clonazepam has been researched along with Bipolar Disorder in 95 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lithium carbonate is the drug of choice for the management of bipolar disorder, but 20% to 40% of patients do not exhibit adequate response to this agent." | 10.16 | Non-lithium treatment for bipolar disorder. ( Post, RM, 1990) |
| "Our Objective is to study the effects of aripiprazole as an adjuvant treatment for obsessive and compulsive (OC) symptoms in patients with bipolar disorder (BD) type I, manic phase." | 9.27 | Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: A randomized, double-blind, placebo-controlled clinical trial. ( Ehsaei, Z; Mowla, A; Sahraian, A, 2018) |
| "The aim of this study is to examine the effects of memantine as an adjuvant treatment for obsessive compulsive (OC) symptoms in patients with bipolar disorder (BD) type I, manic phase." | 9.24 | Memantine as an Adjuvant Treatment for Obsessive Compulsive Symptoms in Manic Phase of Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Ghanizadeh, A; Jahromi, LR; Mowla, A; Sahraian, A, 2017) |
| "The combination of lithium+olanzapine+clonazepam decreased the symptoms of obsessive compulsive disorder in the patients with bipolar disorder type I." | 9.19 | Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial. ( Akhondzadeh, S; Bigdeli, M; Ghanizadeh, A; Sahraian, A, 2014) |
| "The authors describe the first five patients enrolled in an open clinical trial of clonazepam as a maintenance treatment in lithium-refractory bipolar disorder." | 9.06 | Clonazepam treatment of five lithium-refractory patients with bipolar disorder. ( Aronson, TA; Hirschowitz, J; Shukla, S, 1989) |
| "The research literature on alternative drug treatments to lithium therapy for the prevention of recurrences in bipolar disorders is discussed." | 8.78 | Alternative prophylactic treatments to lithium in bipolar disorders. ( Altamura, AC; Mauri, MC; Percudani, M; Regazzetti, MG, 1990) |
| "Lithium carbonate is the drug of choice for the management of bipolar disorder, but 20% to 40% of patients do not exhibit adequate response to this agent." | 6.16 | Non-lithium treatment for bipolar disorder. ( Post, RM, 1990) |
| "Our Objective is to study the effects of aripiprazole as an adjuvant treatment for obsessive and compulsive (OC) symptoms in patients with bipolar disorder (BD) type I, manic phase." | 5.27 | Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: A randomized, double-blind, placebo-controlled clinical trial. ( Ehsaei, Z; Mowla, A; Sahraian, A, 2018) |
| "The aim of this study is to examine the effects of memantine as an adjuvant treatment for obsessive compulsive (OC) symptoms in patients with bipolar disorder (BD) type I, manic phase." | 5.24 | Memantine as an Adjuvant Treatment for Obsessive Compulsive Symptoms in Manic Phase of Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. ( Ghanizadeh, A; Jahromi, LR; Mowla, A; Sahraian, A, 2017) |
| "The combination of lithium+olanzapine+clonazepam decreased the symptoms of obsessive compulsive disorder in the patients with bipolar disorder type I." | 5.19 | Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial. ( Akhondzadeh, S; Bigdeli, M; Ghanizadeh, A; Sahraian, A, 2014) |
| "The authors describe the first five patients enrolled in an open clinical trial of clonazepam as a maintenance treatment in lithium-refractory bipolar disorder." | 5.06 | Clonazepam treatment of five lithium-refractory patients with bipolar disorder. ( Aronson, TA; Hirschowitz, J; Shukla, S, 1989) |
| "The research literature on alternative drug treatments to lithium therapy for the prevention of recurrences in bipolar disorders is discussed." | 4.78 | Alternative prophylactic treatments to lithium in bipolar disorders. ( Altamura, AC; Mauri, MC; Percudani, M; Regazzetti, MG, 1990) |
