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clonazepam and Dementia Praecox

clonazepam has been researched along with Dementia Praecox in 38 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Research Excerpts

ExcerptRelevanceReference
"This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasing the efficacy of an acute 6-week treatment by switching intramuscular haloperidol injection to RIS-OS."9.16Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia. ( Chen, H; Fang, M; Huang, J; Li, LH; Li, Y; Liu, L; Wang, B; Wang, G; Wu, R; Ye, M; Zhang, L; Zhang, Q; Zhao, JP; Zheng, H; Zhou, J; Zhu, S, 2012)
"This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia."7.69Successful treatment of tardive dystonia with clozapine and clonazepam. ( Mckenna, PJ; Mickay, AP; Shapleske, J, 1996)
"The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder."7.68[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992)
" I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride."7.68Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990)
"Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features."6.67Adjunctive clonazepam in the treatment of chronic schizophrenia. ( Alvarez, WA; Freinhar, JP; Herrera, JM; Lawson, WB; Sramek, JJ, 1991)
" Lorazepam and clonazepam are of established value in controlling acute psychotic agitation and catatonia."6.16Emerging uses for high-potency benzodiazepines in psychotic disorders. ( Bodkin, JA, 1990)
"This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasing the efficacy of an acute 6-week treatment by switching intramuscular haloperidol injection to RIS-OS."5.16Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia. ( Chen, H; Fang, M; Huang, J; Li, LH; Li, Y; Liu, L; Wang, B; Wang, G; Wu, R; Ye, M; Zhang, L; Zhang, Q; Zhao, JP; Zheng, H; Zhou, J; Zhu, S, 2012)
"Since the prominent role in clonazepam nitro-reduction and acetylation of 7-amino-clonazepam is assigned to CYP3A and N-acetyl transferase 2 enzymes, respectively, the association between the patients' CYP3A status (CYP3A5 genotype, CYP3A4 expression) or N-acetyl transferase 2 acetylator phenotype and clonazepam metabolism (plasma concentrations of clonazepam and 7-amino-clonazepam) was evaluated in 98 psychiatric patients suffering from schizophrenia or bipolar disorders."3.83Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype. ( Belic, A; Bitter, I; Csukly, G; Déri, M; Háfra, E; Kiss, Á; Menus, Á; Monostory, K; Sirok, D; Tóth, K, 2016)
" The diagnosis of schizophrenia is rapidly raised, motivating further prescription of loxapine 300 mg daily in combination with clonazepam 6 mg daily."3.78[Dysphagia or dysphagias during neuroleptic medication?]. ( Chaumartin, N; Lachaux, B; Monville, M, 2012)
"Postmortem CNS studies have suggested an uncoupling of the gamma-aminobutyric acid (GABA) and benzodiazepine binding sites on the hippocampal GABA(A) receptor in schizophrenia."3.73Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. ( Dean, B; McLeod, M; Scarr, E, 2005)
"Olanzapine is a safely and comprehensively applicable atypical antipsychotic drug, for the treatment of schizophrenia, and of the mild to sever maniac episode."3.73[Akathisia in the course of olanzapine treatment]. ( Csonka, A; Makkos, Z, 2006)
