clonazepam and Depression, Endogenous studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Research Excerpts

Excerpt	Relevance	Reference
"Clonazepam was administered to 55 patients with depressive disorder (DSM-III-R) in average minimal and maximal doses of 2."	7.69	[Effectiveness of clonazepam in depressive disorders]. ( Buresová, A; Cesková, E; Kamenická, V; Svestka, J, 1995)
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy."	7.68	[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992)
" Clonazepam and/or quetiapine were administered for sleep disorders but failed to resolve insomnia and excessive daytime sleepiness (EDS)."	3.83	Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia. ( Chen, YL; Hsu, CH; Liu, IC; Pei, D; Yu, SM, 2016)
"Clonazepam was administered to 55 patients with depressive disorder (DSM-III-R) in average minimal and maximal doses of 2."	3.69	[Effectiveness of clonazepam in depressive disorders]. ( Buresová, A; Cesková, E; Kamenická, V; Svestka, J, 1995)
"The case is described of a neonate who suffered from withdrawal symptoms within 24 hours after birth as a result of the use of clomipramine by the mother during pregnancy."	3.68	[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. ( Boringa, JB; de Jong, GM; Touw, DJ, 1992)
" She was given 25 mg of intramuscular diphenhydramine and 1 mg of intramuscular benztropine mesylate, which resulted in little relief; however, 1 mg clonazepam caused both the myoclonic jerks and dystonias to resolve completely."	3.67	Acute generalized myoclonus following buspirone administration. ( Bridenbaugh, RH; Jabbari, B; Ritchie, EC, 1988)
"Cotherapy was effective in reducing insomnia but not anxiety or core symptoms (low mood, suicidality, reduced interest)."	2.70	Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression? ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 2002)
"Clonazepam/placebo was gradually discontinued during days 21-33."	2.69	Short-term augmentation of fluoxetine with clonazepam in the treatment of depression: a double-blind study. ( Glaudin, V; Londborg, PD; Painter, JR; Smith, WT, 1998)
"Many patients with migraine are poorly responsive to conventional preventive therapies."	2.46	Clonazepam for refractory headache: three cases illustrative of benefit and risk. ( Maizels, M, 2010)
"Two patients who developed choreoathetosis in the course of lithium treatment are described, and other cases of choreoathetosis in lithium-treated patients are reviewed."	2.38	Choreoathetosis: a sign of lithium toxicity. ( Reed, SM; Timmerman, I; Wise, MG, 1989)
"Clonazepam is a high-potency benzodiazepine labeled for use as an anticonvulsant."	2.37	Clonazepam: new uses and potential problems. ( Cohen, LS; Rosenbaum, JF, 1987)
"As a result, SSRIinduced akathisia is very frequently under-recognized."	1.40	A case of akathisia induced by escitalopram: case report & review of literature. ( Basu, B; De, S; Dutta, N; Gangopadhyay, T; Mandal, B; Mondal, S, 2014)
"Ziprasidone was stopped in by tapering 20 mg/day, but the involuntary movements continued and even exacerbated."	1.35	Ziprasidone induced tardive cervical dystonia. ( Altun, NS; Budak, F; Dündar, S; Kutlu, A, 2009)
"One patient died of pulmonary edema and subsequent heart failure, but the rest of the patients recovered without any sequelae."	1.34	Hemoperfusion in the treatment of acute clozapine intoxication in China. ( Cai, ZJ; He, JL; Li, WB; Ungvari, GS; Xiang, YT, 2007)
"Clonazepam was either given as monotherapy, or as in the case of lithium non-responders, as adjunctive therapy."	1.32	Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. ( Barnas, C; Kasper, S; Konstantinidis, A; Pjrek, E; Schindler, S; Stamenkovic, M; Tauscher, J; Willeit, M; Winkler, D; Wolf, R, 2003)
