clonazepam has been researched along with Chronic Illness in 35 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 9.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "The results suggest that clonazepam may be helpful in burning mouth syndrome, inasmuch as 70% of patients (groups 1 and 2) experienced pain reduction with effects at low doses." | 7.70 | An open-label, dose escalation pilot study of the effect of clonazepam in burning mouth syndrome. ( Epstein, J; Grushka, M; Mott, A, 1998) |
| "Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results." | 7.65 | [Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam]. ( Bücking, PH, 1977) |
| "Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features." | 6.67 | Adjunctive clonazepam in the treatment of chronic schizophrenia. ( Alvarez, WA; Freinhar, JP; Herrera, JM; Lawson, WB; Sramek, JJ, 1991) |
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 5.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "The results suggest that clonazepam may be helpful in burning mouth syndrome, inasmuch as 70% of patients (groups 1 and 2) experienced pain reduction with effects at low doses." | 3.70 | An open-label, dose escalation pilot study of the effect of clonazepam in burning mouth syndrome. ( Epstein, J; Grushka, M; Mott, A, 1998) |
| "Clonazepam was used in 22 instances of status epilepticus by intravenous route with particularly good results." | 3.65 | [Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam]. ( Bücking, PH, 1977) |
| "Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep resulted in sustained efficacy in most cases, with low risk of dosage tolerance, adverse effects, or abuse." | 2.68 | Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults. ( Mahowald, MW; Schenck, CH, 1996) |
| "Clonazepam was added to the neuroleptic regimen of 3 treatment-resistant schizophrenic patients with schizoaffective features." | 2.67 | Adjunctive clonazepam in the treatment of chronic schizophrenia. ( Alvarez, WA; Freinhar, JP; Herrera, JM; Lawson, WB; Sramek, JJ, 1991) |
| "Clonazepam was selected for its long duration and its cholinergic/GABA-ergic/serotonergic, anxiolytic, muscle relaxant, and sedative properties." | 2.67 | Administration of clonazepam in the treatment of TMD and associated myofascial pain: a double-blind pilot study. ( Cohen, J; Cueva, L; Harkins, S; Kramer, T; Linford, J, 1991) |
| "Zolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option in the short-term management of sleep-onset insomnia." | 1.48 | Severe Chronic Abuse of Zolpidem in Refractory Insomnia. ( Bianco, G; Castelnovo, A; Chiaro, G; Maffei, P; Manconi, M, 2018) |
| "Burning Mouth Syndrome (BMS) is a chronic pain condition characterized by persistent intraoral burning without related objective findings and unknown etiology that affects elderly females mostly." | 1.46 | Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome. ( Deligianni, CI; Ljubisavljevic, S; Mitsikostas, DD, 2017) |
| "In total, 181 chronic insomnia patients were consecutively recruited." | 1.46 | Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months. ( Chen, H; He, J; Liu, Y; Luan, X; Qiu, H; Shen, H; Tu, X; Zhao, K; Zhu, Z, 2017) |
| "Clonazepam (CNZ) is a drug used for insomnia treatment." | 1.42 | Executive dysfunction in patients with chronic primary insomnia treated with clonazepam. ( Contreras-González, N; Haro, R; Jiménez-Correa, U; Poblano, A; Téllez-Alanís, B, 2015) |
| "Clonazepam has been shown to be an effective supplementary treatment for depression." | 1.34 | Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression. ( Arita, S; Morishita, S, 2007) |
| "Clonazepam is a potent, long-acting benzodiazepine approved for use in myoclonic and petit mal seizures." | 1.28 | Mania associated with clonazepam. ( Dorevitch, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (22.86) | 18.7374 |
| 1990's | 16 (45.71) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 5 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mitsikostas, DD | 1 |
| Ljubisavljevic, S | 1 |
| Deligianni, CI | 1 |
| Zhao, K | 1 |
| Luan, X | 1 |
| Liu, Y | 1 |
| Tu, X | 1 |
| Chen, H | 1 |
| Shen, H | 1 |
| Qiu, H | 1 |
| Zhu, Z | 1 |
| He, J | 1 |
| Chiaro, G | 1 |
| Castelnovo, A | 1 |
| Bianco, G | 1 |
| Maffei, P | 1 |
| Manconi, M | 1 |
| Contreras-González, N | 1 |
| Téllez-Alanís, B | 1 |
| Haro, R | 1 |
| Jiménez-Correa, U | 1 |
| Poblano, A | 1 |