| ", carbamazepine, valproate, clonazepam, oxcarbazepine, and electroconvulsive therapy (ECT), for patients with bipolar disorder." | 4.78 | Anticonvulsants in the treatment of bipolar disorder. ( Keck, PE; McElroy, SL; Nemeroff, CB, 1992) |
| " Drug-drug interactions from her home medications for depression, bipolar disorder and seizures (amitriptyline, cyclobenzaprine, benztropine, topiramate, clonazepam, trazodone) were suspected." | 4.02 | Use of multiple anticholinergic medications can predispose patients to severe non-exertional hyperthermia. ( Kabbani, D; Levine, D; Manivannan, A, 2021) |
| "Since the prominent role in clonazepam nitro-reduction and acetylation of 7-amino-clonazepam is assigned to CYP3A and N-acetyl transferase 2 enzymes, respectively, the association between the patients' CYP3A status (CYP3A5 genotype, CYP3A4 expression) or N-acetyl transferase 2 acetylator phenotype and clonazepam metabolism (plasma concentrations of clonazepam and 7-amino-clonazepam) was evaluated in 98 psychiatric patients suffering from schizophrenia or bipolar disorders." | 3.83 | Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype. ( Belic, A; Bitter, I; Csukly, G; Déri, M; Háfra, E; Kiss, Á; Menus, Á; Monostory, K; Sirok, D; Tóth, K, 2016) |
| "Postmortem CNS studies have suggested an uncoupling of the gamma-aminobutyric acid (GABA) and benzodiazepine binding sites on the hippocampal GABA(A) receptor in schizophrenia." | 3.73 | Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. ( Dean, B; McLeod, M; Scarr, E, 2005) |
| "Topiramate is a novel anticonvulsant agent with a broad spectrum mechanism of action, and recent clinical reports indicate that it may have mood stabilizing properties in bipolar disorder." | 3.71 | Topiramate as a mood stabilizer. ( Kasper, S; Letmaier, M; Schreinzer, D; Wolf, R, 2001) |
| " An association between weight gain, obstructive sleep apnea, and lithium treatment is also illustrated." | 3.68 | Four cases of obstructive sleep apnea associated with treatment-resistant mania. ( Alpert, JE; Frankenburg, FR; Hudson, JI; Keck, PE; Strakowski, SM; Teschke, GC; Tohen, M; Wilson, DR, 1991) |
| "Treatment with lorazepam produced marked improvement in symptomatology, while treatment with clonazepam failed to demonstrate a significant therapeutic effect." | 2.67 | Double-blind comparison of the effects of clonazepam and lorazepam in acute mania. ( Bradwejn, J; Koszycki, D; Meterissian, G; Shriqui, C, 1990) |
| "clonazepam is an effective, safe, but slower-acting alternative to I." | 2.67 | A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms. ( Annable, L; Chouinard, G; Holobow, N; Szkrumelak, N; Turnier, L, 1993) |
| "Clonazepam was found to be significantly more efficacious than lithium in reducing manic symptoms despite the fact that during clonazepam treatment less patients required PRNs of haloperidol." | 2.65 | Antimanic effect of clonazepam. ( Annable, L; Chouinard, G; Young, SN, 1983) |
| "Clonazepam has shown some efficacy in social phobia; however, because this evidence is based on few studies, further studies are warranted before definitive conclusions can be drawn." | 2.43 | Clonazepam in the treatment of psychiatric disorders: an update. ( Nardi, AE; Perna, G, 2006) |
| "Rapid cycling is a clinical subtype of bipolar mood disorder that has four or more episodes during the previous 12 months and has poor response to lithium (Li) prophylaxis treatment." | 2.40 | Algorithm for the treatment of rapid cycling. ( Yamada, K, 1999) |
| "Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981." | 2.40 | [A trial of clonazepam treatment for manic-depressive psychoses]. ( Aoki, S; Morishita, S, 1999) |