"This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia."3.69Successful treatment of tardive dystonia with clozapine and clonazepam. ( Mckenna, PJ; Mickay, AP; Shapleske, J, 1996)
"The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder."3.68[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992)
" I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride."3.68Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990)
"Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features."2.67Adjunctive clonazepam in the treatment of chronic schizophrenia. ( Alvarez, WA; Freinhar, JP; Herrera, JM; Lawson, WB; Sramek, JJ, 1991)
"Chlorpromazine was found to be significantly better than remoxipride on the dropout rate due to inefficacy, Clinical Global Impression (CGI) of severity of illness and Brief Psychiatric Rating Scale (BPRS)."2.67A placebo-controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation. ( Chouinard, G, 1990)
"One patient died of pulmonary edema and subsequent heart failure, but the rest of the patients recovered without any sequelae."1.34Hemoperfusion in the treatment of acute clozapine intoxication in China. ( Cai, ZJ; He, JL; Li, WB; Ungvari, GS; Xiang, YT, 2007)
"Current dosing regimens of psychotropic drugs are based on plasma kinetic considerations, although it is unclear whether plasma levels faithfully reflect brain kinetics of drugs."1.31Significant dissociation of brain and plasma kinetics with antipsychotics. ( Jones, C; Kapur, S; Remington, G; Tauscher, J; Zipursky, RB, 2002)
"Clonazepam is a potent, long-acting benzodiazepine approved for use in myoclonic and petit mal seizures."1.28Mania associated with clonazepam. ( Dorevitch, A, 1991)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19908 (21.05)18.7374
1990's14 (36.84)18.2507
2000's9 (23.68)29.6817
2010's7 (18.42)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, L1
Zhang, W1
Zhang, X1
Yin, L1
Chen, B1
Song, J1
Tóth, K1
Csukly, G1
Sirok, D1
Belic, A1
Kiss, Á1
Háfra, E1
Déri, M1
Menus, Á1
Bitter, I1
Monostory, K1
Viana, Bde M1
Prais, HA1
Camargos, ST1
Cardoso, FE1
Savitz, AJ1
Kahn, TA1
McGovern, KE1
Kahn, JP1
Korkmaz, S1
Işik, U1
Korkmaz, H1
Kovacs, N1
Balas, I1
Janszky, J1
Simon, M1
Fekete, S1
Komoly, S1
Fang, M1
Chen, H1
Li, LH1
Wu, R1
Li, Y1
Liu, L1
Ye, M1
Huang, J1
Zhu, S1
Wang, G1
Zhang, Q1
Zheng, H1
Zhang, L1
Wang, B1
Zhou, J1
Zhao, JP1
Chaumartin, N1
Monville, M1
Lachaux, B1
Wonodi, I1
Adami, H1
Sherr, J1
Avila, M1
Hong, LE1
Thaker, GK1
Dean, B1
Scarr, E1
McLeod, M1
Makkos, Z1
Csonka, A1
Freeman, B1
Levy, W1
Gorman, JM2
Lam, MH1
Fong, SY1
Wing, YK1
Nieves, JE1
Stack, KM1
Harrison, ME1
He, JL1
Xiang, YT1
Li, WB1
Cai, ZJ1
Ungvari, GS1
Karson, CN1
Weinberger, DR1
Bigelow, L1
Wyatt, RJ1
Hertrich, O1
Jones, BD1
Purdon, SE1
Labelle, A1
Finlayson, R1
Zimbroff, DL1
Shapleske, J1
Mickay, AP1
Mckenna, PJ1
Nishimatsu, O2
Horiguchi, J3
Inami, Y2
Sukegawa, T1
Sasaki, A1
Ahlawat, SK1
Tauscher, J1
Jones, C1
Remington, G1
Zipursky, RB1
Kapur, S1
Lima, L1
Carreira, I1
Morales, M1
Silva, C1
Casique, M1
Liukkonen, J1
Koponen, HJ1
Nousiainen, U1
Blake, LM1
Marks, RC1
Nierman, P1
Luchins, DJ1
Herrera, JM1
Alvarez, WA1
Freinhar, JP1
Lawson, WB1
Sramek, JJ1
Dorevitch, A1
Bodkin, JA1
Chouinard, G2
Sandyk, R2
Kutcher, S1
Williamson, P1
MacKenzie, S1
Marton, P1
Ehrlich, M1
Ballard, CG1
Fisher, H1
Frykholm, B1