| Williams, BS | 1 |
| Wong, D | 1 |
| Amin, S | 1 |
| Danhauer, SC | 1 |
| Miller, CS | 1 |
| Rhodus, NL | 1 |
| Carlson, CR | 1 |
| Goforth, HW | 1 |
| Rao, M | 1 |
| Sucholeiki, R | 1 |
| Morishita, S | 1 |
| Arita, S | 1 |
| Matsuo, M | 1 |
| Takahashi, Y | 1 |
| Taniguchi, K | 1 |
| Sasaki, K | 1 |
| Hamasaki, Y | 1 |
| Swerdlow, M | 1 |
| Cundill, JG | 1 |
| Banfi, S | 1 |
| Fonio, W | 1 |
| Allievi, E | 1 |
| Raimondo, S | 1 |
| Baraczka, K | 1 |
| Molnár, G | 1 |
| Sodeyama, N | 1 |
| Orimo, S | 1 |
| Okiyama, R | 1 |
| Arai, M | 1 |
| Tamaki, M | 1 |
| Sullivan, M | 1 |
| Toshima, M | 1 |
| Lynn, P | 1 |
| Roy-Byrne, P | 1 |
| Schenck, CH | 3 |
| Mahowald, MW | 3 |
| Gibbs, JW | 1 |
| Morton, LD | 1 |
| Amaker, B | 1 |
| Ward, JD | 1 |
| Holloway, KL | 1 |
| Coulter, DA | 1 |
| Perney, P | 1 |
| Butterworth, RF | 1 |
| Mousseau, DD | 1 |
| Lavoie, J | 1 |
| Fabbro-Peray, P | 1 |
| Blanc, F | 1 |
| Layrargues, GP | 1 |
| Grushka, M | 1 |
| Epstein, J | 1 |
| Mott, A | 1 |
| Bundlie, SR | 1 |
| Ettinger, MG | 1 |
| Penin, H | 1 |
| Shakir, RA | 1 |
| Nanda, RN | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Bücking, PH | 1 |
| Palacios, E | 1 |
| Court, J | 1 |
| Kase, JC | 1 |
| Horiguchi, J | 1 |
| Nishimatsu, O | 1 |
| Saltz, BL | 1 |
| Hampf, G | 1 |
| Kuoppasalmi, K | 1 |
| Henriksson, M | 1 |
| Achté, K | 1 |
| Herrera, JM | 1 |
| Alvarez, WA | 1 |
| Freinhar, JP | 1 |
| Lawson, WB | 1 |
| Sramek, JJ | 1 |
| Harkins, S | 1 |
| Linford, J | 1 |
| Cohen, J | 1 |
| Kramer, T | 1 |
| Cueva, L | 1 |
| Klein, DS | 1 |
| Schmidt, RE | 1 |
| Dorevitch, A | 1 |
| Bakheit, AM | 1 |
| Behan, PO | 1 |
| Pollack, MH | 1 |
| Otto, MW | 1 |
| Rosenbaum, JF | 1 |
| Sachs, GS | 1 |
| O'Neil, C | 1 |
| Asher, R | 1 |
| Meltzer-Brody, S | 1 |
| Sher, PK | 1 |
| Arai, K | 1 |
| Tokumaru, Y | 1 |
| Yagishita, T | 1 |
| Hirayama, K | 1 |
| Iwasaki, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Study on the Treatment of Burning Mouth Syndrome With Integration of Traditional Chinese Medicine(TCM) and Western Medicine Based on TCM Syndrome Differentiation[NCT04189367] | Phase 3 | 80 participants (Anticipated) | Interventional | 2020-06-20 | Not yet recruiting | ||
| Redictive Risk Factors of Conversion Into Idiopathic RBD. Italian Study [FAttori di Rischio PREdittivi di Conversione Nell'RBD Idiopatico. STudio ItalianO[NCT05262543] | 300 participants (Anticipated) | Observational | 2020-05-25 | Recruiting | |||
| The Role of Orexin in Human Panic Disorder[NCT02593682] | Phase 4 | 3 participants (Actual) | Interventional | 2016-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for clonazepam and Chronic Illness
| Article | Year |
|---|---|
REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Chronic Disease; Clonazepam; Diagnosis, Differential; Elec | 2002 |
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te | 1978 |
6 trials available for clonazepam and Chronic Illness
| Article | Year |
|---|---|
Impact of criteria-based diagnosis of burning mouth syndrome on treatment outcome.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Anticonvulsants; Burning Mouth Syndrome; Carbam | 2002 |
Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study.
Topics: Adult; Anxiety Disorders; Chronic Disease; Clonazepam; Double-Blind Method; Female; Hospitalization; | 1993 |
Long-term, nightly benzodiazepine treatment of injurious parasomnias and other disorders of disrupted nocturnal sleep in 170 adults.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Chronic Disease; Clonazepam; Drug Administration Schedule; F | 1996 |
Usefulness of antiparkinsonian drugs during neuroleptic treatment and the effect of clonazepam on akathisia and parkinsonism occurred after antiparkinsonian drug withdrawal: a double-blind study.
Topics: Akathisia, Drug-Induced; Antiparkinson Agents; Antipsychotic Agents; Chronic Disease; Clonazepam; Do | 1992 |
Adjunctive clonazepam in the treatment of chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Clonazepam; Drug Therapy, Combination; Female; Humans; | 1991 |
Administration of clonazepam in the treatment of TMD and associated myofascial pain: a double-blind pilot study.
Topics: Adolescent; Adult; Chronic Disease; Clonazepam; Double-Blind Method; Female; Humans; Male; Middle Ag | 1991 |
27 other studies available for clonazepam and Chronic Illness
| Article | Year |
|---|---|
Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome.