| "A 23-year-old man had unilateral rubral tremors as a result of a midbrain lesion plus risperidone exposure for treatment of manic symptoms." | 1.35 | Unilateral rubral tremor following treatment with risperidone. ( Shen, YC, 2009) |
| "Clonazepam has been shown to be an effective supplementary treatment for depression." | 1.34 | Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression. ( Arita, S; Morishita, S, 2007) |
| "Patients with unipolar depression had significantly (P=0." | 1.32 | Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder. ( Barnas, C; Kasper, S; Konstantinidis, A; Pjrek, E; Schindler, S; Stamenkovic, M; Tauscher, J; Willeit, M; Winkler, D; Wolf, R, 2003) |
| "However, in the bipolar depression group, only 10." | 1.31 | Clonazepam augmentation of antidepressants: does it distinguish unipolar from bipolar depression? ( Aoki, S; Morishita, S, 2002) |
| "Previous reports document visual illusions resembling hallucinogen persisting perception disorder (HPPD) after risperidone treatment in patients with histories of previous LSD exposure." | 1.31 | Posthallucinogen-like visual illusions (palinopsia) with risperidone in a patient without previous hallucinogen exposure: possible relation to serotonin 5HT2a receptor blockade. ( Abdelhamid, A; Annandale, JB; Lauterbach, EC, 2000) |
| "Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981." | 1.30 | Clonazepam as a therapeutic adjunct to improve the management of psychiatric disorders. ( Aoki, S; Morishita, S; Watanabe, S, 1998) |
| "Clonazepam was administered orally to 11 newly admitted inpatients." | 1.29 | Clonazepam in acute mania: time-blind evaluation of clinical response and concentrations in plasma. ( Alric, R; Barbe, A; Bottaï, T; Hillaire-Buys, D; Hüe, B; Petit, P; Pouget, R, 1995) |
| "Clonazepam is a potent, long-acting benzodiazepine approved for use in myoclonic and petit mal seizures." | 1.28 | Mania associated with clonazepam. ( Dorevitch, A, 1991) |
| "Clonazepam treatment led to a decrease in agitation and logorrhea, without the side effects associated with neuroleptics." | 1.27 | Use of clonazepam in mania and schizoaffective disorders. ( Bell, IR; Binder, RL; Link, NA; Victor, BS, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (27.37) | 18.7374 |
| 1990's | 36 (37.89) | 18.2507 |
| 2000's | 20 (21.05) | 29.6817 |
| 2010's | 9 (9.47) | 24.3611 |
| 2020's | 4 (4.21) | 2.80 |
| Authors | Studies |
|---|---|
| Schoenfeld, E | 1 |
| Viswanathan, R | 2 |
| Larios, DA | 1 |
| Friedman, D | 1 |
| Hafi, B | 1 |
| Uvais, NA | 1 |
| Manivannan, A | 1 |
| Kabbani, D | 1 |
| Levine, D | 1 |
| Sahraian, A | 4 |
| Ghahremanpouri, B | 1 |
| Mowla, A | 3 |
| Zubair, UB | 1 |
| Mumtaz, H | 1 |
| Mansoor, S | 1 |
| Ehsaei, Z | 1 |
| Bigdeli, M | 1 |
| Ghanizadeh, A | 2 |
| Akhondzadeh, S | 1 |
| Gélisse, P | 1 |
| Crespel, A | 1 |
| Tóth, K | 1 |
| Csukly, G | 1 |
| Sirok, D | 1 |
| Belic, A | 1 |
| Kiss, Á | 1 |
| Háfra, E | 1 |
| Déri, M | 1 |
| Menus, Á | 1 |
| Bitter, I | 1 |
| Monostory, K | 1 |
| Jahromi, LR | 1 |
| Shen, YC | 1 |
| Val, AC | 1 |
| Souza, A | 1 |
| Nicolato, R | 1 |
| Teixeira, AL | 1 |
| Salgado, JV | 1 |
| Chen, CY | 1 |
| Shiah, IS | 1 |
| Lee, WK | 1 |
| Kuo, SC | 1 |
| Huang, CC | 1 |
| Wang, TY | 1 |
| Post, RM | 4 |
| Altshuler, LL | 1 |
| Frye, MA | 2 |
| Suppes, T | 1 |
| Keck, PE | 3 |
| McElroy, SL | 2 |
| Leverich, GS | 2 |
| Luckenbaugh, DA | 1 |
| Rowe, M | 1 |
| Pizzarello, S | 1 |
| Kupka, RW | 1 |
| Grunze, H | 1 |
| Nolen, WA | 1 |
| Estabrook, KR | 1 |
| Pheister, M | 1 |
| Lin, HY | 1 |
| Lin, CC | 1 |
| Liu, CC | 1 |
| Morishita, S | 4 |
| Aoki, S | 3 |
| Winkler, D | 1 |
| Willeit, M | 1 |
| Wolf, R | 2 |
| Stamenkovic, M | 1 |
