aged; Anxiety; Clonazepam; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug

2000

Other Studies

8 other studies available for clonazepam and Depressive Disorder, Major

ArticleYear
Hypomania associated with adjunctive aripiprazole in an elder female with recurrent major depressive disorder: dose-related phenomenon?
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:6

    Topics: Aripiprazole; Bipolar Disorder; Clonazepam; Depressive Disorder, Major; Dose-Response Relationship,

2012
A case of "double" depression under outpatient treatment conditions.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2004, Volume: 5, Issue:3

    Topics: Adult; Ambulatory Care; Anticonvulsants; Carbamazepine; Clonazepam; Depressive Disorder, Major; Diag

2004
Ziprasidone-induced galactorrhea: a case report.
    Neuro endocrinology letters, 2005, Volume: 26, Issue:1

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Depressive Disorder, Major; Female; Galact

2005
[Love, humor and psychosis in an atypical depression].
    L'Encephale, 2005, Volume: 31 Pt 2

    Topics: Antidepressive Agents; Antipsychotic Agents; Azabicyclo Compounds; Benzodiazepines; Clonazepam; Cycl

2005
Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression.
    Human psychopharmacology, 2007, Volume: 22, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Chronic Di

2007
Clonazepam as a therapeutic adjunct to improve the management of psychiatric disorders.
    Psychiatry and clinical neurosciences, 1998, Volume: 52, Issue:1

    Topics: Adult; Aged; Akathisia, Drug-Induced; Anticonvulsants; Bipolar Disorder; Clonazepam; Delusions; Depr

1998
Treatment of Meige's syndrome with ECT.
    The journal of ECT, 1999, Volume: 15, Issue:2

    Topics: Anxiety Disorders; Baclofen; Clonazepam; Combined Modality Therapy; Comorbidity; Depressive Disorder

1999
Treating comorbid ADHD, major depression, and panic.
    The Journal of neuropsychiatry and clinical neurosciences, 1999,Fall, Volume: 11, Issue:4

    Topics: Adult; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Clonazepam;

1999