clonazepam has been researched along with Ataxia in 14 studies
Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam." | 7.67 | Clonazepam monotherapy for epilepsy in childhood. ( Ishikawa, A; Kajii, N; Kohsaka, S; Nagashima, T; Sakuma, N, 1985) |
| "LY 300164 [7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4, 5H)-2,3-benzodiazepine], an antagonist of AMPA/kainate receptors, at 5 mg/kg exerted a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled seizures in rats." | 3.70 | Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J; Szadkowski, M, 1999) |
| "Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam." | 3.67 | Clonazepam monotherapy for epilepsy in childhood. ( Ishikawa, A; Kajii, N; Kohsaka, S; Nagashima, T; Sakuma, N, 1985) |
| "Since the emergence of coronavirus disease 2019 (COVID-19), neurological symptoms, syndromes, and complications associated with this multi-organ viral infection have been reported and the various aspects of neurological involvement are increasingly uncovered." | 2.72 | Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature. ( Aghavali, S; Babadi, M; Daraie, P; Emamikhah, M; Jalili, M; Mehrabani, M; Mohaghegh, F; Pouranian, M; Rohani, M; Zaribafian, M, 2021) |
| "Sedation and ataxia were the most common side effects reported, but these effects were mild and transient and did not interfere with treatment outcome." | 2.67 | Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder. ( Cohen, LS; Herman, JB; Otto, MW; Pollack, MH; Rosenbaum, JF; Sachs, GS; Spier, SA; Tesar, GE, 1991) |
| "Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset, X-linked genetic, neurodegenerative disorder caused by a "premutation (PM)" in the fragile X mental retardation 1 (FMR1) gene." | 2.66 | A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS. ( Li, H; Liu, Y; Wang, Y; Yue, Y; Zhang, B; Zhang, J; Zhao, C, 2020) |
| "A 23-year-old man had unilateral rubral tremors as a result of a midbrain lesion plus risperidone exposure for treatment of manic symptoms." | 1.35 | Unilateral rubral tremor following treatment with risperidone. ( Shen, YC, 2009) |
| "Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine." | 1.28 | Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991) |
| "Rotarod ataxia was quantitatively greater and of longer duration in aging animals." | 1.28 | Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals. ( Barnhill, JG; Gaver, A; Greenblatt, DJ; Harmatz, JS; Miller, LG; Shader, RI, 1990) |
| "No significant correlation with ataxia, BDZ radioligand binding, antipentylenetetrazol activity, or other BDZ property was found." | 1.28 | Benzodiazepine-induced shaking behavior in the rat: structure-activity and relation to serotonin and benzodiazepine receptors. ( Pranzatelli, MR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, C | 1 |
| Liu, Y | 1 |
| Wang, Y | 1 |
| Li, H | 1 |
| Zhang, B | 1 |
| Yue, Y | 1 |
| Zhang, J | 1 |
| Emamikhah, M | 1 |
| Babadi, M | 1 |
| Mehrabani, M | 1 |
| Jalili, M | 1 |
| Pouranian, M | 1 |
| Daraie, P | 1 |
| Mohaghegh, F | 1 |
| Aghavali, S | 1 |
| Zaribafian, M | 1 |
| Rohani, M | 1 |
| Shen, YC | 1 |
| Bhatia, KP | 1 |
| Brown, P | 1 |
| Gregory, R | 1 |
| Lennox, GG | 1 |
| Manji, H | 1 |
| Thompson, PD | 1 |
| Ellison, DW | 1 |
| Marsden, CD | 1 |
| Borowicz, KK | 1 |
| Luszczki, J | 1 |
| Szadkowski, M | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Lander, CM | 1 |
| Donnan, GA | 1 |
| Bladin, PF | 1 |
| Vajda, FJ | 1 |
| Shakir, RA | 1 |
| Nanda, RN | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Fazio, C | 1 |
| Manfredi, M | 1 |
| Piccinelli, A | 1 |
| Dolin, SJ | 1 |
| Patch, TL | 1 |
| Rabbani, M | 1 |
| Taberner, PV | 1 |
| Little, HJ | 1 |
| Tesar, GE | 1 |
| Rosenbaum, JF | 1 |
| Pollack, MH | 1 |
| Otto, MW | 1 |
| Sachs, GS | 1 |
| Herman, JB | 1 |
| Cohen, LS | 1 |
| Spier, SA | 1 |
| Barnhill, JG | 1 |
| Greenblatt, DJ | 1 |
| Miller, LG | 1 |
| Gaver, A | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Pranzatelli, MR | 1 |
| Ishikawa, A | 1 |
| Sakuma, N | 1 |
| Nagashima, T | 1 |
| Kohsaka, S | 1 |
| Kajii, N | 1 |
| Edwards, VE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Open Label Controlled Trial of Gluten-Free Diet in Patients With Gluten-Sensitivity and Cerebellar Ataxia[NCT00006492] | 150 participants | Observational | 2000-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for clonazepam and Ataxia
| Article | Year |
|---|---|
A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS.
Topics: Aged; Anticonvulsants; Ataxia; Brain; Clonazepam; Fragile X Syndrome; Humans; Magnetic Resonance Ima | 2020 |
Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature.
Topics: Adult; Anticonvulsants; Ataxia; Azithromycin; Clonazepam; Cough; COVID-19; COVID-19 Drug Treatment; | 2021 |
Progressive myoclonic ataxia associated with coeliac disease. The myoclonus is of cortical origin, but the pathology is in the cerebellum.
Topics: Adult; Aged; Ataxia; Celiac Disease; Cerebellum; Cerebral Cortex; Clonazepam; Electrophysiology; Fem | 1995 |
1 trial available for clonazepam and Ataxia
| Article | Year |
|---|---|
Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder.
Topics: Adult; Alprazolam; Anxiety Disorders; Ataxia; Clonazepam; Double-Blind Method; Female; Humans; Male; | 1991 |
10 other studies available for clonazepam and Ataxia
| Article | Year |
|---|---|
Unilateral rubral tremor following treatment with risperidone.
Topics: Anticonvulsants; Antipsychotic Agents; Ataxia; Behavior Therapy; Bipolar Disorder; Brain; Carbamazep | 2009 |
Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Benzodiazepines; Clonazepam; Drug Sy | 1999 |
Some aspects of the clinical use of clonazepam in refractory epilepsy.
Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
Treatment of epileptic seizures with clonazepam. A reappraisal.
Topics: Administration, Oral; Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Drug Administ | 1975 |
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1991 |
Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals.
Topics: Aging; Animals; Ataxia; Binding Sites; Brain; Chlorides; Clonazepam; Injections, Intraperitoneal; Ma | 1990 |
Benzodiazepine-induced shaking behavior in the rat: structure-activity and relation to serotonin and benzodiazepine receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ataxia; Behavior, Animal; Benzodiazepines; Body Tem | 1989 |
Clonazepam monotherapy for epilepsy in childhood.
Topics: Adolescent; Ataxia; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Electroencephalography; | 1985 |
Side effects of clonazepam therapy.
Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E | 1974 |