| Tauscher, J | 1 |
| Pjrek, E | 1 |
| Konstantinidis, A | 1 |
| Schindler, S | 1 |
| Barnas, C | 1 |
| Kasper, S | 3 |
| Mendhekar, DN | 1 |
| Gupta, D | 1 |
| Girotra, V | 1 |
| Horiuchi, R | 1 |
| Takeuchi, J | 1 |
| Suzuki, H | 1 |
| Kimura, M | 1 |
| Coffey, B | 1 |
| Curtin, F | 1 |
| Schulz, P | 1 |
| Mashiko, H | 1 |
| Kurita, M | 1 |
| Shirakawa, H | 1 |
| Ohtomo, K | 1 |
| Hashimoto, M | 1 |
| Miyashita, N | 1 |
| Niwa, S | 1 |
| Dean, B | 1 |
| Scarr, E | 1 |
| McLeod, M | 1 |
| Dunner, DL | 1 |
| Nardi, AE | 1 |
| Perna, G | 1 |
| Arita, S | 1 |
| McLean, RM | 1 |
| Harrison-Woolrych, M | 1 |
| Lorenz, RA | 1 |
| Weinstein, B | 1 |
| Wickham, R | 1 |
| Varma, A | 1 |
| Chouinard, G | 7 |
| Labonte, A | 1 |
| Fontaine, R | 1 |
| Annable, L | 3 |
| Young, SN | 1 |
| Uhde, TW | 1 |
| Victor, BS | 1 |
| Link, NA | 1 |
| Binder, RL | 2 |
| Bell, IR | 1 |
| Lechin, F | 1 |
| van der Dijs, B | 1 |
| Northcott, C | 1 |
| Lunn, V | 1 |
| Yatham, LN | 1 |
| Benazzi, F | 1 |
| Mazzoli, M | 1 |
| Turecki, G | 1 |
| Mari, Jde J | 1 |
| Del Porto, JA | 1 |
| Turnier, L | 1 |
| Holobow, N | 1 |
| Szkrumelak, N | 1 |
| Glod, CA | 1 |
| Mathieu, J | 1 |
| Gouliaev, G | 2 |
| Licht, RW | 4 |
| Vestergaard, P | 3 |
| Merinder, L | 1 |
| Lund, H | 1 |
| Bjerre, L | 1 |
| Ketter, TA | 1 |
| Denicoff, K | 1 |
| Pazzaglia, PJ | 1 |
| Marangell, LB | 1 |
| Callahan, AM | 1 |
| George, MS | 1 |
| Bottaï, T | 1 |
| Hüe, B | 1 |
| Hillaire-Buys, D | 1 |
| Barbe, A | 1 |
| Alric, R | 1 |
| Pouget, R | 1 |
| Petit, P | 1 |
| Strite, D | 1 |
| Valentine, AD | 1 |
| Meyers, CA | 1 |
| Frydenberg, M | 2 |
| Shimizu, E | 1 |
| Kodama, K | 1 |
| Sakamoto, T | 1 |
| Komatsu, N | 1 |
| Yamanouchi, N | 1 |
| Okada, S | 1 |
| Sato, T | 1 |
| Jensen, J | 1 |
| Watanabe, S | 1 |
| Gouliaev, GH | 1 |
| Ikeda, M | 1 |
| Fujikawa, T | 1 |
| Yanai, I | 1 |
| Horiguchi, J | 1 |
| Yamawaki, S | 1 |
| Gerding, LB | 1 |
| Labbate, LA | 1 |
| Yamada, K | 1 |
| Heiden, A | 1 |
| Frey, R | 1 |
| Presslich, O | 1 |
| Blasbichler, T | 1 |
| Smetana, R | 1 |
| Lauterbach, EC | 2 |
| Abdelhamid, A | 1 |
| Annandale, JB | 1 |
| Letmaier, M | 1 |
| Schreinzer, D | 1 |
| Nemeroff, CB | 1 |
| Spears, TE | 1 |
| Price, ST | 1 |
| Barr, M | 1 |
| Labelle, A | 1 |
| Lapierre, YD | 1 |
| Edwards, R | 1 |
| Stephenson, U | 1 |
| Flewett, T | 1 |
| Dorevitch, A | 1 |
| Sachs, GS | 3 |
| Weilburg, JB | 1 |
| Rosenbaum, JF | 2 |
| Bansil, RK | 1 |
| Strakowski, SM | 1 |
| Hudson, JI | 1 |
| Wilson, DR | 1 |
| Frankenburg, FR | 1 |
| Alpert, JE | 1 |
| Teschke, GC | 1 |
| Tohen, M | 1 |
| Jones, L | 1 |
| Mauri, MC | 1 |
| Percudani, M | 1 |
| Regazzetti, MG | 1 |
| Altamura, AC | 1 |
| Bradwejn, J | 1 |
| Shriqui, C | 1 |
| Koszycki, D | 1 |
| Meterissian, G | 1 |
| Jarecke, CR | 1 |
| De Moya, VF | 1 |
| Ware, MR | 1 |
| Budman, CL | 1 |
| Vandersall, TA | 1 |
| Ghadirian, AM | 1 |
| Kusalic, M | 1 |
| Kutcher, S | 1 |
| Williamson, P | 1 |
| MacKenzie, S | 1 |
| Marton, P | 1 |
| Ehrlich, M | 1 |
| Glickman, L | 1 |
| Aronson, TA | 1 |
| Shukla, S | 1 |
| Hirschowitz, J | 1 |
| Santos, AB | 1 |
| Morton, WA | 1 |
| Koczerginski, D | 1 |
| Kennedy, SH | 1 |
| Swinson, RP | 1 |
| Adler, LW | 1 |
| Amiel, M | 1 |
| Bryan, S | 1 |
| Herjanic, M | 1 |
| Garbutt, JC | 1 |
| Gillette, GM | 1 |
| Marchevsky, S | 1 |
| Isaacs, G | 1 |
| Nitzan, I | 1 |
| Kishimoto, A | 1 |
| Kamata, K | 1 |
| Sugihara, T | 1 |
| Ishiguro, S | 1 |
| Hazama, H | 1 |
| Mizukawa, R | 1 |
| Kunimoto, N | 1 |
| Pande, AC | 1 |
| Alvarez, WA | 1 |
| Freinhar, JP | 2 |
| Kubacki, A | 1 |
| Zetin, M | 1 |
| Freedman, MJ | 1 |
| Lerer, B | 1 |
| Alvarez, WH | 1 |
14 reviews available for clonazepam and Bipolar Disorder
| Article | Year |
|---|---|
[Bipolar II disorder].