"Unipolar depression was significantly more effective than bipolar depression on clonazepam treatment."	1.31	[Clonazepam in the treatment of protracted depression: a hundred-case report]. ( Morishita, S, 2002)
"However, in the bipolar depression group, only 10."	1.31	Clonazepam augmentation of antidepressants: does it distinguish unipolar from bipolar depression? ( Aoki, S; Morishita, S, 2002)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (17.65)	18.7374
1990's	23 (45.10)	18.2507
2000's	9 (17.65)	29.6817
2010's	8 (15.69)	24.3611
2020's	2 (3.92)	2.80

Authors	Studies
Uvais, NA	1
Sharma, VD	1
Gupta, HV	1
Espay, AJ	1
Faye, A	1
Kirpekar, V	1
Tadke, R	1
Gawande, S	1
Bhave, S	1
Basu, B	1
Gangopadhyay, T	1
Dutta, N	1
Mandal, B	1
De, S	1
Mondal, S	1
Kurkjian, N	1
Kurkjian, C	1
Pant, S	1
Tucker, P	1
Jago, BJ	1
Aragones, JM	1
Blanch, CE	1
Guillen-Font, A	1
Escote-Llobet, S	1
Hsu, CH	1
Chen, YL	1
Pei, D	1
Yu, SM	1
Liu, IC	1
Maizels, M	1
Kutlu, A	1
Dündar, S	1
Altun, NS	1
Budak, F	1
Wayhs, CA	1
Manfredini, V	1
Sitta, A	1
Deon, M	1
Ribas, G	1
Vanzin, C	1
Biancini, G	1
Ferri, M	1
Nin, M	1
Barros, HM	1
Vargas, CR	1
Smith, WT	2
Londborg, PD	2
Glaudin, V	2
Painter, JR	2
Morishita, S	3
Aoki, S	2
Winkler, D	1
Willeit, M	1
Wolf, R	1
Stamenkovic, M	1
Tauscher, J	1
Pjrek, E	1
Konstantinidis, A	1
Schindler, S	1
Barnas, C	1
Kasper, S	1
Oberlander, TF	1
Misri, S	1
Fitzgerald, CE	1
Kostaras, X	1
Rurak, D	1
Riggs, W	1
Kahn, JP	1
He, JL	1
Xiang, YT	1
Li, WB	1
Cai, ZJ	1
Ungvari, GS	1
Wolf, J	1
Salo, R	1
Post, RM	1
Uhde, TW	1
Jones, BD	2
Purdon, SE	1
Labelle, A	1
Finlayson, R	1
Donohue, B	1
Acierno, R	1
van Hasselt, VB	1
Hersen, M	1
Adler, LA	2
Angrist, BM	1
Berigan, TR	1
Harazin, J	1
Williams, HL	1
Svestka, J	1
Cesková, E	1
Kamenická, V	1
Buresová, A	1
Eberstein, S	1
Angrist, B	1
Benazzi, F	1
Feiner, NF	1
Maltese, TM	1
Furukawa, T	1
Trachman, SB	1
Boringa, JB	1
de Jong, GM	1
Touw, DJ	1
Saltz, BL	1
Hampf, G	1
Kuoppasalmi, K	1
Henriksson, M	1
Achté, K	1
Diukova, GM	1
Shepeleva, IP	1
Vorob'eva, OV	1
Bakish, D	1
Karagianis, JL	1
March, H	1
Biederman, J	1
Fava, M	2
Borofsky, GF	1
Pollack, MH	1
Otto, MW	1
Rosenbaum, JF	3
Sachs, GS	1
O'Neil, C	1
Asher, R	1
Meltzer-Brody, S	1
Anderson, K	1
Reed, SM	1
Wise, MG	1
Timmerman, I	1
Cohen, LS	1
Eppel, AB	1
Kishimoto, A	1
Kamata, K	1
Sugihara, T	1
Ishiguro, S	1
Hazama, H	1
Mizukawa, R	1
Kunimoto, N	1
Deicken, RF	1
Ritchie, EC	1
Bridenbaugh, RH	1
Jabbari, B	1
Alvarez, WA	1
Freinhar, JP	1
Chouinard, G	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Role of Orexin in Human Panic Disorder[NCT02593682]			Phase 4	3 participants (Actual)	Interventional	2016-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Clonazepam for refractory headache: three cases illustrative of benefit and risk. Headache, 2010, Volume: 50, Issue:4 Topics: Adult; Anxiety Disorders; Clonazepam; Comorbidity; Depressive Disorder; Drug Tolerance; Female; GABA	2010
Treatment of mood disorders with antiepileptic medications: clinical and theoretical implications. Epilepsia, 1983, Volume: 24 Suppl 2 Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Depressive D	1983
The diagnosis and treatment of adolescent anxiety disorders. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Child;	1990
Choreoathetosis: a sign of lithium toxicity. The Journal of neuropsychiatry and clinical neurosciences, 1989,Winter, Volume: 1, Issue:1 Topics: Aged; Athetosis; Chorea; Clonazepam; Delirium; Depressive Disorder; Drug Therapy, Combination; Femal	1989
Clonazepam: new uses and potential problems. The Journal of clinical psychiatry, 1987, Volume: 48 Suppl Topics: Adult; Antipsychotic Agents; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Female; Hum	1987