Topics: Aged; Anticonvulsants; Anxiety; Burning Mouth Syndrome; Chronic Disease; Chronic Pain; Clonazepam; C | 2017 |
Low serum 25-hydroxyvitamin D concentrations in chronic insomnia patients and the association with poor treatment outcome at 2months.
Topics: Adult; Antidepressive Agents; Azabicyclo Compounds; Biomarkers; Case-Control Studies; Chronic Diseas | 2017 |
Severe Chronic Abuse of Zolpidem in Refractory Insomnia.
Topics: Aged; Anticonvulsants; Chronic Disease; Clonazepam; Female; Hospitalization; Humans; Levetiracetam; | 2018 |
Executive dysfunction in patients with chronic primary insomnia treated with clonazepam.
Topics: Adult; Anticonvulsants; Attention; Chronic Disease; Clonazepam; Cognition Disorders; Executive Funct | 2015 |
Case scenario: self-extraction of intrathecal pump medication with a concomitant intrathecal granulomatous mass.
Topics: Acetaminophen; Administration, Cutaneous; Adult; Analgesics; Analgesics, Non-Narcotic; Analgesics, O | 2011 |
Chronic interictal psychosis responsive to aripiprazole.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Chronic Disease; Clonazepam; Delusions; | 2004 |
Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Chronic Di | 2007 |
Chronic myoclonia of subcortical origin with antiglutamate receptor antibodies.
Topics: Antibody Specificity; Anticonvulsants; Autoantibodies; Child; Chronic Disease; Clonazepam; Electroen | 2007 |
Anticonvulsant drugs used in the treatment of lancinating pain. A comparison.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Female; Humans | 1981 |
Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Topics: Animals; Anticonvulsants; Chlorides; Chronic Disease; Clonazepam; Diazepam; Disease Models, Animal; | 1983 |
Possible drug interaction in chronic treatment of epileptic patients: serum level studies.
Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Chronic Disease; Clonazepam; Drug Interac | 1980 |
[A case of chronic thinner intoxication developing hyperkinésie volitionnelle three years after stopping thinner abuse].
Topics: Adult; Brain; Chronic Disease; Clonazepam; Humans; Hyperkinesis; Male; Substance-Related Disorders; | 1993 |
Physiological analysis of Rasmussen's encephalitis: patch clamp recordings of altered inhibitory neurotransmitter function in resected frontal cortical tissue.
Topics: Cell Size; Cells, Cultured; Cerebral Cortex; Child; Chronic Disease; Clonazepam; Dose-Response Relat | 1998 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo | 1998 |
An open-label, dose escalation pilot study of the effect of clonazepam in burning mouth syndrome.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Burning Mouth Syndrome; Chronic Disease; Clonazepam; | 1998 |
Chronic behavioral disorders of human REM sleep: a new category of parasomnia. 1986 [classical article].
Topics: Aged; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Disease; Clonazepam; Desipra | 2002 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
[Electroclinical correlations during anticonvulsive therapy of status epilepticus and chronic focal epilepsies using clonazepam].
Topics: Adolescent; Adult; Benzodiazepinones; Brain; Chronic Disease; Clonazepam; Electroencephalography; Ep | 1977 |
[Epilepsy refractary to usual treatment: the effect of clonazepam (author's transl)].
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Chronic Disease; Clonazepam; Drug Evaluation | 1976 |
Tardive dyskinesia in the elderly patient.
Topics: Aged; Chlorpromazine; Chronic Disease; Clonazepam; Clozapine; Depressive Disorder; Desipramine; Diph | 1992 |
Chronic facial pain together with severe depression is responsive to electroconvulsive therapy. A case report.
Topics: Amitriptyline; Chronic Disease; Clonazepam; Depressive Disorder; Electroconvulsive Therapy; Facial P | 1992 |
Chronic headache resulting from postoperative supraorbital neuralgia.
Topics: Bupivacaine; Chronic Disease; Clonazepam; Female; Headache; Humans; Middle Aged; Nerve Block; Neural | 1991 |
Mania associated with clonazepam.
Topics: Acute Disease; Adult; Bipolar Disorder; Chronic Disease; Clonazepam; Humans; Male; Schizophrenia | 1991 |
Palatal myoclonus successfully treated with clonazepam.
Topics: Aged; Chronic Disease; Clonazepam; Female; Humans; Myoclonus; Neurologic Examination; Palatal Muscle | 1990 |
Longitudinal course of panic disorder: findings from the Massachusetts General Hospital Naturalistic Study.
Topics: Alprazolam; Anxiety Disorders; Child, Preschool; Chronic Disease; Clonazepam; Cognitive Behavioral T | 1990 |
The effects of acidosis on chronically hypoxic neurons in culture.
Topics: Acidosis; Animals; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Cells, Cultured; Chroni | 1990 |
[Chronic toluene intoxication and hyperkinésie volitionnelle].
Topics: Adult; Brain; Chronic Disease; Clonazepam; Electromyography; Gliosis; Humans; Hyperkinesis; Male; To | 1986 |