clonazepam has been researched along with Dementia Praecox in 38 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasing the efficacy of an acute 6-week treatment by switching intramuscular haloperidol injection to RIS-OS." | 9.16 | Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia. ( Chen, H; Fang, M; Huang, J; Li, LH; Li, Y; Liu, L; Wang, B; Wang, G; Wu, R; Ye, M; Zhang, L; Zhang, Q; Zhao, JP; Zheng, H; Zhou, J; Zhu, S, 2012) |
| "This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia." | 7.69 | Successful treatment of tardive dystonia with clozapine and clonazepam. ( Mckenna, PJ; Mickay, AP; Shapleske, J, 1996) |
| "The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder." | 7.68 | [Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992) |
| " I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride." | 7.68 | Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990) |
| "Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features." | 6.67 | Adjunctive clonazepam in the treatment of chronic schizophrenia. ( Alvarez, WA; Freinhar, JP; Herrera, JM; Lawson, WB; Sramek, JJ, 1991) |
| " Lorazepam and clonazepam are of established value in controlling acute psychotic agitation and catatonia." | 6.16 | Emerging uses for high-potency benzodiazepines in psychotic disorders. ( Bodkin, JA, 1990) |
| "This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasing the efficacy of an acute 6-week treatment by switching intramuscular haloperidol injection to RIS-OS." | 5.16 | Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia. ( Chen, H; Fang, M; Huang, J; Li, LH; Li, Y; Liu, L; Wang, B; Wang, G; Wu, R; Ye, M; Zhang, L; Zhang, Q; Zhao, JP; Zheng, H; Zhou, J; Zhu, S, 2012) |
| "Since the prominent role in clonazepam nitro-reduction and acetylation of 7-amino-clonazepam is assigned to CYP3A and N-acetyl transferase 2 enzymes, respectively, the association between the patients' CYP3A status (CYP3A5 genotype, CYP3A4 expression) or N-acetyl transferase 2 acetylator phenotype and clonazepam metabolism (plasma concentrations of clonazepam and 7-amino-clonazepam) was evaluated in 98 psychiatric patients suffering from schizophrenia or bipolar disorders." | 3.83 | Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype. ( Belic, A; Bitter, I; Csukly, G; Déri, M; Háfra, E; Kiss, Á; Menus, Á; Monostory, K; Sirok, D; Tóth, K, 2016) |
| " The diagnosis of schizophrenia is rapidly raised, motivating further prescription of loxapine 300 mg daily in combination with clonazepam 6 mg daily." | 3.78 | [Dysphagia or dysphagias during neuroleptic medication?]. ( Chaumartin, N; Lachaux, B; Monville, M, 2012) |
| "Postmortem CNS studies have suggested an uncoupling of the gamma-aminobutyric acid (GABA) and benzodiazepine binding sites on the hippocampal GABA(A) receptor in schizophrenia." | 3.73 | Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. ( Dean, B; McLeod, M; Scarr, E, 2005) |
| "Olanzapine is a safely and comprehensively applicable atypical antipsychotic drug, for the treatment of schizophrenia, and of the mild to sever maniac episode." | 3.73 | [Akathisia in the course of olanzapine treatment]. ( Csonka, A; Makkos, Z, 2006) |
| "This report adds to two other cases suggesting that the combination of clozapine and clonazepam may be an effective treatment for tardive dystonia." | 3.69 | Successful treatment of tardive dystonia with clozapine and clonazepam. ( Mckenna, PJ; Mickay, AP; Shapleske, J, 1996) |
| "The response to treatment with imipramine or clonazepam was evaluated in patients with panic disorder." | 3.68 | [Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam]. ( Carreira, I; Casique, M; Lima, L; Morales, M; Silva, C, 1992) |
