Page last updated: 2024-10-25

clonazepam and Ataxia

clonazepam has been researched along with Ataxia in 14 studies

Clonazepam: An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of GAMMA-AMINOBUTYRIC ACID receptor responses.
clonazepam : 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation.

Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.

Research Excerpts

ExcerptRelevanceReference
"Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam."7.67Clonazepam monotherapy for epilepsy in childhood. ( Ishikawa, A; Kajii, N; Kohsaka, S; Nagashima, T; Sakuma, N, 1985)
"LY 300164 [7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4, 5H)-2,3-benzodiazepine], an antagonist of AMPA/kainate receptors, at 5 mg/kg exerted a significant anticonvulsant effect, as regards seizure and afterdischarge durations in amygdala-kindled seizures in rats."3.70Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J; Szadkowski, M, 1999)
"Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam."3.67Clonazepam monotherapy for epilepsy in childhood. ( Ishikawa, A; Kajii, N; Kohsaka, S; Nagashima, T; Sakuma, N, 1985)
"Since the emergence of coronavirus disease 2019 (COVID-19), neurological symptoms, syndromes, and complications associated with this multi-organ viral infection have been reported and the various aspects of neurological involvement are increasingly uncovered."2.72Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature. ( Aghavali, S; Babadi, M; Daraie, P; Emamikhah, M; Jalili, M; Mehrabani, M; Mohaghegh, F; Pouranian, M; Rohani, M; Zaribafian, M, 2021)
"Sedation and ataxia were the most common side effects reported, but these effects were mild and transient and did not interfere with treatment outcome."2.67Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder. ( Cohen, LS; Herman, JB; Otto, MW; Pollack, MH; Rosenbaum, JF; Sachs, GS; Spier, SA; Tesar, GE, 1991)
"Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late onset, X-linked genetic, neurodegenerative disorder caused by a "premutation (PM)" in the fragile X mental retardation 1 (FMR1) gene."2.66A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS. ( Li, H; Liu, Y; Wang, Y; Yue, Y; Zhang, B; Zhang, J; Zhao, C, 2020)
"A 23-year-old man had unilateral rubral tremors as a result of a midbrain lesion plus risperidone exposure for treatment of manic symptoms."1.35Unilateral rubral tremor following treatment with risperidone. ( Shen, YC, 2009)
"Clonazepam did not produce anaesthesia, at doses up to 1 g kg-1 or when given with nitrendipine."1.28Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644. ( Dolin, SJ; Little, HJ; Patch, TL; Rabbani, M; Taberner, PV, 1991)
"Rotarod ataxia was quantitatively greater and of longer duration in aging animals."1.28Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals. ( Barnhill, JG; Gaver, A; Greenblatt, DJ; Harmatz, JS; Miller, LG; Shader, RI, 1990)
"No significant correlation with ataxia, BDZ radioligand binding, antipentylenetetrazol activity, or other BDZ property was found."1.28Benzodiazepine-induced shaking behavior in the rat: structure-activity and relation to serotonin and benzodiazepine receptors. ( Pranzatelli, MR, 1989)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19906 (42.86)18.7374
1990's5 (35.71)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Zhao, C1
Liu, Y1
Wang, Y1
Li, H1
Zhang, B1
Yue, Y1
Zhang, J1
Emamikhah, M1
Babadi, M1
Mehrabani, M1
Jalili, M1
Pouranian, M1
Daraie, P1
Mohaghegh, F1
Aghavali, S1
Zaribafian, M1
Rohani, M1
Shen, YC1
Bhatia, KP1
Brown, P1
Gregory, R1
Lennox, GG1
Manji, H1
Thompson, PD1
Ellison, DW1
Marsden, CD1
Borowicz, KK1
Luszczki, J1
Szadkowski, M1
Kleinrok, Z1
Czuczwar, SJ1
Lander, CM1
Donnan, GA1
Bladin, PF1
Vajda, FJ1
Shakir, RA1
Nanda, RN1
Lambie, DG1
Johnson, RH1
Fazio, C1
Manfredi, M1
Piccinelli, A1
Dolin, SJ1
Patch, TL1
Rabbani, M1
Taberner, PV1
Little, HJ1
Tesar, GE1
Rosenbaum, JF1
Pollack, MH1
Otto, MW1
Sachs, GS1
Herman, JB1
Cohen, LS1
Spier, SA1
Barnhill, JG1
Greenblatt, DJ1
Miller, LG1
Gaver, A1
Harmatz, JS1
Shader, RI1
Pranzatelli, MR1
Ishikawa, A1
Sakuma, N1
Nagashima, T1
Kohsaka, S1
Kajii, N1
Edwards, VE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open Label Controlled Trial of Gluten-Free Diet in Patients With Gluten-Sensitivity and Cerebellar Ataxia[NCT00006492]150 participants Observational2000-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for clonazepam and Ataxia