Topics: Antidepressive Agents; Antimanic Agents; Bipolar Disorder; Clonazepam; Diagnostic and Statistical Ma | 2003 |
[Organic manic disorder].
Topics: Bipolar Disorder; Brain Diseases; Carbamazepine; Clonazepam; Diagnostic and Statistical Manual of Me | 2003 |
Clonazepam and lorazepam in acute mania: a Bayesian meta-analysis.
Topics: Bayes Theorem; Bipolar Disorder; Clonazepam; GABA Modulators; Humans; Lorazepam; Placebos; Randomize | 2004 |
Clonazepam in the treatment of psychiatric disorders: an update.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Bipolar Disorder; Clonazepam; Humans; Meta-Analysis as Topic | 2006 |
Treatment of mood disorders with antiepileptic medications: clinical and theoretical implications.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Depressive D | 1983 |
The place of anticonvulsant therapy in bipolar illness.
Topics: Affect; Anticonvulsants; Bipolar Disorder; Calcium Channel Blockers; Carbamazepine; Clonazepam; Drug | 1996 |
Algorithm for the treatment of rapid cycling.
Topics: Algorithms; Antimanic Agents; Bipolar Disorder; Carbamazepine; Clonazepam; Cyclothymic Disorder; Dru | 1999 |
[A trial of clonazepam treatment for manic-depressive psychoses].
Topics: Anticonvulsants; Bipolar Disorder; Clonazepam; Humans; Tranquilizing Agents | 1999 |
Anticonvulsants in the treatment of bipolar disorder.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clonazepam; Drug Therapy, Combination; Electroconv | 1992 |
Bipolar disorder in idiopathic dystonia: clinical features and possible neurobiology.
Topics: Antidepressive Agents; Bipolar Disorder; Clonazepam; Cyclothymic Disorder; Drug Therapy, Combination | 1992 |
Alternative prophylactic treatments to lithium in bipolar disorders.
Topics: Alprazolam; Bipolar Disorder; Calcium Channel Blockers; Carbamazepine; Clonazepam; Humans; Lithium; | 1990 |
Non-lithium treatment for bipolar disorder.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Drug Therapy | 1990 |
Clonazepam in acute and maintenance treatment of bipolar affective disorder.
Topics: Acute Disease; Adult; Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Double-Blind Method; D | 1987 |
Alternative therapies for bipolar disorder.
Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgylin | 1985 |
24 trials available for clonazepam and Bipolar Disorder
| Article | Year |
|---|---|
Is quetiapine effective for obsessive and compulsive symptoms in patients with bipolar disorder? A randomized, double-blind, placebo-controlled clinical trial.
Topics: Bipolar Disorder; Clonazepam; Double-Blind Method; Drug Therapy, Combination; Humans; Lithium; Obses | 2022 |
Aripiprazole as an adjuvant treatment for obsessive and compulsive symptoms in manic phase of bipolar disorder: A randomized, double-blind, placebo-controlled clinical trial.
Topics: Adult; Aripiprazole; Bipolar Disorder; Chemotherapy, Adjuvant; Clonazepam; Compulsive Behavior; Doub | 2018 |
Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial.
Topics: Adult; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Clonazepam; Double-Blind Method; Drug Th | 2014 |
Memantine as an Adjuvant Treatment for Obsessive Compulsive Symptoms in Manic Phase of Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Topics: Adjuvants, Pharmaceutic; Adult; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Dis | 2017 |
New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines.
Topics: Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Bipolar Disorder; Bromazepam; C | 1983 |
Antimanic effect of clonazepam.
Topics: Acute Disease; Adult; Affective Disorders, Psychotic; Benzodiazepinones; Bipolar Disorder; Clonazepa | 1983 |
Treatment of mood disorders with antiepileptic medications: clinical and theoretical implications.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Depressive D | 1983 |
Rapid tranquilization with intramuscular clonazepam.
Topics: Adult; Bipolar Disorder; Clonazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adm | 1994 |
A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms.
Topics: Adolescent; Adult; Arousal; Bipolar Disorder; Clonazepam; Double-Blind Method; Drug Therapy, Combina | 1993 |
Treatment of manic episodes: zuclopenthixol and clonazepam versus lithium and clonazepam.