| " I report a patient who developed the syndrome during treatment for schizophrenia with the antipsychotic agent molindone hydrochloride." | 3.68 | Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen. ( Sandyk, R, 1990) |
| "Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features." | 2.67 | Adjunctive clonazepam in the treatment of chronic schizophrenia. ( Alvarez, WA; Freinhar, JP; Herrera, JM; Lawson, WB; Sramek, JJ, 1991) |
| "Chlorpromazine was found to be significantly better than remoxipride on the dropout rate due to inefficacy, Clinical Global Impression (CGI) of severity of illness and Brief Psychiatric Rating Scale (BPRS)." | 2.67 | A placebo-controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation. ( Chouinard, G, 1990) |
| "One patient died of pulmonary edema and subsequent heart failure, but the rest of the patients recovered without any sequelae." | 1.34 | Hemoperfusion in the treatment of acute clozapine intoxication in China. ( Cai, ZJ; He, JL; Li, WB; Ungvari, GS; Xiang, YT, 2007) |
| "Current dosing regimens of psychotropic drugs are based on plasma kinetic considerations, although it is unclear whether plasma levels faithfully reflect brain kinetics of drugs." | 1.31 | Significant dissociation of brain and plasma kinetics with antipsychotics. ( Jones, C; Kapur, S; Remington, G; Tauscher, J; Zipursky, RB, 2002) |
| "Clonazepam is a potent, long-acting benzodiazepine approved for use in myoclonic and petit mal seizures." | 1.28 | Mania associated with clonazepam. ( Dorevitch, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (21.05) | 18.7374 |
| 1990's | 14 (36.84) | 18.2507 |
| 2000's | 9 (23.68) | 29.6817 |
| 2010's | 7 (18.42) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, L | 1 |
| Zhang, W | 1 |
| Zhang, X | 1 |
| Yin, L | 1 |
| Chen, B | 1 |
| Song, J | 1 |
| Tóth, K | 1 |
| Csukly, G | 1 |
| Sirok, D | 1 |
| Belic, A | 1 |
| Kiss, Á | 1 |
| Háfra, E | 1 |
| Déri, M | 1 |
| Menus, Á | 1 |
| Bitter, I | 1 |
| Monostory, K | 1 |
| Viana, Bde M | 1 |
| Prais, HA | 1 |
| Camargos, ST | 1 |
| Cardoso, FE | 1 |
| Savitz, AJ | 1 |
| Kahn, TA | 1 |
| McGovern, KE | 1 |
| Kahn, JP | 1 |
| Korkmaz, S | 1 |
| Işik, U | 1 |
| Korkmaz, H | 1 |
| Kovacs, N | 1 |
| Balas, I | 1 |
| Janszky, J | 1 |
| Simon, M | 1 |
| Fekete, S | 1 |
| Komoly, S | 1 |
| Fang, M | 1 |
| Chen, H | 1 |
| Li, LH | 1 |
| Wu, R | 1 |
| Li, Y | 1 |
| Liu, L | 1 |
| Ye, M | 1 |
| Huang, J | 1 |
| Zhu, S | 1 |
| Wang, G | 1 |
| Zhang, Q | 1 |
| Zheng, H | 1 |
| Zhang, L | 1 |
| Wang, B | 1 |
| Zhou, J | 1 |
| Zhao, JP | 1 |
| Chaumartin, N | 1 |
| Monville, M | 1 |
| Lachaux, B | 1 |
| Wonodi, I | 1 |
| Adami, H | 1 |
| Sherr, J | 1 |
| Avila, M | 1 |
| Hong, LE | 1 |
| Thaker, GK | 1 |
| Dean, B | 1 |
| Scarr, E | 1 |
| McLeod, M | 1 |
| Makkos, Z | 1 |
| Csonka, A | 1 |
| Freeman, B | 1 |
| Levy, W | 1 |
| Gorman, JM | 2 |
| Lam, MH | 1 |
| Fong, SY | 1 |
| Wing, YK | 1 |
| Nieves, JE | 1 |
| Stack, KM | 1 |
| Harrison, ME | 1 |
| He, JL | 1 |
| Xiang, YT | 1 |
| Li, WB | 1 |
| Cai, ZJ | 1 |
| Ungvari, GS | 1 |
| Karson, CN | 1 |
| Weinberger, DR | 1 |
| Bigelow, L | 1 |
| Wyatt, RJ | 1 |
| Hertrich, O | 1 |
| Jones, BD | 1 |
| Purdon, SE | 1 |
| Labelle, A | 1 |
| Finlayson, R | 1 |
| Zimbroff, DL | 1 |
| Shapleske, J | 1 |
| Mickay, AP | 1 |
| Mckenna, PJ | 1 |
| Nishimatsu, O | 2 |
| Horiguchi, J | 3 |
| Inami, Y | 2 |
| Sukegawa, T | 1 |
| Sasaki, A | 1 |
| Ahlawat, SK | 1 |
| Tauscher, J | 1 |
| Jones, C | 1 |
| Remington, G | 1 |
| Zipursky, RB | 1 |
| Kapur, S | 1 |
| Lima, L | 1 |
| Carreira, I | 1 |