Article	Year
Is extended clonazepam cotherapy of fluoxetine effective for outpatients with major depression? Journal of affective disorders, 2002, Volume: 70, Issue:3 Topics: Administration, Oral; Adult; Antidepressive Agents, Second-Generation; Anxiety; Clonazepam; Depressi	2002
Treatment of mood disorders with antiepileptic medications: clinical and theoretical implications. Epilepsia, 1983, Volume: 24 Suppl 2 Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Depressive D	1983
Short-term augmentation of fluoxetine with clonazepam in the treatment of depression: a double-blind study. The American journal of psychiatry, 1998, Volume: 155, Issue:10 Topics: Adult; Ambulatory Care; Clonazepam; Depressive Disorder; Double-Blind Method; Drug Administration Sc	1998
Clonazepam in the treatment of prolonged depression. Journal of affective disorders, 1999, Volume: 53, Issue:3 Topics: Antidepressive Agents, Tricyclic; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug;	1999
[Treatment of autonomic crises (attacks of panic)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1991, Volume: 91, Issue:5 Topics: Amitriptyline; Anxiety Disorders; Autonomic Nervous System Diseases; Clonazepam; Depressive Disorder	1991
Treatment of depression with clonazepam. Acta psychiatrica Scandinavica, 1988, Volume: 77, Issue:1 Topics: Adult; Aged; Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Depressive Disorder; Dose-Respo	1988

clonazepam and Depression, Endogenous

Research Excerpts

Research

Studies (51)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Psychological Impact of the COVID-19 Pandemic Among the Elderly: A Case Series From India. The primary care companion for CNS disorders, 2020, 06-25, Volume: 22, Issue:4 Topics: Acetamides; Aged; Aged, 80 and over; Anti-Anxiety Agents; Antidepressive Agents; Betacoronavirus; Ci	2020
Copulatory Dyskinesia: Pathognomonic Manifestation of Tardive Dyskinesia. Tremor and other hyperkinetic movements (New York, N.Y.), 2020, 12-16, Volume: 10 Topics: Adrenergic beta-Antagonists; Aged; Aripiprazole; Clonazepam; Deprescriptions; Depressive Disorder; D	2020
Obsession of pregnancy: Does it exist? Asian journal of psychiatry, 2017, Volume: 29 Topics: Attitude to Health; Citalopram; Clomipramine; Clonazepam; Cognitive Behavioral Therapy; Depressive D	2017
A case of akathisia induced by escitalopram: case report & review of literature. Current drug safety, 2014, Volume: 9, Issue:1 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Second-Generation; Breast Neoplasms; Citalopram;	2014
Psycho-oncology: a brief history and case study. The Journal of the Oklahoma State Medical Association, 2013, Volume: 106, Issue:12 Topics: Antidepressive Agents, Second-Generation; Carcinoma, Squamous Cell; Citalopram; Clonazepam; Depressi	2013
My sleep fest: an autoethnographic short story. Health communication, 2015, Volume: 30, Issue:1 Topics: Anthropology, Cultural; Antipsychotic Agents; Aripiprazole; Clonazepam; Depressive Disorder; GABA Mo	2015
[Buccolingual dyskinesia with justified hallucinations]. Revista de neurologia, 2014, Nov-16, Volume: 59, Issue:10 Topics: Alcoholism; Benzodiazepines; Clonazepam; Depressive Disorder; Dibenzothiazepines; Disulfiram; Female	2014
Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016, 07-15, Volume: 12, Issue:7 Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Clonazepam; Depressive Disorder; Disorders of Ex	2016
Ziprasidone induced tardive cervical dystonia. Psychopharmacology bulletin, 2009, Volume: 42, Issue:4 Topics: Antipsychotic Agents; Botulinum Toxins, Type A; Clonazepam; Depressive Disorder; Dyskinesia, Drug-In	2009
Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect. Metabolic brain disease, 2010, Volume: 25, Issue:3 Topics: Animals; Clonazepam; Depressive Disorder; Diabetes Complications; Disease Models, Animal; GABA Modul	2010
[Clonazepam in the treatment of protracted depression: a hundred-case report]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2002, Volume: 22, Issue:3 Topics: Adult; Aged; Anticonvulsants; Antidepressive Agents; Clonazepam; Depressive Disorder; Dose-Response	2002
Clonazepam augmentation of antidepressants: does it distinguish unipolar from bipolar depression? Journal of affective disorders, 2002, Volume: 71, Issue:1-3 Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Clonazepam; Depressive Disorder; Diagnosis, Differen	2002
Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:2 Topics: Adult; Aged; Bipolar Disorder; Clonazepam; Depressive Disorder; Female; Humans; Male; Middle Aged; P	2003
Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposure. The Journal of clinical psychiatry, 2004, Volume: 65, Issue:2 Topics: Adult; Anti-Anxiety Agents; Anxiety Disorders; Clonazepam; Cohort Studies; Depressive Disorder; Dose	2004
Agitated depression, panic anxiety, and clonazepam. The Journal of clinical psychiatry, 2006, Volume: 67, Issue:12 Topics: Clonazepam; Comorbidity; Depressive Disorder; GABA Modulators; Humans; Panic Disorder; Psychomotor A	2006
Hemoperfusion in the treatment of acute clozapine intoxication in China. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6 Topics: Acute Disease; Adult; Alprazolam; Antipsychotic Agents; China; Clonazepam; Clozapine; Depressive Dis	2007
Water, water, everywhere, nor any drop to drink: climate change delusion. The Australian and New Zealand journal of psychiatry, 2008, Volume: 42, Issue:4 Topics: Adolescent; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Climate	2008
Risperidone treatment for severe negative symptoms. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1994, Volume: 39, Issue:6 Topics: Adult; Antipsychotic Agents; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Humans; Iso	1994
Social skills training in a depressed, visually impaired older adult. Journal of behavior therapy and experimental psychiatry, 1995, Volume: 26, Issue:1 Topics: Activities of Daily Living; Aged; Assertiveness; Behavior Therapy; Clonazepam; Combined Modality The	1995
Paroxetine and akathisia. Biological psychiatry, 1995, Mar-01, Volume: 37, Issue:5 Topics: Akathisia, Drug-Induced; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Adm	1995
Use of flumazenil in conjunction with electroconvulsive therapy. The American journal of psychiatry, 1995, Volume: 152, Issue:6 Topics: Adult; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Female; Flumazenil; Humans; Subst	1995
[Effectiveness of clonazepam in depressive disorders]. Ceska a slovenska psychiatrie, 1995, Volume: 91, Issue:4 Topics: Adult; Aged; Antidepressive Agents; Clonazepam; Depressive Disorder; Female; Humans; Male; Middle Ag	1995
Nefazodone and akathisia. Biological psychiatry, 1996, Oct-15, Volume: 40, Issue:8 Topics: Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Clonazepam; Depressive Disorder;	1996
Dangerous interaction with nefazodone added to fluoxetine, desipramine, venlafaxine, valproate and clonazepam combination therapy. Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:2 Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Desipramine; Drug Ther	1997
Antiepileptic drug augmentation for treatment-resistant depression. The Journal of clinical psychiatry, 1997, Volume: 58, Issue:8 Topics: Alprazolam; Anticonvulsants; Antidepressive Agents; Clonazepam; Comorbidity; Depressive Disorder; Di	1997
