clonazepam has been researched along with Depression in 26 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model." | 7.79 | The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013) |
| "The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder." | 7.68 | [Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 6.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "Clonazepam is useful for treatment-resistant and/or protracted depression, as well as for acceleration of response to conventional antidepressants." | 6.45 | Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review. ( Morishita, S, 2009) |
| "Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981." | 6.42 | [Clonazepam as a therapeutic adjunct to improve the management of depression]. ( Morishita, S, 2004) |
| "Female sex, refractoriness, and clonazepam use may be risk factors for depression after epilepsy diagnosis." | 3.96 | Factors associated with depression in people with epilepsy: a retrospective case-control analysis. ( Chang, RSK; Ho, PH; Leung, IYH; Leung, WCY, 2020) |
| " The Numeric Rating Scale (NRS), the Total Pain Rating Index (T-PRI), the Hamilton rating scales for Depression (HAM-D) and Anxiety (HAM-A) were performed at baseline (time 0), after 2 months of topical clonazepam (time 1) and after 6 months of benzodiazepine and antidepressant drugs (time 2)." | 3.88 | Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( Adamo, D; Aria, M; Fortuna, G; Mignogna, MD; Pecoraro, G, 2018) |
| "It is known that oxidative stress occurs in peripheral blood in an experimental animal model of diabetes and depression, and acute treatment with insulin and clonazepam (CNZ) has a protective effect on oxidative stress in this model." | 3.79 | The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression. ( Barros, HM; Mescka, CP; Moreira, JC; Nin, MS; Pasquali, MA; Schnorr, CE; Tortato, C; Vargas, CR; Wayhs, CA, 2013) |
| " There is a well recognized association between depression and diabetes, once prevalence of depression in diabetic patients is higher than in general population, and clonazepam is being used to treat this complication." | 3.79 | Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior. ( Barros, HM; Guerreiro, G; Manfredini, V; Mescka, CP; Nin, MS; Ribas, GS; Vanzin, CS; Vargas, CR; Wayhs, CA, 2013) |
| "The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder." | 3.68 | [Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992) |
| "Add-on effect of Shirodhara reduced the daytime sleepiness." | 2.77 | Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study. ( Chandrashekar, CR; Kutty, BM; Lavekar, GS; Prabha, TN; Sudhakar, D; Tubaki, BR, 2012) |
| "Clonazepam improvement was unrelated to changes in anxiety and occurred early in treatment." | 2.67 | Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder. ( Agras, WS; Hewlett, WA; Vinogradov, S, 1992) |
| "FOXG1 syndrome is a severe encephalopathy that exhibit intellectual disability, emotional disorder, and limited social communication." | 1.51 | Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors. ( Chen, D; Chen, H; Li, M; She, X; Wang, C; Yuan, Y; Zhang, W; Zhao, C, 2019) |
| "Clonazepam was the drug most commonly involved with dose escalation; among individuals escalating to doses higher than 60 DMEs, 91% were using clonazepam." | 1.43 | Sustained Use of Benzodiazepines and Escalation to High Doses in a Canadian Population. ( Alessi-Severini, S; Bolton, JM; Chateau, D; Collins, DM; Dahl, ME; Enns, MW; Sareen, J, 2016) |
| "Clonazepam was administered 24, 5 and 1 h before test." | 1.34 | Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect. ( Barden, AT; Barros, HM; Barschak, AG; da Silva Haeser, A; Deon, M; Gomez, R; Landgraff, S; Schmitt, GO; Sitta, A; Vargas, CR, 2007) |
