clonazepam has been researched along with Costen's Syndrome in 2 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clonazepam was selected for its long duration and its cholinergic/GABA-ergic/serotonergic, anxiolytic, muscle relaxant, and sedative properties." | 2.67 | Administration of clonazepam in the treatment of TMD and associated myofascial pain: a double-blind pilot study. ( Cohen, J; Cueva, L; Harkins, S; Kramer, T; Linford, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herman, CR | 1 |
| Schiffman, EL | 1 |
| Look, JO | 1 |
| Rindal, DB | 1 |
| Harkins, S | 1 |
| Linford, J | 1 |
| Cohen, J | 1 |
| Kramer, T | 1 |
| Cueva, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preliminary Findings of the Efficacy of Botulinum Toxin in Temporomandibular Disorders: A Randomized Clinical Trial[NCT05651256] | Phase 2/Phase 3 | 20 participants (Actual) | Interventional | 2021-03-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for clonazepam and Costen's Syndrome
| Article | Year |
|---|---|
The effectiveness of adding pharmacologic treatment with clonazepam or cyclobenzaprine to patient education and self-care for the treatment of jaw pain upon awakening: a randomized clinical trial.
Topics: Adult; Amitriptyline; Clonazepam; Female; GABA Modulators; Health Education, Dental; Humans; Male; M | 2002 |
Administration of clonazepam in the treatment of TMD and associated myofascial pain: a double-blind pilot study.
Topics: Adolescent; Adult; Chronic Disease; Clonazepam; Double-Blind Method; Female; Humans; Male; Middle Ag | 1991 |