Reviews

1 review available for clonazepam and Dementia Praecox

ArticleYear
Emerging uses for high-potency benzodiazepines in psychotic disorders.
    The Journal of clinical psychiatry, 1990, Volume: 51 Suppl

    Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum

1990

Trials

12 trials available for clonazepam and Dementia Praecox

ArticleYear
Carbon dioxide induction of panic anxiety in schizophrenia with auditory hallucinations.
    Psychiatry research, 2011, Aug-30, Volume: 189, Issue:1

    Topics: Adult; Anticonvulsants; Carbon Dioxide; Clonazepam; Double-Blind Method; Female; Hallucinations; Hum

2011
Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia.
    International clinical psychopharmacology, 2012, Volume: 27, Issue:2

    Topics: Administration, Oral; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; China; Clonazepam; Diagn

2012
Naltrexone treatment of tardive dyskinesia in patients with schizophrenia.
    Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:4

    Topics: Adult; Analysis of Variance; Antipsychotic Agents; Clonazepam; Cross-Over Studies; Double-Blind Meth

2004
Clonazepam treatment of chronic schizophrenia: negative results in a double-blind, placebo-controlled trial.
    The American journal of psychiatry, 1982, Volume: 139, Issue:12

    Topics: Adult; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Double-Blind Method; Female; Humans;

1982
Periodic limb movement disorder in neuroleptic-induced akathisia.
    The Kobe journal of medical sciences, 1997, Volume: 43, Issue:5

    Topics: Adult; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Clonazepam; Electromyography;

1997
Usefulness of antiparkinsonian drugs during neuroleptic treatment and the effect of clonazepam on akathisia and parkinsonism occurred after antiparkinsonian drug withdrawal: a double-blind study.
    The Japanese journal of psychiatry and neurology, 1992, Volume: 46, Issue:3

    Topics: Akathisia, Drug-Induced; Antiparkinson Agents; Antipsychotic Agents; Chronic Disease; Clonazepam; Do

1992
Adjunctive clonazepam in the treatment of chronic schizophrenia.
    International journal of psychosomatics : official publication of the International Psychosomatics Institute, 1991, Volume: 38, Issue:1-4

    Topics: Adult; Antipsychotic Agents; Chronic Disease; Clonazepam; Drug Therapy, Combination; Female; Humans;

1991
Emerging uses for high-potency benzodiazepines in psychotic disorders.
    The Journal of clinical psychiatry, 1990, Volume: 51 Suppl

    Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum

1990
A placebo-controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation.
    Acta psychiatrica Scandinavica. Supplementum, 1990, Volume: 358

    Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Benzamides; Chlorpromazine; Clonazepam; Dose

1990
Successful clonazepam treatment of neuroleptic-induced akathisia in older adolescents and young adults: a double-blind, placebo-controlled study.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:6

    Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Doub

1989
Effect of clonazepam on neuroleptic-induced oculogyric crisis.
    Acta psychiatrica Scandinavica, 1989, Volume: 80, Issue:5

    Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Clonazepam; Dyskinesia, Drug-Induced; Eye Mov

1989
The use of benzodiazepines in the treatment of manic-depressive illness.
    The Journal of clinical psychiatry, 1988, Volume: 49 Suppl

    Topics: Acute Disease; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Basal Ga

1988

Other Studies

26 other studies available for clonazepam and Dementia Praecox

ArticleYear
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.
    Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22

    Topics: Animals; Antipsychotic Agents; Ether-A-Go-Go Potassium Channels; Humans; Mice; Oxazoles; Patch-Clamp

2015
Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype.
    The international journal of neuropsychopharmacology, 2016, Volume: 19, Issue:12

    Topics: Acetylation; Adult; Aged; Antipsychotic Agents; Arylamine N-Acetyltransferase; Biotransformation; Bi

2016
Ziprasidone-related oculogyric crisis in an adult.
    Clinical neurology and neurosurgery, 2009, Volume: 111, Issue:10

    Topics: Adult; Antipsychotic Agents; Clonazepam; Dyskinesia, Drug-Induced; Electroencephalography; Female; G

2009
Raynaud’s phenomenon in a patient with schizophrenia and obsessive-compulsive disorder: a case report.
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2011,Summer, Volume: 22, Issue:2

    Topics: Amlodipine; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Clonaze

2011
Status dystonicus in tardive dystonia successfully treated by bilateral deep brain stimulation.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:9

    Topics: Adolescent; Antipsychotic Agents; Clonazepam; Deep Brain Stimulation; Disability Evaluation; Electro

2011
[Dysphagia or dysphagias during neuroleptic medication?].
    L'Encephale, 2012, Volume: 38, Issue:4

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Clonazepam; Deglutition Disorders; Diagn

2012
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
    Brain research. Molecular brain research, 2005, Aug-18, Volume: 138, Issue:2

    Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil

2005
[Akathisia in the course of olanzapine treatment].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2006, Volume: 8, Issue:4

    Topics: Aged; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Azabicyclo Compounds; Benzodia

