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clonazepam and Depression

clonazepam has been researched along with Depression in 26 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model."7.79The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013)
"The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder."7.68[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992)
"Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment."6.67Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992)
"Clonazepam is useful for treatment-resistant and/or protracted depression, as well as for acceleration of response to conventional antidepressants."6.45Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review. ( Morishita, S, 2009)
"Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981."6.42[Clonazepam as a therapeutic adjunct to improve the management of depression]. ( Morishita, S, 2004)
"Female sex, refractoriness, and clonazepam use may be risk factors for depression after epilepsy diagnosis."3.96Factors associated with depression in people with epilepsy: a retrospective case-control analysis. ( Chang, RSK; Ho, PH; Leung, IYH; Leung, WCY, 2020)
" The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2)."3.88Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( Adamo, D; Aria, M; Fortuna, G; Mignogna, MD; Pecoraro, G, 2018)
"It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model."3.79The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013)
" There is a well recognized association between depression and diabetes, once prevalence of depression in diabetic patients is higher than in general population, and clonazepam is being used to treat this complication."3.79Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior. ( Barros, HM; Guerreiro, G; Manfredini, V; Mescka, CP; Nin, MS; Ribas, GS; Vanzin, CS; Vargas, CR; Wayhs, CA, 2013)
"The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder."3.68[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992)
"Add-on effect of Shirodhara reduced the daytime sleepiness."2.77Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study. ( Chandrashekar, CR; Kutty, BM; Lavekar, GS; Prabha, TN; Sudhakar, D; Tubaki, BR, 2012)
"Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment."2.67Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992)
"FOXG1 syndrome is a severe encephalopathy that exhibit intellectual disability, emotional disorder, and limited social communication."1.51Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors. ( Chen, D; Chen, H; Li, M; She, X; Wang, C; Yuan, Y; Zhang, W; Zhao, C, 2019)
"Clonazepam was the drug most commonly involved with dose escalation; among individuals escalating to doses higher than 60 DMEs, 91% were using clonazepam."1.43Sustained Use of Benzodiazepines and Escalation to High Doses in a Canadian Population. ( Alessi-Severini, S; Bolton, JM; Chateau, D; Collins, DM; Dahl, ME; Enns, MW; Sareen, J, 2016)
"Clonazepam was administered 24, 5 and 1 h before test."1.34Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. ( Barden, AT; Barros, HM; Barschak, AG; da Silva Haeser, A; Deon, M; Gomez, R; Landgraff, S; Schmitt, GO; Sitta, A; Vargas, CR, 2007)
"Treatment with clonazepam, frequent hospitalizations (drug-resistancy) and lack of occupational activity were revealed to be additional significant contributing factors."1.33Risk factors for depression in patients with epilepsy. ( Fiszer, U; Grabowska-Grzyb, A; Jedrzejczak, J; Nagańska, E, 2006)
"We report on four cases of primary orthostatic tremor."1.31[Primary orthostatic tremor: report of 4 cases]. ( Cavallazzi, LO; Machado, SN; Matosinho, P; Pio, FJ, 2000)
"Clonazepam treatment in a dose 1-2 mg/day brought about a significant stabilization of blood pressure in 82."1.31[Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment]. ( Dmitriev, KV; Fedorova, VI; Nedostup, AV, 2000)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19902 (7.69)18.7374
1990's3 (11.54)18.2507
2000's10 (38.46)29.6817
2010's9 (34.62)24.3611
2020's2 (7.69)2.80