| Morales, M | 1 |
| Silva, C | 1 |
| Casique, M | 1 |
| Liukkonen, J | 1 |
| Koponen, HJ | 1 |
| Nousiainen, U | 1 |
| Blake, LM | 1 |
| Marks, RC | 1 |
| Nierman, P | 1 |
| Luchins, DJ | 1 |
| Herrera, JM | 1 |
| Alvarez, WA | 1 |
| Freinhar, JP | 1 |
| Lawson, WB | 1 |
| Sramek, JJ | 1 |
| Dorevitch, A | 1 |
| Bodkin, JA | 1 |
| Chouinard, G | 2 |
| Sandyk, R | 2 |
| Kutcher, S | 1 |
| Williamson, P | 1 |
| MacKenzie, S | 1 |
| Marton, P | 1 |
| Ehrlich, M | 1 |
| Ballard, CG | 1 |
| Fisher, H | 1 |
| Frykholm, B | 1 |
1 review available for clonazepam and Dementia Praecox
| Article | Year |
|---|---|
Emerging uses for high-potency benzodiazepines in psychotic disorders.
Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum | 1990 |
12 trials available for clonazepam and Dementia Praecox
| Article | Year |
|---|---|
Carbon dioxide induction of panic anxiety in schizophrenia with auditory hallucinations.
Topics: Adult; Anticonvulsants; Carbon Dioxide; Clonazepam; Double-Blind Method; Female; Hallucinations; Hum | 2011 |
Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia.
Topics: Administration, Oral; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; China; Clonazepam; Diagn | 2012 |
Naltrexone treatment of tardive dyskinesia in patients with schizophrenia.
Topics: Adult; Analysis of Variance; Antipsychotic Agents; Clonazepam; Cross-Over Studies; Double-Blind Meth | 2004 |
Clonazepam treatment of chronic schizophrenia: negative results in a double-blind, placebo-controlled trial.
Topics: Adult; Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Double-Blind Method; Female; Humans; | 1982 |
Periodic limb movement disorder in neuroleptic-induced akathisia.
Topics: Adult; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Clonazepam; Electromyography; | 1997 |
Usefulness of antiparkinsonian drugs during neuroleptic treatment and the effect of clonazepam on akathisia and parkinsonism occurred after antiparkinsonian drug withdrawal: a double-blind study.
Topics: Akathisia, Drug-Induced; Antiparkinson Agents; Antipsychotic Agents; Chronic Disease; Clonazepam; Do | 1992 |
Adjunctive clonazepam in the treatment of chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Clonazepam; Drug Therapy, Combination; Female; Humans; | 1991 |
Emerging uses for high-potency benzodiazepines in psychotic disorders.
Topics: Alprazolam; Anti-Anxiety Agents; Catatonia; Child; Clinical Trials as Topic; Clonazepam; Female; Hum | 1990 |
A placebo-controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation.
Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Benzamides; Chlorpromazine; Clonazepam; Dose | 1990 |
Successful clonazepam treatment of neuroleptic-induced akathisia in older adolescents and young adults: a double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Doub | 1989 |
Effect of clonazepam on neuroleptic-induced oculogyric crisis.
Topics: Adult; Antipsychotic Agents; Clinical Trials as Topic; Clonazepam; Dyskinesia, Drug-Induced; Eye Mov | 1989 |
The use of benzodiazepines in the treatment of manic-depressive illness.
Topics: Acute Disease; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Basal Ga | 1988 |
26 other studies available for clonazepam and Dementia Praecox
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.
Topics: Animals; Antipsychotic Agents; Ether-A-Go-Go Potassium Channels; Humans; Mice; Oxazoles; Patch-Clamp | 2015 |
Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype.
Topics: Acetylation; Adult; Aged; Antipsychotic Agents; Arylamine N-Acetyltransferase; Biotransformation; Bi | 2016 |
Ziprasidone-related oculogyric crisis in an adult.