2006
Successful monotherapy treatment with aripiprazole in a patient with schizophrenia and prolactinoma.
    Journal of psychiatric practice, 2007, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Cabergoline; Clonazepam; Dopamine A

2007
Sexual disinhibition in schizophrenia possibly induced by risperidone and quetiapine.
    Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:3

    Topics: Adult; Antimanic Agents; Antipsychotic Agents; Clonazepam; Dibenzothiazepines; Female; GABA Modulato

2007
Dysphagia: a rare form of dyskinesia?
    Journal of psychiatric practice, 2007, Volume: 13, Issue:3

    Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Deglutition Disorders; Dyskinesia, Drug-Induced;

2007
Hemoperfusion in the treatment of acute clozapine intoxication in China.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6

    Topics: Acute Disease; Adult; Alprazolam; Antipsychotic Agents; China; Clonazepam; Clozapine; Depressive Dis

2007
[Ataractic treatment in psychiatry and general medicine. Overview of preparations, 3].
    Fortschritte der Medizin, 1983, Jun-09, Volume: 101, Issue:22

    Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Chlorprothixene; Clobaza

1983
Risperidone treatment for severe negative symptoms.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1994, Volume: 39, Issue:6

    Topics: Adult; Antipsychotic Agents; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Humans; Iso

1994
Switching patients from clozapine to risperidone therapy.
    The American journal of psychiatry, 1995, Volume: 152, Issue:7

    Topics: Antipsychotic Agents; Clonazepam; Clozapine; Drug Administration Schedule; Drug Therapy, Combination

1995
Successful treatment of tardive dystonia with clozapine and clonazepam.
    The British journal of psychiatry : the journal of mental science, 1996, Volume: 168, Issue:4

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Clozapine; Drug Therapy, Combination; Dyst

1996
Severe hyponatremia in a chronic schizophrenic patient.
    The Journal of the Association of Physicians of India, 1999, Volume: 47, Issue:7

    Topics: Anticonvulsants; Antipsychotic Agents; Benztropine; Clonazepam; Humans; Hyponatremia; Inappropriate

1999
Significant dissociation of brain and plasma kinetics with antipsychotics.
    Molecular psychiatry, 2002, Volume: 7, Issue:3

    Topics: Adult; Antipsychotic Agents; Benzodiazepines; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Clon

2002
[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam].
    Investigacion clinica, 1992, Volume: 33, Issue:1

    Topics: Adult; Anxiety Disorders; Clonazepam; Depression; Female; Humans; Imipramine; Lactates; Lactic Acid;

1992
Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment.
    Psychiatry research, 1992, Volume: 44, Issue:2

    Topics: Adult; Carbamazepine; Clonazepam; Clozapine; Electroencephalography; Epilepsies, Myoclonic; Epilepsy

1992
Clozapine and clonazepam in tardive dystonia.
    Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:4

    Topics: Adult; Antipsychotic Agents; Clonazepam; Clozapine; Dystonia; Female; Humans; Schizophrenia

1991
Mania associated with clonazepam.
    DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:9

    Topics: Acute Disease; Adult; Bipolar Disorder; Chronic Disease; Clonazepam; Humans; Male; Schizophrenia

1991
Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen.
    Italian journal of neurological sciences, 1990, Volume: 11, Issue:6

    Topics: Baclofen; Causalgia; Clonazepam; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans;

1990
Successful therapeutic intervention in a schizophrenic patient with blepharospasm.
    Journal of neurology, neurosurgery, and psychiatry, 1989, Volume: 52, Issue:11

    Topics: Adult; Blepharospasm; Clonazepam; Eyelid Diseases; Humans; Male; Schizophrenia; Schizophrenic Psycho

1989
Clonazepam-haloperidol therapy in schizophrenia.
    Acta psychiatrica Scandinavica, 1988, Volume: 78, Issue:1

    Topics: Clonazepam; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Haloperidol; Humans; Schizophrenia

1988
Clonazepam--antipsychotic effect in a case of schizophrenia-like psychosis with epilepsy and in three cases of atypical psychosis.
    Acta psychiatrica Scandinavica, 1985, Volume: 71, Issue:5

    Topics: Adult; Benzodiazepinones; Clonazepam; Combined Modality Therapy; Electroconvulsive Therapy; Epilepsy

1985