clonazepam has been researched along with Coma in 13 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyclic coma in a 4-year-old boy followed an ingestion of clonazepam, a new benzodiazepine, utilized in treatment of convulsive disorders." | 7.65 | Clonazepam overdose resulting in cyclic coma. ( Hammond, K; Rumack, BH; Welch, TR, 1977) |
| "Clonazepam (CZP) was administered with PRO, and other antiepileptic drugs (AEDs) concomitant with PRO and THP." | 5.32 | Propofol treatment of refractory status epilepticus: a study of 31 episodes. ( Bogousslavsky, J; Despland, PA; Reichhart, MD; Rossetti, AO; Schaller, MD, 2004) |
| "Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit." | 5.29 | Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994) |
| "Cyclic coma in a 4-year-old boy followed an ingestion of clonazepam, a new benzodiazepine, utilized in treatment of convulsive disorders." | 3.65 | Clonazepam overdose resulting in cyclic coma. ( Hammond, K; Rumack, BH; Welch, TR, 1977) |
| "Clonazepam (CZP) was administered with PRO, and other antiepileptic drugs (AEDs) concomitant with PRO and THP." | 1.32 | Propofol treatment of refractory status epilepticus: a study of 31 episodes. ( Bogousslavsky, J; Despland, PA; Reichhart, MD; Rossetti, AO; Schaller, MD, 2004) |
| "Status epilepticus is one of the most frequent neurological emergencies in the intensive care unit." | 1.29 | Propofol in the management of refractory status epilepticus: a case report. ( Borgeat, A; Jallon, P; Suter, PM; Wilder-Smith, OH, 1994) |
| "The patients were comatose for 6 and 7 days and required mechanical ventilation for 7 and 10 days." | 1.29 | Life threatening intoxication with sodium valproate. ( Andersen, GO; Ritland, S, 1995) |
| "Coma, convulsions, and cardiac conduction defects were observed, similar to those noted with tricyclic and tetracyclic antidepressant poisoning." | 1.28 | Severe self-poisoning with oxetorone: report of one case. ( Deghmani, M; Droy, JM; Galerneau, V; Leroy, A; Leroy, J; Oksenhendler, G; Petit, J; Winckler, C, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van Hulst, AM | 1 |
| Lammers, HJW | 1 |
| Koekkoek, WACK | 1 |
| Smulders, CA | 1 |
| Tjan, DHT | 1 |
| Rossetti, AO | 1 |
| Reichhart, MD | 1 |
| Schaller, MD | 1 |
| Despland, PA | 1 |
| Bogousslavsky, J | 1 |
| Schorl, M | 1 |
| Borgeat, A | 1 |
| Wilder-Smith, OH | 1 |
| Jallon, P | 1 |
| Suter, PM | 1 |
| Andersen, GO | 1 |
| Ritland, S | 1 |
| Erer, B | 1 |
| Polchi, P | 1 |
| Lucarelli, G | 1 |
| Angelucci, E | 1 |
| Baronciani, D | 1 |
| Galimberti, M | 1 |
| Giardini, C | 1 |
| Gaziev, D | 1 |
| Maiello, A | 1 |
| Welch, TR | 1 |
| Rumack, BH | 1 |
| Hammond, K | 1 |
| Goulon, M | 1 |
| Nouailhat, F | 1 |
| Escourolle, R | 1 |
| Zarranz-Imirizaldu, JJ | 1 |
| Grosbuis, S | 1 |
| Lévy-Alcover, MA | 1 |
| Lichtigfeld, FJ | 1 |
| Gillman, MA | 1 |
| Galerneau, V | 1 |
| Petit, J | 1 |
| Deghmani, M | 1 |
| Leroy, J | 1 |
| Droy, JM | 1 |
| Leroy, A | 1 |
| Oksenhendler, G | 1 |
| Winckler, C | 1 |
| Martényi, F | 1 |
| Harangozó, J | 1 |
| Mód, L | 1 |
| Fahn, S | 1 |
| Honer, WG | 1 |
| Rosenberg, RG | 1 |
| Turey, M | 1 |
| Fisher, WA | 1 |
1 review available for clonazepam and Coma
| Article | Year |
|---|---|
Posthypoxic action myoclonus: literature review update.
Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans | 1986 |
12 other studies available for clonazepam and Coma
| Article | Year |
|---|---|
A Comatose Patient with a Bluish Tongue.
Topics: Adult; Clonazepam; Color; Coma; GABA Modulators; Humans; Male; Tongue | 2018 |
Propofol treatment of refractory status epilepticus: a study of 31 episodes.
Topics: Adult; Anesthetics, Intravenous; Anticonvulsants; Clonazepam; Coma; Dose-Response Relationship, Drug | 2004 |
Giant somatosensory evoked potentials as indicator of nonconvulsive status epilepticus.
Topics: Aged; Anticonvulsants; Clonazepam; Coma; Electroencephalography; Evoked Potentials, Somatosensory; F | 2008 |
Propofol in the management of refractory status epilepticus: a case report.
Topics: Clonazepam; Coma; Drug Therapy, Combination; Electroencephalography; Glasgow Coma Scale; Humans; Inf | 1994 |
Life threatening intoxication with sodium valproate.
Topics: Adult; Clonazepam; Coma; Female; Humans; Pancreatitis; Valproic Acid | 1995 |
CsA-associated neurotoxicity and ineffective prophylaxis with clonazepam in patients transplanted for thalassemia major: analysis of risk factors.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Adult; Anticonvulsants; beta-Thalassemia; Blood | 1996 |
Clonazepam overdose resulting in cyclic coma.
Topics: Benzodiazepinones; Child, Preschool; Clonazepam; Coma; Humans; Male; Recurrence | 1977 |
[Methyl bromide poisoning. 3 cases, 1 fatal. Neruopathological study of one case of coma with myoclonus followed for 5 years].
Topics: Adolescent; Adult; Baclofen; Cerebellum; Cerebral Cortex; Chlormethiazole; Clonazepam; Coma; Cortica | 1975 |
Dangerous synergism between sedatives and a hyponatraemic state.
Topics: Clonazepam; Coma; Female; Humans; Hypnotics and Sedatives; Hyponatremia; Middle Aged; Promethazine; | 1990 |
Severe self-poisoning with oxetorone: report of one case.
Topics: Adult; Benzoxepins; Chromatography, High Pressure Liquid; Clonazepam; Coma; Electrocardiography; Eme | 1990 |
Clonazepam for the treatment of stupor in catatonic schizophrenia.
Topics: Adolescent; Adult; Clonazepam; Coma; Humans; Male; Schizophrenia, Catatonic | 1989 |
Respiratory failure after clonazepam and amobarbital.
Topics: Amobarbital; Clonazepam; Coma; Drug Therapy, Combination; Humans; Male; Middle Aged; Psychotic Disor | 1986 |