Topics: Adult; Antipsychotic Agents; Clonazepam; Dyskinesia, Drug-Induced; Electroencephalography; Female; G | 2009 |
Raynaud’s phenomenon in a patient with schizophrenia and obsessive-compulsive disorder: a case report.
Topics: Amlodipine; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Clonaze | 2011 |
Status dystonicus in tardive dystonia successfully treated by bilateral deep brain stimulation.
Topics: Adolescent; Antipsychotic Agents; Clonazepam; Deep Brain Stimulation; Disability Evaluation; Electro | 2011 |
[Dysphagia or dysphagias during neuroleptic medication?].
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Clonazepam; Deglutition Disorders; Diagn | 2012 |
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil | 2005 |
[Akathisia in the course of olanzapine treatment].
Topics: Aged; Akathisia, Drug-Induced; Anticonvulsants; Antipsychotic Agents; Azabicyclo Compounds; Benzodia | 2006 |
Successful monotherapy treatment with aripiprazole in a patient with schizophrenia and prolactinoma.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Aripiprazole; Cabergoline; Clonazepam; Dopamine A | 2007 |
Sexual disinhibition in schizophrenia possibly induced by risperidone and quetiapine.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Clonazepam; Dibenzothiazepines; Female; GABA Modulato | 2007 |
Dysphagia: a rare form of dyskinesia?
Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Deglutition Disorders; Dyskinesia, Drug-Induced; | 2007 |
Hemoperfusion in the treatment of acute clozapine intoxication in China.
Topics: Acute Disease; Adult; Alprazolam; Antipsychotic Agents; China; Clonazepam; Clozapine; Depressive Dis | 2007 |
[Ataractic treatment in psychiatry and general medicine. Overview of preparations, 3].
Topics: Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Chlorprothixene; Clobaza | 1983 |
Risperidone treatment for severe negative symptoms.
Topics: Adult; Antipsychotic Agents; Clonazepam; Depressive Disorder; Drug Therapy, Combination; Humans; Iso | 1994 |
Switching patients from clozapine to risperidone therapy.
Topics: Antipsychotic Agents; Clonazepam; Clozapine; Drug Administration Schedule; Drug Therapy, Combination | 1995 |
Successful treatment of tardive dystonia with clozapine and clonazepam.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Clozapine; Drug Therapy, Combination; Dyst | 1996 |
Severe hyponatremia in a chronic schizophrenic patient.
Topics: Anticonvulsants; Antipsychotic Agents; Benztropine; Clonazepam; Humans; Hyponatremia; Inappropriate | 1999 |
Significant dissociation of brain and plasma kinetics with antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Clon | 2002 |
[Treatment of patients with panic disorder and an elevated urinary excretion of MHPG using imipramine or clonazepam].
Topics: Adult; Anxiety Disorders; Clonazepam; Depression; Female; Humans; Imipramine; Lactates; Lactic Acid; | 1992 |
Clinical picture and long-term course of epileptic seizures that occur during clozapine treatment.
Topics: Adult; Carbamazepine; Clonazepam; Clozapine; Electroencephalography; Epilepsies, Myoclonic; Epilepsy | 1992 |
Clozapine and clonazepam in tardive dystonia.
Topics: Adult; Antipsychotic Agents; Clonazepam; Clozapine; Dystonia; Female; Humans; Schizophrenia | 1991 |
Mania associated with clonazepam.
Topics: Acute Disease; Adult; Bipolar Disorder; Chronic Disease; Clonazepam; Humans; Male; Schizophrenia | 1991 |
Neuroleptic-induced "painful legs and moving toes" syndrome: successful treatment with clonazepam and baclofen.
Topics: Baclofen; Causalgia; Clonazepam; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Humans; | 1990 |
Successful therapeutic intervention in a schizophrenic patient with blepharospasm.
Topics: Adult; Blepharospasm; Clonazepam; Eyelid Diseases; Humans; Male; Schizophrenia; Schizophrenic Psycho | 1989 |
Clonazepam-haloperidol therapy in schizophrenia.
Topics: Clonazepam; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Haloperidol; Humans; Schizophrenia | 1988 |
Clonazepam--antipsychotic effect in a case of schizophrenia-like psychosis with epilepsy and in three cases of atypical psychosis.
Topics: Adult; Benzodiazepinones; Clonazepam; Combined Modality Therapy; Electroconvulsive Therapy; Epilepsy | 1985 |