clonazepam has been researched along with Delayed Effects, Prenatal Exposure in 8 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring." | 3.67 | Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986) |
| "To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy." | 1.56 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020) |
| "One also had features of infantile autism." | 1.29 | Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Daugaard, CA | 1 |
| Pedersen, L | 1 |
| Sun, Y | 1 |
| Dreier, JW | 1 |
| Christensen, J | 1 |
| Yang, Y | 1 |
| Wang, B | 1 |
| Zhong, Z | 1 |
| Chen, H | 1 |
| Ding, W | 1 |
| Hoi, MPM | 1 |
| Collins, KO | 1 |
| Comer, JB | 1 |
| Christianson, AL | 1 |
| Chesler, N | 1 |
| Kromberg, JG | 1 |
| Oberlander, TF | 1 |
| Eckstein Grunau, R | 1 |
| Fitzgerald, C | 1 |
| Ellwood, AL | 1 |
| Misri, S | 1 |
| Rurak, D | 1 |
| Riggs, KW | 1 |
| Schlumpf, M | 1 |
| Parmar, R | 1 |
| Ramseier, HR | 1 |
| Lichtensteiger, W | 1 |
| Miranda, RC | 1 |
| Wagner, JP | 1 |
| Kellogg, CK | 1 |
| Sobrian, SK | 1 |
| Nandedkar, AK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Transcranial Direct Current Stimulation (tDCS) for Depression in Pregnancy: A Pilot Study[NCT02116127] | 20 participants (Actual) | Interventional | 2014-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for clonazepam and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen | 2020 |
Clonazepam attenuates neurobehavioral abnormalities in offspring exposed to maternal immune activation by enhancing GABAergic neurotransmission.
Topics: Animals; Clonazepam; Female; GABA Modulators; GABA-A Receptor Agonists; GABAergic Neurons; Male; Men | 2021 |
Maternal haloperidol therapy associated with dyskinesia in a newborn.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Clonazepam; Dyskinesia, Drug-Induced; Female; Haloperi | 2003 |
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family | 1994 |
Prolonged prenatal psychotropic medication exposure alters neonatal acute pain response.
Topics: Animals; Clonazepam; Facial Expression; Female; GABA Modulators; Heart Rate; Humans; Infant, Newborn | 2002 |
Prenatal benzodiazepine immunosuppression: possible involvement of peripheral benzodiazepine site.
Topics: Animals; Autoradiography; Benzodiazepinones; Binding Sites; Cell Division; Clonazepam; Convulsants; | 1990 |
Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats.
Topics: Animals; Benzodiazepines; Brain; Clonazepam; Diazepam; Female; Flumazenil; Gestational Age; Pregnanc | 1989 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; | 1986 |