Topics: Administration, Oral; Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Citrates; Clo | 1996 |
Generalisability of results from randomised drug trials. A trial on antimanic treatment.
Topics: Adolescent; Adult; Aged; Antimanic Agents; Bipolar Disorder; Clonazepam; Clopenthixol; Data Collecti | 1997 |
Validation of the Bech-Rafaelsen Mania Scale using latent structure analysis.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Clonazepam; Clopenthixol; Drug Therapy, Combination; Fema | 1997 |
[May results from randomized clinical trials be generalized? An example from psychopharmacology].
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Clopenthixol; Denmark; Female; Huma | 1998 |
Clonazepam in acute mania: a double blind trial.
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Chlorpromazine; Clonazepam; Double-Blind Method; Drug The | 1991 |
Clonazepam vs. neuroleptics as adjuncts to lithium maintenance.
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Therapy, Combination; Female; | 1990 |
Non-lithium treatment for bipolar disorder.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Clonazepam; Drug Therapy | 1990 |
Double-blind comparison of the effects of clonazepam and lorazepam in acute mania.
Topics: Acute Disease; Adult; Bipolar Disorder; Clonazepam; Double-Blind Method; Drug Therapy, Combination; | 1990 |
Successful clonazepam treatment of neuroleptic-induced akathisia in older adolescents and young adults: a double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Doub | 1989 |
Clonazepam treatment of five lithium-refractory patients with bipolar disorder.
Topics: Adult; Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Drug Therapy, Combination; Female; Hu | 1989 |
Use of benzodiazepines to improve management of manic agitation.
Topics: Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Drug Administration Schedule; Humans; Loraze | 1989 |
The use of benzodiazepines in the treatment of manic-depressive illness.
Topics: Acute Disease; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Basal Ga | 1988 |
Treatment of depression with clonazepam.
Topics: Adult; Aged; Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Depressive Disorder; Dose-Respo | 1988 |
Clonazepam in acute and maintenance treatment of bipolar affective disorder.
Topics: Acute Disease; Adult; Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Double-Blind Method; D | 1987 |
Antimanic effects of clonazepam.
Topics: Adult; Benzodiazepinones; Bipolar Disorder; Clinical Trials as Topic; Clonazepam; Double-Blind Metho | 1985 |
60 other studies available for clonazepam and Bipolar Disorder
| Article | Year |
|---|---|
Clonazepam to the Rescue? Post-Steroid Mania and a Paradoxical Response to an Atypical Antipsychotic.
Topics: Antipsychotic Agents; Bipolar Disorder; Clonazepam; Humans; Mania; Steroids | 2022 |
Clonazepam-Induced Acute Itch.
Topics: Bipolar Disorder; Clonazepam; Humans; Pruritus | 2023 |
Use of multiple anticholinergic medications can predispose patients to severe non-exertional hyperthermia.
Topics: Bipolar Disorder; Cholinergic Antagonists; Clonazepam; Drug Interactions; Female; Humans; Hypertherm | 2021 |
Bipolar Affective Disorder in a Patient of Profound Deafness.
Topics: Adolescent; Bipolar Disorder; Clonazepam; Female; Humans; Persons With Hearing Impairments; Psychiat | 2018 |
Mixed myoclonic-absence status epilepticus in juvenile myoclonic epilepsy.
Topics: Anticonvulsants; Bipolar Disorder; Catatonia; Clonazepam; Electroencephalography; Epilepsies, Myoclo | 2015 |
Optimization of Clonazepam Therapy Adjusted to Patient's CYP3A Status and NAT2 Genotype.
Topics: Acetylation; Adult; Aged; Antipsychotic Agents; Arylamine N-Acetyltransferase; Biotransformation; Bi | 2016 |
Unilateral rubral tremor following treatment with risperidone.
Topics: Anticonvulsants; Antipsychotic Agents; Ataxia; Behavior Therapy; Bipolar Disorder; Brain; Carbamazep | 2009 |
[Catatonic syndrome associated with mixed bipolar disorder: a case report and therapeutic considerations].
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Catatonia; Clonazepam; Female; Humans; Middle A | 2008 |
Dependence on quetiapine in combination with zolpidem and clonazepam in bipolar depression.
Topics: Antipsychotic Agents; Bipolar Disorder; Clonazepam; Dibenzothiazepines; Female; Humans; Hypnotics an | 2009 |
Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder.
Topics: Adult; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; Antimanic Agent | 2010 |
A case of quetiapine XR and divalproex-associated neutropenia followed by successful use of ziprasidone.
Topics: Adult; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Anxiety Disorders; Bipolar Disor | 2012 |
Hypomania associated with adjunctive aripiprazole in an elder female with recurrent major depressive disorder: dose-related phenomenon?