Authors

AuthorsStudies
Rossella, I1
Alessandro, V1
Naman, R1
Gary, K1
Hervé, SY1
Ho, PH1
Leung, WCY1
Leung, IYH1
Chang, RSK1
Adamo, D1
Mignogna, MD1
Pecoraro, G1
Aria, M1
Fortuna, G1
Walden, J1
Chen, D1
Wang, C1
Li, M1
She, X1
Yuan, Y1
Chen, H1
Zhang, W1
Zhao, C1
Wayhs, CA3
Mescka, CP3
Vanzin, CS1
Ribas, GS1
Guerreiro, G2
Nin, MS3
Manfredini, V1
Barros, HM5
Vargas, CR4
Moraes, TB1
Jacques, CE1
Rosa, AP1
Ferri, MK1
Dutra-Filho, CS1
Alessi-Severini, S1
Bolton, JM1
Enns, MW1
Dahl, ME1
Chateau, D1
Collins, DM1
Sareen, J1
Morishita, S2
Barker, KE1
Batstone, MD1
Savage, NW1
Bhatia, MS1
Jhanjee, A1
Srivastava, S1
Kumar, P1
Tubaki, BR1
Chandrashekar, CR1
Sudhakar, D1
Prabha, TN1
Lavekar, GS1
Kutty, BM1
Tortato, C1
Pasquali, MA1
Schnorr, CE1
Moreira, JC1
Sattar, SP1
Gastfriend, DR1
Dunner, DL1
Grabowska-Grzyb, A1
Jedrzejczak, J1
Nagańska, E1
Fiszer, U1
da Silva Haeser, A1
Sitta, A1
Barschak, AG1
Deon, M1
Barden, AT1
Schmitt, GO1
Landgraff, S1
Gomez, R2
Bhatara, VS1
Bandettini, FC1
Cavallazzi, LO1
Machado, SN1
Matosinho, P1
Pio, FJ1
Nedostup, AV1
Fedorova, VI1
Dmitriev, KV1
Lander, CM1
Donnan, GA1
Bladin, PF1
Vajda, FJ1
Lima, L1
Carreira, I1
Morales, M1
Silva, C1
Casique, M1
Hewlett, WA1
Vinogradov, S1
Agras, WS1
Wollman, M1
Lavie, P1
Peled, R1

Reviews

2 reviews available for clonazepam and Depression

ArticleYear
Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review.
    Human psychopharmacology, 2009, Volume: 24, Issue:3

    Topics: Antidepressive Agents; Clonazepam; Depression; Humans

2009
[Clonazepam as a therapeutic adjunct to improve the management of depression].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2004, Volume: 24, Issue:2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Clonazepam; Depression; Drug Therapy, C

2004

Trials

2 trials available for clonazepam and Depression

ArticleYear
Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study.
    Journal of alternative and complementary medicine (New York, N.Y.), 2012, Volume: 18, Issue:6

    Topics: Adult; Anxiety; Anxiety Disorders; Bacopa; Biological Products; Clonazepam; Depression; Disorders of

2012
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:6

    Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind

1992

Other Studies

22 other studies available for clonazepam and Depression

ArticleYear
Topical clonazepam for burning mouth syndrome: Is it efficacious in patients with anxiety or depression?
    Journal of oral rehabilitation, 2022, Volume: 49, Issue:1

    Topics: Anxiety; Burning Mouth Syndrome; Clonazepam; Depression; Humans; Retrospective Studies

2022
Factors associated with depression in people with epilepsy: a retrospective case-control analysis.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2020, Volume: 26, Issue:4

    Topics: Adult; Anticonvulsants; Case-Control Studies; Clonazepam; Depression; Epilepsy; Female; Humans; Male

2020
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
    The Journal of dermatological treatment, 2018, Volume: 29, Issue:6

    Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Benzodiazepines; Burning Mouth Syndrome; Cl

2018
Fear.
    Family medicine, 2019, Volume: 51, Issue:3

    Topics: Anticonvulsants; Anxiety; Clonazepam; Depression; Family Practice; Fear; Female; Fluoxetine; Humans;

2019
Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors.
    Cerebral cortex (New York, N.Y. : 1991), 2019, 07-22, Volume: 29, Issue:8