ArticleYear
A Chinese case of fragile X-associated tremor/ataxia syndrome (FXTAS) with orthostatic tremor:case report and literature review on tremor in FXTAS.
    BMC neurology, 2020, Apr-20, Volume: 20, Issue:1

    Topics: Aged; Anticonvulsants; Ataxia; Brain; Clonazepam; Fragile X Syndrome; Humans; Magnetic Resonance Ima

2020
Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature.
    Journal of neurovirology, 2021, Volume: 27, Issue:1

    Topics: Adult; Anticonvulsants; Ataxia; Azithromycin; Clonazepam; Cough; COVID-19; COVID-19 Drug Treatment;

2021
Progressive myoclonic ataxia associated with coeliac disease. The myoclonus is of cortical origin, but the pathology is in the cerebellum.
    Brain : a journal of neurology, 1995, Volume: 118 ( Pt 5)

    Topics: Adult; Aged; Ataxia; Celiac Disease; Cerebellum; Cerebral Cortex; Clonazepam; Electrophysiology; Fem

1995

Trials

1 trial available for clonazepam and Ataxia

ArticleYear
Double-blind, placebo-controlled comparison of clonazepam and alprazolam for panic disorder.
    The Journal of clinical psychiatry, 1991, Volume: 52, Issue:2

    Topics: Adult; Alprazolam; Anxiety Disorders; Ataxia; Clonazepam; Double-Blind Method; Female; Humans; Male;

1991

Other Studies

10 other studies available for clonazepam and Ataxia

ArticleYear
Unilateral rubral tremor following treatment with risperidone.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 2

    Topics: Anticonvulsants; Antipsychotic Agents; Ataxia; Behavior Therapy; Bipolar Disorder; Brain; Carbamazep

2009
Influence of LY 300164, an antagonist of AMPA/kainate receptors, on the anticonvulsant activity of clonazepam.
    European journal of pharmacology, 1999, Sep-10, Volume: 380, Issue:2-3

    Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Avoidance Learning; Benzodiazepines; Clonazepam; Drug Sy

1999
Some aspects of the clinical use of clonazepam in refractory epilepsy.
    Clinical and experimental neurology, 1979, Volume: 16

    Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati

1979
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
    Archives of neurology, 1979, Volume: 36, Issue:5

    Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy;

1979
Treatment of epileptic seizures with clonazepam. A reappraisal.
    Archives of neurology, 1975, Volume: 32, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Drug Administ

1975
Differential interactions between benzodiazepines and the dihydropyridines, nitrendipine and Bay K 8644.
    Neuropharmacology, 1991, Volume: 30, Issue:3

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1991
Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:3

    Topics: Aging; Animals; Ataxia; Binding Sites; Brain; Chlorides; Clonazepam; Injections, Intraperitoneal; Ma

1990
Benzodiazepine-induced shaking behavior in the rat: structure-activity and relation to serotonin and benzodiazepine receptors.
    Experimental neurology, 1989, Volume: 104, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Ataxia; Behavior, Animal; Benzodiazepines; Body Tem

1989
Clonazepam monotherapy for epilepsy in childhood.
    Brain & development, 1985, Volume: 7, Issue:6

    Topics: Adolescent; Ataxia; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Electroencephalography;

1985
Side effects of clonazepam therapy.
    Proceedings of the Australian Association of Neurologists, 1974, Volume: 11

    Topics: Adolescent; Adult; Aggression; Ataxia; Benzodiazepinones; Clonazepam; Drug Interactions; Epilepsy; E

1974