Topics: Aripiprazole; Bipolar Disorder; Clonazepam; Depressive Disorder, Major; Dose-Response Relationship, | 2012 |
Clonazepam augmentation of antidepressants: does it distinguish unipolar from bipolar depression?
Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Clonazepam; Depressive Disorder; Diagnosis, Differen | 2002 |
Clonazepam in the long-term treatment of patients with unipolar depression, bipolar and schizoaffective disorder.
Topics: Adult; Aged; Bipolar Disorder; Clonazepam; Depressive Disorder; Female; Humans; Male; Middle Aged; P | 2003 |
Sertraline-induced hypomania: a genuine side-effect.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Clonazepam; Female; Humans; Sertral | 2003 |
Clinical case presentation: therapeutic challenges in adolescent-onset bipolar disorder.
Topics: Adolescent; Aggression; Anti-Anxiety Agents; Antimanic Agents; Antipsychotic Agents; Bipolar Disorde | 2003 |
Case of bipolar disorder successfully stabilized with clonazepam, valproate and lithium after numerous relapses for 47 years.
Topics: Aged; Antimanic Agents; Bipolar Disorder; Clonazepam; Drug Resistance; Drug Therapy, Combination; Fe | 2004 |
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil | 2005 |
Interactive case conference. First episode: depression and panic disorder.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Citalopram; Clonazepam; Depression; | 2005 |
Possible predictors of response to clonazepam augmentation therapy in patients with protracted depression.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Chronic Di | 2007 |
Alopecia associated with quetiapine.
Topics: Adult; Affective Disorders, Psychotic; Alopecia; Antipsychotic Agents; Azabicyclo Compounds; Bipolar | 2007 |
Resolution of haloperidol-induced hyperprolactinemia with aripiprazole.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Aripiprazole; Bipolar Disorder; Clonazepam; Dose-Resp | 2007 |
Ziprasidone-associated mania in a case of obssessive-compulsive disorder.
Topics: Anticonvulsants; Bipolar Disorder; Citalopram; Clonazepam; Dose-Response Relationship, Drug; Drug In | 2007 |
Use of clonazepam in mania and schizoaffective disorders.
Topics: Acute Disease; Adult; Benzodiazepinones; Bipolar Disorder; Clonazepam; Drug Administration Schedule; | 1984 |
Antimanic effect of clonazepam.
Topics: Benzodiazepinones; Bipolar Disorder; Clonazepam; Humans | 1983 |
Parkinsonism and bipolar affective disorder.
Topics: Aged; Antiparkinson Agents; Bipolar Disorder; Carbidopa; Clonazepam; Dopamine; Drug Combinations; Dr | 1995 |
Bipolar disorder following a left basal-ganglia stroke.
Topics: Basal Ganglia; Bipolar Disorder; Cerebrovascular Disorders; Clonazepam; Humans; Lithium; Male; Middl | 1993 |
Expanding uses of anticonvulsants in the treatment of bipolar disorder.
Topics: Bipolar Disorder; Carbamazepine; Clonazepam; Humans; Valproic Acid | 1993 |
Clonazepam in acute mania: time-blind evaluation of clinical response and concentrations in plasma.
Topics: Acute Disease; Adolescent; Adult; Aged; Antimanic Agents; Bipolar Disorder; Clonazepam; Dose-Respons | 1995 |
Manic episodes in two patients treated with interferon alpha.
Topics: Adult; Bipolar Disorder; Clonazepam; Cognition Disorders; Dopamine Antagonists; Female; GABA Modulat | 1997 |
Recovery from neuroendocrinological abnormalities and frontal hypoperfusion after remission in a case with rapid cycling bipolar disorder.
Topics: Anticonvulsants; Bipolar Disorder; Carbamazepine; Clonazepam; Dexamethasone; Drug Therapy, Combinati | 1997 |
Clonazepam as a therapeutic adjunct to improve the management of psychiatric disorders.
Topics: Adult; Aged; Akathisia, Drug-Induced; Anticonvulsants; Bipolar Disorder; Clonazepam; Delusions; Depr | 1998 |
Clonazepam-induced maniacal reaction in a patient with bipolar disorder.
Topics: Bipolar Disorder; Clonazepam; GABA Modulators; Humans; Male; Middle Aged | 1998 |
Use of clonazepam in an elderly bipolar patient with tardive dyskinesia: a case report.
Topics: Age Factors; Aged; Aged, 80 and over; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Dyskinesia | 1999 |
Treatment of severe mania with intravenous magnesium sulphate as a supplementary therapy.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Clonazepam; Dose-Response Relationship, Drug; Drug Admini | 1999 |
Posthallucinogen-like visual illusions (palinopsia) with risperidone in a patient without previous hallucinogen exposure: possible relation to serotonin 5HT2a receptor blockade.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Female | 2000 |
Topiramate as a mood stabilizer.