    Topics: Animals; Behavior, Animal; Brain Diseases; Cerebral Cortex; Clonazepam; Cognition; Depression; Emoti

2019
Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior.
    Metabolic brain disease, 2013, Volume: 28, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Clonazepam; Depression; Diabetes Mellitus, Experimental; DNA Damag

2013
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain.
    Cell biochemistry and function, 2014, Volume: 32, Issue:8

    Topics: Animals; Anticonvulsants; Antioxidants; Brain Diseases; Cerebral Cortex; Clonazepam; Corpus Striatum

2014
Sustained Use of Benzodiazepines and Escalation to High Doses in a Canadian Population.
    Psychiatric services (Washington, D.C.), 2016, 09-01, Volume: 67, Issue:9

    Topics: Adolescent; Adult; Aged; Benzodiazepines; Child; Child, Preschool; Clonazepam; Cohort Studies; Depre

2016
Comparison of treatment modalities in burning mouth syndrome.
    Australian dental journal, 2009, Volume: 54, Issue:4

    Topics: Anxiety; Burning Mouth Syndrome; Chi-Square Distribution; Clonazepam; Depression; Diazepam; Female;

2009
An uncommon case of hypersexual behaviour with frotteurism.
    Medicine, science, and the law, 2010, Volume: 50, Issue:4

    Topics: Antidepressive Agents, Second-Generation; Child; Clonazepam; Depression; Female; Fluoxetine; GABA Mo

2010
The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression.
    Pharmaceutical biology, 2013, Volume: 51, Issue:5

    Topics: Animals; Catalase; Clonazepam; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal;

2013
Visual inspection of medications in preventing unexplained relapses.
    The Annals of pharmacotherapy, 2002, Volume: 36, Issue:10

    Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Aspirin; Benzodiazepines; Cetirizine; Clonazepam

2002
Interactive case conference. First episode: depression and panic disorder.
    CNS spectrums, 2005, Volume: 10, Issue:9

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Citalopram; Clonazepam; Depression;

2005
Risk factors for depression in patients with epilepsy.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Depression; Epilepsies, Partial; Epilepsy, Complex P

2006
Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect.
    Brain research, 2007, Jun-18, Volume: 1154

    Topics: Analysis of Variance; Animals; Behavior, Animal; Catalase; Clonazepam; Depression; Diabetes Mellitus

2007
Possible interaction between sertraline and tranylcypromine.
    Clinical pharmacy, 1993, Volume: 12, Issue:3

    Topics: 1-Naphthylamine; Clonazepam; Depression; Drug Administration Schedule; Drug Interactions; Humans; Ma

1993
[Primary orthostatic tremor: report of 4 cases].
    Arquivos de neuro-psiquiatria, 2000, Volume: 58, Issue:1

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Arm; Clonazepam; Depression; Diagnosis, Differential; E

2000
Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:2

    Topics: Animals; Antidepressive Agents; Blood Glucose; Brain; Clonazepam; Depression; Diabetes Mellitus, Exp

2000
[Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment].
    Klinicheskaia meditsina, 2000, Volume: 78, Issue:7

    Topics: Aged; Aged, 80 and over; Anxiety; Autonomic Nervous System; Blood Pressure; Circadian Rhythm; Clonaz

2000
Some aspects of the clinical use of clonazepam in refractory epilepsy.
    Clinical and experimental neurology, 1979, Volume: 16

    Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati

1979
[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam].
    Investigacion clinica, 1992, Volume: 33, Issue:1

    Topics: Adult; Anxiety Disorders; Clonazepam; Depression; Female; Humans; Imipramine; Lactates; Lactic Acid;

1992
A hypernychthemeral sleep-wake syndrome: a treatment attempt.
    Chronobiology international, 1985, Volume: 2, Issue:4

    Topics: Adult; Circadian Rhythm; Clonazepam; Depression; Fatigue; Humans; Male; Sleep Wake Disorders

1985