| "Treatment with clonazepam, frequent hospitalizations (drug-resistancy) and lack of occupational activity were revealed to be additional significant contributing factors." | 1.33 | Risk factors for depression in patients with epilepsy. ( Fiszer, U; Grabowska-Grzyb, A; Jedrzejczak, J; Nagańska, E, 2006) |
| "We report on four cases of primary orthostatic tremor." | 1.31 | [Primary orthostatic tremor: report of 4 cases]. ( Cavallazzi, LO; Machado, SN; Matosinho, P; Pio, FJ, 2000) |
| "Clonazepam treatment in a dose 1-2 mg/day brought about a significant stabilization of blood pressure in 82." | 1.31 | [Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment]. ( Dmitriev, KV; Fedorova, VI; Nedostup, AV, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.69) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 9 (34.62) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Rossella, I | 1 |
| Alessandro, V | 1 |
| Naman, R | 1 |
| Gary, K | 1 |
| Hervé, SY | 1 |
| Ho, PH | 1 |
| Leung, WCY | 1 |
| Leung, IYH | 1 |
| Chang, RSK | 1 |
| Adamo, D | 1 |
| Mignogna, MD | 1 |
| Pecoraro, G | 1 |
| Aria, M | 1 |
| Fortuna, G | 1 |
| Walden, J | 1 |
| Chen, D | 1 |
| Wang, C | 1 |
| Li, M | 1 |
| She, X | 1 |
| Yuan, Y | 1 |
| Chen, H | 1 |
| Zhang, W | 1 |
| Zhao, C | 1 |
| Wayhs, CA | 3 |
| Mescka, CP | 3 |
| Vanzin, CS | 1 |
| Ribas, GS | 1 |
| Guerreiro, G | 2 |
| Nin, MS | 3 |
| Manfredini, V | 1 |
| Barros, HM | 5 |
| Vargas, CR | 4 |
| Moraes, TB | 1 |
| Jacques, CE | 1 |
| Rosa, AP | 1 |
| Ferri, MK | 1 |
| Dutra-Filho, CS | 1 |
| Alessi-Severini, S | 1 |
| Bolton, JM | 1 |
| Enns, MW | 1 |
| Dahl, ME | 1 |
| Chateau, D | 1 |
| Collins, DM | 1 |
| Sareen, J | 1 |
| Morishita, S | 2 |
| Barker, KE | 1 |
| Batstone, MD | 1 |
| Savage, NW | 1 |
| Bhatia, MS | 1 |
| Jhanjee, A | 1 |
| Srivastava, S | 1 |
| Kumar, P | 1 |
| Tubaki, BR | 1 |
| Chandrashekar, CR | 1 |
| Sudhakar, D | 1 |
| Prabha, TN | 1 |
| Lavekar, GS | 1 |
| Kutty, BM | 1 |
| Tortato, C | 1 |
| Pasquali, MA | 1 |
| Schnorr, CE | 1 |
| Moreira, JC | 1 |
| Sattar, SP | 1 |
| Gastfriend, DR | 1 |
| Dunner, DL | 1 |
| Grabowska-Grzyb, A | 1 |
| Jedrzejczak, J | 1 |
| Nagańska, E | 1 |
| Fiszer, U | 1 |
| da Silva Haeser, A | 1 |
| Sitta, A | 1 |
| Barschak, AG | 1 |
| Deon, M | 1 |
| Barden, AT | 1 |
| Schmitt, GO | 1 |
| Landgraff, S | 1 |
| Gomez, R | 2 |
| Bhatara, VS | 1 |
| Bandettini, FC | 1 |
| Cavallazzi, LO | 1 |
| Machado, SN | 1 |
| Matosinho, P | 1 |
| Pio, FJ | 1 |
| Nedostup, AV | 1 |
| Fedorova, VI | 1 |
| Dmitriev, KV | 1 |
| Lander, CM | 1 |
| Donnan, GA | 1 |
| Bladin, PF | 1 |
| Vajda, FJ | 1 |
| Lima, L | 1 |
| Carreira, I | 1 |
| Morales, M | 1 |
| Silva, C | 1 |
| Casique, M | 1 |
| Hewlett, WA | 1 |
| Vinogradov, S | 1 |
| Agras, WS | 1 |
| Wollman, M | 1 |
| Lavie, P | 1 |
| Peled, R | 1 |
2 reviews available for clonazepam and Depression
| Article | Year |
|---|---|
Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review.
Topics: Antidepressive Agents; Clonazepam; Depression; Humans | 2009 |
[Clonazepam as a therapeutic adjunct to improve the management of depression].
Topics: Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Clonazepam; Depression; Drug Therapy, C | 2004 |
2 trials available for clonazepam and Depression
| Article | Year |
|---|---|
Clinical efficacy of Manasamitra Vataka (an Ayurveda medication) on generalized anxiety disorder with comorbid generalized social phobia: a randomized controlled study.
Topics: Adult; Anxiety; Anxiety Disorders; Bacopa; Biological Products; Clonazepam; Depression; Disorders of | 2012 |
Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.
Topics: Adult; Analysis of Variance; Anxiety; Clomipramine; Clonazepam; Clonidine; Depression; Double-Blind | 1992 |
22 other studies available for clonazepam and Depression
| Article | Year |
|---|---|
Topical clonazepam for burning mouth syndrome: Is it efficacious in patients with anxiety or depression?