Topics: Acute Disease; Adaptation, Psychological; Adult; Antimanic Agents; Bipolar Disorder; Clonazepam; Dos | 2001 |
Assessment of improvement in treatment trials of acute mania.
Topics: Bipolar Disorder; Clonazepam; Humans; Personality Assessment; Psychomotor Agitation | 1991 |
Keratodermia: side effects of lithium.
Topics: Bipolar Disorder; Clonazepam; Drug Eruptions; Drug Therapy, Combination; Humans; Keratoderma, Palmop | 1991 |
Mania associated with clonazepam.
Topics: Acute Disease; Adult; Bipolar Disorder; Chronic Disease; Clonazepam; Humans; Male; Schizophrenia | 1991 |
Use of clonazepam for bipolar affective disorder.
Topics: Acute Disease; Adult; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Therapy, Combination; | 1990 |
Clonazepam and bipolar affective disorder.
Topics: Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Therapy, Combination; Humans; Prospective S | 1990 |
Four cases of obstructive sleep apnea associated with treatment-resistant mania.
Topics: Adult; Bipolar Disorder; Clonazepam; Female; Follow-Up Studies; Hospitalization; Humans; Lithium; Mi | 1991 |
Adjunctive clonazepam for maintenance treatment of bipolar affective disorder.
Topics: Adult; Bipolar Disorder; Clonazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1990 |
A case of mania secondary to hemodialysis: successful treatment with clonazepam.
Topics: Bipolar Disorder; Clonazepam; Humans; Kidney Failure, Chronic; Middle Aged; Neurocognitive Disorders | 1990 |
Clonazepam treatment of acute mania in an AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; Bipolar Disorder; Clonazepam; Female; Huma | 1990 |
Rapid cycling following antidepressant in an adolescent.
Topics: Adolescent; Bipolar Disorder; Clonazepam; Dibenzazepines; Drug Administration Schedule; Drug Therapy | 1990 |
Clonazepam in treatment of bipolar psychotic patients after discontinuation of neuroleptics.
Topics: Antipsychotic Agents; Bipolar Disorder; Clonazepam; Drug Administration Schedule; Humans; Research D | 1989 |
Clonazepam in the treatment of steroid-induced mania in a patient after renal transplantation.
Topics: Adult; Bipolar Disorder; Clonazepam; Humans; Kidney Transplantation; Male; Postoperative Complicatio | 1989 |
Clonazepam and lithium--a toxic combination in the treatment of mania?
Topics: Adult; Bipolar Disorder; Clonazepam; Female; Humans; Lithium; Male; Middle Aged; Nervous System; Syn | 1989 |
Mixed bipolar disorder responsive to lithium and clonazepam.
Topics: Benzodiazepinones; Bipolar Disorder; Clonazepam; Drug Therapy, Combination; Female; Humans; Lithium; | 1986 |
Clonazepam in the treatment of bipolar disorder in patients with non-lithium-induced renal insufficiency.
Topics: Bipolar Disorder; Clonazepam; Female; Humans; Kidney Diseases; Lithium; Lithium Carbonate; Middle Ag | 1987 |
Apparent complex partial seizures in a bipolar patient after withdrawal of carbamazepine.
Topics: Bipolar Disorder; Carbamazepine; Clonazepam; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Fem | 1988 |
Behavioral disinhibition with clonazepam.
Topics: Adult; Bipolar Disorder; Clonazepam; Humans; Inhibition, Psychological; Male; Personality Disorders | 1988 |
Clonazepam treatment of atypical bipolar disorder.
Topics: Bipolar Disorder; Clonazepam; Female; Humans; Male; Middle Aged | 1988 |
Clonazepam: an antidepressant?
Topics: Bipolar Disorder; Clonazepam; Depressive Disorder; Humans | 1987 |
Three case reports of behavioral disinhibition with clonazepam.
Topics: Adult; Aggression; Bipolar Disorder; Clonazepam; Humans; Inhibition, Psychological; Male | 1987 |
Sexual disinhibition on clonazepam.
Topics: Adult; Bipolar Disorder; Clonazepam; Female; Humans; Inhibition, Psychological; Male; Psychoses, Alc | 1987 |
Clonazepam in bipolar affective disorder.
Topics: Adult; Benzodiazepinones; Bipolar Disorder; Clonazepam; Female; Humans; Middle Aged | 1986 |
Use of clonazepam in two cases of acute mania.
Topics: Administration, Oral; Adult; Benzodiazepinones; Bipolar Disorder; Clonazepam; Humans; Male | 1985 |