Adjunctive lamotrigine treatment for major depression. The American journal of psychiatry, 1999, Volume: 156, Issue:11 Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Drug Therapy, Combinat	1999
Antidepressant-benzodiazepine combination therapy. The American journal of psychiatry, 1999, Volume: 156, Issue:11 Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Benzodiazepines; Clonaze	1999
Buspirone-induced psychosis in a human immunodeficiency virus-infected man. Psychosomatics, 1992,Summer, Volume: 33, Issue:3 Topics: Attitude to Health; Buspirone; Clonazepam; Depressive Disorder; HIV Seropositivity; Humans; Life Cha	1992
[Neonatal withdrawal symptoms following the use of clomipramine during pregnancy]. Nederlands tijdschrift voor geneeskunde, 1992, Jul-25, Volume: 136, Issue:30 Topics: Adult; Clomipramine; Clonazepam; Depressive Disorder; Female; Humans; Infant, Newborn; Male; Neonata	1992
Tardive dyskinesia in the elderly patient. Hospital practice (Office ed.), 1992, Apr-15, Volume: 27, Issue:4 Topics: Aged; Chlorpromazine; Chronic Disease; Clonazepam; Clozapine; Depressive Disorder; Desipramine; Diph	1992
Chronic facial pain together with severe depression is responsive to electroconvulsive therapy. A case report. Acta odontologica Scandinavica, 1992, Volume: 50, Issue:3 Topics: Amitriptyline; Chronic Disease; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Facial P	1992
Fluoxetine potentiation by buspirone: three case histories. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:10 Topics: Adult; Buspirone; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Synergism;	1991
Flushing reaction associated with the interaction of phenelzine and clonazepam. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:5 Topics: Adult; Anxiety Disorders; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Th	1991
Sexual disinhibition during treatment with a benzodiazepine: a case report. International journal of psychiatry in medicine, 1991, Volume: 21, Issue:1 Topics: Anxiety Disorders; Clonazepam; Depressive Disorder; Female; Humans; Panic; Sexual Behavior; Social E	1991
Longitudinal course of panic disorder: findings from the Massachusetts General Hospital Naturalistic Study. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl A Topics: Alprazolam; Anxiety Disorders; Child, Preschool; Chronic Disease; Clonazepam; Cognitive Behavioral T	1990
"Anger attacks": possible variants of panic and major depressive disorders. The American journal of psychiatry, 1990, Volume: 147, Issue:7 Topics: Adult; Anger; Anxiety Disorders; Clomipramine; Clonazepam; Depressive Disorder; Desipramine; Diagnos	1990
Imipramine and clonazepam for panic disorder. The American journal of psychiatry, 1989, Volume: 146, Issue:2 Topics: Anxiety Disorders; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Fear; Humans; Imipram	1989
Clonazepam-induced reduction in serum desipramine concentration. Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:1 Topics: Adult; Clonazepam; Depressive Disorder; Desipramine; Drug Therapy, Combination; Humans; Male	1988
Acute generalized myoclonus following buspirone administration. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:6 Topics: Acute Disease; Akathisia, Drug-Induced; Anxiety Disorders; Buspirone; Clonazepam; Depressive Disorde	1988
Clonazepam: an antidepressant? The American journal of psychiatry, 1987, Volume: 144, Issue:4 Topics: Bipolar Disorder; Clonazepam; Depressive Disorder; Humans	1987
Clonazepam in the treatment of recurrent symptoms of depression and anxiety in a patient with systemic lupus erythematosus. The American journal of psychiatry, 1985, Volume: 142, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Anxiety Disorders; Benzodiazepinones; Clonazepam; Depressive Disorde	1985