Topics: Anxiety; Burning Mouth Syndrome; Clonazepam; Depression; Humans; Retrospective Studies | 2022 |
Factors associated with depression in people with epilepsy: a retrospective case-control analysis.
Topics: Adult; Anticonvulsants; Case-Control Studies; Clonazepam; Depression; Epilepsy; Female; Humans; Male | 2020 |
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Anxiety; Benzodiazepines; Burning Mouth Syndrome; Cl | 2018 |
Fear.
Topics: Anticonvulsants; Anxiety; Clonazepam; Depression; Family Practice; Fear; Female; Fluoxetine; Humans; | 2019 |
Loss of Foxg1 Impairs the Development of Cortical SST-Interneurons Leading to Abnormal Emotional and Social Behaviors.
Topics: Animals; Behavior, Animal; Brain Diseases; Cerebral Cortex; Clonazepam; Cognition; Depression; Emoti | 2019 |
Brain effect of insulin and clonazepam in diabetic rats under depressive-like behavior.
Topics: Animals; Behavior, Animal; Brain; Clonazepam; Depression; Diabetes Mellitus, Experimental; DNA Damag | 2013 |
Diabetic encephalopathy-related depression: experimental evidence that insulin and clonazepam restore antioxidant status in rat brain.
Topics: Animals; Anticonvulsants; Antioxidants; Brain Diseases; Cerebral Cortex; Clonazepam; Corpus Striatum | 2014 |
Sustained Use of Benzodiazepines and Escalation to High Doses in a Canadian Population.
Topics: Adolescent; Adult; Aged; Benzodiazepines; Child; Child, Preschool; Clonazepam; Cohort Studies; Depre | 2016 |
Comparison of treatment modalities in burning mouth syndrome.
Topics: Anxiety; Burning Mouth Syndrome; Chi-Square Distribution; Clonazepam; Depression; Diazepam; Female; | 2009 |
An uncommon case of hypersexual behaviour with frotteurism.
Topics: Antidepressive Agents, Second-Generation; Child; Clonazepam; Depression; Female; Fluoxetine; GABA Mo | 2010 |
The association effect of insulin and clonazepam on oxidative stress in liver of an experimental animal model of diabetes and depression.
Topics: Animals; Catalase; Clonazepam; Depression; Diabetes Mellitus, Experimental; Disease Models, Animal; | 2013 |
Visual inspection of medications in preventing unexplained relapses.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Aspirin; Benzodiazepines; Cetirizine; Clonazepam | 2002 |
Interactive case conference. First episode: depression and panic disorder.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Citalopram; Clonazepam; Depression; | 2005 |
Risk factors for depression in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Clonazepam; Depression; Epilepsies, Partial; Epilepsy, Complex P | 2006 |
Oxidative stress parameters in diabetic rats submitted to forced swimming test: the clonazepam effect.
Topics: Analysis of Variance; Animals; Behavior, Animal; Catalase; Clonazepam; Depression; Diabetes Mellitus | 2007 |
Possible interaction between sertraline and tranylcypromine.
Topics: 1-Naphthylamine; Clonazepam; Depression; Drug Administration Schedule; Drug Interactions; Humans; Ma | 1993 |
[Primary orthostatic tremor: report of 4 cases].
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Arm; Clonazepam; Depression; Diagnosis, Differential; E | 2000 |
Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats.
Topics: Animals; Antidepressive Agents; Blood Glucose; Brain; Clonazepam; Depression; Diabetes Mellitus, Exp | 2000 |
[Labile hypertension in elderly: clinical features, autonomic regulation of circulation, approaches to treatment].
Topics: Aged; Aged, 80 and over; Anxiety; Autonomic Nervous System; Blood Pressure; Circadian Rhythm; Clonaz | 2000 |
Some aspects of the clinical use of clonazepam in refractory epilepsy.
Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati | 1979 |
[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam].
Topics: Adult; Anxiety Disorders; Clonazepam; Depression; Female; Humans; Imipramine; Lactates; Lactic Acid; | 1992 |
A hypernychthemeral sleep-wake syndrome: a treatment attempt.
Topics: Adult; Circadian Rhythm; Clonazepam; Depression; Fatigue; Humans; Male; Sleep Wake Disorders | 1985 |